| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annat Raiter, Rinat Yerushalmi, Britta Hard. Pharmacological induction of cell surface GRP78 contributes to apoptosis in triple negative breast cancer cells. Oncotarget. vol 5. issue 22. 2015-09-24. PMID:25360516. |
here, we show that induction in cell surface grp78 by doxorubicin and tunicamycin was associated with chop/gadd153 upregulation and increase in apoptosis in triple negative breast cancer tumor cells. |
2015-09-24 |
2023-08-13 |
Not clear |
| Annat Raiter, Rinat Yerushalmi, Britta Hard. Pharmacological induction of cell surface GRP78 contributes to apoptosis in triple negative breast cancer cells. Oncotarget. vol 5. issue 22. 2015-09-24. PMID:25360516. |
grp78 is a major regulator of the stress induced unfolded protein response pathway and chop/gadd153 is a pro-apoptotic transcription factor associated exclusively with stress induced apoptosis. |
2015-09-24 |
2023-08-13 |
Not clear |
| Annat Raiter, Rinat Yerushalmi, Britta Hard. Pharmacological induction of cell surface GRP78 contributes to apoptosis in triple negative breast cancer cells. Oncotarget. vol 5. issue 22. 2015-09-24. PMID:25360516. |
the blocking of cell surface grp78 by anti-grp78 antibody prevented apoptosis, suggesting that induction of cell surface grp78 by doxorubicin and tunicamycin is required for apoptosis. |
2015-09-24 |
2023-08-13 |
Not clear |
| Min Wang, Xiang-bao Meng, Ying-li Yu, Gui-bo Sun, Xu-dong Xu, Xiao-po Zhang, Xi Dong, Jing-xue Ye, Hui-bo Xu, Yi-fan Sun, Xiao-bo Su. Elatoside C protects against hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes through the reduction of endoplasmic reticulum stress partially depending on STAT3 activation. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25326083. |
these changes were associated with the inhibition of er stress-associated apoptosis markers (grp78, chop, caspase-12 and jnk), as well as the increased phosphorylation of stat3 and an increased bcl2/bax ratio. |
2015-09-14 |
2023-08-13 |
Not clear |
| Yun-Ying Huang, Xiong-Qin Huang, Li-Yan Zhao, Fang-Yun Sun, Wen-Liang Chen, Jie-Yi Du, Feng Yuan, Jie Li, Xue-Lian Huang, Jie Liu, Xiao-Fei Lv, Yong-Yuan Guan, Jian-Wen Chen, Guan-Lei Wan. ClC-3 deficiency protects preadipocytes against apoptosis induced by palmitate in vitro and in type 2 diabetes mice. Apoptosis : an international journal on programmed cell death. vol 19. issue 11. 2015-09-04. PMID:25218423. |
clc-3 specific sirna attenuated palmitate-induced apoptosis and increased protein levels of grp78, atf4, chop and phosphorylation of jnk1/2, whereas had no effects on increased phospho-perk and phospho-eif2α protein expression. |
2015-09-04 |
2023-08-13 |
mouse |
| Ying Han, Wenxia Yi, Jiong Qin, Yang Zhao, Jing Zhang, Xingzhi Chan. Carbon monoxide offers neuroprotection from hippocampal cell damage induced by recurrent febrile seizures through the PERK-activated ER stress pathway. Neuroscience letters. vol 585. 2015-08-19. PMID:25434873. |
in the present study, using a rat model of recurrent febrile seizures (fss), we found an increase in plasma co, evidence of neuronal damage and apoptosis, an increase in the expression of the endoplasmic reticulum stress (ers) marker glucose-regulated protein 78 (grp78) and c/ebp homologous binding protein (chop), and an increase in phosphorylated protein kinase rna-like endoplasmic reticulum kinase (p-perk)/eukaryotic translation initiation factor 2 alpha (p-eif2α) in the hippocampus after 10 fss. |
2015-08-19 |
2023-08-13 |
rat |
