| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Won-Seok Lee, Myung-Soon Sung, Eun-Gyeong Lee, Han-Gyul Yoo, Yun-Hong Cheon, Han-Jung Chae, Wan-Hee Yo. A pathogenic role for ER stress-induced autophagy and ER chaperone GRP78/BiP in T lymphocyte systemic lupus erythematosus. Journal of leukocyte biology. vol 97. issue 2. 2015-03-24. PMID:25516752. |
the molecular mechanism of altered autophagy and apoptosis was investigated in t lymphocytes transfected with sirna for beclin 1 and chop and t lymphocytes overexpressing grp78. |
2015-03-24 |
2023-08-13 |
Not clear |
| Syng-Ook Lee, Un-Ho Jin, Jeong Han Kang, Sang Bae Kim, Aaron S Guthrie, Sandeep Sreevalsan, Ju-Seog Lee, Stephen Saf. The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Molecular cancer research : MCR. vol 12. issue 4. 2015-02-19. PMID:24515801. |
rna interference of nr4a1 expression in panc-1 cells induced apoptosis and subsequent proteomic analysis revealed the induction of several markers of endoplasmic reticulum stress, including glucose-related protein 78 (grp78), ccaat/enhancer-binding protein-homologous protein (chop), and activating transcription factor-4 (atf-4). |
2015-02-19 |
2023-08-12 |
Not clear |
| Jayashree C Jagtap, D Parveen, Reecha D Shah, Aarti Desai, Dipali Bhosale, Ashish Chugh, Deepak Ranade, Swapnil Karnik, Bhushan Khedkar, Aaishwarya Mathur, Kumar Natesh, Goparaju Chandrika, Padma Shastr. Secretory prostate apoptosis response (Par)-4 sensitizes multicellular spheroids (MCS) of glioblastoma multiforme cells to tamoxifen-induced cell death. FEBS open bio. vol 5. 2015-02-16. PMID:25685660. |
since membrane grp78 is overexpressed in most cancer cells but not normal cells, and secretory par-4 induces apoptosis by binding to membrane grp78, secretory par-4 is an attractive candidate for potentially overcoming therapy-resistance not only in malignant glioma but in broad spectrum of cancers. |
2015-02-16 |
2023-08-13 |
human |
| Hui Wu, Qizhu Tang, Jun Yang, Jiawang Ding, Ming Ye, Wusong Don. Atorvastatin ameliorates myocardial ischemia/reperfusion injury through attenuation of endoplasmic reticulum stress-induced apoptosis. International journal of clinical and experimental medicine. vol 7. issue 12. 2015-02-09. PMID:25663988. |
the expression levels of the genes encoding glucose-regulated protein-78 (grp78, widely used as a marker of ers), c/ebp homologous protein (chop) and caspase-12 (widely used as markers of ers-induced apoptosis) were assessed using rt-pcr. |
2015-02-09 |
2023-08-13 |
rat |
| Jin-Hyung Ahn, Hyun-Kyung Yu, Ho-Jeong Lee, Soon Won Hong, Sun Jin Kim, Jang-Seong Ki. Suppression of colorectal cancer liver metastasis by apolipoprotein(a) kringle V in a nude mouse model through the induction of apoptosis in tumor-associated endothelial cells. PloS one. vol 9. issue 4. 2015-01-29. PMID:24699568. |
the interaction of rhlk8 with glucose-regulated protein 78 (grp78) may be involved in the induction of apoptosis because the inhibition of grp78 by grp78-specific antibodies or sirna knockdown inhibited the rhlk8-mediated apoptosis of human umbilical vein endothelial cells in vitro. |
2015-01-29 |
2023-08-13 |
mouse |
| M Chen, Y Zhang, V C Yu, Y-S Chong, T Yoshioka, R G. Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell death and differentiation. vol 21. issue 5. 2015-01-22. PMID:24464222. |
isthmin targets cell-surface grp78 and triggers apoptosis via induction of mitochondrial dysfunction. |
2015-01-22 |
2023-08-12 |
mouse |
| M Chen, Y Zhang, V C Yu, Y-S Chong, T Yoshioka, R G. Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell death and differentiation. vol 21. issue 5. 2015-01-22. PMID:24464222. |
we demonstrated that ism-grp78 interaction triggers apoptosis not only in activated ecs but also in cancer cells expressing high level of cell-surface grp78. |
2015-01-22 |
2023-08-12 |
mouse |
| M Chen, Y Zhang, V C Yu, Y-S Chong, T Yoshioka, R G. Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell death and differentiation. vol 21. issue 5. 2015-01-22. PMID:24464222. |
normal cells and benign tumor cells tend to express low level of cell-surface grp78 and are resistant to ism-induced apoptosis. |
2015-01-22 |
2023-08-12 |
mouse |
| M Chen, Y Zhang, V C Yu, Y-S Chong, T Yoshioka, R G. Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell death and differentiation. vol 21. issue 5. 2015-01-22. PMID:24464222. |
once inside the cell, ism co-targets with grp78 to mitochondria where it interacts with adp/atp carriers on the inner membrane and blocks atp transport from mitochondria to cytosol, thereby causing apoptosis. |
2015-01-22 |
2023-08-12 |
mouse |
| M Chen, Y Zhang, V C Yu, Y-S Chong, T Yoshioka, R G. Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell death and differentiation. vol 21. issue 5. 2015-01-22. PMID:24464222. |
