| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Liu, Subrata Chowdhury, Xin Fang, Jun-Li Liu, Coimbatore B Srikan. Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells. FEBS letters. vol 588. issue 11. 2014-07-07. PMID:24801175. |
attenuation of unfolded protein response and apoptosis by mreg2 induced grp78 in mouse insulinoma cells. |
2014-07-07 |
2023-08-13 |
mouse |
| Lu Liu, Subrata Chowdhury, Xin Fang, Jun-Li Liu, Coimbatore B Srikan. Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells. FEBS letters. vol 588. issue 11. 2014-07-07. PMID:24801175. |
expanding on our previous work showing that overexpression of mreg2 protects min6 insulinoma cells against streptozotocin-induced apoptosis, we now demonstrate that mreg2 induces glucose-regulated peptide 78 (grp78) expression via the akt-mtorc1 axis and protects min6 cells against er stress induced by thapsigargin and glucolipotoxicity. |
2014-07-07 |
2023-08-13 |
mouse |
| Shanshan Zhou, Xia Yin, Yang Zheng, Xiao Miao, Wenke Feng, Jun Cai, Lu Ca. Metallothionein prevents intermittent hypoxia-induced cardiac endoplasmic reticulum stress and cell death likely via activation of Akt signaling pathway in mice. Toxicology letters. vol 227. issue 2. 2014-06-27. PMID:24680926. |
ih exposures for 3 days to 4 weeks significantly increased cardiac er stress and apoptosis, shown by the increased expression of grp78, atf6 and chop, the activation of caspase-12 and capase-3, and the decreased bcl2/bax expression ratio, predominantly in the 3rd week of ih exposures. |
2014-06-27 |
2023-08-12 |
mouse |
| Hao Wang, Zhi-Min Zheng, Bu-Lang Ga. Guanxinkang Decoction Exerts Its Antiatherosclerotic Effect Partly through Inhibiting the Endoplasmic Reticulum Stress. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-06-23. PMID:24955103. |
at 3, 6, 12, and 24 h after hcy had been incubated with the cells, the huvec were collected for test of the apoptosis rate, mmp, and grp78 protein (reflecting ers). |
2014-06-23 |
2023-08-13 |
human |
| Xia Jiang, Tatsuo Kanda, Shingo Nakamoto, Tatsuo Miyamura, Shuang Wu, Osamu Yokosuk. Involvement of androgen receptor and glucose-regulated protein 78 kDa in human hepatocarcinogenesis. Experimental cell research. vol 323. issue 2. 2014-06-15. PMID:24583399. |
sorafenib strongly induced significant apoptosis in hepg2 cells by the inhibition of ar and inhibition of the downstream grp78. |
2014-06-15 |
2023-08-12 |
human |
| E Sanchez-Lopez, T Zimmerman, T Gomez del Pulgar, M P Moyer, J C Lacal Sanjuan, A Cebria. Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells. Cell death & disease. vol 4. 2014-06-12. PMID:24287694. |
silencing of chop expression leads to a reduction in c/ebpβ, atf3 and grp78 protein levels and abrogates apoptosis in tumor cells after treatment with chokis, suggesting that chop maintains er stress responses and triggers the pro-apoptotic signal. |
2014-06-12 |
2023-08-12 |
Not clear |
| M Seervi, P K Sobhan, J Joseph, K Ann Mathew, T R Santhoshkuma. ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1). Cell death & disease. vol 4. 2014-06-12. PMID:24357799. |
xbp1 mrna splicing and grp78 upregulation confirmed er stress even in bax/bak double knockout and pac-1-resistant apaf-1-knockout cells, indicating an induction of er stress-mediated mitochondrial apoptosis by pac-1. |
2014-06-12 |
2023-08-12 |
Not clear |
| Jiahong Xue, Jin Wei, Xin Dong, Canzhan Zhu, Yongqin Li, Anqi Song, Zhongwei Li. ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway. The journal of physiological sciences : JPS. vol 63. issue 6. 2014-06-03. PMID:23897420. |
