| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiang Gao, Lili Fu, Min Xiao, Chenggang Xu, Lijun Sun, Tong Zhang, Feng Zheng, Changlin Me. The nephroprotective effect of tauroursodeoxycholic acid on ischaemia/reperfusion-induced acute kidney injury by inhibiting endoplasmic reticulum stress. Basic & clinical pharmacology & toxicology. vol 111. issue 1. 2012-10-18. PMID:22212133. |
in conclusion, tudca had a nephroprotective effect on ir-induced aki by inhibiting ers and by blocking grp78 and chop expression, reducing caspase 12 activation and inhibiting cell apoptosis. |
2012-10-18 |
2023-08-12 |
mouse |
| Yoshifumi Sato, Mitsutoki Hatta, Md Fazlul Karim, Tomohiro Sawa, Fan-Yan Wei, Shoki Sato, Mark A Magnuson, Frank J Gonzalez, Kazuhito Tomizawa, Takaaki Akaike, Tatsuya Yoshizawa, Kazuya Yamagat. Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells. The Journal of biological chemistry. vol 287. issue 27. 2012-09-11. PMID:22589549. |
anks4b, a novel target of hnf4α protein, interacts with grp78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells. |
2012-09-11 |
2023-08-12 |
Not clear |
| Yoshifumi Sato, Mitsutoki Hatta, Md Fazlul Karim, Tomohiro Sawa, Fan-Yan Wei, Shoki Sato, Mark A Magnuson, Frank J Gonzalez, Kazuhito Tomizawa, Takaaki Akaike, Tatsuya Yoshizawa, Kazuya Yamagat. Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells. The Journal of biological chemistry. vol 287. issue 27. 2012-09-11. PMID:22589549. |
anks4b bound to glucose-regulated protein 78 (grp78), a major endoplasmic reticulum (er) chaperone protein, and overexpression of anks4b enhanced the er stress response and er stress-associated apoptosis of min6 cells. |
2012-09-11 |
2023-08-12 |
Not clear |
| Katherine L Cook, Ayesha N Shajahan, Anni Wärri, Lu Jin, Leena A Hilakivi-Clarke, Robert Clark. Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness. Cancer research. vol 72. issue 13. 2012-09-10. PMID:22752300. |
mechanistically, grp78 integrated multiple cellular signaling pathways to inhibit apoptosis and stimulate prosurvival autophagy, which was dependent on tsc2/ampk-mediated mtor inhibition but not on beclin-1. |
2012-09-10 |
2023-08-12 |
human |
| Katherine L Cook, Ayesha N Shajahan, Anni Wärri, Lu Jin, Leena A Hilakivi-Clarke, Robert Clark. Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness. Cancer research. vol 72. issue 13. 2012-09-10. PMID:22752300. |
together, our findings reveal a novel role for grp78 in the integration of cellular signaling pathways including the unfolded protein response, apoptosis, and autophagy to determine cell fate in response to antiestrogen therapy. |
2012-09-10 |
2023-08-12 |
human |
| Yufeng Jiang, Hailong Lv, Min Liao, Xiaoyuan Xu, Shanshan Huang, Huiping Tan, Ting Peng, Yinong Zhang, He L. GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins. Neuroscience letters. vol 516. issue 2. 2012-09-04. PMID:22490889. |
the er-localized chaperone glucose-regulated protein (grp78) protects neurons against excitotoxicity and apoptosis. |
2012-09-04 |
2023-08-12 |
Not clear |
| Qing Sun, Jun Hua, Qi Wang, Wei Xu, Jiaxing Zhang, Jun Zhang, Jiuhong Kang, Maoquan L. Expressions of GRP78 and Bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer. Molecular biology reports. vol 39. issue 6. 2012-08-13. PMID:22297694. |
