| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Martin, H K Lamb, C Brady, B Lefkove, M Y Bonner, P Thompson, P E Lovat, J L Arbiser, A R Hawkins, C P F Redfer. Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78. British journal of cancer. vol 109. issue 2. 2013-10-17. PMID:23807168. |
inducing apoptosis of cancer cells using small-molecule plant compounds that bind to grp78. |
2013-10-17 |
2023-08-12 |
Not clear |
| Michael Thornton, Mohammed A Aslam, Elizabeth M Tweedle, Chin Ang, Fiona Campbell, Richard Jackson, Eithne Costello, Paul S Rooney, Nikolina Vlatković, Mark T Boy. The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer. International journal of cancer. vol 133. issue 6. 2013-09-12. PMID:23456958. |
in vitro, inhibition of grp78 reduces apoptosis in response to 5-fu in p53 wild-type cells. |
2013-09-12 |
2023-08-12 |
Not clear |
| Kun Shi, Daode Wang, Xiaojian Cao, Yingbin G. Endoplasmic reticulum stress signaling is involved in mitomycin C (MMC)-induced apoptosis in human fibroblasts via PERK pathway. PloS one. vol 8. issue 3. 2013-09-11. PMID:23533616. |
mmc-induced apoptosis was correlated with elevation of 78-kda glucose-regulated protein (grp78) and c/ebp homologous protein (chop), which are hallmarks of er stress. |
2013-09-11 |
2023-08-12 |
human |
| Cun Wang, Kai Jiang, Dongmei Gao, Xiaonan Kang, Chun Sun, Qinle Zhang, Yan Li, Lu Sun, Shu Zhang, Kun Guo, Yinkun Li. Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78. PloS one. vol 8. issue 2. 2013-08-26. PMID:23457489. |
clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through grp78. |
2013-08-26 |
2023-08-12 |
Not clear |
| Cun Wang, Kai Jiang, Dongmei Gao, Xiaonan Kang, Chun Sun, Qinle Zhang, Yan Li, Lu Sun, Shu Zhang, Kun Guo, Yinkun Li. Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78. PloS one. vol 8. issue 2. 2013-08-26. PMID:23457489. |
knockdown of clu expression in smmc7721 and hcclm3 cells inhibited grp78 expression after tn treatment and enhanced er stress-induced apoptosis, whereas over-expression of clu in hepg2 cells increased grp78 expression after tn induction and abolished the effect of tn on cell apoptosis. |
2013-08-26 |
2023-08-12 |
Not clear |
| Cun Wang, Kai Jiang, Dongmei Gao, Xiaonan Kang, Chun Sun, Qinle Zhang, Yan Li, Lu Sun, Shu Zhang, Kun Guo, Yinkun Li. Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78. PloS one. vol 8. issue 2. 2013-08-26. PMID:23457489. |
the effect of clu knockdown on grp78 expression and cell apoptosis in hcc tumors were further determined in orthotopic xenograft tumor model. |
2013-08-26 |
2023-08-12 |
Not clear |
| Cun Wang, Kai Jiang, Dongmei Gao, Xiaonan Kang, Chun Sun, Qinle Zhang, Yan Li, Lu Sun, Shu Zhang, Kun Guo, Yinkun Li. Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78. PloS one. vol 8. issue 2. 2013-08-26. PMID:23457489. |
taken together, these findings reveal that clu protects hcc cells from er stress induced apoptosis at least partially through interacting with grp78. |
2013-08-26 |
2023-08-12 |
Not clear |
| Xiaojie Liu, Mingshan Wang, Huailong Chen, Yunliang Guo, Fuguo Ma, Fei Shi, Yanlin Bi, Ying L. Hypothermia protects the brain from transient global ischemia/reperfusion by attenuating endoplasmic reticulum response-induced apoptosis through CHOP. PloS one. vol 8. issue 1. 2013-08-20. PMID:23301071. |
the results showed that hypothermia significantly attenuated brain i/r injury, as shown by reduction in cell apoptosis, chop expression, and increase in grp78 expression. |
2013-08-20 |
2023-08-12 |
rat |
| YuZhen Li, ZhenRong Lv, XiuHua Liu, WenTing Su, Chen Wang, Nana Li, Dandan Song, Tianqi Ta. Hypoxic postconditioning inhibits endoplasmic reticulum stress-mediated cardiomyocyte apoptosis by targeting PUMA. Shock (Augusta, Ga.). vol 39. issue 3. 2013-07-30. PMID:23364433. |
our results demonstrated that postconditioning could inhibit grp78 (78-kda glucose-regulated protein) expression, caspase-12 activation, and cardiomyocyte apoptosis by regulating puma expression. |
2013-07-30 |
2023-08-12 |
Not clear |
| Jinghua Yang, Qiufang Liu, Shengwen Wu, Qi Xi, Yuan Ca. Effects of lanthanum chloride on glutamate level, intracellular calcium concentration and caspases expression in the rat hippocampus. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 26. issue 1. 2013-07-12. PMID:23097080. |
besides, lacl(3) exposure increased grp78, grp94, gadd153 and p-jnk expression, promoted the activation of caspase-3, caspase-9 and caspase-12, induced parp cleavage and caused excessive apoptosis. |
2013-07-12 |
2023-08-12 |
rat |
| N Li, A Zoubeidi, E Beraldi, M E Gleav. GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer. Oncogene. vol 32. issue 15. 2013-06-19. PMID:22689054. |
