| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weiping Zhang, Lihong Chen, Yuxian Shen, Jianming X. Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicology in vitro : an international journal published in association with BIBRA. vol 36. 2017-03-24. PMID:27470132. |
we found that rfp increased the cell apoptosis rate, decreased cell survival, and increased the protein and gene levels of grp78, perk, atf4 and chop in both a dose-dependent and a time-dependent manner. |
2017-03-24 |
2023-08-13 |
Not clear |
| Peizhen Li, Jun Ying, Qingli Chang, Wen Zhu, Guangjian Yang, Teng Xu, Huiguang Yi, Ruowang Pan, Enyong Zhang, Xiaofeng Zeng, Chunxia Yan, Qiyu Bao, Shengbin L. Effects of phycoerythrin from Gracilaria lemaneiformis in proliferation and apoptosis of SW480 cells. Oncology reports. vol 36. issue 6. 2017-03-17. PMID:27748904. |
grp78, npm1, mthsp75, ezrin and annexin a2 were decreased and hsp60 was increased after pe treatment, indicating that pe may target multiple proteins to induce apoptosis. |
2017-03-17 |
2023-08-13 |
human |
| Xuan Zhou, Xiaoming Xing, Shuping Zhang, Lili Liu, Chengqin Wang, Lin Li, Qiuxia Ji, Huamin Li. Glucose-regulated protein 78 contributes to the proliferation and tumorigenesis of human colorectal carcinoma via AKT and ERK pathways. Oncology reports. vol 36. issue 5. 2017-03-13. PMID:27634156. |
in addition, grp78 knockdown enhanced the apoptosis induced by 5-fluorouracil (5-fu) in crc cells. |
2017-03-13 |
2023-08-13 |
human |
| Lili Wen, Fang Han, Yuxiu Shi, Xiaoyan L. Role of the Endoplasmic Reticulum Pathway in the Medial Prefrontal Cortex in Post-Traumatic Stress Disorder Model Rats. Journal of molecular neuroscience : MN. vol 59. issue 4. 2017-03-09. PMID:27112439. |
in addition, the er molecular chaperone 78-kda glucose-regulated protein (grp78) and the er-related apoptosis factors caspase family and bax also were examined. |
2017-03-09 |
2023-08-13 |
rat |
| Lili Wen, Fang Han, Yuxiu Shi, Xiaoyan L. Role of the Endoplasmic Reticulum Pathway in the Medial Prefrontal Cortex in Post-Traumatic Stress Disorder Model Rats. Journal of molecular neuroscience : MN. vol 59. issue 4. 2017-03-09. PMID:27112439. |
in addition, the protein and mrna expression of grp78 was increased in sps rats; the upregulation of er-related apoptosis factors and apoptosis neurons after sps stimulation was observed. |
2017-03-09 |
2023-08-13 |
rat |
| Jingwei Huang, Changyan Chen, Hua Gu, Chen Li, Xing Fu, Ming Jiang, Hui Sun, Jun Xu, Jianmin Fang, Lingjing Ji. Mesencephalic astrocyte-derived neurotrophic factor reduces cell apoptosis via upregulating GRP78 in SH-SY5Y cells. Cell biology international. vol 40. issue 7. 2017-02-21. PMID:27145383. |
mesencephalic astrocyte-derived neurotrophic factor reduces cell apoptosis via upregulating grp78 in sh-sy5y cells. |
2017-02-21 |
2023-08-13 |
Not clear |
| Jingwei Huang, Changyan Chen, Hua Gu, Chen Li, Xing Fu, Ming Jiang, Hui Sun, Jun Xu, Jianmin Fang, Lingjing Ji. Mesencephalic astrocyte-derived neurotrophic factor reduces cell apoptosis via upregulating GRP78 in SH-SY5Y cells. Cell biology international. vol 40. issue 7. 2017-02-21. PMID:27145383. |
furthermore, grp78 overexpression inhibited 6-ohda-induced apoptosis. |
2017-02-21 |
2023-08-13 |
Not clear |
| Jingwei Huang, Changyan Chen, Hua Gu, Chen Li, Xing Fu, Ming Jiang, Hui Sun, Jun Xu, Jianmin Fang, Lingjing Ji. Mesencephalic astrocyte-derived neurotrophic factor reduces cell apoptosis via upregulating GRP78 in SH-SY5Y cells. Cell biology international. vol 40. issue 7. 2017-02-21. PMID:27145383. |
