| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Lepretti, G Paolella, D Giordano, A Marabotti, F Gay, A Capaldo, C Esposito, I Caput. 4-Nonylphenol reduces cell viability and induces apoptosis and ER-stress in a human epithelial intestinal cell line. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 7. 2016-06-07. PMID:25998160. |
in addition, 4-nonylphenol induced apoptosis, involving the activation of caspase-3, and triggered an endoplasmic reticulum-stress response, as revealed by over-expression of grp78 (78 kda glucose-regulated protein) and activation of xbp1 (x-box binding protein-1). |
2016-06-07 |
2023-08-13 |
human |
| Lili Liu, Bingyou Yang, Yupeng Cheng, Hongjin Li. Ameliorative Effects of Selenium on Cadmium-Induced Oxidative Stress and Endoplasmic Reticulum Stress in the Chicken Kidney. Biological trace element research. vol 167. issue 2. 2016-06-03. PMID:25805271. |
cd administration significantly increased the accumulation of cd, the malondialdehyde (mda) content, no production, inos activity, inos expression levels, expression levels of er stress-related genes (grp78, grp94, atf4, atf6, and ire) and the pro-apoptosis gene caspase 3, and the rate of apoptosis. |
2016-06-03 |
2023-08-13 |
human |
| Jingtao Zhong, Peng Xiu, Xiaofeng Dong, Fuhai Wang, Honglong Wei, Xin Wang, Zongzhen Xu, Feng Liu, Tao Li, Yong Wang, Jie L. Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis. Oncology reports. vol 34. issue 4. 2016-05-24. PMID:26252057. |
grp78 knockdown by sirna or co-treatment with mg132 significantly increased this combination treatment-induced apoptosis. |
2016-05-24 |
2023-08-13 |
human |
| Hua-chuan Zheng, Jing Li, Dao-fu Shen, Xue-feng Yang, Shuang Zhao, Ya-zhou Wu, Yasuo Takano, Hong-zhi Sun, Rong-jian Su, Jun-sheng Luo, Wen-feng Go. BTG1 expression correlates with pathogenesis, aggressive behaviors and prognosis of gastric cancer: a potential target for gene therapy. Oncotarget. vol 6. issue 23. 2016-05-23. PMID:26050197. |
after treated with cisplatin, mg132, paclitaxel and saha, both btg1 transfectants showed lower mrna viability and higher apoptosis than the control in both time- and dose-dependent manners (p < 0.05) with the hypoexpression of chemoresistance-related genes (slug, cd147, grp78, grp94, fbxw7 top1, top2 and gst-π). |
2016-05-23 |
2023-08-13 |
Not clear |
| Hong-Yan Lu, Jie Zhang, Qiu-Xia Wang, Wei Tang, Lu-Jie Zhan. Activation of the endoplasmic reticulum stress pathway involving CHOP in the lungs of rats with hyperoxia‑induced bronchopulmonary dysplasia. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26099737. |
it was demonstrated that the mrna and protein levels of grp78 and chop, and the levels of cell apoptosis in the hyperoxia group differed significantly from those in the control group (p<0.05) at different time‑points, and increased with extension of the duration of hyperoxic exposure. |
2016-05-17 |
2023-08-13 |
rat |
| Jiqian Xu, Houxiang Hu, Bin Chen, Rongchuan Yue, Zhou Zhou, Yin Liu, Shuang Zhang, Lei Xu, Huan Wang, Zhengping Y. Lycopene Protects against Hypoxia/Reoxygenation Injury by Alleviating ER Stress Induced Apoptosis in Neonatal Mouse Cardiomyocytes. PloS one. vol 10. issue 8. 2016-05-13. PMID:26291709. |
we observed that lycopene alleviated the h/r injury as revealed by improving cell viability and reducing apoptosis, suppressed reactive oxygen species (ros) generation and improved the phosphorylated ampk expression, attenuated er stress as evidenced by decreasing the expression of grp78, atf6 mrna, sxbp-1 mrna, eif2α mrna and eif2α phosphorylation, alleviated er stress-induced apoptosis as manifested by reducing chop/gadd153 expression, the ratio of bax/bcl-2, caspase-12 and caspase-3 activity in h/r-treated cardiomyocytes. |
2016-05-13 |
2023-08-13 |
mouse |
