| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zachary Rosenes, Terrence D Mulhern, Danny M Hatters, Leodevico L Ilag, Barbara E Power, Chris Hosking, Frank Hensel, Geoffrey J Howlett, Yee-Foong Mo. The anti-cancer IgM monoclonal antibody PAT-SM6 binds with high avidity to the unfolded protein response regulator GRP78. PloS one. vol 7. issue 9. 2013-03-05. PMID:23028685. |
we propose that the biological action of pat-sm6 in tumour cell apoptosis may depend on the multivalent nature of pat-sm6 and the high avidity of its interaction with multiple grp78 molecules clustered on the tumour cell surface. |
2013-03-05 |
2023-08-12 |
human |
| Yan-Ping Cao, Yong-Mei Hao, Qing-Juan Liu, Jian Wang, Hang Li, Hui-Jun Dua. [The relationship between endoplasmic reticulum stress and its particular apoptosis way caspase-12 and apoptosis in renal cortex of diabetic rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 27. issue 2. 2013-02-21. PMID:21845883. |
to investigate the expressions of 78-kda glucose-regulated protein (grp78) and caspase-12 and their relationship with apoptosis in renal cortex of diabetic rats. |
2013-02-21 |
2023-08-12 |
rat |
| Tzu-Rong Su, Feng-Jen Tsai, Jen-Jie Lin, Han Hsiang Huang, Chien-Chih Chiu, Jui-Hsin Su, Ya-Ting Yang, Jeff Yi-Fu Chen, Bing-Sang Wong, Yu-Jen W. Induction of apoptosis by 11-dehydrosinulariolide via mitochondrial dysregulation and ER stress pathways in human melanoma cells. Marine drugs. vol 10. issue 8. 2013-02-20. PMID:23015779. |
immunoblotting data displayed up-regulations of perk/eif2α/atf4/chop and atf6/chop coupling with elevation of er stress chaperones grp78, grp94, calnexin, calreticulin and pdi, implicating the involvement of these factors in er stress-mediated apoptosis induced by 11-dehydrosinulariolide. |
2013-02-20 |
2023-08-12 |
human |
| Dah-Yuu Lu, Chih-Shiang Chang, Wei-Lan Yeh, Chih-Hsin Tang, Chi-Wai Cheung, Yuk-Man Leung, Ju-Fang Liu, Kar-Lok Won. The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 19. issue 12. 2013-01-22. PMID:22819448. |
taken together, the present study provides evidences to support that ros generation, grp78 and chop activation are mediating the bfp-induced human glioma cell apoptosis. |
2013-01-22 |
2023-08-12 |
human |
| Marcela Gimenez, Suely K N Marie, Sueli M Oba-Shinjo, Miyuki Uno, Roseli da Silva, Helen Julie Laure, Clarice Izumi, Andreia Otake, Roger Chammas, Jose Cesar Ros. Quantitative proteomic analysis and functional studies reveal that nucleophosmin is involved in cell death in glioblastoma cell line transfected with siRNA. Proteomics. vol 12. issue 17. 2013-01-08. PMID:22745010. |
gene ontology assigned most of the hypoexpressed proteins to apoptosis regulation, including grp78. |
2013-01-08 |
2023-08-12 |
Not clear |
| Somasundaram Arumugam, Rajarajan A Thandavarayan, Punniyakoti T Veeraveedu, Takashi Nakamura, Wawaimuli Arozal, Flori R Sari, Vijayasree V Giridharan, Vivian Soetikno, Suresh S Palaniyandi, Meilei Harima, Kenji Suzuki, Masaki Nagata, Makoto Kodama, Kenichi Watanab. Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy. Journal of cellular and molecular medicine. vol 16. issue 9. 2013-01-07. PMID:22268705. |
left ventricular (lv) expression of nadph oxidase subunits (p47(phox), p67(phox), gp91(phox) and nox4), fibrosis markers (tgf-β(1) and opn), endoplasmic reticulum (er) stress markers (grp78 and gadd 153) and apoptosis markers (cytochrome c and caspase-3) were measured by western blotting. |
2013-01-07 |
2023-08-12 |
rat |
| Yu Ou, Zhijun Yuan, Kepeng Li, Xuegan Yan. Phycocyanin may suppress D-galactose-induced human lens epithelial cell apoptosis through mitochondrial and unfolded protein response pathways. Toxicology letters. vol 215. issue 1. 2012-12-31. PMID:23036742. |
the results demonstrated that phycocyanin suppressed sra01/04 cells' morphologic changes and apoptosis induced by d-galactose, inhibited the expression and activation of caspase 3, alternated the bax/bcl-2 ratio, and down-regulated the level of p53, grp78, and chop in d-galactose-treated sra01/04 cells. |
2012-12-31 |
2023-08-12 |
human |
| Yu Ou, Zhijun Yuan, Kepeng Li, Xuegan Yan. Phycocyanin may suppress D-galactose-induced human lens epithelial cell apoptosis through mitochondrial and unfolded protein response pathways. Toxicology letters. vol 215. issue 1. 2012-12-31. PMID:23036742. |
these results suggest that phycocyanin might suppress d-galactose-induced hlec apoptosis through two pathways: mitochondrial pathway, involving p53 and bcl-2 family protein expression, and unfolded protein response pathway, involving grp78 and chop expression. |
2012-12-31 |
2023-08-12 |
human |
| Yong Liu, Zong-Guang Zhou, Ke-Ling Chen, Bing Zhou, Lie Yang, Hui Yan, Yuan L. The ER chaperone GRP78 is associated with the severity of cerulein-induced pancreatic inflammation via regulating apoptosis of pancreatic acinar cells. Hepato-gastroenterology. vol 59. issue 118. 2012-12-11. PMID:22640899. |
the er chaperone grp78 is associated with the severity of cerulein-induced pancreatic inflammation via regulating apoptosis of pancreatic acinar cells. |
