| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Liu, Lie Yang, Ke-Ling Chen, Bin Zhou, Hui Yan, Zong-Guang Zhou, Yuan L. Knockdown of GRP78 promotes apoptosis in pancreatic acinar cells and attenuates the severity of cerulein and LPS induced pancreatic inflammation. PloS one. vol 9. issue 3. 2014-11-25. PMID:24643222. |
knockdown of grp78 promotes apoptosis in pancreatic acinar cells and attenuates the severity of cerulein and lps induced pancreatic inflammation. |
2014-11-25 |
2023-08-12 |
Not clear |
| Yong Liu, Lie Yang, Ke-Ling Chen, Bin Zhou, Hui Yan, Zong-Guang Zhou, Yuan L. Knockdown of GRP78 promotes apoptosis in pancreatic acinar cells and attenuates the severity of cerulein and LPS induced pancreatic inflammation. PloS one. vol 9. issue 3. 2014-11-25. PMID:24643222. |
this study used rna interference (rnai) approach to investigate the potential role of grp78 in regulating apoptosis during ap. |
2014-11-25 |
2023-08-12 |
Not clear |
| Yong Liu, Lie Yang, Ke-Ling Chen, Bin Zhou, Hui Yan, Zong-Guang Zhou, Yuan L. Knockdown of GRP78 promotes apoptosis in pancreatic acinar cells and attenuates the severity of cerulein and LPS induced pancreatic inflammation. PloS one. vol 9. issue 3. 2014-11-25. PMID:24643222. |
furthermore, knockdown of grp78 expression markedly promoted apoptosis and reduced necrosis in pancreatic acinar cells. |
2014-11-25 |
2023-08-12 |
Not clear |
| Nikhil Hebbar, Tripti Shrestha-Bhattarai, Vivek M Rangneka. Cancer-selective apoptosis by tumor suppressor par-4. Advances in experimental medicine and biology. vol 818. 2014-11-21. PMID:25001535. |
intracellularly par-4 acts through the inhibition of pro-survival pathways and activation of fas mediated apoptosis whereas extracellular (secreted par-4) acts by binding to cell surface grp78 leading to activation of the extrinsic apoptotic pathway. |
2014-11-21 |
2023-08-13 |
Not clear |
| Ching-Lung Liao, Shu-Chun Hsu, Chien-Chih Yu, Jai-Sing Yang, Nou-Ying Tang, Wellington Gibson Wood, Jaung-Geng Lin, Jing-Gung Chun. The crude extract of Corni Fructus induces apoptotic cell death through reactive oxygen species-modulated pathways in U-2 OS human osteosarcoma cells. Environmental toxicology. vol 29. issue 9. 2014-11-14. PMID:23239598. |
cecf increased protein levels of caspase-3, caspase-9, bax, cytochrome c, grp78, aif, atf-6α, fas, trail, p21, p27, and p16 which were associated with cell-cycle arrest and apoptosis. |
2014-11-14 |
2023-08-12 |
human |
| Shuying Shen, Yi Zhang, Zhen Wang, Rui Liu, Xingguo Gon. Bufalin induces the interplay between apoptosis and autophagy in glioma cells through endoplasmic reticulum stress. International journal of biological sciences. vol 10. issue 2. 2014-11-07. PMID:24550689. |
in addition, bufalin was also found to induce er stress-mediated apoptosis, which was supported by the up- regulation of er stress markers, chop and grp78, and augmented phosphorylation of perk and eif2α as well as cleavage of caspase-4. |
2014-11-07 |
2023-08-12 |
Not clear |
| Zongwei Li, Chao Zhao, Zhuoyu Li, Yarui Zhao, Shuhua Shan, Tonglin Shi, Jianguo L. Reconstructed mung bean trypsin inhibitor targeting cell surface GRP78 induces apoptosis and inhibits tumor growth in colorectal cancer. The international journal of biochemistry & cell biology. vol 47. 2014-11-06. PMID:24333163. |
reconstructed mung bean trypsin inhibitor targeting cell surface grp78 induces apoptosis and inhibits tumor growth in colorectal cancer. |
2014-11-06 |
2023-08-12 |
human |
