| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Yan Lu, Xiao-Qing Chen, Wei Tang, Qiu-Xia Wang, Jie Zhan. GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway. Molecular medicine reports. vol 16. issue 2. 2018-05-10. PMID:28586043. |
grp78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via chop pathway. |
2018-05-10 |
2023-08-13 |
human |
| Hong-Yan Lu, Xiao-Qing Chen, Wei Tang, Qiu-Xia Wang, Jie Zhan. GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway. Molecular medicine reports. vol 16. issue 2. 2018-05-10. PMID:28586043. |
the expression levels of er stress‑associated genes were determined, and a significant increase in c/ebp homologous protein (chop) expression and apoptosis of a549 cells was observed, following grp78 knockdown. |
2018-05-10 |
2023-08-13 |
human |
| Hong-Yan Lu, Xiao-Qing Chen, Wei Tang, Qiu-Xia Wang, Jie Zhan. GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway. Molecular medicine reports. vol 16. issue 2. 2018-05-10. PMID:28586043. |
these results suggested that grp78 silencing promoted lung epithelial cell apoptosis during hyperoxia, via regulation of the chop pathway. |
2018-05-10 |
2023-08-13 |
human |
| Ting-Xia Li, Jian-Hua Mao, Lei Huang, Hai-Dong Fu, Shuo-Hui Chen, Ai-Min Liu, Yu-Qin Lian. Beneficial effects of Huaiqihuang on hyperglycemia-induced MPC5 podocyte dysfunction through the suppression of mitochondrial dysfunction and endoplasmic reticulum stress. Molecular medicine reports. vol 16. issue 2. 2018-05-10. PMID:28627684. |
furthermore, grp78 loss‑of‑function attenuated hg‑induced podocyte dysfunction, including cell apoptosis and dna damage. |
2018-05-10 |
2023-08-13 |
Not clear |
| Huai-Ching Tai, Shiu-Dong Chung, Chiang-Ting Chien, Hong-Jeng Y. Sulforaphane Improves Ischemia-Induced Detrusor Overactivity by Downregulating the Enhancement of Associated Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Rat Bladder. Scientific reports. vol 6. 2018-05-03. PMID:27824068. |
we found that bpao significantly induced the presence of detrusor overactivity (do) and upregulated the expression of several molecular reactions, including biomarkers in endoplasmic reticulum stress (78 kda glucose-regulated protein, grp78 and c/ebp-homologous protein, chop), autophagy (beclin-1, p62 and lc3 ii) and apoptosis (caspase 3). |
2018-05-03 |
2023-08-13 |
rat |
| Jun Yang, Zhao Wang, Dong-Lin Che. Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis, inflammation, apoptosis and ER stress. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 93. 2018-04-20. PMID:28753907. |
in iso-induced cardiac injury, shikonin significantly ameliorated heart function, decreased myocardial fibrosis, suppressed inflammation, attenuated apoptosis and er stress through impeding collagen accumulation, toll like receptor 4/nuclear transcription factor κb (tlr4/nf-κb), caspase-3 and glucose-regulated protein 78 (grp78) signaling pathways activity, relieving heart failure in vivo. |
2018-04-20 |
2023-08-13 |
mouse |
| Yang Zhou, Wei-Kun Jia, Zhao Jian, Liang Zhao, Chen-Cheng Liu, Yong Wang, Ying-Bin Xia. Downregulation of microRNA‑199a‑5p protects cardiomyocytes in cyanotic congenital heart disease by attenuating endoplasmic reticulum stress. Molecular medicine reports. vol 16. issue 3. 2018-04-16. PMID:28713984. |
in addition, the mir‑199a‑5p mimic and inhibitor were evidently able to change grp78 and atf6 gene expression and er stress‑associated apoptosis in hypoxia‑treated cardiomyocytes. |