expressions of grp78 and bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer. |
2012-08-13 |
2023-08-12 |
human |
| Qing Sun, Jun Hua, Qi Wang, Wei Xu, Jiaxing Zhang, Jun Zhang, Jiuhong Kang, Maoquan L. Expressions of GRP78 and Bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer. Molecular biology reports. vol 39. issue 6. 2012-08-13. PMID:22297694. |
the purpose of this study was to detect the expressions of grp78 and bax in human non-small cell lung cancer (nsclc) tissues, to analyze their correlations with carcinogenesis and the development of nsclc, and to investigate the relationship of grp78 expression to metastasis and apoptosis in the nsclc cell line hcc827. |
2012-08-13 |
2023-08-12 |
human |
| Qing Sun, Jun Hua, Qi Wang, Wei Xu, Jiaxing Zhang, Jun Zhang, Jiuhong Kang, Maoquan L. Expressions of GRP78 and Bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer. Molecular biology reports. vol 39. issue 6. 2012-08-13. PMID:22297694. |
grp78 expression with sirna interference in the human nsclc cell line hcc827 can reduce metastasis and promote apoptosis in hcc827 cells. |
2012-08-13 |
2023-08-12 |
human |
| Kuo-How Huang, Kuan-Lin Kuo, Shyh-Chyan Chen, Te-I Weng, Yuan-Ting Chuang, Yu-Chieh Tsai, Yeong-Shiau Pu, Chih-Kang Chiang, Shing-Hwa Li. Down-regulation of glucose-regulated protein (GRP) 78 potentiates cytotoxic effect of celecoxib in human urothelial carcinoma cells. PloS one. vol 7. issue 3. 2012-08-13. PMID:22438966. |
celecoxib possessed the ability to activate er stress-related chaperones (ire-1α and grp78), caspase-4, and ccaat/enhancer binding protein homologous protein (chop), which were involved in uc cell apoptosis. |
2012-08-13 |
2023-08-12 |
human |
| Kuo-How Huang, Kuan-Lin Kuo, Shyh-Chyan Chen, Te-I Weng, Yuan-Ting Chuang, Yu-Chieh Tsai, Yeong-Shiau Pu, Chih-Kang Chiang, Shing-Hwa Li. Down-regulation of glucose-regulated protein (GRP) 78 potentiates cytotoxic effect of celecoxib in human urothelial carcinoma cells. PloS one. vol 7. issue 3. 2012-08-13. PMID:22438966. |
down-regulation of grp78 by sirna, co-treatment with egcg (a grp78 inhibitor) or with mg132 (a proteasome inhibitor) could enhance celecoxib-induced apoptosis. |
2012-08-13 |
2023-08-12 |
human |
| Rosa Martín-Pérez, Maho Niwa, Abelardo López-Riva. ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2. Apoptosis : an international journal on programmed cell death. vol 17. issue 4. 2012-07-30. PMID:22072062. |
in addition, glucose-regulated protein of 78 kda (grp78) knockdown by rna interference induces er stress and facilitates apoptosis by trail. |
2012-07-30 |
2023-08-12 |
Not clear |
| Jeong Han Kang, Young-Chae Chang, Michael R Mauriz. 4-O-carboxymethyl ascochlorin causes ER stress and induced autophagy in human hepatocellular carcinoma cells. The Journal of biological chemistry. vol 287. issue 19. 2012-07-30. PMID:22433868. |
3-ma also blocked induction of grp78 and chop, suggesting that pi3-kinase, which is known to mediate er stress-induced autophagy, also plays a role in initiating apoptosis in response to er stress. |
2012-07-30 |
2023-08-12 |
mouse |
| Nitza Goldenberg-Cohen, Annat Raiter, Vera Gaydar, Olga Dratviman-Storobinsky, Tamar Goldstein, Abraham Weizman, Britta Hard. Peptide-binding GRP78 protects neurons from hypoxia-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 17. issue 3. 2012-06-18. PMID:22120956. |