| Yi Zhang, Li Zhao, Xin Li, Yajing Wang, Jing Yao, Hu Wang, Fanni Li, Zhiyu Li, Qinglong Gu. V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. Archives of toxicology. vol 88. issue 1. 2014-10-28. PMID:23835921. |
moreover, knocking down chop partly decreased the effect of v8-mediated apoptosis and activation of grp78, p-perk, p-eif2α, atf4 and chop modulated er stress triggered by v8. |
2014-10-28 |
2023-08-12 |
mouse |
| Yong Zhou, Furong Shu, Xinyu Liang, Hui Chang, Linying Shi, Xiaoli Peng, Jundong Zhu, Mantian M. Ampelopsin induces cell growth inhibition and apoptosis in breast cancer cells through ROS generation and endoplasmic reticulum stress pathway. PloS one. vol 9. issue 2. 2014-10-14. PMID:24551210. |
blocking er stress using 4-phenylbutyric acid not only down-regulated amp-induced grp78 and chop expression, but also significantly decreased amp-induced cell growth inhibition and apoptosis, whereas er stress inducer thapsigargin played opposing effects. |
2014-10-14 |
2023-08-12 |
human |
| Yu Ou, Shuya Xu, Dandan Zhu, Xuegan Yan. Molecular mechanisms of exopolysaccharide from Aphanothece halaphytica (EPSAH) induced apoptosis in HeLa cells. PloS one. vol 9. issue 1. 2014-09-29. PMID:24466342. |
our results suggest that epash induces apoptosis in hela cells by targeting a master unfolded protein response (upr) regulator grp78. |
2014-09-29 |
2023-08-12 |
human |
| Yu Ou, Shuya Xu, Dandan Zhu, Xuegan Yan. Molecular mechanisms of exopolysaccharide from Aphanothece halaphytica (EPSAH) induced apoptosis in HeLa cells. PloS one. vol 9. issue 1. 2014-09-29. PMID:24466342. |
grp78 further promotes the expression of chop and downregulates expression of survivin, which leads to activate mitochondria-mediated downstream molecules and p53-survivin pathway, resulting in caspase-3 activation and causing apoptosis. |
2014-09-29 |
2023-08-12 |
human |
| Yun-Shan Guo, Zhen Sun, Jie Ma, Wei Cui, Bo Gao, Hong-Yang Zhang, Yue-Hu Han, Hui-Min Hu, Long Wang, Jing Fan, Liu Yang, Juan Tang, Zhuo-Jing Lu. 17β-Estradiol inhibits ER stress-induced apoptosis through promotion of TFII-I-dependent Grp78 induction in osteoblasts. Laboratory investigation; a journal of technical methods and pathology. vol 94. issue 8. 2014-09-26. PMID:24933421. |
17β-estradiol inhibits er stress-induced apoptosis through promotion of tfii-i-dependent grp78 induction in osteoblasts. |
2014-09-26 |
2023-08-13 |
Not clear |
| Yun-Shan Guo, Zhen Sun, Jie Ma, Wei Cui, Bo Gao, Hong-Yang Zhang, Yue-Hu Han, Hui-Min Hu, Long Wang, Jing Fan, Liu Yang, Juan Tang, Zhuo-Jing Lu. 17β-Estradiol inhibits ER stress-induced apoptosis through promotion of TFII-I-dependent Grp78 induction in osteoblasts. Laboratory investigation; a journal of technical methods and pathology. vol 94. issue 8. 2014-09-26. PMID:24933421. |
together, 17β-e₂ protected mc3t3-e1 cells against er stress-induced apoptosis by promoting ras-erk1/2-tfii-i signaling pathway-dependent grp78 induction. |
2014-09-26 |
2023-08-13 |
Not clear |
| Rachel E Carlisle, Elise Brimble, Kaitlyn E Werner, Gaile L Cruz, Kjetil Ask, Alistair J Ingram, Jeffrey G Dickhou. 4-Phenylbutyrate inhibits tunicamycin-induced acute kidney injury via CHOP/GADD153 repression. PloS one. vol 9. issue 1. 2014-09-10. PMID:24416259. |
this was accompanied by a reduction in apoptosis and grp78 expression. |
2014-09-10 |
2023-08-12 |
mouse |
| Yu-Kyoung Park, Byeong-Churl Jan. UVB-induced anti-survival and pro-apoptotic effects on HaCaT human keratinocytes via caspase- and PKC-dependent downregulation of PKB, HIAP-1, Mcl-1, XIAP and ER stress. International journal of molecular medicine. vol 33. issue 3. 2014-09-09. PMID:24356997. |
