| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Uma Kant Misra, Yvonne Mowery, Steven Kaczowka, Salvatore Vincent Pizz. Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis. Molecular cancer therapeutics. vol 8. issue 5. 2011-11-22. PMID:19417154. |
we now show that antibodies directed against the grp78 cooh-terminal domain inhibit [(3)h]thymidine uptake and cellular proliferation while promoting apoptosis as measured by dna fragmentation, annexin v assay, and clonogenic assay. |
2011-11-22 |
2023-08-12 |
human |
| Uma Kant Misra, Yvonne Mowery, Steven Kaczowka, Salvatore Vincent Pizz. Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis. Molecular cancer therapeutics. vol 8. issue 5. 2011-11-22. PMID:19417154. |
however, overexpression of grp78 in pc-3 cells causes translocation of grp78 to the cell surface and promotes apoptosis when these cells are treated with antibody directed against its cooh-terminal domain. |
2011-11-22 |
2023-08-12 |
human |
| Yanming Zhao, Ravshan Burikhanov, Jason Brandon, Shirley Qiu, Brent J Shelton, Brett Spear, Subbarao Bondada, Scott Bryson, Vivek M Rangneka. Systemic Par-4 inhibits non-autochthonous tumor growth. Cancer biology & therapy. vol 12. issue 2. 2011-11-07. PMID:21613819. |
extracellular par-4 induces caspase-dependent apoptosis in cancer cell cultures by binding, via its effector sac domain, to cell surface grp78 receptor. |
2011-11-07 |
2023-08-12 |
mouse |
| Marie Cohen, Patrick Petigna. Purified autoantibodies against glucose-regulated protein 78 (GRP78) promote apoptosis and decrease invasiveness of ovarian cancer cells. Cancer letters. vol 309. issue 1. 2011-11-07. PMID:21658840. |
purified autoantibodies against glucose-regulated protein 78 (grp78) promote apoptosis and decrease invasiveness of ovarian cancer cells. |
2011-11-07 |
2023-08-12 |
Not clear |
| Guang-Qian Li, Hai-Ping Wang, Chun-Ming Jian. [Effects of edaravone on the expression of GRP78, Caspase-12, and neuron apoptosis in juvenile rat hippocampus after status convulsive]. Zhonghua er ke za zhi = Chinese journal of pediatrics. vol 49. issue 1. 2011-11-03. PMID:21429313. |
[effects of edaravone on the expression of grp78, caspase-12, and neuron apoptosis in juvenile rat hippocampus after status convulsive]. |
2011-11-03 |
2023-08-12 |
rat |
| Guang-Qian Li, Hai-Ping Wang, Chun-Ming Jian. [Effects of edaravone on the expression of GRP78, Caspase-12, and neuron apoptosis in juvenile rat hippocampus after status convulsive]. Zhonghua er ke za zhi = Chinese journal of pediatrics. vol 49. issue 1. 2011-11-03. PMID:21429313. |
to observe the expression of grp78 (glucose regulated protein, grp78), caspase-12 and the change of neuron apoptosis in the juvenile rat hippocampus after status convulsive (sc), and to explore the effect of edaravone on them. |
2011-11-03 |
2023-08-12 |
rat |
| Ye Ding, Jun Zou, Zhili Li, Jijing Tian, Saed Abdelalim, Fang Du, Ruiping She, Desheng Wang, Cheng Tan, Huijuan Wang, Wenjuan Chen, Dongqiang Lv, Lingling Chan. Study of histopathological and molecular changes of rat kidney under simulated weightlessness and resistance training protective effect. PloS one. vol 6. issue 5. 2011-10-17. PMID:21625440. |
glucose regulated protein 78 (grp78), one of the endoplasmic reticulum (er) chaperones, was up-regulated significantly in the kidney of tail suspension rat, which implied that er-stress was associated with apoptosis. |
2011-10-17 |
2023-08-12 |
rat |
| Cheng Ji, Neil Kaplowitz, Mo Yin Lau, Eddy Kao, Lydia M Petrovic, Amy S Le. Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice. Hepatology (Baltimore, Md.). vol 54. issue 1. 2011-09-30. PMID:21503947. |
our studies using this novel mouse model revealed that liver grp78 was required for neonatal survival, and a loss of grp78 in the adult liver greater than 50% caused an er stress response and dilation of the er compartment, which was accompanied by the onset of apoptosis. |
