| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ze-Qun Jiang, Zhi-Hua Yao, Zheng-Ting Deng, Xin-Chao Jiang, Xiao-Jing Yan, Wei-Ping Che. [Study on antagonistic effect of liangxue huayu recipe on endoplasmic reticulum stress-induced L02 hepatocyte apoptosis and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 38. issue 20. 2014-02-25. PMID:24490570. |
after the administration of lhr of different concentrations, compared with the tnf-alpha/galn injury group, lhr could significantly alleviated l02 hepatocyte proliferation, decreased cell apoptosis, inhibited growth of intracytoplasmic free calcium content, and gradually reduced the protein expressions of phosphorylated perk, phosphorylated elf2alpha, cleaved caspase-12, grp78 and chop. |
2014-02-25 |
2023-08-12 |
Not clear |
| De-Hui Kong, Qiang Zhang, Xin Meng, Zhi-Hong Zong, Chao Li, Bao-Qin Liu, Yifu Guan, Hua-Qin Wan. BAG3 sensitizes cancer cells exposed to DNA damaging agents via direct interaction with GRP78. Biochimica et biophysica acta. vol 1833. issue 12. 2014-02-24. PMID:24080088. |
furthermore, overexpression of grp78 significantly blocked the enhancing effects of bag3 on activation of caspase-7 and induction of apoptosis by genotoxic stress. |
2014-02-24 |
2023-08-12 |
Not clear |
| Kuen Yao Ho, Tai Sheng Yeh, Han Hsiang Huang, Kuo Feng Hung, Chee Yin Chai, Wan Tzu Chen, Shih Meng Tsai, Ning Chia Chang, Chen Yu Chien, Hsun Mo Wang, Yu Jen W. Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth. International journal of molecular sciences. vol 14. issue 7. 2014-02-11. PMID:23852020. |
upregulations of grp75, grp78 and grp94 in keratinocytes may be able to counter endoplasmic reticulum stress, to inhibit cell apoptosis, to prevent protein unfolding and to promote cholesteatoma growth. |
2014-02-11 |
2023-08-12 |
Not clear |
| Dan Zhang, Bin Zhou, Yuan Li, Mojin Wang, Cun Wang, Zongguang Zhou, Xiaofeng Su. Polymorphisms of glucose-regulated protein 78 and risk of colorectal cancer: a case-control study in southwest China. PloS one. vol 8. issue 6. 2014-01-30. PMID:23818965. |
glucose-regulated protein 78 (grp78), an endoplasmic reticulum chaperone, up-regulation serves as an efficient mechanism to promote malignant transformation of colorectal cancer (crc) and protect crc cells against apoptosis. |
2014-01-30 |
2023-08-12 |
Not clear |
| Chang-Nim Im, Byeong Mo Kim, Eun-Yi Moon, Da-Won Hong, Joung Whan Park, Sung Hee Hon. Characterization of H460R, a Radioresistant Human Lung Cancer Cell Line, and Involvement of Syntrophin Beta 2 (SNTB2) in Radioresistance. Genomics & informatics. vol 11. issue 4. 2014-01-27. PMID:24465237. |
in addition, h460r cells were resistant to ir, exhibiting reduced expression levels of ionizing responsive proteins (p-p53 and γ-h2ax); apoptosis-related molecules, such as cleaved poly(adp ribose) polymerase; and endoplasmic reticulum stress-related molecules, such as glucose-regulated protein (grp78) and c/ebp-homologous protein compared with parental cells, whereas the expression of anti-apoptotic x-linked inhibitor of apoptosis protein was increased. |
2014-01-27 |
2023-08-12 |
human |
| Yong Liu, Zong-Guang Zhou, Bing Zhou, Rong Wang, Hui Yan, Yuan L. Downregulation of GRP78 and XIAP is correlated with apoptosis during cerulein-induced acute pancreatitis in rats via regulation of caspase activation. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23254244. |
downregulation of grp78 and xiap is correlated with apoptosis during cerulein-induced acute pancreatitis in rats via regulation of caspase activation. |
2014-01-03 |
2023-08-12 |
rat |