moreover, reduction of abcg1 promoted endothelial apoptosis and expression of endoplasmic reticulum (er) stress-related molecules grp78 and chop. |
2014-06-03 |
2023-08-12 |
human |
| Jiahong Xue, Jin Wei, Xin Dong, Canzhan Zhu, Yongqin Li, Anqi Song, Zhongwei Li. ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway. The journal of physiological sciences : JPS. vol 63. issue 6. 2014-06-03. PMID:23897420. |
in contrast, transfection of abcg1 overexpression plasmid reversed endothelial apoptosis and intracellular lipid accumulation as well as decreased expression of grp78 and chop in abcg1-deficient endothelial cells. |
2014-06-03 |
2023-08-12 |
human |
| Jiahong Xue, Jin Wei, Xin Dong, Canzhan Zhu, Yongqin Li, Anqi Song, Zhongwei Li. ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway. The journal of physiological sciences : JPS. vol 63. issue 6. 2014-06-03. PMID:23897420. |
furthermore, endothelial apoptosis and er stress-related molecules were induced by repletion of endothelial cells with cholesterol-loaded cyclodextrin, otherwise endothelial apoptotic response and expression of grp78 and chop were suppressed by depletion of cellular cholesterol in abcg1-deficient endothelial cells. |
2014-06-03 |
2023-08-12 |
human |
| Baimei He, Bailing Luo, Qiong Chen, Lemeng Zhan. Cigarette smoke extract induces the expression of GRP78 in A549 cells via the p38/MAPK pathway. Molecular medicine reports. vol 8. issue 6. 2014-05-28. PMID:24126384. |
to determine the involvement of glucose‑regulated protein 78 (grp78) in the cigarette smoke extract (cse)‑induced apoptosis of alveolar epithelial cells and the potential mechanisms underlying this effect, a549 cells that originate from alveolar type ii epithelial cells were exposed to various cse conditions in the present study. |
2014-05-28 |
2023-08-12 |
Not clear |
| Baimei He, Bailing Luo, Qiong Chen, Lemeng Zhan. Cigarette smoke extract induces the expression of GRP78 in A549 cells via the p38/MAPK pathway. Molecular medicine reports. vol 8. issue 6. 2014-05-28. PMID:24126384. |
grp78 expression and its effect on the apoptosis of a549 cells were investigated using techniques such as rt-pcr, western blot analysis, gene knockdown by grp78 sirna interference and the terminal deoxynucleotidyl transferase dutp nick‑end labeling assay. |
2014-05-28 |
2023-08-12 |
Not clear |
| Xiaoli Huang, Li Li, Linyou Zhang, Zhihong Zhang, Xiaolin Wang, Xuguang Zhang, Liying Hou, Kun W. Crosstalk between endoplasmic reticulum stress and oxidative stress in apoptosis induced by α-tocopheryl succinate in human gastric carcinoma cells. The British journal of nutrition. vol 109. issue 4. 2014-05-27. PMID:22676837. |
in response to α-tos, cytological changes typical of apoptosis, induction of glucose-regulated protein 78 (grp78) and ccaat/enhancer-binding protein (c/ebp) homologous protein transcription factor (chop), and activation of caspase-4 were observed. |
2014-05-27 |
2023-08-12 |
human |
| Le Li, Qing-guo Zhang, Lu-ying Lai, Xian-jie Wen, Ting Zheng, Chi-wai Cheung, Shu-qin Zhou, Shi-yuan X. Neuroprotective effect of ginkgolide B on bupivacaine-induced apoptosis in SH-SY5Y cells. Oxidative medicine and cellular longevity. vol 2013. 2014-05-12. PMID:24228138. |
gb suppressed bupivacaine-induced mitochondrial depolarization and mitochondria complex i and iii inhibition and increased cleaved caspase-3 and htra2 expression, which was strongly indicative of activation of mitochondria-dependent apoptosis with concomitantly enhanced expressions of grp78, caspase-12 mrna, protein, and er stress. |