2018-04-16 |
2023-08-13 |
human |
| Qiang Niu, Jingwen Chen, Tao Xia, Pei Li, Guoyu Zhou, Chunyan Xu, Qian Zhao, Lixin Dong, Shun Zhang, Aiguo Wan. Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity. Environmental pollution (Barking, Essex : 1987). vol 233. 2018-04-06. PMID:29100748. |
moreover, naf exposure induced excessive er stress and associated apoptosis, as manifested by elevated ire1α, grp78, cleaved caspase-12 and cleaved-caspase-3, as well as defective autophagy, as shown by increased beclin1, lc3-ii and p62 expression in hippocampus. |
2018-04-06 |
2023-08-13 |
rat |
| Xiaolei Li, Hui Chen, Yu Sun, Jihang Dai, Shuguang Wang, Jingcheng Wang, Lianqi Ya. Hydroxycamptothecin prevents intraarticular scar adhesion by activating the PERK signal pathway. European journal of pharmacology. vol 810. 2018-04-05. PMID:28603046. |
hcpt-induced apoptosis was correlated with elevation of grp78 and chop, which were hallmarks of er stress. |
2018-04-05 |
2023-08-13 |
human |
| Xiaolei Li, Hui Chen, Yu Sun, Jihang Dai, Shuguang Wang, Jingcheng Wang, Lianqi Ya. Hydroxycamptothecin prevents intraarticular scar adhesion by activating the PERK signal pathway. European journal of pharmacology. vol 810. 2018-04-05. PMID:28603046. |
knockdown of perk decreased the ratio of bax/bcl-2, grp78 and chop expression, suggesting that perk signal pathway was involved in hcpt-induced fibroblast apoptosis. |
2018-04-05 |
2023-08-13 |
human |
| Fenghua Li, Yang Yang, Lili Yang, Kai Wang, Xing Zhang, Yunlong Zong, Yixin Ding, Changhong Wang, Li Zhang, Guang J. Resveratrol alleviates FFA and CCl4 induced apoptosis in HepG2 cells via restoring endoplasmic reticulum stress. Oncotarget. vol 8. issue 27. 2018-03-29. PMID:28415630. |
the expression of molecules related to apoptosis (caspases, bcl-2/bax) and er stress (grp78, ire1, atf6, perk, et al.) |
2018-03-29 |
2023-08-13 |
Not clear |
| Danni Ran, Jiani Mao, Qing Shen, Cao Xie, Changyou Zhan, Ruifeng Wang, Weiyue L. GRP78 enabled micelle-based glioma targeted drug delivery. Journal of controlled release : official journal of the Controlled Release Society. vol 255. 2018-03-08. PMID:28344016. |
grp78, a specific cancer cell-surface marker, is implicated in cancer cells proliferation, apoptosis resistance, metastasis and drug resistance. |
2018-03-08 |
2023-08-13 |
Not clear |
| Chengmin Li, Bin Zhang, Wuwu Lv, Chen Lai, Zhikang Chen, Ran Wang, Xueying Long, Xueping Fen. Triptolide inhibits cell growth and GRP78 protein expression but induces cell apoptosis in original and radioresistant NPC cells. Oncotarget. vol 7. issue 31. 2018-02-23. PMID:27391061. |
triptolide inhibits cell growth and grp78 protein expression but induces cell apoptosis in original and radioresistant npc cells. |
2018-02-23 |
2023-08-13 |
mouse |
| Bin Wang, Lilu Lin, Haidong Wang, Honglei Guo, Yong Gu, Wei Din. Overexpressed cyclophilin B suppresses aldosterone-induced proximal tubular cell injury both in vitro and in vivo. Oncotarget. vol 7. issue 43. 2018-02-21. PMID:27732567. |
we report that overexpression of wild-type cypb attenuated aldosterone-induced oxidative stress (evidenced by reduced production of reactive oxygen species and improved mitochondrial dysfunction), ers (indicated by reduced expression of the ers markers glucose-regulated protein 78 [grp78] and c/-ebp homologous protein [chop]), and tubular cell apoptosis in comparison with aldosterone-induced human kidney-2 (hk-2) cells. |
2018-02-21 |
2023-08-13 |
human |
