| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fen Yang, Xiao Yan Tang, Hao Liu, Zhi Wen Jian. Inhibition of mitogen-activated protein kinase signaling pathway sensitizes breast cancer cells to endoplasmic reticulum stress-induced apoptosis. Oncology reports. vol 35. issue 4. 2016-12-26. PMID:26796921. |
this sensitization of breast cancer cells to tm-induced apoptosis by inhibition of mek/erk and grp78 is caspase-dependent, at least in part, by activation of caspase-4. |
2016-12-26 |
2023-08-13 |
human |
| Fengjie Cui, Xinyi Zan, Yunhong Li, Wenjing Sun, Yan Yang, Lifeng Pin. Grifola frondosa Glycoprotein GFG-3a Arrests S phase, Alters Proteome, and Induces Apoptosis in Human Gastric Cancer Cells. Nutrition and cancer. vol 68. issue 2. 2016-12-21. PMID:27040446. |
gfg-3a treatment resulted in the differential expression of 21 proteins in sgc-7901 cells by upregulating 10 proteins including rbbp4 associated with cell cycle arrest and downregulating 11 proteins including ruvbl1, npm, hsp90ab1, and grp78 involved in apoptosis and stress response. |
2016-12-21 |
2023-08-13 |
human |
| Chun Yan Wang, Su Tang Guo, Jia Yu Wang, Fen Liu, Yuan Yuan Zhang, Hamed Yari, Xu Guang Yan, Lei Jin, Xu Dong Zhang, Chen Chen Jian. Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress. Molecular cancer therapeutics. vol 15. issue 3. 2016-12-13. PMID:26832792. |
conversely, sirna knockdown of grp78 or xbp-1 enhanced auy922-induced apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yang Gao, Pengyu Jia, WenQi Shu, Dalin Ji. The protective effect of lycopene on hypoxia/reoxygenation-induced endoplasmic reticulum stress in H9C2 cardiomyocytes. European journal of pharmacology. vol 774. 2016-12-13. PMID:26845695. |
detect the survival rate, lactic dehydrogenase (ldh) activity, apoptosis ratio, glucose-regulated proteins 78 (grp78), c/ebp homologous protein (chop), c-jun-n-terminal protein kinase (jnk) and caspase-12 mrna and protein expression and phosphorylation of jnk (p-jnk) protein expression. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yang Gao, Pengyu Jia, WenQi Shu, Dalin Ji. The protective effect of lycopene on hypoxia/reoxygenation-induced endoplasmic reticulum stress in H9C2 cardiomyocytes. European journal of pharmacology. vol 774. 2016-12-13. PMID:26845695. |
ldh activity, apoptosis ratio and grp78 protein expression increase in the h/r group, reduced by lycopene. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yang Gao, Pengyu Jia, WenQi Shu, Dalin Ji. The protective effect of lycopene on hypoxia/reoxygenation-induced endoplasmic reticulum stress in H9C2 cardiomyocytes. European journal of pharmacology. vol 774. 2016-12-13. PMID:26845695. |
the apoptosis ratio, the expression of grp78, chop and caspase-12 mrna and protein and p-jnk protein increase in the h/r and tg groups, weaken in the lycopene+h/r, 4-pba+h/r and lycopene+tg groups. |
2016-12-13 |
2023-08-13 |
Not clear |
| Xiangguo Wang, Pengfei Lin, Yang Li, Caixia Xiang, Yanlong Yin, Zhi Chen, Yue Du, Dong Zhou, Yaping Jin, Aihua Wan. Brucella suis Vaccine Strain 2 Induces Endoplasmic Reticulum Stress that Affects Intracellular Replication in Goat Trophoblast Cells In vitro. Frontiers in cellular and infection microbiology. vol 6. 2016-11-11. PMID:26904517. |
the unfolded protein response (upr) chaperone molecule grp78 also promoted b.suis.s2 proliferation in gtcs by inhibiting er stress-induced apoptosis. |
2016-11-11 |
2023-08-13 |
Not clear |