hence, ism is a novel proapoptotic ligand that targets cell-surface grp78 to trigger apoptosis by inducing mitochondrial dysfunction. |
2015-01-22 |
2023-08-12 |
mouse |
| M Chen, Y Zhang, V C Yu, Y-S Chong, T Yoshioka, R G. Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell death and differentiation. vol 21. issue 5. 2015-01-22. PMID:24464222. |
the restricted and high-level expression of cell-surface grp78 on cancer cells and cancer ecs make them uniquely susceptible to ism-targeted apoptosis. |
2015-01-22 |
2023-08-12 |
mouse |
| Te-Chun Hsia, Chien-Chih Yu, Shu-Chun Hsu, Nou-Ying Tang, Hsu-Feng Lu, Yi-Ping Huang, Shin-Hwar Wu, Jaung-Geng Lin, Jing-Gung Chun. Cantharidin induces apoptosis of H460 human lung cancer cells through mitochondria-dependent pathways. International journal of oncology. vol 45. issue 1. 2015-01-15. PMID:24818581. |
ctd promoted er stress associated protein expression such as grp78, ire1α, ire1β, atf6α and caspase-4 and it also promoted the expression of calpain 2 and xbp-1, but inhibited calpain 1 that is associated with apoptosis pathways. |
2015-01-15 |
2023-08-13 |
human |
| Marie Cohen, Pascale Ribaux, Manuella Epiney, Olivier Irio. Role of prostate apoptosis response 4 in translocation of GRP78 from the endoplasmic reticulum to the cell surface of trophoblastic cells. PloS one. vol 8. issue 11. 2015-01-02. PMID:24282526. |
role of prostate apoptosis response 4 in translocation of grp78 from the endoplasmic reticulum to the cell surface of trophoblastic cells. |
2015-01-02 |
2023-08-12 |
Not clear |
| Marie Cohen, Pascale Ribaux, Manuella Epiney, Olivier Irio. Role of prostate apoptosis response 4 in translocation of GRP78 from the endoplasmic reticulum to the cell surface of trophoblastic cells. PloS one. vol 8. issue 11. 2015-01-02. PMID:24282526. |
in this study, we have investigated whether prostate apoptosis response 4 (par-4), a protein identified as a partner of grp78 relocation to the cell surface in prostate cancer cells, is present in trophoblastic cells and is involved in the translocation of grp78 to the cell surface of ctb. |
2015-01-02 |
2023-08-12 |
Not clear |
| Huiling Li, Xiaohua Zhu, Fang Fang, Deyong Jiang, Luosheng Tan. Down-regulation of GRP78 enhances apoptosis via CHOP pathway in retinal ischemia-reperfusion injury. Neuroscience letters. vol 575. 2014-12-22. PMID:24880098. |
down-regulation of grp78 enhances apoptosis via chop pathway in retinal ischemia-reperfusion injury. |
2014-12-22 |
2023-08-13 |
rat |
| Huiling Li, Xiaohua Zhu, Fang Fang, Deyong Jiang, Luosheng Tan. Down-regulation of GRP78 enhances apoptosis via CHOP pathway in retinal ischemia-reperfusion injury. Neuroscience letters. vol 575. 2014-12-22. PMID:24880098. |
partial inhibition of the endogenous expression of grp78 with antisense oligonucleotide resulted in significant retinal damage and apoptosis in i/r injury rats. |
2014-12-22 |
2023-08-13 |
rat |
| Huiling Li, Xiaohua Zhu, Fang Fang, Deyong Jiang, Luosheng Tan. Down-regulation of GRP78 enhances apoptosis via CHOP pathway in retinal ischemia-reperfusion injury. Neuroscience letters. vol 575. 2014-12-22. PMID:24880098. |
importantly, the persistent high expression of chop might serve as a possible mechanism that contributes to the enhanced the i/r-induced apoptosis after grp78 down-regulation. |
2014-12-22 |
2023-08-13 |
rat |
| Ling-Fei Wu, Yi-Tian Guo, Qing-Hua Zhang, Meng-Qi Xiang, Wei Deng, Yan-Qing Ye, Ze-Jin Pu, Jia-Lin Feng, Guan-You Huan. Enhanced antitumor effects of adenoviral-mediated siRNA against GRP78 gene on adenosine-induced apoptosis in human hepatoma HepG2 cells. International journal of molecular sciences. vol 15. issue 1. 2014-12-18. PMID:24394318. |
enhanced antitumor effects of adenoviral-mediated sirna against grp78 gene on adenosine-induced apoptosis in human hepatoma hepg2 cells. |
2014-12-18 |
2023-08-12 |
human |
| Ling-Fei Wu, Yi-Tian Guo, Qing-Hua Zhang, Meng-Qi Xiang, Wei Deng, Yan-Qing Ye, Ze-Jin Pu, Jia-Lin Feng, Guan-You Huan. Enhanced antitumor effects of adenoviral-mediated siRNA against GRP78 gene on adenosine-induced apoptosis in human hepatoma HepG2 cells. International journal of molecular sciences. vol 15. issue 1. 2014-12-18. PMID:24394318. |
effects of knockdown of grp78 on adenosine-induced cell viabilities, cell-cycle distribution and apoptosis, as well as relative protein expressions were determined by flow cytometry and/or western blot analysis. |
2014-12-18 |
2023-08-12 |
human |
| Ahmed M Osman, Henk van Lovere. Matrin 3 co-immunoprecipitates with the heat shock proteins glucose-regulated protein 78 (GRP78), GRP75 and glutathione S-transferase π isoform 2 (GSTπ2) in thymoma cells. Biochimie. vol 101. 2014-12-09. PMID:24491357. |
the grp78 protein is known to protect cells from apoptosis by complexing with procaspase 7 thereby preventing caspase activation cascade. |
2014-12-09 |
2023-08-12 |
Not clear |