| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arun Prasath Lakshmanan, Rajarajan A Thandavarayan, Suresh S Palaniyandi, Flori R Sari, Harima Meilei, Vijayasree V Giridharan, Vivian Soetikno, Kenji Suzuki, Makoto Kodama, Kenichi Watanab. Modulation of AT-1R/CHOP-JNK-Caspase12 pathway by olmesartan treatment attenuates ER stress-induced renal apoptosis in streptozotocin-induced diabetic mice. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 44. issue 5. 2012-03-25. PMID:22033153. |
we employed western blot analysis to measure the renal protein expressions level of nadph oxidase subunits, er chaperone grp78 and the er-associated apoptosis proteins. |
2012-03-25 |
2023-08-12 |
mouse |
| Arun Prasath Lakshmanan, Rajarajan A Thandavarayan, Suresh S Palaniyandi, Flori R Sari, Harima Meilei, Vijayasree V Giridharan, Vivian Soetikno, Kenji Suzuki, Makoto Kodama, Kenichi Watanab. Modulation of AT-1R/CHOP-JNK-Caspase12 pathway by olmesartan treatment attenuates ER stress-induced renal apoptosis in streptozotocin-induced diabetic mice. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 44. issue 5. 2012-03-25. PMID:22033153. |
the diabetic kidney mice were found to have increased protein expressions of nadph oxidase subunits, grp78 and er-associated apoptosis proteins, such as traf2, ire-1α, chop, p-jnk and procaspase-12, in comparison to normal mice, and which were significantly blunted by the olmesartan treatment in diabetic kidney mice. |
2012-03-25 |
2023-08-12 |
mouse |
| Shan Chen, Fang-Fang He, Hui Wang, Zhan Fang, Ning Shao, Xiu-Juan Tian, Jian-She Liu, Zhong-Hua Zhu, Yu-Mei Wang, Sheng Wang, Kai Huang, Chun Zhan. Calcium entry via TRPC6 mediates albumin overload-induced endoplasmic reticulum stress and apoptosis in podocytes. Cell calcium. vol 50. issue 6. 2012-03-20. PMID:21959089. |
moreover, albumin overload induced expression of the endoplasmic reticulum (er) stress protein grp78, led to caspase-12 activation and ultimately podocyte apoptosis, all of which were abolished by the knockdown of trpc6 using trpc6 sirna. |
2012-03-20 |
2023-08-12 |
Not clear |
| Francesca Rovetta, Alessandra Stacchiotti, Antonella Consiglio, Moris Cadei, Pier Giovanni Grigolato, Antonio Lavazza, Rita Rezzani, Maria Francesca Ale. ER signaling regulation drives the switch between autophagy and apoptosis in NRK-52E cells exposed to cisplatin. Experimental cell research. vol 318. issue 3. 2012-03-15. PMID:22146761. |
by studying the expression of er specific hallmarks, such as grp78, grp94 and gadd153/chop, we found a possible pivotal role of er signaling modulation in the crosstalk between autophagy and apoptosis induced by cispt. |
2012-03-15 |
2023-08-12 |
Not clear |
| Shiuan Wey, Biquan Luo, Chun-Chih Tseng, Min Ni, Hui Zhou, Yong Fu, Deepa Bhojwani, William L Carroll, Amy S Le. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood. vol 119. issue 3. 2012-03-13. PMID:21937694. |
in agreement with pi3k/akt as an effector for cytosine arabinoside resistance in acute myeloid leukemia, overexpression of grp78 renders human leukemic cells more resistant to cytosine arabinoside-induced apoptosis, whereas knockdown of grp78 sensitizes them. |
2012-03-13 |
2023-08-12 |
mouse |
| ZhenZhen Zhang, NianTin Tong, YuanYuan Gong, QingHua Qiu, LiLi Yin, XiuHong Lv, XingWei W. Valproate protects the retina from endoplasmic reticulum stress-induced apoptosis after ischemia-reperfusion injury. Neuroscience letters. vol 504. issue 2. 2012-02-07. PMID:21939735. |
vpa increased grp78 expression and acetylation of histone h3, attenuated upregulation of chop and activation of caspase-12 in group d. our results suggest that vpa can protect ischemic retinas from er stress-induced apoptosis by mechanisms that may involve hdac inhibition. |