| Ying Han, Wenxia Yi, Jiong Qin, Yang Zhao, Jing Zhang, Xingzhi Chan. Carbon monoxide offers neuroprotection from hippocampal cell damage induced by recurrent febrile seizures through the PERK-activated ER stress pathway. Neuroscience letters. vol 585. 2015-08-19. PMID:25434873. |
administration of hemin (a co donor) in fs rats alleviated the neuronal damage, reduced neuronal apoptosis, upregulated grp78 expression, decreased chop, and increased p-perk and p-eif2α expression in the hippocampus, compared to fs control rats. |
2015-08-19 |
2023-08-13 |
rat |
| Ying Han, Wenxia Yi, Jiong Qin, Yang Zhao, Jing Zhang, Xingzhi Chan. Carbon monoxide offers neuroprotection from hippocampal cell damage induced by recurrent febrile seizures through the PERK-activated ER stress pathway. Neuroscience letters. vol 585. 2015-08-19. PMID:25434873. |
in contrast, treating fs rats with znpp-ix (a co synthase inhibitor) aggravated the neuronal damage, enhanced neuronal apoptosis, downregulated grp78 expression, increased chop, and decreased p-perk and p-eif2α expression, compared to fs control rats. |
2015-08-19 |
2023-08-13 |
rat |
| Zhao Zhao, Tao Sun, Yun Jiang, Lijiang Wu, Xiangzhong Cai, Xiaodong Sun, Xiangjun Su. Photooxidative damage in retinal pigment epithelial cells via GRP78 and the protective role of grape skin polyphenols. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 74. 2015-07-28. PMID:25447759. |
exposure of a2e containing arpe-19 cells to blue light resulted in significant apoptosis and increases in levels of grp78, chop, p-jnk, bax, cleaved caspase-9, and cleaved caspase-3, indicating that photooxidative damage to rpe cells is mediated by the er-stress-induced intrinsic apoptotic pathway. |
2015-07-28 |
2023-08-13 |
Not clear |
| Osman Salis, Abdulkerim Bedir, Sedat Gulten, Ali Okuyucu, Canan Kulcu, Hasan Alaca. Cytotoxic effect of fluvastatin on MCF-7 cells possibly through a reduction of the mRNA expression levels of SGK1 and CAV1. Cancer biotherapy & radiopharmaceuticals. vol 29. issue 9. 2015-07-09. PMID:25347557. |
at the same time, we measured the mrna expression levels of glucose-regulated protein 78 (grp78), ccaat/enhancer binding protein, homologous protein (chop), caveolin-1 (cav1), ndrg1 variant 1 and variant 2, hmox1, sgk1, and prostate apoptosis response-4 (par4) genes using quantitative real-time polymerase chain reaction (lightcycler 480 ii). |
2015-07-09 |
2023-08-13 |
Not clear |
| Huifang M Zhang, Huanqin Dai, Paul J Hanson, Huidong Li, Hui Guo, Xin Ye, Maged G Hemida, Luoqiang Wang, Yaojun Tong, Ye Qiu, Selina Liu, Fengping Wang, Fuhang Song, Buchang Zhang, Jian-Guo Wang, Li-Xin Zhang, Decheng Yan. Antiviral activity of an isatin derivative via induction of PERK-Nrf2-mediated suppression of cap-independent translation. ACS chemical biology. vol 9. issue 4. 2015-07-01. PMID:24547890. |
this observation was further verified by using sirnas of grp78 or nrf2, which blocked both the translocation of nrf2 and up-regulation of its target genes, leading to aggressive viral replication and enhanced cell apoptosis. |
2015-07-01 |
2023-08-12 |
Not clear |
| Uma Kant Misra, Salvatore Vincent Pizz. Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses. The Journal of biological chemistry. vol 290. issue 15. 2015-06-26. PMID:25720493. |
ligation of cell surface grp78 by activated α2-macroglobulin (α2m*) promotes cell proliferation and suppresses apoptosis. |
2015-06-26 |
2023-08-13 |
human |
| Tong Lu, Weimin Yang, Zhihua Wang, Zhiquan Hu, Xing Zeng, Chunguang Yang, Ye Wang, Yong Zhang, Fan Li, Zhuo Liu, Dongbiao Wang, Zhangqun Y. Knockdown of glucose-regulated protein 78/binding immunoglobulin heavy chain protein expression by asymmetric small interfering RNA induces apoptosis in prostate cancer cells and attenuates migratory capability. Molecular medicine reports. vol 11. issue 1. 2015-06-25. PMID:25338653. |
