| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Si-Pin Zhu, Zhou-Guang Wang, Ying-Zheng Zhao, Jiang Wu, Hong-Xue Shi, Li-Bing Ye, Fen-Zan Wu, Yi Cheng, Hong-Yu Zhang, Songbin He, Xiaojie Wei, Xiao-Bing Fu, Xiao-Kun Li, Hua-Zi Xu, Jian Xia. Gelatin Nanostructured Lipid Carriers Incorporating Nerve Growth Factor Inhibit Endoplasmic Reticulum Stress-Induced Apoptosis and Improve Recovery in Spinal Cord Injury. Molecular neurobiology. vol 53. issue 7. 2018-01-08. PMID:26232067. |
the er stress-induced apoptosis response proteins chop, grp78 and caspase-12 inhibited by ngf-gnl treatment were more obvious. |
2018-01-08 |
2023-08-13 |
rat |
| Stefania Martucciello, Gaetana Paolella, Tamara Muzashvili, Alexandre Skhirtladze, Cosimo Pizza, Ivana Caputo, Sonia Piacent. Steroids from Helleborus caucasicus reduce cancer cell viability inducing apoptosis and GRP78 down-regulation. Chemico-biological interactions. vol 279. 2018-01-03. PMID:29126784. |
steroids from helleborus caucasicus reduce cancer cell viability inducing apoptosis and grp78 down-regulation. |
2018-01-03 |
2023-08-13 |
Not clear |
| Jin-Sang Kil, Sun-Oh Jeong, Hun-Taeg Chung, Hyun-Ock Pa. Piceatannol attenuates homocysteine-induced endoplasmic reticulum stress and endothelial cell damage via heme oxygenase-1 expression. Amino acids. vol 49. issue 4. 2017-12-13. PMID:27995330. |
hcy increased annexin v-positive cells, dhe oxidation, grp78 and chop expression and xbp-1 mrna splicing, indicating that hcy induces apoptosis, oxidative stress and er stress. |
2017-12-13 |
2023-08-13 |
human |
| Xin Zhou, Dewu Han, Xi Yang, Xiangyu Wang, Aixiu Qia. Glucose regulated protein 78 is potentially an important player in the development of nonalcoholic steatohepatitis. Gene. vol 637. 2017-12-12. PMID:28951310. |
in addition, grp78 expression levels were positively correlated with the levels of alt, tnfα, cd68 and hepatocytic apoptosis. |
2017-12-12 |
2023-08-13 |
rat |
| Li Zhang, Feng Ren, Xiangying Zhang, Xinxin Wang, Hongbo Shi, Li Zhou, Sujun Zheng, Yu Chen, Dexi Chen, Liying Li, Caiyan Zhao, Zhongping Dua. Peroxisome proliferator-activated receptor alpha acts as a mediator of endoplasmic reticulum stress-induced hepatocyte apoptosis in acute liver failure. Disease models & mechanisms. vol 9. issue 7. 2017-12-04. PMID:27482818. |
indeed, (1) pparα activation decreased the expression of glucose-regulated protein 78 (grp78), grp94 and c/ebp-homologous protein (chop) in vivo; (2) the liver protection by 4-pba resulted from the induction of pparα expression, as 4-pba pre-treatment promoted upregulation of pparα, and inhibition of pparα by small interfering rna (sirna) treatment reversed liver protection and increased hepatocyte apoptosis; (3) in vitro pparα activation by wy-14643 decreased hepatocyte apoptosis induced by severe er stress, and pparα inhibition by sirna treatment decreased the hepatocyte survival induced by mild er stress. |
2017-12-04 |
2023-08-13 |
Not clear |
| Wei Deying, Geng Feng, Liang Shumei, Zhao Hui, Liu Ming, Wang Hongqin. CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells. Bioscience reports. vol 37. issue 2. 2017-12-04. PMID:28258248. |
moreover, hgf in caf matrix attenuated paclitaxel (pac)-caused inhibition of cell proliferation and increase in cell apoptosis through activating c-met/pi3k/akt and grp78 pathways in skov3 and ho-8910 cells. |
2017-12-04 |
2023-08-13 |
human |
