| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Qiang Wang, Juliette A Aka, Tang Li, Dan Xu, Charles J Doillon, Sheng-Xiang Li. Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78. The Journal of steroid biochemistry and molecular biology. vol 172. 2017-08-22. PMID:28645527. |
however, inh7 treatment of t47d, another widely used epithelial er+ breast cancer cell line, led to an up-regulation of grp78 expression, resulting in a limited increase in apoptosis. |
2017-08-22 |
2023-08-13 |
Not clear |
| Xiao-Qiang Wang, Juliette A Aka, Tang Li, Dan Xu, Charles J Doillon, Sheng-Xiang Li. Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78. The Journal of steroid biochemistry and molecular biology. vol 172. 2017-08-22. PMID:28645527. |
down-regulation of grp78 via 17β-hsd7 inhibition enhances cell apoptosis in response to letrozole. |
2017-08-22 |
2023-08-13 |
Not clear |
| Hiroshi Nakagawa, Kazuki Hazama, Katsumasa Ishida, Masayuki Komori, Kazuhiko Nishimura, Saburou Matsu. Inhibition of PLD1 activity causes ER stress via regulation of COPII vesicle formation. Biochemical and biophysical research communications. vol 490. issue 3. 2017-08-18. PMID:28648601. |
pld1 knockdown in nrk cells was associated with increased expression of the er stress marker grp78 and apoptosis. |
2017-08-18 |
2023-08-13 |
rat |
| Jiaying Lin, Suyoun Chung, Koji Ueda, Koichi Matsuda, Yusuke Nakamura, Jae-Hyun Par. GALNT6 Stabilizes GRP78 Protein by O-glycosylation and Enhances its Activity to Suppress Apoptosis Under Stress Condition. Neoplasia (New York, N.Y.). vol 19. issue 1. 2017-08-07. PMID:28110670. |
galnt6 stabilizes grp78 protein by o-glycosylation and enhances its activity to suppress apoptosis under stress condition. |
2017-08-07 |
2023-08-13 |
Not clear |
| Jun Wang, Yunjie Li, Fangfang Ma, Huifeng Zhou, Rong Ding, Binbin Lu, Li Zou, Junxia Li, Rugang L. Inhibitory effect of Par-4 combined with cisplatin on human Wilms' tumor cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 7. 2017-07-26. PMID:28720068. |
in addition, we found that ectopic par-4 co-localized with cell surface grp78 and induced high expression of the endoplasmic reticulum proteins atf4 and bax, which activated the endoplasmic reticulum apoptosis pathway. |
2017-07-26 |
2023-08-13 |
mouse |
| Jun Wang, Yunjie Li, Fangfang Ma, Huifeng Zhou, Rong Ding, Binbin Lu, Li Zou, Junxia Li, Rugang L. Inhibitory effect of Par-4 combined with cisplatin on human Wilms' tumor cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 7. 2017-07-26. PMID:28720068. |
thus, in vitro and in vivo upregulation of par-4 expression is indispensable for the trafficking of grp78 to the cell membrane and subsequent apoptosis of cancer cells. |
2017-07-26 |
2023-08-13 |
mouse |
| Dan Xu, Juliette A Aka, Ruixuan Wang, Sheng-Xiang Li. 17beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation. The Journal of steroid biochemistry and molecular biology. vol 171. 2017-07-18. PMID:28457968. |
17beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor grp78 and tumor-secreted protein pgk1, and modulates breast cancer cell viability and proliferation. |
2017-07-18 |
2023-08-13 |
Not clear |
| Dan Xu, Juliette A Aka, Ruixuan Wang, Sheng-Xiang Li. 17beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation. The Journal of steroid biochemistry and molecular biology. vol 171. 2017-07-18. PMID:28457968. |
we also showed that expression of 17β-hsd5 and that of the apoptosis inhibitor grp78 are strongly but negatively correlated. |
2017-07-18 |
2023-08-13 |
Not clear |
| Per Flodby, Changgong Li, Yixin Liu, Hongjun Wang, Crystal N Marconett, Ite A Laird-Offringa, Parviz Minoo, Amy S Lee, Beiyun Zho. The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. American journal of respiratory cell and molecular biology. vol 55. issue 1. 2017-06-30. PMID:26816051. |
lung epithelial-specific grp78 ko disrupted lung morphogenesis, causing developmental arrest, increased alveolar epithelial type ii cell apoptosis, and decreased surfactant protein and type i cell marker expression in perinatal lungs. |
2017-06-30 |
2023-08-13 |
mouse |
| Per Flodby, Changgong Li, Yixin Liu, Hongjun Wang, Crystal N Marconett, Ite A Laird-Offringa, Parviz Minoo, Amy S Lee, Beiyun Zho. The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. American journal of respiratory cell and molecular biology. vol 55. issue 1. 2017-06-30. PMID:26816051. |
increased smad3 phosphorylation and expression of transforming growth factor-β/smad3 targets cdkn1a (encoding p21) and gadd45a suggest that interactions among the apoptotic arm of the upr, oxidative stress, and transforming growth factor-β/smad signaling pathways contribute to grp78 ko-induced aec apoptosis and developmental arrest. |
2017-06-30 |
2023-08-13 |
mouse |
| Lichao Zhang, Zongwei Li, Tonglin Shi, Xiaoqin La, Hanqing Li, Zhuoyu L. Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells. BMC biotechnology. vol 16. issue 1. 2017-06-27. PMID:27585649. |