the effect of grp78 silencing on pc-3 cell apoptosis and migration, and the possible mechanisms governing these biological processes were examined. |
2015-06-25 |
2023-08-13 |
human |
| Tong Lu, Weimin Yang, Zhihua Wang, Zhiquan Hu, Xing Zeng, Chunguang Yang, Ye Wang, Yong Zhang, Fan Li, Zhuo Liu, Dongbiao Wang, Zhangqun Y. Knockdown of glucose-regulated protein 78/binding immunoglobulin heavy chain protein expression by asymmetric small interfering RNA induces apoptosis in prostate cancer cells and attenuates migratory capability. Molecular medicine reports. vol 11. issue 1. 2015-06-25. PMID:25338653. |
grp78 depletion in pc-3 cells resulted in increased apoptosis and decreased migration of these cells. |
2015-06-25 |
2023-08-13 |
human |
| Kazushi Matsumura, Chika Sakai, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashid. Inhibition of cancer cell growth by GRP78 siRNA lipoplex via activation of unfolded protein response. Biological & pharmaceutical bulletin. vol 37. issue 4. 2015-06-05. PMID:24694610. |
in accordance with past findings that expression of grp78 is elevated in cancer cells and helps to resist stress-induced apoptosis, grp78 knockdown could be effective in anticancer therapy. |
2015-06-05 |
2023-08-13 |
Not clear |
| Kazushi Matsumura, Chika Sakai, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashid. Inhibition of cancer cell growth by GRP78 siRNA lipoplex via activation of unfolded protein response. Biological & pharmaceutical bulletin. vol 37. issue 4. 2015-06-05. PMID:24694610. |
these results suggest that grp78 knockdown might be an effective strategy for cancer therapy targeting upr-induced apoptosis. |
2015-06-05 |
2023-08-13 |
Not clear |
| Hongyan Lu, Chuchu Gao, Wei Tang, Ting Zhan. [Effect of glucose regulated protein 78 gene silencing on hyperoxia-induced apoptosis in alveolar epithelial cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 30. issue 12. 2015-05-18. PMID:25481178. |
to investigate the effect and possible mechanism of small interfering rna (sirna)-mediated glucose regulated protein 78 (grp78) gene silencing on hyperoxia-induced apoptosis of alveolar epithelial cells. |
2015-05-18 |
2023-08-13 |
Not clear |
| Jin-Ping Lu, Xia Li, Ya-Lei Jin, Mei-Xiang Che. Endoplasmic reticulum stress-mediated aldosterone-induced apoptosis in vascular endothelial cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 34. issue 6. 2015-05-04. PMID:25480576. |
glucose-regulated protein 78 (grp78) and c/ebp homologous protein (chop, a hallmark of er-associated apoptosis) were used to evaluate er stress. |
2015-05-04 |
2023-08-13 |
human |
| Jin-Ping Lu, Xia Li, Ya-Lei Jin, Mei-Xiang Che. Endoplasmic reticulum stress-mediated aldosterone-induced apoptosis in vascular endothelial cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 34. issue 6. 2015-05-04. PMID:25480576. |
aldo promoted apoptosis of huvecs and induced er stress, as evidenced by increased expression of grp78 and chop. |
2015-05-04 |
2023-08-13 |
human |
| Y Lei, B R Henderson, C Emmanuel, P R Harnett, A deFazi. Inhibition of ANKRD1 sensitizes human ovarian cancer cells to endoplasmic reticulum stress-induced apoptosis. Oncogene. vol 34. issue 4. 2015-04-08. PMID:24531715. |
we first demonstrated that cisplatin-induced apoptosis in ovarian cancer cell lines was associated with endoplasmic reticulum (er) stress, evidenced by induction of glucose-regulated protein 78 (grp78), growth arrest- and dna damage-inducible gene 153 (gadd153) and increased intracellular ca(2+) release. |
2015-04-08 |
2023-08-12 |
human |