2014-05-12 |
2023-08-12 |
Not clear |
| Li-Jia Wan, Xing-Heng W. [Effects of erythropoietin on cardiomyocyte apoptosis and endoplasmic reticulum stress-related proteins in neonatal rats with asphyxia]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 15. issue 10. 2014-04-24. PMID:24131844. |
to study the effects of erythropoietin (epo) on cardiomyocyte apoptosis and endoplasmic reticulum stress (ers)-related proteins, glucose-regulated protein 78 (grp78) and c/ebp homologous protein (chop), in neonatal rats with asphyxia. |
2014-04-24 |
2023-08-12 |
rat |
| Andrea Hartner, Nada Cordasic, Bernd Klanke, Carlos Menendez-Castro, Roland Veelken, Roland E Schmieder, Karl F Hilger. Renal protection by low dose irbesartan in diabetic nephropathy is paralleled by a reduction of inflammation, not of endoplasmic reticulum stress. Biochimica et biophysica acta. vol 1842. issue 4. 2014-04-23. PMID:24418215. |
podocyte damage was ameliorated but markers of er stress (calnexin, grp78) and apoptosis were not reduced by irbesartan. |
2014-04-23 |
2023-08-12 |
rat |
| Andrea Stefaniková, Katarína Kliková, Jozef Hatok, Peter Rača. ABT-737 accelerates butyrate-induced death of HL-60 cells. Involvement of mitochondrial apoptosis pathway. General physiology and biophysics. vol 32. issue 4. 2014-03-28. PMID:23940089. |
it seems that abt-737 accelerates nabu-induced death of hl-60 cells due to mitochondrial apoptosis resulting from abt-737-mediated inhibition of functions and nabu-induced decrease of the levels of anti-apoptotic bcl-2 family proteins as well as due to accelerated decrease of grp78 observed after the treatment of cells with combination of nabu and abt-737. |
2014-03-28 |
2023-08-12 |
Not clear |
| Amanda Croft, Kwang H Tay, Suzanah C Boyd, Su T Guo, Chen C Jiang, Fritz Lai, Hsin-Yi Tseng, Lei Jin, Helen Rizos, Peter Hersey, Xu D Zhan. Oncogenic activation of MEK/ERK primes melanoma cells for adaptation to endoplasmic reticulum stress. The Journal of investigative dermatology. vol 134. issue 2. 2014-03-25. PMID:23921951. |
similar to knockdown of glucose-regulated protein 78 (grp78), inhibition of xbp1 decelerated melanoma cell proliferation and enhanced apoptosis induced by the pharmacological er stress inducers tunicamycin and thapasigargin. |
2014-03-25 |
2023-08-12 |
Not clear |
| Qiufang Zhang, Hongliang Li, Shanshan Wang, Ming Liu, Yibin Feng, Xuanbin Wan. Icariin protects rat cardiac H9c2 cells from apoptosis by inhibiting endoplasmic reticulum stress. International journal of molecular sciences. vol 14. issue 9. 2014-03-19. PMID:23999590. |
these results indicated that icariin could protect h9c2 cardiomyoblast cells from ers-mitochondrial apoptosis in vitro, the mechanisms may be associated with its inhibiting of grp78, grp94 and chop and decreasing ros generation directly. |
2014-03-19 |
2023-08-12 |
rat |
| Ze-Qun Jiang, Zhi-Hua Yao, Zheng-Ting Deng, Xin-Chao Jiang, Xiao-Jing Yan, Wei-Ping Che. [Study on antagonistic effect of liangxue huayu recipe on endoplasmic reticulum stress-induced L02 hepatocyte apoptosis and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 38. issue 20. 2014-02-25. PMID:24490570. |
it found that tnf-alpha and d-galn could obviously inhibit hepatocyte proliferation, induce cell apoptosis, and significantly increase free calcium ions in cytoplasms, as well as protein expressions of ers apoptosis-related signal molecules phosphorylated perk, phosphorylated elf2alpha, cleaved caspase-12, grp78 and chop. |
2014-02-25 |
2023-08-12 |
Not clear |