2012-02-07 |
2023-08-12 |
rat |
| Shuang-feng Chen, Hai-ying Chen, Xian-bin Liu, Ying-xin Zhang, Wei Liu, Wei-hua Wang, Bin Zhang, Le-Xin Wan. Apoptotic effect of MG-132 on human tongue squamous cell carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 65. issue 5. 2012-01-25. PMID:21775096. |
the mg-132-induced apoptosis may involve downregulation of e3 ubiquitin ligase, and upregulation of grp78 and caspase-12. |
2012-01-25 |
2023-08-12 |
human |
| Flori R Sari, Kenichi Watanabe, Bambang Widyantoro, Rajarajan A Thandavarayan, Meilei Harima, Makoto Kodama, Yoshifusa Aizaw. Sex differences play a role in cardiac endoplasmic reticulum stress (ERS) and ERS-initiated apoptosis induced by pressure overload and thapsigargin. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 20. issue 5. 2012-01-05. PMID:20850991. |
furthermore, during ers induction using thap, myocardial apoptosis and the expression levels of cardiac grp78, inositol-requiring enzyme (ire)1α and tumor necrosis factor receptor-associated factor (traf)2 were significantly increased in male mice relative to female mice. |
2012-01-05 |
2023-08-12 |
mouse |
| Xiaoming Xing, Yujun Li, Huamin Liu, Lili Wang, Lingling Su. Glucose regulated protein 78 (GRP78) is overexpressed in colorectal carcinoma and regulates colorectal carcinoma cell growth and apoptosis. Acta histochemica. vol 113. issue 8. 2011-12-27. PMID:21156321. |
glucose regulated protein 78 (grp78) is overexpressed in colorectal carcinoma and regulates colorectal carcinoma cell growth and apoptosis. |
2011-12-27 |
2023-08-12 |
Not clear |
| Xiaoming Xing, Yujun Li, Huamin Liu, Lili Wang, Lingling Su. Glucose regulated protein 78 (GRP78) is overexpressed in colorectal carcinoma and regulates colorectal carcinoma cell growth and apoptosis. Acta histochemica. vol 113. issue 8. 2011-12-27. PMID:21156321. |
furthermore, knockdown of grp78 not only efficiently suppressed proliferation of rko cells, but also induced early apoptosis of cells. |
2011-12-27 |
2023-08-12 |
Not clear |
| Xiaoming Xing, Yujun Li, Huamin Liu, Lili Wang, Lingling Su. Glucose regulated protein 78 (GRP78) is overexpressed in colorectal carcinoma and regulates colorectal carcinoma cell growth and apoptosis. Acta histochemica. vol 113. issue 8. 2011-12-27. PMID:21156321. |
the expression of grp78 is associated with the enhanced proliferation of colorectal carcinoma cells and with their resistance to apoptosis. |
2011-12-27 |
2023-08-12 |
Not clear |
| T Winder, P Bohanes, W Zhang, D Yang, D G Power, Y Ning, A Gerger, P M Wilson, L H Tang, M Shah, A S Lee, H-J Len. GRP78 promoter polymorphism rs391957 as potential predictor for clinical outcome in gastric and colorectal cancer patients. Annals of oncology : official journal of the European Society for Medical Oncology. vol 22. issue 11. 2011-12-19. PMID:21382870. |
recently, the analysis of gastric and colorectal tumor specimens determined that 78-kilodalton glucose-regulated protein (grp78), an endoplasmic reticulum chaperone, up-regulation serves as an efficient mechanism protecting cells against apoptosis and can confer drug resistance. |
2011-12-19 |
2023-08-12 |
Not clear |
| Atsushi Kuga, Yutaka Ohsawa, Tadashi Okada, Fumio Kanda, Motoi Kanagawa, Tatsushi Toda, Yoshihide Sunad. Endoplasmic reticulum stress response in P104L mutant caveolin-3 transgenic mice. Human molecular genetics. vol 20. issue 15. 2011-12-14. PMID:21610159. |
moreover, signaling downstream of grp78 in the myofibers was activated toward apoptosis. |
2011-12-14 |
2023-08-12 |
mouse |
