| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Jiang, Jiashun Chen, Shaojuan Liu, Gang Liu, Kang Yao, Yulong Yi. l-Glutamine Attenuates Apoptosis Induced by Endoplasmic Reticulum Stress by Activating the IRE1α-XBP1 Axis in IPEC-J2: A Novel Mechanism of l-Glutamine in Promoting Intestinal Health. International journal of molecular sciences. vol 18. issue 12. 2018-08-27. PMID:29206200. |
prolonged tuni-induced ers was found to increase apoptosis mediated by c/enhancer binding protein homologous protein (chop), accompanied by grp78 downregulation. |
2018-08-27 |
2023-08-13 |
Not clear |
| Qian Jiang, Jiashun Chen, Shaojuan Liu, Gang Liu, Kang Yao, Yulong Yi. l-Glutamine Attenuates Apoptosis Induced by Endoplasmic Reticulum Stress by Activating the IRE1α-XBP1 Axis in IPEC-J2: A Novel Mechanism of l-Glutamine in Promoting Intestinal Health. International journal of molecular sciences. vol 18. issue 12. 2018-08-27. PMID:29206200. |
finally, in the milieu of tuni-induced ers, l-glutamine was found to maintain a high level of grp78, alleviate chop-mediated apoptosis and activate the inositol requiring enzyme 1α (ire1α)-x-box binding protein 1 (xbp1) axis. |
2018-08-27 |
2023-08-13 |
Not clear |
| Ji-Ye Han, Yun-Ji Lim, Ji-Ae Choi, Jung-Hwan Lee, Sung-Hee Jo, Sung-Man Oh, Chang-Hwa Son. The Role of Prostate Apoptosis Response-4 (Par-4) in Mycobacterium tuberculosis Infected Macrophages. Scientific reports. vol 6. 2018-08-20. PMID:27552917. |
prostate apoptosis response-4 (par-4) is a tumor suppressor protein that forms a complex with glucose-regulated protein 78 (grp78) to induce apoptosis. |
2018-08-20 |
2023-08-13 |
Not clear |
| Ji-Ye Han, Yun-Ji Lim, Ji-Ae Choi, Jung-Hwan Lee, Sung-Hee Jo, Sung-Man Oh, Chang-Hwa Son. The Role of Prostate Apoptosis Response-4 (Par-4) in Mycobacterium tuberculosis Infected Macrophages. Scientific reports. vol 6. 2018-08-20. PMID:27552917. |
furthermore, par-4 and grp78 translocate to the surface of mtb h37ra-infected macrophages and induce apoptosis via caspase activation. |
2018-08-20 |
2023-08-13 |
Not clear |
| Rong-rong Liu, Xuan Zhang, Bin Xiao, Xue-wu Zhan. [Mechanism of TTF1-NP induced implanted hepatoma tumor apoptosis in nude mice by endoplasmic reticulum stress pathway]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 51. issue 3. 2018-08-16. PMID:29859020. |
morphological changes of implanted tumor cells were observed by he staining; apoptosis of tumor cells was detected by tunel; the protein expression of grp78, p-jnk and caspase 12 were analyzed using immunocytochemistry staining and western blotting. |
2018-08-16 |
2023-08-13 |
mouse |
| Rong-rong Liu, Xuan Zhang, Bin Xiao, Xue-wu Zhan. [Mechanism of TTF1-NP induced implanted hepatoma tumor apoptosis in nude mice by endoplasmic reticulum stress pathway]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 51. issue 3. 2018-08-16. PMID:29859020. |
in comparison with the vehicle group, the treated groups exhibited alteration in cell morphology and apoptosis of tumor cells, and expression of grp78, p-jnk and caspase 12, which were observed by immunocytochemistry staining and western blotting. |
2018-08-16 |
2023-08-13 |
mouse |
| Sharada H Sharma, Vinothkumar Rajamanickam, Sangeetha Nagaraja. Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer. Chemico-biological interactions. vol 291. 2018-07-27. PMID:29879413. |
supplementation of p-ca downregulated grp78 and activated upr mediated apoptosis both in in vitro and in vivo models of colon cancer. |
2018-07-27 |
2023-08-13 |
Not clear |