of note, results of pharmacological inhibition studies have demonstrated that pretreatment with z-vad-fmk, a pan-caspase inhibitor strongly attenuated uvb-induced apoptosis, the activation of caspase-9, downregulation of mcl-1, xiap and pkb (but not hiap-1), and upregulation of grp78, while pretreatment with gf109203 or go6983, pan-pkc inhibitors, substantially blocked the uvb-induced reduction of cell survival, activation of caspase-9, downregulation of hiap-1, xiap, and pkb (but not mcl-1), and grp78 upregulation in hacat cells. |
2014-09-09 |
2023-08-12 |
human |
| Gaetano Calì, Luigi Insabato, Domenico Conza, Giuseppe Bifulco, Luca Parrillo, Paola Mirra, Francesca Fiory, Claudia Miele, Gregory Alexander Raciti, Bruno Di Jeso, Giuseppe Terrazzano, Francesco Beguinot, Luca Ulianic. GRP78 mediates cell growth and invasiveness in endometrial cancer. Journal of cellular physiology. vol 229. issue 10. 2014-09-05. PMID:24526410. |
intriguingly, flow cytometry experiments showed that the treatment with a specific antibody targeting grp78 c-terminal domain caused apoptosis in an3ca but not in ishikawa cells. |
2014-09-05 |
2023-08-12 |
Not clear |
| Nizar M Mhaidat, Karem H Alzoubi, Sayer I Al-Azzam, Alhareth A Alsaa. Caffeine inhibits paclitaxel‑induced apoptosis in colorectal cancer cells through the upregulation of Mcl‑1 levels. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24173825. |
colorectal cancer (crc) cells have been previously observed to be resistant to paclitaxel‑induced apoptosis by activation of the mitogen‑activated protein/extracellular signal‑regulated kinase (mek)/erk signaling pathway and increased expression of glucose‑regulated protein 78 (grp78). |
2014-07-29 |
2023-08-12 |
Not clear |
| Chengye Yao, Jiancheng Zhang, Gongping Liu, Fang Chen, Yun Li. Neuroprotection by (-)-epigallocatechin-3-gallate in a rat model of stroke is mediated through inhibition of endoplasmic reticulum stress. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24193141. |
egcg, when applied immediately following ischemia, significantly decreased the expression of endoplasmic reticulum stress (ers)‑related markers, [glucose‑regulated protein 78 (grp78), c/ebp‑homologous protein (chop) and caspase‑12] and apoptosis 24 h following reperfusion. |
2014-07-29 |
2023-08-12 |
rat |
| K M Li, X Sun, H K Koon, W N Leung, M C Fung, R N S Wong, Maria L Lung, C K Chang, N K Ma. Apoptosis and expression of cytokines triggered by pyropheophorbide-a methyl ester-mediated photodynamic therapy in nasopharyngeal carcinoma cells. Photodiagnosis and photodynamic therapy. vol 3. issue 4. 2014-07-25. PMID:25046989. |
mppa pdt-induced apoptosis was associated with the collapse of mitochondrial membrane potential, release of cytochrome c, the up-regulation of endoplasmic reticulum (er) stress proteins (calnexin, grp 94 and grp78), and the activation of caspases-3 and -9. |
2014-07-25 |
2023-08-13 |
human |
| Nameeta Mujumdar, Sulagna Banerjee, Zhiyu Chen, Veena Sangwan, Rohit Chugh, Vikas Dudeja, Masato Yamamoto, Selwyn M Vickers, Ashok K Saluj. Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells. American journal of physiology. Gastrointestinal and liver physiology. vol 306. issue 11. 2014-07-14. PMID:24699326. |
our results further show that glucose-regulated protein 78 (grp78), one of the major regulators of er stress, is downregulated by triptolide, leading to cell death by apoptosis in mia paca-2 cells and autophagy in s2-vp10 cells. |
2014-07-14 |
2023-08-13 |
Not clear |