| Jie Dai, Hongmei Liu, Jun Zhou, Kaixun Huan. Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress. International journal of molecular sciences. vol 17. issue 2. 2016-11-04. PMID:26875981. |
when selr-gene-silenced hle cells were exposed to d-galactose, glucose-regulated protein 78 (grp78) protein level was further increased, mitochondrial membrane potential was significantly decreased and accompanied by a release of mitochondrial cytochrome c. at the same time, the apoptosis cells percentage and the caspase-3 activity were visibly elevated in hle cells. |
2016-11-04 |
2023-08-13 |
human |
| Ping-An Peng, Le Wang, Qian Ma, Yi Xin, Ou Zhang, Hong-Ya Han, Xiao-Li Liu, Qing-Wei Ji, Yu-Jie Zhou, Ying-Xin Zha. Valsartan protects HK-2 cells from contrast media-induced apoptosis by inhibiting endoplasmic reticulum stress. Cell biology international. vol 39. issue 12. 2016-10-13. PMID:26248489. |
the results showed that meglumine diatrizoate caused significant cell apoptosis by up-regulating the expression of er stress markers, including glucose-regulated protein 78 (grp78), activating transcription factor 4 (atf4), ccaat/enhancer-binding protein-homologous protein (chop) and caspase 12, in a time- and dose-dependent manner, which could be alleviated by preincubation with valsartan. |
2016-10-13 |
2023-08-13 |
mouse |
| Qiucheng Lei, Jingcheng Bi, Xinying Wang, Tingting Jiang, Chao Wu, Feng Tian, Xuejin Gao, Xiao Wan, Huijun Zhen. GLP-2 Prevents Intestinal Mucosal Atrophy and Improves Tissue Antioxidant Capacity in a Mouse Model of Total Parenteral Nutrition. Nutrients. vol 8. issue 1. 2016-09-29. PMID:26761030. |
this effect may be dependent on enhanced epithelial cell proliferation, reduced apoptosis, and upregulated grp78 expression. |
2016-09-29 |
2023-08-13 |
mouse |
| Vitaliy M Sviripa, Ravshan Burikhanov, Josiah M Obiero, Yaxia Yuan, Justin R Nickell, Linda P Dwoskin, Chang-Guo Zhan, Chunming Liu, Oleg V Tsodikov, Vivek M Rangnekar, David S Wat. Par-4 secretion: stoichiometry of 3-arylquinoline binding to vimentin. Organic & biomolecular chemistry. vol 14. issue 1. 2016-09-23. PMID:26548370. |
prostate apoptosis response-4 protein (par-4) is a tumor suppressor that causes apoptosis in therapy-resistant prostate cancer cells by binding specifically to a receptor, glucose-regulated protein-78 (grp78), found only on the surface of cancer cells. |
2016-09-23 |
2023-08-13 |
Not clear |
| Kyung Seok Han, Na Li, Pater A Raven, Ladan Fazli, Sebastian Frees, Susan Ettinger, Ki Chung Park, Sung Joon Hong, Martin E Gleave, Alan I S. Inhibition of endoplasmic reticulum chaperone protein glucose-regulated protein 78 potentiates anti-angiogenic therapy in renal cell carcinoma through inactivation of the PERK/eIF2α pathway. Oncotarget. vol 6. issue 33. 2016-08-30. PMID:26472187. |
knockdown of grp78 using sirna inhibited cancer cell survival and induced apoptosis in rcc cells in vitro and also resulted in er stress-induced apoptosis and hypoxic/hypoglycemic stress-induced apoptosis by inactivating the perk/eif-2α pathway. |
2016-08-30 |
2023-08-13 |
Not clear |
| Liang Wang, Judy Y Chan, Xinhua Zhou, Guozhen Cui, Zhixiang Yan, Li Wang, Ru Yan, Lijun Di, Yuqiang Wang, Maggie P Hoi, Luchen Shan, Simon M Le. A Novel Agent Enhances the Chemotherapeutic Efficacy of Doxorubicin in MCF-7 Breast Cancer Cells. Frontiers in pharmacology. vol 7. 2016-08-25. PMID:27559313. |
both endoplasmic reticulum stress inhibitor 4-pba and knockdown of the expression of grp78 protein potentiated dt-010-mediated apoptosis in mcf-7 cells. |