| Sharada H Sharma, Vinothkumar Rajamanickam, Sangeetha Nagaraja. Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer. Chemico-biological interactions. vol 291. 2018-07-27. PMID:29879413. |
further mechanistic insights revealed that p-ca inhibits grp78 upregulation in cancer cells through activation of perk-eif2α-atf-4-chop pathway that culminates in apoptosis inducing effect of p-ca. |
2018-07-27 |
2023-08-13 |
Not clear |
| Rui Wang, Da-Zhuang Sun, Chun-Qing Song, Yong-Min Xu, Wei Liu, Zhi Liu, Xue-Song Don. Eukaryotic translation initiation factor 2 subunit α (eIF2α) inhibitor salubrinal attenuates paraquat-induced human lung epithelial-like A549 cell apoptosis by regulating the PERK-eIF2α signaling pathway. Toxicology in vitro : an international journal published in association with BIBRA. vol 46. 2018-07-20. PMID:28986289. |
the data showed that pq significantly reduced a549 cell viability, changed cell morphology, induced cell apoptosis and significantly upregulated the levels of grp78, chop, p-perk, c-atf6 and p-ire1α. |
2018-07-20 |
2023-08-13 |
human |
| Jian Zhang, Aiyou Sun, Yuguo Dong, Dongzhi We. Recombinant Production and Characterization of SAC, the Core Domain of Par-4, by SUMO Fusion System. Applied biochemistry and biotechnology. vol 184. issue 4. 2018-07-10. PMID:28971310. |
prostate apoptosis response-4 (par-4), an anticancer protein that interacts with cell surface receptor grp78, can selectively suppress proliferation and induce apoptosis of cancer cells. |
2018-07-10 |
2023-08-13 |
Not clear |
| Jian Zhang, Aiyou Sun, Yuguo Dong, Dongzhi We. Recombinant Production and Characterization of SAC, the Core Domain of Par-4, by SUMO Fusion System. Applied biochemistry and biotechnology. vol 184. issue 4. 2018-07-10. PMID:28971310. |
immunofluorescence analysis and competitive binding reaction showed that recombinant sac could specifically induce apoptosis of skov-3 cells through combination with cell surface receptor, grp78. |
2018-07-10 |
2023-08-13 |
Not clear |
| Dong Han, Xiang Li, Shuang Li, Tao Su, Li Fan, Wen-Si Fan, Hong-Yu Qiao, Jiang-Wei Chen, Miao-Miao Fan, Xiu-Juan Li, Ya-Bin Wang, Sai Ma, Ya Qiu, Zu-Hong Tian, Feng Ca. Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist. Free radical biology & medicine. vol 113. 2018-07-05. PMID:28993270. |
furthermore, the levels of myocardial inflammatory cytokines (tnf-α, il-6, il-1β, mcp-1, mpo and hmgb1), oxidative stress (ros generation, mda), endoplasmic-reticulum (er) stress (protein levels of chop, grp78, grp94, ire1α, and atf6), and cardiac apoptosis following clp were inhibited by t0901317 treatment in wild-type mice but not in sirt1-/- mice. |
2018-07-05 |
2023-08-13 |
mouse |
| Benhong Zhou, Jun Tan, Chan Zhang, Yue W. Neuroprotective effect of polysaccharides from Gastrodia elata blume against corticosterone‑induced apoptosis in PC12 cells via inhibition of the endoplasmic reticulum stress‑mediated pathway. Molecular medicine reports. vol 17. issue 1. 2018-07-05. PMID:29115511. |
subsequently, intracellular ros level was detected by using dcfh‑da method, the morphology staining of the endoplasmic reticulum in pc12 cells was determined using the cationic probe, and levels of five proteins involved in apoptosis, i.e., glucose‑regulated protein, 78k da (grp78), x‑box binding protein 1 (xbp‑1), growth arrest‑ and dna damage‑inducible gene 153 (gadd153), caspase 9 and caspase 12 were determined by western blotting. |
2018-07-05 |
2023-08-13 |
Not clear |
| Ritesh K Srivastava, Changzhao Li, Zhiping Weng, Anupam Agarwal, Craig A Elmets, Farrukh Afaq, Mohammad Atha. Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototype. Scientific reports. vol 6. 2018-07-02. PMID:27725709. |