| Yue Zhang, Xiang Gao, Shuanggang Chen, Min Zhao, Jing Chen, Rui Liu, Shengyang Cheng, Mengyuan Qi, Shuo Wang, Wei Li. Cyclin-dependent kinase 5 contributes to endoplasmic reticulum stress induced podocyte apoptosis via promoting MEKK1 phosphorylation at Ser280 in diabetic nephropathy. Cellular signalling. vol 31. 2017-11-27. PMID:28024901. |
the results showed that along with induction of cdk5 and apoptosis, grp78 and its two sensors as well as chop and cleaved caspase-12 were induced in high glucose treated podocytes. |
2017-11-27 |
2023-08-13 |
Not clear |
| Jun Hee Lee, Yeo Min Yoon, Sang Hun Le. GRP78 Regulates Apoptosis, Cell Survival and Proliferation in 5-Fluorouracil-resistant SNUC5 Colon Cancer Cells. Anticancer research. vol 37. issue 9. 2017-10-25. PMID:28870916. |
grp78 regulates apoptosis, cell survival and proliferation in 5-fluorouracil-resistant snuc5 colon cancer cells. |
2017-10-25 |
2023-08-13 |
Not clear |
| Jun Hee Lee, Yeo Min Yoon, Sang Hun Le. GRP78 Regulates Apoptosis, Cell Survival and Proliferation in 5-Fluorouracil-resistant SNUC5 Colon Cancer Cells. Anticancer research. vol 37. issue 9. 2017-10-25. PMID:28870916. |
in the presence of 5-fu, grp78 knockdown induced apoptosis via activation of caspase-3 and poly(adp-ribose)-polymerase 1. |
2017-10-25 |
2023-08-13 |
Not clear |
| Radha Pujari, Jemy Jose, Varsha Bhavnani, Natesh Kumar, Padma Shastry, Jayanta K Pa. Tamoxifen-induced cytotoxicity in breast cancer cells is mediated by glucose-regulated protein 78 (GRP78) via AKT (Thr308) regulation. The international journal of biochemistry & cell biology. vol 77. issue Pt A. 2017-10-10. PMID:27262235. |
in the present study, we show that among a panel of drugs, namely paclitaxel (tax), doxorubicin (dox), 5-fluorouracil (5-fu), ucn-01 and tamoxifen (tam) used, tam alone up-regulated the expression of grp78 significantly and induced apoptosis in mcf-7 and mda-mb-231 cells. |
2017-10-10 |
2023-08-13 |
Not clear |
| Radha Pujari, Jemy Jose, Varsha Bhavnani, Natesh Kumar, Padma Shastry, Jayanta K Pa. Tamoxifen-induced cytotoxicity in breast cancer cells is mediated by glucose-regulated protein 78 (GRP78) via AKT (Thr308) regulation. The international journal of biochemistry & cell biology. vol 77. issue Pt A. 2017-10-10. PMID:27262235. |
interestingly, inhibition of grp78 by a specific pharmacological inhibitor, ver-155008 augmented tam-induced apoptosis, and overexpression of grp78 rendered the cells resistant to tam-induced cell death suggesting a role for grp78 in tam-induced cytotoxicity. |
2017-10-10 |
2023-08-13 |
Not clear |
| Suresh Ranga Rao, Rajasekaran Subbarayan, Supraja Ajitkumar, Dinesh Murugan Girij. 4PBA strongly attenuates endoplasmic reticulum stress, fibrosis, and mitochondrial apoptosis markers in cyclosporine treated human gingival fibroblasts. Journal of cellular physiology. vol 233. issue 1. 2017-10-10. PMID:28158898. |
after 24 hr of incubation, mrna expression of er stress markers (grp78, chop, xbp1, and xbps) and matrix protein markers (like α-sma, vegf, tgf-β, ctgf), and mitochondrial apoptosis markers estimated and compared with housekeeping gene gapdh. |
2017-10-10 |
2023-08-13 |
human |
| Lingyue Zou, Li Su, Yifan Sun, Aijie Han, Xuhong Chang, An Zhu, Fangfang Liu, Jin Li, Yingbiao Su. Nickel sulfate induced apoptosis via activating ROS-dependent mitochondria and endoplasmic reticulum stress pathways in rat Leydig cells. Environmental toxicology. vol 32. issue 7. 2017-10-05. PMID:28296042. |