2016-08-25 |
2023-08-13 |
Not clear |
| Sonia Meynier, Marianne Kramer, Pascale Ribaux, Jean-Christophe Tille, Florence Delie, Patrick Petignat, Marie Cohe. Role of PAR-4 in ovarian cancer. Oncotarget. vol 6. issue 26. 2016-08-04. PMID:26246468. |
we determined that par-4 induces cell apoptosis in response to stimuli, in vitro, but is also involved in the relocation of grp78 from endoplasmic reticulum to the cell surface of ovarian cancer cell line (skov-3 cells). |
2016-08-04 |
2023-08-13 |
Not clear |
| Lili Zhang, Huiying Zhang, Minli Lv, Jiantao Jia, Yimin Fan, Xiaoxia Tian, Xujiong Li, Baohong Li, Jingquan Ji, Limin Wang, Zhongfu Zhao, Dewu Han, Cheng J. Increased expression of 78 kD glucose-regulated protein promotes cardiomyocyte apoptosis in a rat model of liver cirrhosis. International journal of clinical and experimental pathology. vol 8. issue 8. 2016-08-03. PMID:26464674. |
this study was to investigate the role and underlying mechanism of 78 kd glucose-regulated protein (grp78) in cardiomyocyte apoptosis in a rat model of liver cirrhosis. |
2016-08-03 |
2023-08-13 |
rat |
| Rituparna Bhattacharjee, Arpita Devi, Seema Mishr. Molecular docking and molecular dynamics studies reveal structural basis of inhibition and selectivity of inhibitors EGCG and OSU-03012 toward glucose regulated protein-78 (GRP78) overexpressed in glioblastoma. Journal of molecular modeling. vol 21. issue 10. 2016-07-11. PMID:26419972. |
upregulated grp78 expression in cancer cells inhibits apoptosis and promotes chemoresistance. |
2016-07-11 |
2023-08-13 |
Not clear |
| M Jeon, H Choi, S I Lee, J S Kim, M Park, K Kim, S Lee, S J Byu. GRP78 is required for cell proliferation and protection from apoptosis in chicken embryo fibroblast cells. Poultry science. vol 95. issue 5. 2016-06-30. PMID:26944959. |
grp78 is required for cell proliferation and protection from apoptosis in chicken embryo fibroblast cells. |
2016-06-30 |
2023-08-13 |
chicken |
| Zhangyuan Xiong, Rong Jiang, Xiangzhu Li, Yanna Liu, Fengjin Gu. Different Roles of GRP78 on Cell Proliferation and Apoptosis in Cartilage Development. International journal of molecular sciences. vol 16. issue 9. 2016-06-17. PMID:26370957. |
different roles of grp78 on cell proliferation and apoptosis in cartilage development. |
2016-06-17 |
2023-08-13 |
Not clear |
| Zhangyuan Xiong, Rong Jiang, Xiangzhu Li, Yanna Liu, Fengjin Gu. Different Roles of GRP78 on Cell Proliferation and Apoptosis in Cartilage Development. International journal of molecular sciences. vol 16. issue 9. 2016-06-17. PMID:26370957. |
furthermore, overexpression of grp78 inhibited er stress-mediated apoptosis and then reduced apoptosis in chondrogenesis induced by bmp2, as assayed by cleaved caspase3, caspase12, c/ebp homologous protein (chop/ddit3/gadd153), p-jnk (phosphorylated c-jun n-terminal kinase) expression during the course of chondrocyte differentiation by western blot. |
2016-06-17 |
2023-08-13 |
Not clear |
| Zhangyuan Xiong, Rong Jiang, Xiangzhu Li, Yanna Liu, Fengjin Gu. Different Roles of GRP78 on Cell Proliferation and Apoptosis in Cartilage Development. International journal of molecular sciences. vol 16. issue 9. 2016-06-17. PMID:26370957. |
collectively, these findings reveal a novel critical role of grp78 in regulating er stress-mediated apoptosis in cartilage development and the molecular mechanisms involved. |
2016-06-17 |
2023-08-13 |
Not clear |