similar to its effects in murine epidermis, a dose- and time-dependent upregulation of ros, cytokines, upr proteins (grp78, p-perk, p-eif2α, atf4 and chop) and apoptosis were observed in pao-treated human skin keratinocytes nhek and hacat. |
2018-07-02 |
2023-08-13 |
human |
| Shuhuan Fang, Honghai Hong, Lei Li, Dan He, Zumin Xu, Shaoyuan Zuo, Jing Han, Qiyuan Wu, Zhiyu Dai, Weibin Cai, Jianxing Ma, Chunkui Shao, Guoquan Gao, Xia Yan. Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1α and GRP78. Cell death & disease. vol 8. issue 10. 2018-07-02. PMID:29072683. |
the present study aims to elucidate the dual effects of plasminogen kringle 5 (k5) on tumour angiogenesis and apoptosis induction by targeting hypoxia-inducible factor 1α (hif-1α) and grp78. |
2018-07-02 |
2023-08-13 |
Not clear |
| Shuhuan Fang, Honghai Hong, Lei Li, Dan He, Zumin Xu, Shaoyuan Zuo, Jing Han, Qiyuan Wu, Zhiyu Dai, Weibin Cai, Jianxing Ma, Chunkui Shao, Guoquan Gao, Xia Yan. Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1α and GRP78. Cell death & disease. vol 8. issue 10. 2018-07-02. PMID:29072683. |
furthermore, k5 decreased grp78 expression via downregulation of phosphorylated extracellular-regulated protein kinase, leading to caspase-7 cleavage and tumour cell apoptosis. |
2018-07-02 |
2023-08-13 |
Not clear |
| Weigang Cui, Songtao Wang, Zhongping Wang, Zhiyong Wang, Chunli Sun, Yinghua Zhan. Inhibition of PTEN Attenuates Endoplasmic Reticulum Stress and Apoptosis via Activation of PI3K/AKT Pathway in Alzheimer's Disease. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28819903. |
the expression in grp78, chop and apoptosis levels by bpv was reversed after pi3k inhibitor treatment. |
2018-06-26 |
2023-08-13 |
mouse |
| Xin Wang, Dalin Jia, Juncheng Zhang, Wei Wan. Grape seed proanthocyanidins protect cardiomyocytes against hypoxia/reoxygenation injury by attenuating endoplasmic reticulum stress through PERK/eIF2α pathway. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:29039545. |
cell viability was assessed, as well as lactic dehydrogenase (ldh) activity, cell apoptosis rate, expression levels of glucose‑regulated protein 78 (grp78), c/ebp‑homologous protein (chop), protein kinase rna‑like er kinase (perk), and eukaryotic translation initiation factor‑2 (eif2α) mrna and protein. |
2018-06-26 |
2023-08-13 |
Not clear |
| Lu Zou, Xiaoyan Li, Nan Wu, Pengyu Jia, Chunting Liu, Dalin Ji. Palmitate induces myocardial lipotoxic injury via the endoplasmic reticulum stress‑mediated apoptosis pathway. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901411. |
western blotting was used to evaluate the expression change of er stress‑mediated apoptosis pathway proteins, including 78 kda glucose‑regulated protein (grp78), eukaryotic initiation factor 2 α (eif2α), protein kinase r‑like endoplasmic reticulum kinase (perk), c/ebp homologous protein (chop) and cleaved caspase‑12. |
2018-06-04 |
2023-08-13 |
Not clear |
| Jiaxin Liu, Shuai Zhou, Xiying Qian, Yueting Zhang, Jianhua Zha. [Over-expressed Bax inhibitor 1 (BI-1) inhibits apoptosis of hippocampal neurons via endoplasmic reticulum IRE1-JNK pathway in rats with subarachnoid hemorrhage]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 10. 2018-05-15. PMID:29169414. |
results bi-1 over-expression improved neurobehavioral score, decreased brain water content and hippocampal neuron apoptosis rate, and also down-regulated grp78 and ire1 protein levels in the rats with sah. |
2018-05-15 |
2023-08-13 |
rat |