| Yong Liu, Zong-Guang Zhou, Bing Zhou, Rong Wang, Hui Yan, Yuan L. Downregulation of GRP78 and XIAP is correlated with apoptosis during cerulein-induced acute pancreatitis in rats via regulation of caspase activation. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23254244. |
our aim in the present study was to investigate the potential roles of the 78-kda glucose-regulated protein (grp78) and the x-linked inhibitor of apoptosis protein (xiap) in the regulation of apoptosis during cerulein-induced acute pancreatitis (cap). |
2014-01-03 |
2023-08-12 |
rat |
| Yong Liu, Zong-Guang Zhou, Bing Zhou, Rong Wang, Hui Yan, Yuan L. Downregulation of GRP78 and XIAP is correlated with apoptosis during cerulein-induced acute pancreatitis in rats via regulation of caspase activation. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23254244. |
pancreatic acinar cell apoptosis was determined by terminal-deoxynucleotidyl-transferase-mediated dutp nick-end labeling (tunel) assay, and the expression of grp78, xiap and the apoptotic genes caspase-3, -7 and -9 were determined by real‑time quantitative pcr and western blotting. |
2014-01-03 |
2023-08-12 |
rat |
| Yong Liu, Zong-Guang Zhou, Bing Zhou, Rong Wang, Hui Yan, Yuan L. Downregulation of GRP78 and XIAP is correlated with apoptosis during cerulein-induced acute pancreatitis in rats via regulation of caspase activation. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23254244. |
this study suggests that the downregulation of grp78 and xiap were correlated with apoptosis in pancreatic acinar cells, and that this may occur through the regulation of caspase activation during cap. |
2014-01-03 |
2023-08-12 |
rat |
| Leo Rasche, Johannes Duell, Charlotte Morgner, Manik Chatterjee, Frank Hensel, Andreas Rosenwald, Hermann Einsele, Max S Topp, Stephanie Brändlei. The natural human IgM antibody PAT-SM6 induces apoptosis in primary human multiple myeloma cells by targeting heat shock protein GRP78. PloS one. vol 8. issue 5. 2013-12-17. PMID:23667612. |
the natural human igm antibody pat-sm6 induces apoptosis in primary human multiple myeloma cells by targeting heat shock protein grp78. |
2013-12-17 |
2023-08-12 |
human |
| Su-Rong Zhao, Hai-Feng Duan, Pei Zhang, Hao Liu, Chen-Chen Jiang, Zhi-Wen Jian. [2-DG enhances TRAIL-induced apoptosis of leukemia HL-60 cells]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 2. 2013-12-16. PMID:23628031. |
apoptosis was analyzed by flow cytometry with pi staining; the expression of rip1, grp78, and parp was analyzed by western blot; the activity of caspase-3 was detected by special detection kit. |
2013-12-16 |
2023-08-12 |
Not clear |
| H-Y Tsai, Y-F Yang, A T Wu, C-J Yang, Y-P Liu, Y-H Jan, C-H Lee, Y-W Hsiao, C-T Yeh, C-N Shen, P-J Lu, M-S Huang, M Hsia. Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78. Oncogene. vol 32. issue 41. 2013-12-04. PMID:23318453. |
endoplasmic reticulum ribosome-binding protein 1 (rrbp1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of grp78. |
2013-12-04 |
2023-08-12 |
Not clear |
| H-Y Tsai, Y-F Yang, A T Wu, C-J Yang, Y-P Liu, Y-H Jan, C-H Lee, Y-W Hsiao, C-T Yeh, C-N Shen, P-J Lu, M-S Huang, M Hsia. Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78. Oncogene. vol 32. issue 41. 2013-12-04. PMID:23318453. |
ectopic expression of rrbp1 alleviated apoptosis that was induced by the er-stress agent tunicamycin, 2-deoxy-d-glucose (2dg) or doxorubicin via enhancing grp78 protein expression. |
2013-12-04 |
2023-08-12 |
Not clear |
| Joo Hee Lee, Eun Jeong Kwon, Do Han Ki. Calumenin has a role in the alleviation of ER stress in neonatal rat cardiomyocytes. Biochemical and biophysical research communications. vol 439. issue 3. 2013-11-18. PMID:24012670. |