subtilase cytotoxic is a virulent cytotoxin, and the subunit a (suba) of it is able to destroy the structure of glucose-regulated protein 78 (grp78) to induce cell apoptosis, and to be expected as anti-cancer drugs, however, the ubiquitous receptor of subunit b of subtilase cytotoxic (subb) restricts its application on cancer therapy. |
2017-06-27 |
2023-08-13 |
Not clear |
| Mingfang Jiang, Qiang Yun, Feng Shi, Guangming Niu, Yang Gao, Shenghui Xie, Shengyuan Y. Downregulation of miR-384-5p attenuates rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through inhibiting endoplasmic reticulum stress. American journal of physiology. Cell physiology. vol 310. issue 9. 2017-05-26. PMID:26864693. |
in addition, knockdown of grp78 significantly abrogated the inhibitory effect of mir-384-5p inhibitors on cell apoptosis and er stress signaling. |
2017-05-26 |
2023-08-13 |
Not clear |
| Heng-Jing Hu, Zhi-Sheng Jiang, Jie Qiu, Sheng-Hua Zhou, Qi-Ming Li. Protective effects of hydrogen sulfide against angiotensin II-induced endoplasmic reticulum stress in HUVECs. Molecular medicine reports. vol 15. issue 4. 2017-05-15. PMID:28259956. |
treatment with nahs attenuated ros production, inhibited chop and grp78 expression, and decreased cell apoptosis. |
2017-05-15 |
2023-08-13 |
human |
| Jie Xie, Zhong-Hua Tao, Jiang Zhao, Ting Li, Zheng-Hua Wu, Jin-Feng Zhang, Jian Zhang, Xi-Chun H. Glucose regulated protein 78 (GRP78) inhibits apoptosis and attentinutes chemosensitivity of gemcitabine in breast cancer cell via AKT/mitochondrial apoptotic pathway. Biochemical and biophysical research communications. vol 474. issue 3. 2017-05-08. PMID:27012209. |
glucose regulated protein 78 (grp78) inhibits apoptosis and attentinutes chemosensitivity of gemcitabine in breast cancer cell via akt/mitochondrial apoptotic pathway. |
2017-05-08 |
2023-08-13 |
Not clear |
| Jie Xie, Zhong-Hua Tao, Jiang Zhao, Ting Li, Zheng-Hua Wu, Jin-Feng Zhang, Jian Zhang, Xi-Chun H. Glucose regulated protein 78 (GRP78) inhibits apoptosis and attentinutes chemosensitivity of gemcitabine in breast cancer cell via AKT/mitochondrial apoptotic pathway. Biochemical and biophysical research communications. vol 474. issue 3. 2017-05-08. PMID:27012209. |
ectopic expression of grp78 changes gemcitabine chemosensitivity and apoptosis levels in breast cancer cells. |
2017-05-08 |
2023-08-13 |
Not clear |
| Ehab A Ayaub, Philipp S Kolb, Zahraa Mohammed-Ali, Victor Tat, James Murphy, Pierre-Simon Bellaye, Chiko Shimbori, Felix J Boivin, Rocky Lai, Edward G Lynn, Šárka Lhoták, Darren Bridgewater, Martin Rj Kolb, Mark D Inman, Jeffrey G Dickhout, Richard C Austin, Kjetil As. GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis. The Journal of pathology. vol 239. issue 4. 2017-05-04. PMID:27135434. |
grp78 and chop modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis. |
2017-05-04 |
2023-08-13 |
mouse |
| Weinan Li, Yun Jiang, Tao Sun, Xiaomin Yao, Xiangjun Su. Supplementation of procyanidins B2 attenuates photooxidation-induced apoptosis in ARPE-19 cells. International journal of food sciences and nutrition. vol 67. issue 6. 2017-04-25. PMID:27251367. |
moreover, pb2 inhibition of apoptosis is dependent on the upr chaperone grp78, indicating pb2 inhibits vitamin a dimer-mediated apoptosis in rpe cells by activating the upr. |
2017-04-25 |
2023-08-13 |
Not clear |
| He-Ming Min, Yan Wang, Da-Yong Ren, Xue Cheng, Jian Li, Xing-Qian Jiang, Lian-Qiu Min, Cui-Fen Ba. Protective effect of 2-deoxy-D-glucose on the brain tissue in rat cerebral ischemia-reperfusion models by inhibiting Caspase-apoptotic pathway. Histology and histopathology. vol 32. issue 1. 2017-04-14. PMID:27109833. |
nerve cell apoptosis, and the expressions of mrna and protein of glucose regulated protein 78 (grp78), cleaved-caspase-9 and cleaved-caspase-3 were determined with tunel, western blotting and rt-pcr, respectively, in rat cerebral hippocampal ca1 area at each time point. |
2017-04-14 |
2023-08-13 |
rat |
| Kana Miyahara, Hiromi Kazama, Hiroko Kokuba, Seiichiro Komatsu, Ayako Hirota, Jun Takemura, Kazuhiro Hirasawa, Shota Moriya, Akihisa Abe, Masaki Hiramoto, Takashi Ishikawa, Keisuke Miyazaw. Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines. International journal of oncology. vol 49. issue 5. 2017-04-11. PMID:27601063. |
combined treatment using bz and vnr, but not ptx, enhanced the cytotoxic effect and apoptosis induction along with pronounced er stress loading such as upregulation of grp78 and chop/gadd153. |
2017-04-11 |
2023-08-13 |
Not clear |
| Weiping Zhang, Lihong Chen, Yuxian Shen, Jianming X. Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicology in vitro : an international journal published in association with BIBRA. vol 36. 2017-03-24. PMID:27470132. |
in our study, l02 cells were treated with different concentrations of rfp for different time intervals, and cell apoptosis, the survival rate, and the gene and protein expression of grp78, perk, atf4, and chop were measured. |
2017-03-24 |
2023-08-13 |
Not clear |