our data suggest that manf inhibits apoptosis induced by 6-ohda and overexpressed α-synuclein in sh-sy5y cells via upregulating grp78 in the transcriptional pattern. |
2017-02-21 |
2023-08-13 |
Not clear |
| Yongxia Cai, Yanbo Shen, Guangling Xu, Ran Tao, Weiyan Yuan, Zhongwei Huang, Dongmei Zhan. TRAM1 protects AR42J cells from caerulein-induced acute pancreatitis through ER stress-apoptosis pathway. In vitro cellular & developmental biology. Animal. vol 52. issue 5. 2017-02-13. PMID:27105999. |
furthermore, we showed that knockdown of tram1 led to hyperactivation of 78 kda glucose-regulated protein precursor (grp78) and c/ebp homologous protein (chop) and the activation of downstream apoptosis pathway. |
2017-02-13 |
2023-08-13 |
rat |
| Yachao Wang, Li Jiang, Yuanfeng Li, Xuegang Luo, Jian H. Excessive Selenium Supplementation Induced Oxidative Stress and Endoplasmic Reticulum Stress in Chicken Spleen. Biological trace element research. vol 172. issue 2. 2017-02-03. PMID:26740217. |
in addition, the er stress genes grp78 and atf6 were highly expressed (p < 0.05), and the apoptosis genes caspase 3 and caspase 12 were increased, but bcl 2 was decreased by se treatment (p < 0.05). |
2017-02-03 |
2023-08-13 |
chicken |
| Jyoti Kureel, Aijaz A John, Ashutosh Raghuvanshi, Pallavi Awasthi, Atul Goel, Divya Sing. Identification of GRP78 as a molecular target of medicarpin in osteoblast cells by proteomics. Molecular and cellular biochemistry. vol 418. issue 1-2. 2017-02-02. PMID:27316719. |
med targets grp78 by inhibiting mitochondrial-mediated apoptosis which is evident by reduced levels of cytochrome c, caspase-3, bax/bcl2 ratio, and enhanced expression of survivin. |
2017-02-02 |
2023-08-13 |
Not clear |
| Jyoti Kureel, Aijaz A John, Ashutosh Raghuvanshi, Pallavi Awasthi, Atul Goel, Divya Sing. Identification of GRP78 as a molecular target of medicarpin in osteoblast cells by proteomics. Molecular and cellular biochemistry. vol 418. issue 1-2. 2017-02-02. PMID:27316719. |
finally, annexin-pi staining of apoptotic cells revealed that med inhibition of grp78 leads to reduced osteoblast apoptosis and increased osteoblast survival. |
2017-02-02 |
2023-08-13 |
Not clear |
| Jyoti Kureel, Aijaz A John, Ashutosh Raghuvanshi, Pallavi Awasthi, Atul Goel, Divya Sing. Identification of GRP78 as a molecular target of medicarpin in osteoblast cells by proteomics. Molecular and cellular biochemistry. vol 418. issue 1-2. 2017-02-02. PMID:27316719. |
altogether, our data show that med inhibits er stress-induced apoptosis and promotes osteoblast cell survival by targeting grp78. |
2017-02-02 |
2023-08-13 |
Not clear |
| Xiaoxue Zhang, Rui Zhang, HuiOu Yang, Qian Xiang, Qing Jiang, Qi He, Ting Zhang, Chen Chen, Huifen Zhu, Qiang Wang, Qin Ning, Yiwu Li, Ping Lei, Guanxin She. Hepatitis B virus enhances cisplatin-induced hepatotoxicity via a mechanism involving suppression of glucose-regulated protein of 78 Kda. Chemico-biological interactions. vol 254. 2017-01-31. PMID:27234046. |
furthermore, we found that hbv disrupted grp78 synthesis in response to cisplatin stimulation, which may trigger severe and prolonged endoplasmic reticulum (er) stress that can induce cellular apoptosis. |
2017-01-31 |
2023-08-13 |
Not clear |
| Haitao Yu, Juan Zhen, Yang Yang, Jinning Gu, Suisheng Wu, Quan Li. Ginsenoside Rg1 ameliorates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress-induced apoptosis in a streptozotocin-induced diabetes rat model. Journal of cellular and molecular medicine. vol 20. issue 4. 2017-01-06. PMID:26869403. |