| Hsu-Feng Lu, Yu-Jie Chie, Ming-Sung Yang, Kung-Wen Lu, Jene-John Fu, Jai-Sing Yang, Hung-Yi Chen, Te-Chun Hsia, Chia-Yu Ma, Siu-Wan Ip, Jing-Gung Chun. Apigenin induces apoptosis in human lung cancer H460 cells through caspase- and mitochondria-dependent pathways. Human & experimental toxicology. vol 30. issue 8. 2011-12-07. PMID:20937639. |
in the present studies, h460 cells were treated with apigenin for different time and then were analyzed for the morphological changes, induction of apoptosis, protein levels associated with apoptosis and results in dose-dependent induction of morphological changes, decrease in the percentage of viability, induced dna damage and apoptosis; down-modulation of the protein expression of bid, bcl-2, procaspase-8; up-regulation of protein levels of bax, caspase-3, aif, cytochrome c, grp78 and gadd153; decreased the levels of mitochondrial membrane potential and increased the productions of reactive oxygen species (ros) and ca(2+) in h460 cells. |
2011-12-07 |
2023-08-12 |
human |
| Ming-Feng Wu, Ping-Chia Li, Chin-Chiu Chen, Su-Shin Ye, Chiang-Ting Chien, Chia-Cherng Y. Cordyceps sobolifera extract ameliorates lipopolysaccharide-induced renal dysfunction in the rat. The American journal of Chinese medicine. vol 39. issue 3. 2011-12-06. PMID:21598419. |
lps enhanced renal tubular er stress, autophagy and apoptosis via by increase protein expressions of grp78, caspase 12, beclin-1 and bax/bcl-2 ratio. |
2011-12-06 |
2023-08-12 |
rat |
| Ming-Feng Wu, Ping-Chia Li, Chin-Chiu Chen, Su-Shin Ye, Chiang-Ting Chien, Chia-Cherng Y. Cordyceps sobolifera extract ameliorates lipopolysaccharide-induced renal dysfunction in the rat. The American journal of Chinese medicine. vol 39. issue 3. 2011-12-06. PMID:21598419. |
these findings are associated with the significant staining in renal proximal and distal tubular ed-1, grp78, beclin-1 autophagy, and tunel apoptosis in the lps-treated kidneys. |
2011-12-06 |
2023-08-12 |
rat |
| Ming-Feng Wu, Ping-Chia Li, Chin-Chiu Chen, Su-Shin Ye, Chiang-Ting Chien, Chia-Cherng Y. Cordyceps sobolifera extract ameliorates lipopolysaccharide-induced renal dysfunction in the rat. The American journal of Chinese medicine. vol 39. issue 3. 2011-12-06. PMID:21598419. |
two months of cs supplement significantly improved rbf, gfr and wbc values and reduced ed-1, grp78, beclin-1 autophagy and tunel apoptosis in the lps-treated kidneys. |
2011-12-06 |
2023-08-12 |
rat |
| Te-Mao Li, Tsang-Yu Lin, Sheng-Feng Hsu, Chi-Ming Wu, Yi-Chang Su, Shung-Te Kao, Chih-Shiang Chang, Yi-Chin Fong, Chih-Hsin Tan. The novel benzimidazole derivative, MPTB, induces cell apoptosis in human chondrosarcoma cells. Molecular carcinogenesis. vol 50. issue 10. 2011-12-05. PMID:21374734. |
transfection of cells with grp78 or calpain sirna reduced mptb-mediated cell apoptosis in jj012 cells. |
2011-12-05 |
2023-08-12 |
human |
| Peter Baumeister, Dezheng Dong, Yong Fu, Amy S Le. Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis. Molecular cancer therapeutics. vol 8. issue 5. 2011-11-22. PMID:19417144. |
furthermore, overexpression of grp78 confers resistance to hdac inhibitor-induced apoptosis in cancer cells, and conversely, suppression of grp78 sensitizes them to hdac inhibitors. |
2011-11-22 |
2023-08-12 |
Not clear |
| Uma Kant Misra, Yvonne Mowery, Steven Kaczowka, Salvatore Vincent Pizz. Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis. Molecular cancer therapeutics. vol 8. issue 5. 2011-11-22. PMID:19417154. |
ligation of cancer cell surface grp78 with antibodies directed against its cooh-terminal domain up-regulates p53 activity and promotes apoptosis. |
2011-11-22 |
2023-08-12 |
human |