moreover, subcellular fractionation and confocal microscopy with clugfp indicated that grp78 increased stress-induced clu retrotranslocation from the er with co-localized redistribution to the mitochondria, thereby reducing stress-induced apoptosis by cooperatively stabilizing mitochondrial membrane integrity. |
2013-06-19 |
2023-08-12 |
human |
| N Li, A Zoubeidi, E Beraldi, M E Gleav. GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer. Oncogene. vol 32. issue 15. 2013-06-19. PMID:22689054. |
grp78 silencing reduced clu protein, but not mrna levels, and enhanced paclitaxel-induced cell apoptosis. |
2013-06-19 |
2023-08-12 |
human |
| Mehdi Hammadi, Agathe Oulidi, Florian Gackière, Maria Katsogiannou, Christian Slomianny, Morad Roudbaraki, Etienne Dewailly, Philippe Delcourt, Gilbert Lepage, Sabine Lotteau, Sylvie Ducreux, Natalia Prevarskaya, Fabien Van Coppenoll. Modulation of ER stress and apoptosis by endoplasmic reticulum calcium leak via translocon during unfolded protein response: involvement of GRP78. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 4. 2013-06-17. PMID:23322163. |
modulation of er stress and apoptosis by endoplasmic reticulum calcium leak via translocon during unfolded protein response: involvement of grp78. |
2013-06-17 |
2023-08-12 |
Not clear |
| Ling-Fei Wu, Bi-Liu Wei, Yi-Tian Guo, Yan-Qing Ye, Guo-Ping Li, Ze-Jin Pu, Jia-Lin Fen. Apoptosis induced by adenosine involves endoplasmic reticulum stress in EC109 cells. International journal of molecular medicine. vol 30. issue 4. 2013-05-24. PMID:22859272. |
this is the first demonstration that adenosine inhibits cell proliferation, increases grp78 and nf-κb p65 expression and induces apoptosis by chop and caspase-4 pathways. |
2013-05-24 |
2023-08-12 |
Not clear |
| Qi Shi, Xiao-Ping Don. (Ctm)PrP and ER stress: a neurotoxic mechanism of some special PrP mutants. Prion. vol 5. issue 3. 2013-04-11. PMID:21795854. |
the retention of the ctmprp in er subsequently is able to induce er stress and apoptosis, which is supported by up-regulation of er chaperone synthesis, such as grp78, grp58, grp94, bip and the transcription factor chop/gadd153. |
2013-04-11 |
2023-08-12 |
mouse |
| Joanna DeSalvo, Jeffim N Kuznetsov, Jianfeng Du, Gilles M Leclerc, Guy J Leclerc, Theodore J Lampidis, Julio C Barred. Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia. Molecular cancer research : MCR. vol 10. issue 7. 2013-04-04. PMID:22692960. |
2-dg-treated all cells exhibit upregulation of p-ampk, p-akt, and induction of er stress/upr markers (ire1α, grp78, p-eif2α, and chop), which correlate with parp cleavage and apoptosis. |
2013-04-04 |
2023-08-12 |
Not clear |
| Ravshan Burikhanov, Tripti Shrestha-Bhattarai, Shirley Qiu, Nidhi Shukla, Nikhil Hebbar, Subodh M Lele, Craig Horbinski, Vivek M Rangneka. Novel mechanism of apoptosis resistance in cancer mediated by extracellular PAR-4. Cancer research. vol 73. issue 2. 2013-03-26. PMID:23204231. |
in this study, we describe a novel mechanism of antiapoptosis by nf-κb, revealing that it can block par-4-mediated apoptosis by downregulating trafficking of the par-4 receptor grp78 from the endoplasmic reticulum to the cell surface. |
2013-03-26 |
2023-08-12 |
Not clear |
| Ravshan Burikhanov, Tripti Shrestha-Bhattarai, Shirley Qiu, Nidhi Shukla, Nikhil Hebbar, Subodh M Lele, Craig Horbinski, Vivek M Rangneka. Novel mechanism of apoptosis resistance in cancer mediated by extracellular PAR-4. Cancer research. vol 73. issue 2. 2013-03-26. PMID:23204231. |
this pathway of antiapoptosis could be inhibited by suppressing levels of nf-κb or uaca expression, which enhanced endoplasmic reticulum stress and restored grp78 trafficking to the cell surface, thereby sensitizing cancer cells to apoptosis by extracellular par-4 or grp78 agonistic antibody. |
2013-03-26 |
2023-08-12 |
Not clear |
| Ravshan Burikhanov, Tripti Shrestha-Bhattarai, Shirley Qiu, Nidhi Shukla, Nikhil Hebbar, Subodh M Lele, Craig Horbinski, Vivek M Rangneka. Novel mechanism of apoptosis resistance in cancer mediated by extracellular PAR-4. Cancer research. vol 73. issue 2. 2013-03-26. PMID:23204231. |
in summary, our results identify a novel intracellular pathway of apoptosis mediated by nf-κb through uaca elevation, which by attenuating endoplasmic reticulum stress and grp78 translocation to the cell surface can blunt the sensitivity of cancer cells to apoptosis. |
2013-03-26 |
2023-08-12 |
Not clear |
| Zongwei Li, Zhuoyu L. Glucose regulated protein 78: a critical link between tumor microenvironment and cancer hallmarks. Biochimica et biophysica acta. vol 1826. issue 1. 2013-03-12. PMID:22426159. |
grp78 is implicated in tumor cell proliferation, apoptosis resistance, immune escape, metastasis and angiogenesis, and its elevated expression usually correlates with a variety of tumor microenvironmental stresses, including hypoxia, glucose deprivation, lactic acidosis and inflammatory response. |
2013-03-12 |
2023-08-12 |
Not clear |