| Manli Chen, Qin Liu, Lijian Chen, Lei Zhang, Erwei G. Remifentanil postconditioning ameliorates histone H3 acetylation modification in H9c2 cardiomyoblasts after hypoxia/reoxygenation via attenuating endoplasmic reticulum stress. Apoptosis : an international journal on programmed cell death. vol 22. issue 5. 2018-02-21. PMID:28205129. |
results showed that rpc increased cell viability and prevented cell apoptosis (evidenced by cck-8 cell viability assays and flow cytometry), and these effects were accompanied by lower levels of expression of grp78, chop, cleaved caspase-12, and cleaved caspase-3. |
2018-02-21 |
2023-08-13 |
Not clear |
| Wen-Ji Shangguan, Yue-Hui Zhang, Zhan-Chun Li, Lu-Min Tang, Jiang Shao, He L. Naringin inhibits vascular endothelial cell apoptosis via endoplasmic reticulum stress‑ and mitochondrial‑mediated pathways and promotes intraosseous angiogenesis in ovariectomized rats. International journal of molecular medicine. vol 40. issue 6. 2018-02-14. PMID:29039439. |
naringin also significantly reduced serum starvation‑induced apoptosis in endothelial cells, inhibited the expression of grp78, chop, caspase‑12, and cyt.c proteins, and reduced mitochondrial membrane potential as well as reduced the activities of caspase‑3 and ‑9. |
2018-02-14 |
2023-08-13 |
rat |
| Supriya Chakraborty, Swatilekha Ghosh, Bhaswati Banerjee, Abhishek Santra, Jyotsna Bhat, Arghya Adhikary, Subhrangsu Chatterjee, Anup K Misra, Parimal C Se. Mephebrindole, a synthetic indole analog coordinates the crosstalk between p38MAPK and eIF2α/ATF4/CHOP signalling pathways for induction of apoptosis in human breast carcinoma cells. Apoptosis : an international journal on programmed cell death. vol 21. issue 10. 2018-02-13. PMID:27392939. |
detailed evaluations revealed that mephebrindole by activating p38mapk also regulated grp78 and eif2α/atf4 downstream to promote apoptosis. |
2018-02-13 |
2023-08-13 |
mouse |
| Haopeng Yang, Shengjun Fan, Yu An, Xin Wang, Yan Pan, Yilixiati Xiaokaiti, Jianhui Duan, Xin Li, Lu Tie, Min Ye, Xuejun L. Bisdemethoxycurcumin exerts pro-apoptotic effects in human pancreatic adenocarcinoma cells through mitochondrial dysfunction and a GRP78-dependent pathway. Oncotarget. vol 7. issue 50. 2018-02-05. PMID:27845899. |
we then reveal that bdmc upregulates grp78 and facilitates apoptosis through eif2α/chop pathway. |
2018-02-05 |
2023-08-13 |
human |
| Mohd Kamil, Ejazul Haque, Safia Irfan, Saba Sheikh, Adria Hasan, Aamir Nazir, Mohtashim Lohani, Snober S Mi. ER chaperone GRP78 regulates autophagy by modulation of p53 localization. Frontiers in bioscience (Elite edition). vol 9. 2018-01-31. PMID:27814589. |
its anti-apoptotic and pro-autophagic activity makes it an intriguing target to study the relationship between grp78 and p53, which is also a major regulator of apoptosis and autophagy. |
2018-01-31 |
2023-08-13 |
human |
| Min Sun, Jiale Ma, Zeyanqiu Yu, Zihao Pan, Chengping Lu, Huochun Ya. Identification of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from different pathways. Veterinary research. vol 48. issue 1. 2018-01-18. PMID:28854955. |
otherwise, a novel variation (16-20 aa deletion and an l25p mutation) in the transmembrane domain of the e protein affected multiple infection processes, including up-regulation of the production of the er stress indicator grp78, improving the expression of pro-inflammatory cytokines il-6 and il-8, and promoting apoptosis. |
2018-01-18 |
2023-08-13 |
Not clear |