| Jiqian Xu, Houxiang Hu, Bin Chen, Rongchuan Yue, Zhou Zhou, Yin Liu, Shuang Zhang, Lei Xu, Huan Wang, Zhengping Y. Lycopene Protects against Hypoxia/Reoxygenation Injury by Alleviating ER Stress Induced Apoptosis in Neonatal Mouse Cardiomyocytes. PloS one. vol 10. issue 8. 2016-05-13. PMID:26291709. |
our results showed that lycopene was able to prevent tg-induced er stress as reflected by attenuating the protein expression of grp78 and chop/gadd153 compared to tg group, significantly improve tg-caused a loss of cell viability and decrease apoptosis in tg-treated cardiomyocytes. |
2016-05-13 |
2023-08-13 |
mouse |
| Jun-Shan Mu, Hang Lin, Jian-Xin Ye, Min Lin, Xiao-Ping Cu. Rg1 exhibits neuroprotective effects by inhibiting the endoplasmic reticulum stress-mediated c-Jun N-terminal protein kinase apoptotic pathway in a rat model of Alzheimer's disease. Molecular medicine reports. vol 12. issue 3. 2016-05-09. PMID:26016457. |
the expression levels of the endoplasmic reticulum (er) stress biomarker, glucose‑regulated protein 78 (grp78), and the mitochondrial apoptosis biomarkers, b‑cell lymphoma 2 (bcl‑2) and bcl‑2‑associated x protein (bax), were analyzed by western blotting. |
2016-05-09 |
2023-08-13 |
rat |
| Nizar M Mhaidat, Karem H Alzoubi, Omar F Khabour, Mohammed N Banihani, Qosay A Al-Balas, Sulaiman Swaida. GRP78 regulates sensitivity of human colorectal cancer cells to DNA targeting agents. Cytotechnology. vol 68. issue 3. 2016-04-27. PMID:25399254. |
moreover, the levels of grp78 were inversely associated with sensitivity of crc cells to chemotherapy-induced apoptosis. |
2016-04-27 |
2023-08-13 |
human |
| Li-Zhou Sun, Xiao-Tian Ma, Zhi-Ping Ge, Ping Ha. [Effect of endoplasmic reticulum stress-responsive protein glucose-regulated protein 78, 94 and endoplasmic reticulum apoptosis factor caspase-12 in trophocyte on the pathogenesis of preeclampsia]. Zhonghua fu chan ke za zhi. vol 45. issue 12. 2016-04-23. PMID:21211418. |
to evaluate the relationship between pathogenesis of preeclampsia (pe) and the ultrastructure change of the endoplasmic reticulum in trophocyte, mrna and protein expression levels of endoplasmic reticulum molecular chaperone glucose-regulated protein 78 (grp78), glucose-regulated protein 94 (grp94), endoplasmic reticulum apoptosis factor cysteine protease protein 12 (caspase-12). |
2016-04-23 |
2023-08-12 |
Not clear |
| Xiaoli Yao, Hua Liu, Xinghua Zhang, Liang Zhang, Xiang Li, Changhua Wang, Shengrong Su. Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3. PloS one. vol 10. issue 5. 2016-04-13. PMID:25973748. |
furthermore, genetic and pharmacological inhibition of stat3 reversed the impacts of grp78 on cell proliferation, apoptosis, and migration. |
2016-04-13 |
2023-08-13 |
human |
| Min Li, Jing Tian, Quanxin Q. [Effect of glucose regulated protein 78 on autophagy and apoptosis in ovarian epithelial carcinoma]. Zhonghua fu chan ke za zhi. vol 50. issue 11. 2016-04-07. PMID:26887774. |
to explore the effect and mechanism of glucose regulated protein 78 (grp78) on autophagy and apoptosis in ovarian carcinoma, and to investigate the influence on the growth and sensitivity to cisplatin on the ovarian cancer cells. |
2016-04-07 |
2023-08-13 |
Not clear |
| Li Ying, Ziwei Zhu, Zhiyun Xu, Tianrui He, Encheng Li, Zhe Guo, Fen Liu, Chunmeng Jiang, Qi Wan. Cancer Associated Fibroblast-Derived Hepatocyte Growth Factor Inhibits the Paclitaxel-Induced Apoptosis of Lung Cancer A549 Cells by Up-Regulating the PI3K/Akt and GRP78 Signaling on a Microfluidic Platform. PloS one. vol 10. issue 6. 2016-04-06. PMID:26115510. |
cancer associated fibroblast-derived hepatocyte growth factor inhibits the paclitaxel-induced apoptosis of lung cancer a549 cells by up-regulating the pi3k/akt and grp78 signaling on a microfluidic platform. |
