| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Binbin Chen, Guangyi Liu, Peimei Zou, Xing Li, Qiufa Hao, Bei Jiang, Xiangdong Yang, Zhao H. Epigallocatechin-3-gallate protects against cisplatin-induced nephrotoxicity by inhibiting endoplasmic reticulum stress-induced apoptosis. Experimental biology and medicine (Maywood, N.J.). vol 240. issue 11. 2016-02-23. PMID:25716017. |
besides, expression of phosphorylated-extracellular signal-regulated kinase (p-erk), glucose-regulated protein 78 (grp78), caspase-12, and apoptosis of kidney were decreased by egcg via inhibition of endoplasmic reticulum (er) stress-induced apoptosis. |
2016-02-23 |
2023-08-13 |
mouse |
| Song Zhao, Hongdan Li, Qingjun Wang, Chang Su, Guan Wang, Huijuan Song, Liang Zhao, Zhidong Luan, Rongjian S. The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated α2M. BMC cancer. vol 15. 2016-02-04. PMID:25958313. |
association of cell surface grp78 with α2m* is involved in the regulation of cell proliferation, survival and apoptosis in human cancers. |
2016-02-04 |
2023-08-13 |
human |
| Pengfei Lin, Fenglei Chen, Jin Sun, Jinhua Zhou, Xiangguo Wang, Nan Wang, Xiao Li, Zhe Zhang, Aihua Wang, YaPing Ji. Mycotoxin zearalenone induces apoptosis in mouse Leydig cells via an endoplasmic reticulum stress-dependent signalling pathway. Reproductive toxicology (Elmsford, N.Y.). vol 52. 2016-01-29. PMID:25720297. |
further, pre-treating the cells with 4-phenylbutyrate or knocking down grp78 using lentivirus-encoded shrna significantly diminished zen-induced apoptosis and inhibited the expression of chop and caspase-12. |
2016-01-29 |
2023-08-13 |
mouse |
| Y G Lin, J Shen, E Yoo, R Liu, H-Y Yen, A Mehta, A Rajaei, W Yang, P Mhawech-Fauceglia, F J DeMayo, J Lydon, P Gill, A S Le. Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis. Oncogene. vol 34. issue 43. 2016-01-28. PMID:25684138. |
consistent with previous findings that cell surface grp78 is an upstream regulator of pi3k/akt signaling, we show here that in vivo short-term systemic treatment with a highly specific monoclonal antibody against grp78 suppressed akt activation and increased apoptosis in the cpten(f/f) tumors. |
2016-01-28 |
2023-08-13 |
mouse |
| Lu Liu, Ying Zhang, Hefeng Gu, Kaiqiang Zhang, Lin M. Fluorosis induces endoplasmic reticulum stress and apoptosis in osteoblasts in vivo. Biological trace element research. vol 164. issue 1. 2016-01-21. PMID:25434583. |
the expression of ers chaperones (glucose-regulated protein 78 (grp78), x-box binding protein l (xbp1), cysteine aspartate specific protease-12 (caspase-12), and growth arrest and dna damage-inducible gene 153 (gadd153/chop) was analyzed by immunohistochemistry staining, and osteoblast apoptosis was determined by tunel staining and flow cytometry. |
2016-01-21 |
2023-08-13 |
rat |
| Yanzhou Yang, Miao Sun, Yuanyuan Shan, Xiaomin Zheng, Huiming Ma, Wenzhi Ma, Zhisheng Wang, Xiuying Pei, Yanrong Wan. Endoplasmic reticulum stress-mediated apoptotic pathway is involved in corpus luteum regression in rats. Reproductive sciences (Thousand Oaks, Calif.). vol 22. issue 5. 2016-01-20. PMID:25332219. |
the ers markers glucose-regulated protein 78 (grp78), ccaat/enhancer-binding protein homologous protein (chop), x-box binding protein 1 (xbp1), activating transcription factor 6α (atf6α), eukaryotic initiation factor 2α (eif2α), inositol-requiring protein 1α (ire1α), caspase 12, and apoptosis marker caspase 3 were analyzed by real-time polymerase chain reaction (pcr) and immunohistochemistry, in agreement with the results of the tunel assay; the expression levels of chop, caspase 12, and caspase 3 were increased during the process of cl regression. |
2016-01-20 |
2023-08-13 |
rat |
| Yanzhou Yang, Miao Sun, Yuanyuan Shan, Xiaomin Zheng, Huiming Ma, Wenzhi Ma, Zhisheng Wang, Xiuying Pei, Yanrong Wan. Endoplasmic reticulum stress-mediated apoptotic pathway is involved in corpus luteum regression in rats. Reproductive sciences (Thousand Oaks, Calif.). vol 22. issue 5. 2016-01-20. PMID:25332219. |