after 12 weeks of treatment, rats were killed and serum samples obtained to determine cardiac troponin (ctn)-i. myocardial tissues were harvested for morphological analysis to detect myocardial cell apoptosis, and to analyse protein expression of glucose-regulated protein 78 (grp78), c/ebp homologous protein (chop), and caspase-12. |
2017-01-06 |
2023-08-13 |
rat |
| Qi Liu, Dong Zhao, Yun-Xiang Ji, Xiao-Yuan Huang, Peng Yang, Ye-Zhong Wang, Ting Le. Role of glucose-regulated protein 78 in early brain injury after experimental subarachnoid hemorrhage in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 2. 2016-12-30. PMID:27072957. |
neurological scores, ultrastructures of neurons, apoptosis, and grp78 expression in the hippocampus were examined using garcia scoring system, transmission electron microscopy, terminal deoxynucleotidyl transferase-mediated dutp nick-end labelling, and western blotting at 1, 6, 12, 24, 48, and 72 h after sah, respectively. |
2016-12-30 |
2023-08-13 |
rat |
| Qi Liu, Dong Zhao, Yun-Xiang Ji, Xiao-Yuan Huang, Peng Yang, Ye-Zhong Wang, Ting Le. Role of glucose-regulated protein 78 in early brain injury after experimental subarachnoid hemorrhage in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 2. 2016-12-30. PMID:27072957. |
the number of apoptotic cells was significantly increased in the operated group as compared with that in control and sham-operated groups at 6, 12, 24, 48, and 72 h. the grp78 protein expression levels in the operated group were significantly elevated at all time points and reached the peak at 12 h. grp78 expression was positively associated with apoptosis cells and negatively with neurological scores. |
2016-12-30 |
2023-08-13 |
rat |
| Xinyue Liu, Linjing Li, Jing Li, Yan Cheng, Jing Chen, Minghui Shen, Shangdi Zhang, Hulai We. Insulin resistance contributes to multidrug resistance in HepG2 cells via activation of the PERK signaling pathway and upregulation of Bcl-2 and P-gp. Oncology reports. vol 35. issue 5. 2016-12-27. PMID:26935266. |
our results demonstrated that insulin resistance in hepg2 cells promoted a protective unfolded protein response and upregulated the expression of er chaperone protein grp78, which resulted in the phosphorylation of perk kinase to activate the perk-mediated er stress signal transduction pathway and the upregulation of bcl-2 and p-gp, leading to the inhibition of the caspase-3-dependent apoptosis pathway and to the survival of liver tumor cells. |
2016-12-27 |
2023-08-13 |
Not clear |
| Fen Yang, Xiao Yan Tang, Hao Liu, Zhi Wen Jian. Inhibition of mitogen-activated protein kinase signaling pathway sensitizes breast cancer cells to endoplasmic reticulum stress-induced apoptosis. Oncology reports. vol 35. issue 4. 2016-12-26. PMID:26796921. |
higher levels of grp78 expression indicates constitutive activation of the upr in breast cancer leading to breast cancer cells that are relatively resistant to er stress-induced apoptosis. |
2016-12-26 |
2023-08-13 |
human |
| Fen Yang, Xiao Yan Tang, Hao Liu, Zhi Wen Jian. Inhibition of mitogen-activated protein kinase signaling pathway sensitizes breast cancer cells to endoplasmic reticulum stress-induced apoptosis. Oncology reports. vol 35. issue 4. 2016-12-26. PMID:26796921. |
inhibition of grp78 by sirna knockdown enhances tm- and u0126-induced apoptosis in breast cancer cells. |
2016-12-26 |
2023-08-13 |
human |