2016-04-06 |
2023-08-13 |
Not clear |
| Li Ying, Ziwei Zhu, Zhiyun Xu, Tianrui He, Encheng Li, Zhe Guo, Fen Liu, Chunmeng Jiang, Qi Wan. Cancer Associated Fibroblast-Derived Hepatocyte Growth Factor Inhibits the Paclitaxel-Induced Apoptosis of Lung Cancer A549 Cells by Up-Regulating the PI3K/Akt and GRP78 Signaling on a Microfluidic Platform. PloS one. vol 10. issue 6. 2016-04-06. PMID:26115510. |
in this study, we fabricated a three-dimensional (3d) microfluidic chip using polydimethylsiloxane (pdms) to investigate the impact of hepatocyte growth factor (hgf) from cancer-associated fibroblasts (caf) on the met/pi3k/akt activation, glucose regulatory protein (grp78) expression and the paclitaxel-induced a549 cell apoptosis. |
2016-04-06 |
2023-08-13 |
Not clear |
| Li Ying, Ziwei Zhu, Zhiyun Xu, Tianrui He, Encheng Li, Zhe Guo, Fen Liu, Chunmeng Jiang, Qi Wan. Cancer Associated Fibroblast-Derived Hepatocyte Growth Factor Inhibits the Paclitaxel-Induced Apoptosis of Lung Cancer A549 Cells by Up-Regulating the PI3K/Akt and GRP78 Signaling on a Microfluidic Platform. PloS one. vol 10. issue 6. 2016-04-06. PMID:26115510. |
furthermore, inhibition of pi3k or grp78 enhanced spontaneous and paclitaxel-induced a549 cell apoptosis. |
2016-04-06 |
2023-08-13 |
Not clear |
| Li Ying, Ziwei Zhu, Zhiyun Xu, Tianrui He, Encheng Li, Zhe Guo, Fen Liu, Chunmeng Jiang, Qi Wan. Cancer Associated Fibroblast-Derived Hepatocyte Growth Factor Inhibits the Paclitaxel-Induced Apoptosis of Lung Cancer A549 Cells by Up-Regulating the PI3K/Akt and GRP78 Signaling on a Microfluidic Platform. PloS one. vol 10. issue 6. 2016-04-06. PMID:26115510. |
inhibition of pi3k or grp78 attenuated the caf matrix-mediated inhibition on paclitaxel-induced a549 cell apoptosis. |
2016-04-06 |
2023-08-13 |
Not clear |
| Li Ying, Ziwei Zhu, Zhiyun Xu, Tianrui He, Encheng Li, Zhe Guo, Fen Liu, Chunmeng Jiang, Qi Wan. Cancer Associated Fibroblast-Derived Hepatocyte Growth Factor Inhibits the Paclitaxel-Induced Apoptosis of Lung Cancer A549 Cells by Up-Regulating the PI3K/Akt and GRP78 Signaling on a Microfluidic Platform. PloS one. vol 10. issue 6. 2016-04-06. PMID:26115510. |
our data indicated that hgf in the caf matrix activated the met/pi3k/akt and up-regulated grp78 expression, promoting chemoresistance to paclitaxel-mediated apoptosis in a549 cells. |
2016-04-06 |
2023-08-13 |
Not clear |
| Fang Yao, Zhen Li, Takashi Ehara, Lin Yang, Dandan Wang, Lulu Feng, Yiming Zhang, Kun Wang, Yonghong Shi, Huijun Duan, Lianshan Zhan. Fatty Acid-Binding Protein 4 mediates apoptosis via endoplasmic reticulum stress in mesangial cells of diabetic nephropathy. Molecular and cellular endocrinology. vol 411. 2016-03-23. PMID:25958041. |
along with the induction of fabp4 and apoptosis, grp78 and its three sensors as well as c/ebp homologous protein (chop) and caspase-12 were induced in hmcs treated with nefa or high glucose and these responses were attenuated or even abrogated by treating with fabp4 inhibitor or fabp4 sirna. |
2016-03-23 |
2023-08-13 |
human |
| Huinan Weng, Fenghua Liu, Shuiwang Hu, Li Li, Yifeng Wan. GnRH agonists induce endometrial epithelial cell apoptosis via GRP78 down-regulation. Journal of translational medicine. vol 12. 2016-02-26. PMID:25367189. |
gnrh agonists induce endometrial epithelial cell apoptosis via grp78 down-regulation. |
2016-02-26 |
2023-08-13 |
Not clear |
| S Jagannathan, M A Y Abdel-Malek, E Malek, N Vad, T Latif, K C Anderson, J J Driscol. Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib. Leukemia. vol 29. issue 11. 2016-02-24. PMID:26108695. |
metformin co-treatment with bortezomib suppressed induction of the critical upr effector glucose-regulated protein 78 (grp78) to impair autophagosome formation and enhance apoptosis. |
2016-02-24 |
2023-08-13 |
Not clear |