nickel sulfate-triggered leydig cells apoptosis via mitochondria and ers pathways was characterized by the upregulated mrna and proteins expression of bak, cytochrome c, caspase 9, caspase 3, grp78, gadd153, and caspase 12, which were inhibited by nac and tempo respectively. |
2017-10-05 |
2023-08-13 |
mouse |
| Rui Li, Gu Yanjiao, He Wubin, Wang Yue, Huang Jianhua, Zheng Huachuan, Su Rongjian, Luan Zhidon. Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells. Oncotarget. vol 8. issue 12. 2017-10-05. PMID:28423613. |
further studies showed that secreted grp78 facilitated the proliferation and inhibited the apoptosis induced by sorafenib both in hcc cell lines and in tumor xenografts. |
2017-10-05 |
2023-08-13 |
Not clear |
| Cheng Zhan. Roles of Grp78 in Female Mammalian Reproduction. Advances in anatomy, embryology, and cell biology. vol 222. 2017-09-26. PMID:28389754. |
grp78 as a central regulator of er stress (ers) plays many important roles in cell survival and apoptosis through controlling the activation of transmembrane ers sensors: pkr-like er-associated kinase (perk), inositol requiring kinase 1 (ire1), and activating transcription factor 6 (atf6). |
2017-09-26 |
2023-08-13 |
Not clear |
| Manish K Gupta, Farzaneh G Tahrir, Tijana Knezevic, Martyn K White, Jennifer Gordon, Joseph Y Cheung, Kamel Khalili, Arthur M Feldma. GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis. Journal of cellular biochemistry. vol 117. issue 8. 2017-09-15. PMID:26729625. |
grp78 interacting partner bag5 responds to er stress and protects cardiomyocytes from er stress-induced apoptosis. |
2017-09-15 |
2023-08-13 |
Not clear |
| Beatrix Schoenhacker-Alte, Thomas Mohr, Christine Pirker, Kushtrim Kryeziu, Paul-Steffen Kuhn, Alicia Buck, Thilo Hofmann, Christopher Gerner, Gerrit Hermann, Gunda Koellensperger, Bernhard K Keppler, Walter Berger, Petra Heffete. Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis. Cancer letters. vol 404. 2017-09-11. PMID:28716523. |
sensitivity towards the grp78 inhibitor kp1339/it-139 is characterized by apoptosis induction via caspase 8 upon disruption of er homeostasis. |
2017-09-11 |
2023-08-13 |
Not clear |
| Junpei Soeda, Paul Cordero, Jiawei Li, Angelina Mouralidarane, Esra Asilmaz, Shuvra Ray, Vi Nguyen, Rebeca Carter, Marco Novelli, Manlio Vinciguerra, Lucilla Poston, Paul D Taylor, Jude A Obe. Hepatic rhythmicity of endoplasmic reticulum stress is disrupted in perinatal and adult mice models of high-fat diet-induced obesity. International journal of food sciences and nutrition. vol 68. issue 4. 2017-09-05. PMID:27899042. |
the double obesogenic hit increased liver apoptosis measured by tunel staining, active caspase-3 and phospho-jnk and grp78 promoter methylation levels. |
2017-09-05 |
2023-08-13 |
mouse |
| Xiao-Qiang Wang, Juliette A Aka, Tang Li, Dan Xu, Charles J Doillon, Sheng-Xiang Li. Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78. The Journal of steroid biochemistry and molecular biology. vol 172. 2017-08-22. PMID:28645527. |
inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating grp78. |
2017-08-22 |
2023-08-13 |
Not clear |
| Xiao-Qiang Wang, Juliette A Aka, Tang Li, Dan Xu, Charles J Doillon, Sheng-Xiang Li. Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78. The Journal of steroid biochemistry and molecular biology. vol 172. 2017-08-22. PMID:28645527. |
the expression of 78kda glucose-regulated protein (grp78) and anti-apoptosis factor bcl-2 were significantly suppressed via 17β-hsd7 inhibition with inh7, consequently induced mcf-7 cell apoptosis. |
2017-08-22 |
2023-08-13 |
Not clear |