upon 7.5-fold overexpression of calumenin using a recombinant adenovirus system, the expression levels of ers markers (grp78, p-perk, and p-elf2α) and er-initiated apoptosis markers (chop and p-jnk) were reduced, whereas the survival protein bcl-2 was upregulated during ers compared to the control. |
2013-11-18 |
2023-08-12 |
rat |
| S-F Su, Y-W Chang, C Andreu-Vieyra, J Y Fang, Z Yang, B Han, A S Lee, G Lian. miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. Oncogene. vol 32. issue 39. 2013-11-15. PMID:23085757. |
we show that in c42b prostate cancer cells, these mirnas down-regulate grp78 and induce apoptosis by directly targeting its 3' untranslated region. |
2013-11-15 |
2023-08-12 |
human |
| Rui Wang, Fangyuan Shao, Zhong Liu, Jiaxuan Zhang, Shaoxiang Wang, Jinyun Liu, Hui Liu, Hongyuan Chen, Kaisheng Liu, Min Xia, Yifei Wan. The Hsp90 inhibitor SNX-2112, induces apoptosis in multidrug resistant K562/ADR cells through suppression of Akt/NF-κB and disruption of mitochondria-dependent pathways. Chemico-biological interactions. vol 205. issue 1. 2013-11-13. PMID:23777986. |
the expression levels of p-glycoprotein (p-gp) and several chaperons related to drug resistance and apoptosis were also shown to be inhibited, including the grp78 and hsp90 isoforms, grp94 and trap1. |
2013-11-13 |
2023-08-12 |
human |
| Shuxi Qiao, Christopher M Cabello, Sarah D Lamore, Jessica L Lesson, Georg T Wondra. D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis : an international journal on programmed cell death. vol 17. issue 10. 2013-11-12. PMID:22843330. |
focused gene expression array analysis followed by immunoblot detection revealed that dp rapidly activates the cytotoxic unfolded protein response (upr; involving phospho-perk, phospho-eif2α, grp78, chop, and hsp70) and the mitochondrial pathway of apoptosis with p53 upregulation and modulation of bcl-2 family members (involving noxa, mcl-1, and bcl-2). |
2013-11-12 |
2023-08-12 |
human |
| Zachary Rosenes, Yee-Foong Mok, Shuo Yang, Michael D W Griffin, Terrence D Mulhern, Danny M Hatters, Frank Hensel, Geoffrey J Howlet. Simultaneous binding of the anti-cancer IgM monoclonal antibody PAT-SM6 to low density lipoproteins and GRP78. PloS one. vol 8. issue 4. 2013-11-11. PMID:23620733. |
these results support the hypothesis that the biological action of pat-sm6 in tumour cell apoptosis depends on the multivalent nature of pat-sm6 and the ability to interact simultaneously with ldl and multiple grp78 molecules clustered on the tumour cell surface. |
2013-11-11 |
2023-08-12 |
Not clear |
| Hiroki Matsumoto, Shuichi Miyazaki, Satoshi Matsuyama, Masayuki Takeda, Makoto Kawano, Hiroshi Nakagawa, Kazuhiko Nishimura, Saburo Matsu. Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Biology open. vol 2. issue 10. 2013-10-29. PMID:24167719. |
thapsigargin-induced er-stress caused only apoptosis after ∼2 hr with ire1 phosphorylation, and grp78, atf4, and chop expressions. |
2013-10-29 |
2023-08-12 |
Not clear |
| Bin Qiu, Shengdi Hu, Libing Liu, Man Chen, Lai Wang, Xianwei Zeng, Shigong Zh. CART attenuates endoplasmic reticulum stress response induced by cerebral ischemia and reperfusion through upregulating BDNF synthesis and secretion. Biochemical and biophysical research communications. vol 436. issue 4. 2013-10-21. PMID:23770418. |
the results showed that cart was effective in reducing the neuronal apoptosis and expression of er stress markers (grp78, chop and cleaved caspase12), and increasing the bdnf expression in i/r injury rat cortex both in vivo and in vitro. |
2013-10-21 |
2023-08-12 |
rat |