peptide-binding grp78 protects neurons from hypoxia-induced apoptosis. |
2012-06-18 |
2023-08-12 |
mouse |
| Seung-Ah Yoo, Sungyong You, Hyung-Ju Yoon, Dong-Ho Kim, Hyun-Sook Kim, Kyungho Lee, Jin Hee Ahn, Daehee Hwang, Amy S Lee, Ki-Jo Kim, Yune-Jung Park, Chul-Soo Cho, Wan-Uk Ki. A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis. The Journal of experimental medicine. vol 209. issue 4. 2012-06-04. PMID:22430489. |
down-regulation of grp78 transcripts increased the apoptosis of ra synoviocytes while abolishing tnf- or tgf-β-induced synoviocyte proliferation and cyclin d1 up-regulation. |
2012-06-04 |
2023-08-12 |
mouse |
| Seung-Ah Yoo, Sungyong You, Hyung-Ju Yoon, Dong-Ho Kim, Hyun-Sook Kim, Kyungho Lee, Jin Hee Ahn, Daehee Hwang, Amy S Lee, Ki-Jo Kim, Yune-Jung Park, Chul-Soo Cho, Wan-Uk Ki. A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis. The Journal of experimental medicine. vol 209. issue 4. 2012-06-04. PMID:22430489. |
conversely, overexpression of the grp78 gene prevented synoviocyte apoptosis. |
2012-06-04 |
2023-08-12 |
mouse |
| Kenji Kuroda, Akio Horiguchi, Takako Asano, Keiichi Ito, Junichi Asakuma, Akinori Sato, Hidehiko Yoshii, Masamichi Hayakawa, Makoto Sumitomo, Tomohiko Asan. Glucose-regulated protein 78 positivity as a predictor of poor survival in patients with renal cell carcinoma. Urologia internationalis. vol 87. issue 4. 2012-04-27. PMID:22076227. |
glucose-regulated protein 78 (grp78), a chaperone for newly formed proteins during folding and glycosylation, is associated with resistance to apoptosis in some forms of cancer. |
2012-04-27 |
2023-08-12 |
Not clear |
| Hui Wang, Yan Ye, Jian-Hong Chu, Guo-Yuan Zhu, Wang-Fun Fong, Zhi-Ling Y. Proteomic and functional analyses reveal the potential involvement of endoplasmic reticulum stress and α-CP1 in the anticancer activities of oridonin in HepG2 cells. Integrative cancer therapies. vol 10. issue 2. 2012-04-16. PMID:20926737. |
treatment with 40 μm oridonin for 24 hours induced apoptosis determined by nuclear morphologic changes of dapi-stained cells and flow cytometric analysis of annexin v-fitc/pi-stained cells, which was accompanied by grp78 upregulation and α-cp1 downregulation identified by proteomic analysis. |
2012-04-16 |
2023-08-12 |
Not clear |
| Wei Ding, Lei Yang, Minmin Zhang, Yong G. Reactive oxygen species-mediated endoplasmic reticulum stress contributes to aldosterone-induced apoptosis in tubular epithelial cells. Biochemical and biophysical research communications. vol 418. issue 3. 2012-04-11. PMID:22281495. |
aldo promoted tubular epithelial cell apoptosis, increased intracellular ros production and induced er stress, as evidenced by increased expression of glucose-regulated protein 78 (grp78) and caat/enhancer-binding protein homologous protein (chop) in a dose- and time-dependent manner. |
2012-04-11 |
2023-08-12 |
Not clear |
| Xiangming Sun, Xiaodong Huo, Ting Luo, Minjing Li, Yancun Yin, Yangfu Jian. The anticancer flavonoid chrysin induces the unfolded protein response in hepatoma cells. Journal of cellular and molecular medicine. vol 15. issue 11. 2012-04-10. PMID:21199322. |
grp78 knockdown potentiates chrysin-induced caspase-7 cleavage in hepatoma cells and enhances chrysin-induced apoptosis. |
2012-04-10 |
2023-08-12 |
Not clear |