the ers markers grp78, chop, xbp1s, atf6α, eif2α, ire1α, caspase 12, and apoptotic execute marker caspase 3 were analyzed by real-time pcr and immunofluorescence, and the results suggested that the expression of chop, caspase 12, and caspase 3 were increased, and there was increased apoptosis of luteal cells. |
2016-01-20 |
2023-08-13 |
rat |
| Pingan Peng, Qian Ma, Le Wang, Ou Zhang, Hongya Han, Xiaoli Liu, Yujie Zhou, Yingxin Zha. Preconditioning With Tauroursodeoxycholic Acid Protects Against Contrast-Induced HK-2 Cell Apoptosis by Inhibiting Endoplasmic Reticulum Stress. Angiology. vol 66. issue 10. 2016-01-11. PMID:25818106. |
cell viability test, hoechst 33258 staining, and flow cytometry were used to detect meglumine diatrizoate-induced cell apoptosis, while real-time polymerase chain reaction and western blot analysis were used to measure the expressions of ers markers of glucose-regulated protein 78 (grp78), activating transcription factor 4 (atf4), and the apoptosis-related marker of caspase 12. |
2016-01-11 |
2023-08-13 |
Not clear |
| Pingan Peng, Qian Ma, Le Wang, Ou Zhang, Hongya Han, Xiaoli Liu, Yujie Zhou, Yingxin Zha. Preconditioning With Tauroursodeoxycholic Acid Protects Against Contrast-Induced HK-2 Cell Apoptosis by Inhibiting Endoplasmic Reticulum Stress. Angiology. vol 66. issue 10. 2016-01-11. PMID:25818106. |
cell apoptosis and messenger rna (mrna) expression of grp78 (p = .005), atf4 (p = .01), and caspase 12 (p = .001) were significantly higher in the cm 4 hours group than the control as well as the protein expressions. |
2016-01-11 |
2023-08-13 |
Not clear |
| Meng-Liang Lin, Shih-Shun Chen, Sue-Hwee N. CHM-1 Suppresses Formation of Cell Surface-associated GRP78-p85α Complexes, Inhibiting PI3K-AKT Signaling and Inducing Apoptosis of Human Nasopharyngeal Carcinoma Cells. Anticancer research. vol 35. issue 10. 2016-01-04. PMID:26408697. |
using cell surface biotinylation, flow cytometric analysis, co-immunoprecipitation, and ectopic expression of grp78, we demonstrated that the attenuation of the cell surface localization and complex formation with p85α of grp78 by chm-1 was involved in the inhibition of pi3k-akt signaling and the induction of apoptosis. |
2016-01-04 |
2023-08-13 |
human |
| Ying Liu, Yan-Yan Chen, Ji-Yu Cao, Fang-Biao Tao, Xiao-Xia Zhu, Ci-Jiang Yao, Dao-Jun Chen, Zhen Che, Qi-Hong Zhao, Long-Ping We. Oxidative stress, apoptosis, and cell cycle arrest are induced in primary fetal alveolar type II epithelial cells exposed to fine particulate matter from cooking oil fumes. Environmental science and pollution research international. vol 22. issue 13. 2015-12-09. PMID:25634364. |
furthermore, the results also showed that cof-derived pm2.5 induced apoptosis through the endoplasmic reticulum (er) stress pathway, which is indicated by the increased expression of er stress-related apoptotic markers, namely grp78 and caspase-12. |
2015-12-09 |
2023-08-13 |
Not clear |
| Tian-Qi Tao, Xiao-Reng Wang, Mi Liu, Fei-Fei Xu, Xiu-Hua Li. Myofibrillogenesis regulator-1 attenuated hypoxia/reoxygenation-induced apoptosis by inhibiting the PERK/Nrf2 pathway in neonatal rat cardiomyocytes. Apoptosis : an international journal on programmed cell death. vol 20. issue 3. 2015-11-16. PMID:25542256. |
mr-1 overexpression attenuated h/r-induced apoptosis, decreased grp78 (p < 0.01) and chop expression (p < 0.05), and increased the bcl-2/bax ratio (p < 0.01). |
2015-11-16 |
2023-08-13 |
rat |
| Tian-Qi Tao, Xiao-Reng Wang, Mi Liu, Fei-Fei Xu, Xiu-Hua Li. Myofibrillogenesis regulator-1 attenuated hypoxia/reoxygenation-induced apoptosis by inhibiting the PERK/Nrf2 pathway in neonatal rat cardiomyocytes. Apoptosis : an international journal on programmed cell death. vol 20. issue 3. 2015-11-16. PMID:25542256. |