2012-12-11 |
2023-08-12 |
Not clear |
| Yu-Jia Chang, Yi-Ping Huang, Zih-Ling Li, Ching-Hsein Che. GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells. PloS one. vol 7. issue 4. 2012-11-19. PMID:22529978. |
grp78 knockdown enhances apoptosis via the down-regulation of oxidative stress and akt pathway after epirubicin treatment in colon cancer dld-1 cells. |
2012-11-19 |
2023-08-12 |
Not clear |
| Elena Fasano, Simona Serini, Elisabetta Piccioni, Amelia Toesca, Giovanni Monego, Achille R Cittadini, Franco O Ranelletti, Gabriella Calviell. DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. Biochimica et biophysica acta. vol 1822. issue 11. 2012-11-13. PMID:22898250. |
dha induces apoptosis by altering the expression and cellular location of grp78 in colon cancer cell lines. |
2012-11-13 |
2023-08-12 |
Not clear |
| Elena Fasano, Simona Serini, Elisabetta Piccioni, Amelia Toesca, Giovanni Monego, Achille R Cittadini, Franco O Ranelletti, Gabriella Calviell. DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. Biochimica et biophysica acta. vol 1822. issue 11. 2012-11-13. PMID:22898250. |
dha treatment induced apoptosis in three colon cancer cell lines (ht-29, hct116 and sw480), and inhibited their total and surface grp78 expression. |
2012-11-13 |
2023-08-12 |
Not clear |
| Elena Fasano, Simona Serini, Elisabetta Piccioni, Amelia Toesca, Giovanni Monego, Achille R Cittadini, Franco O Ranelletti, Gabriella Calviell. DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. Biochimica et biophysica acta. vol 1822. issue 11. 2012-11-13. PMID:22898250. |
the cell ability to undergo dha-induced apoptosis was inversely related to their level of grp78 expression. |
2012-11-13 |
2023-08-12 |
Not clear |
| Elena Fasano, Simona Serini, Elisabetta Piccioni, Amelia Toesca, Giovanni Monego, Achille R Cittadini, Franco O Ranelletti, Gabriella Calviell. DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. Biochimica et biophysica acta. vol 1822. issue 11. 2012-11-13. PMID:22898250. |
the transfection of the low grp78-expressing sw480 cells with grp78-gfp cdna significantly induced cell growth and inhibited the dha-driven apoptosis, thus supporting the essential role of grp78 in dha pro-apoptotic effect. |
2012-11-13 |
2023-08-12 |
Not clear |
| H R Jin, J Zhao, Z Zhang, Y Liao, C-Z Wang, W-H Huang, S-P Li, T-C He, C-S Yuan, W D. The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress. Cell death & disease. vol 3. 2012-11-08. PMID:22914324. |
decreasing the level of er stress, either by overexpressing the er chaperone protein glucose-regulated protein 78 (grp78) or by knockout of components of the upr pathway, reduces fad-induced apoptosis. |
2012-11-08 |
2023-08-12 |
Not clear |
| H R Jin, J Zhao, Z Zhang, Y Liao, C-Z Wang, W-H Huang, S-P Li, T-C He, C-S Yuan, W D. The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress. Cell death & disease. vol 3. 2012-11-08. PMID:22914324. |
in contrast, increasing the level of er stress by knocking down grp78 potentiates fad-induced apoptosis. |
2012-11-08 |
2023-08-12 |
Not clear |
| Chao Li, Aki Harada, Youngman O. IGFBP-3 sensitizes antiestrogen-resistant breast cancer cells through interaction with GRP78. Cancer letters. vol 325. issue 2. 2012-11-07. PMID:22801219. |
overexpression of igfbp-3 in antiestrogen-resistant lcc9 cells showed that igfbp-3 interacted with grp78, resulting in disruption of the grp78-caspase-7 complex, thereby activating caspase-7, and further inducing apoptosis. |
2012-11-07 |
2023-08-12 |
human |
| Nikhil Hebbar, Chi Wang, Vivek M Rangneka. Mechanisms of apoptosis by the tumor suppressor Par-4. Journal of cellular physiology. vol 227. issue 12. 2012-11-06. PMID:22552839. |
as systemic par-4 induces apoptosis via cell surface grp78, strategies that promote grp78 trafficking to the cell surface are expected sensitize cancer cells to circulating levels of par-4. |
2012-11-06 |
2023-08-12 |
mouse |
| Qiang Wang, Rong Shu, Huijun He, Li Wang, Yuan Ma, Huifen Zhu, Zhihua Wang, Shuo Wang, Guanxin Shen, Ping Le. Co-silencing of Birc5 (survivin) and Hspa5 (Grp78) induces apoptosis in hepatoma cells more efficiently than single gene interference. International journal of oncology. vol 41. issue 2. 2012-10-19. PMID:22581315. |
co-silencing of birc5 (survivin) and hspa5 (grp78) induces apoptosis in hepatoma cells more efficiently than single gene interference. |
2012-10-19 |
2023-08-12 |
mouse |
| Xiang Gao, Lili Fu, Min Xiao, Chenggang Xu, Lijun Sun, Tong Zhang, Feng Zheng, Changlin Me. The nephroprotective effect of tauroursodeoxycholic acid on ischaemia/reperfusion-induced acute kidney injury by inhibiting endoplasmic reticulum stress. Basic & clinical pharmacology & toxicology. vol 111. issue 1. 2012-10-18. PMID:22212133. |
tudca intervention not only decreased the renal tubular necrosis score and the cell apoptosis index but also down-regulated grp78 and chop expression and caspase 12 activation. |
2012-10-18 |
2023-08-12 |
mouse |