while mr-1 knockdown aggravated h/r-induced apoptosis, increased expression of grp78 and chop (p < 0.05), and decreased the bcl-2/bax ratio (p < 0.01). |
2015-11-16 |
2023-08-13 |
rat |
| Shaobo Tian, Weilong Chang, Hansong Du, Jie Bai, Zhenhai Sun, Qing Zhang, Hui Wang, Guangsheng Zhu, Kaixiong Tao, Yueping Lon. The interplay between GRP78 expression and Akt activation in human colon cancer cells under celecoxib treatment. Anti-cancer drugs. vol 26. issue 9. 2015-11-16. PMID:26225471. |
besides, silencing the grp78 expression regulated akt activation in a time-dependent manner and increased the induction of the c/ebp homologous protein (chop) as well as considerably promoted celecoxib-induced apoptosis. |
2015-11-16 |
2023-08-13 |
human |
| Jin Muk Kang, Sujin Park, Staci Jakyong Kim, Hyojung Kim, Bona Lee, Junil Kim, Jinah Park, Shin Tae Kim, Han-Kwang Yang, Woo Ho Kim, Seong-Jin Ki. KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78. Cancer research. vol 75. issue 15. 2015-10-26. PMID:26045166. |
kiaa1324 blocked oncogenic activities of grp78 by inhibiting grp78-caspase-7 interaction and suppressing grp78-mediated akt activation, thereby inducing apoptosis. |
2015-10-26 |
2023-08-13 |
Not clear |
| Jianqiong Yang, Haiqing Liu, Linfu Li, Hai Liu, Weimei Shi, Longhuo W. The Chondroprotective Role of TMF in PGE2-Induced Apoptosis Associating with Endoplasmic Reticulum Stress. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-10-05. PMID:26435723. |
by treatment with pge2, the chondrocytes apoptosis was significantly increased, the proapoptotic chop and jnk were upregulated, the prosurvival grp78 and xbp1 were downregulated, and gsk-3β was also upregulated. |
2015-10-05 |
2023-08-13 |
Not clear |
| Bao Li, Jing Tian, Yi Sun, Tao-Rui Xu, Rui-Fang Chi, Xiao-Li Zhang, Xin-Ling Hu, Yue-An Zhang, Fu-Zhong Qin, Wei-Fang Zhan. Activation of NADPH oxidase mediates increased endoplasmic reticulum stress and left ventricular remodeling after myocardial infarction in rabbits. Biochimica et biophysica acta. vol 1852. issue 5. 2015-10-01. PMID:25615792. |
the apocynin treatment prevented increases in the nox2 expression, nadph oxidase activity, oxidative stress, myocyte apoptosis and grp78, chop and cleaved caspase 12 protein expression in the remote myocardium. |
2015-10-01 |
2023-08-13 |
Not clear |
| Lihua Song, Lijun Ma, Fengsong Cong, Xiuhua Shen, Pu Jing, Xiong Ying, Haiyue Zhou, Jing Jiang, Yongye Fu, Hongli Ya. Radioprotective effects of genistein on HL-7702 cells via the inhibition of apoptosis and DNA damage. Cancer letters. vol 366. issue 1. 2015-09-30. PMID:26095601. |
in the present study, we showed that low concentration of gen (1.5 µm) protected l-02 cells against radiation damage via inhibition of apoptosis, alleviation of dna damage and chromosome aberration, down-regulation of grp78 and up-regulation of herp, hus1 and hhr23a. |
2015-09-30 |
2023-08-13 |
human |
| Lihua Song, Lijun Ma, Fengsong Cong, Xiuhua Shen, Pu Jing, Xiong Ying, Haiyue Zhou, Jing Jiang, Yongye Fu, Hongli Ya. Radioprotective effects of genistein on HL-7702 cells via the inhibition of apoptosis and DNA damage. Cancer letters. vol 366. issue 1. 2015-09-30. PMID:26095601. |
in contrast, high concentration of gen (20 µm) demonstrated radiosensitizing characteristics through the promotion of apoptosis and chromosome aberration, impairment of dna repair, up-regulation of grp78, and down-regulation of hus1, sirt1, rad17, rad51 and rnf8. |
2015-09-30 |
2023-08-13 |
human |
| Annat Raiter, Rinat Yerushalmi, Britta Hard. Pharmacological induction of cell surface GRP78 contributes to apoptosis in triple negative breast cancer cells. Oncotarget. vol 5. issue 22. 2015-09-24. PMID:25360516. |
pharmacological induction of cell surface grp78 contributes to apoptosis in triple negative breast cancer cells. |
2015-09-24 |
2023-08-13 |
Not clear |