2011-09-30 |
2023-08-12 |
mouse |
| Fangfang He, Shan Chen, Hui Wang, Ning Shao, Xiujuan Tian, Huajun Jiang, Jianshe Liu, Zhonghua Zhu, Xianfang Meng, Chun Zhan. Regulation of CD2-associated protein influences podocyte endoplasmic reticulum stress-mediated apoptosis induced by albumin overload. Gene. vol 484. issue 1-2. 2011-09-29. PMID:21679752. |
accumulation of albumin in podocytes induced er stress and apoptosis in a concentration-dependent manner as indicated by upregulation of grp78 and caspase-12. |
2011-09-29 |
2023-08-12 |
mouse |
| Fangfang He, Shan Chen, Hui Wang, Ning Shao, Xiujuan Tian, Huajun Jiang, Jianshe Liu, Zhonghua Zhu, Xianfang Meng, Chun Zhan. Regulation of CD2-associated protein influences podocyte endoplasmic reticulum stress-mediated apoptosis induced by albumin overload. Gene. vol 484. issue 1-2. 2011-09-29. PMID:21679752. |
transfection of cd2ap eukaryotic expression vector into podocytes increased cd2ap expression, depressed grp78 and caspase-12 expressions, and inhibited podocyte apoptosis. |
2011-09-29 |
2023-08-12 |
mouse |
| Hui Zhou, Yi Zhang, Yong Fu, Lauren Chan, Amy S Le. Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK). The Journal of biological chemistry. vol 286. issue 29. 2011-09-16. PMID:21622563. |
previously, we demonstrated that apoptosis triggered by bik in estrogen-starved human breast cancer cells is suppressed by grp78, a major endoplasmic reticulum chaperone. |
2011-09-16 |
2023-08-12 |
human |
| Hui Zhou, Yi Zhang, Yong Fu, Lauren Chan, Amy S Le. Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK). The Journal of biological chemistry. vol 286. issue 29. 2011-09-16. PMID:21622563. |
these cells exhibit elevated level of grp78, which protects them from estrogen starvation-induced apoptosis. |
2011-09-16 |
2023-08-12 |
human |
| Hui Zhou, Yi Zhang, Yong Fu, Lauren Chan, Amy S Le. Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK). The Journal of biological chemistry. vol 286. issue 29. 2011-09-16. PMID:21622563. |
our studies revealed that overexpression of grp78 suppresses apoptosis induced by bik and noxa, either alone or in combination. |
2011-09-16 |
2023-08-12 |
human |
| Chin-Chung Lin, Chao-Lin Kuo, Mau-Hwa Lee, Kuang-Chi Lai, Jing-Pin Lin, Jai-Sing Yang, Chun-Shu Yu, Chi-Cheng Lu, Jo-Hua Chiang, Fu-Shin Chueh, Jing-Gung Chun. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. International journal of oncology. vol 39. issue 1. 2011-09-09. PMID:21573491. |
also, results from western blotting indicated that wogonin increased the levels of bad, bax, cytochrome c, cleaved caspase-9, cleaved caspase-3, aif, endo g, fas/cd95, caspase-8, gadd153, grp78, atf-6α, calpain 1, calpain 2 and caspase-4 then leading to cell apoptosis. |
2011-09-09 |
2023-08-12 |
human |
| U K Misra, Y M Mowery, G Gawdi, S V Pizz. Loss of cell surface TFII-I promotes apoptosis in prostate cancer cells stimulated with activated α₂ -macroglobulin. Journal of cellular biochemistry. vol 112. issue 6. 2011-08-25. PMID:21503958. |
in conclusion, we demonstrate that not only does cell surface grp78 regulate apoptosis, but it also regulates ca(2+) homeostasis by controlling cell surface localization of tfii-i. |
2011-08-25 |
2023-08-12 |
human |
| Junhao Yan, Li Li, Nikan H Khatibi, Lei Yang, Ke Wang, Weiguang Zhang, Robert D Martin, Jingyan Han, John Zhang, Changman Zho. Blood-brain barrier disruption following subarchnoid hemorrhage may be faciliated through PUMA induction of endothelial cell apoptosis from the endoplasmic reticulum. Experimental neurology. vol 230. issue 2. 2011-08-15. PMID:21586287. |
immunohistochemical staining and western blot analysis demonstrated an increased expression of puma, bax, bak, grp78 and drp1 in the microvascular endothelial cells of the hippocampus, which was accompanied with endothelium apoptosis. |
2011-08-15 |
2023-08-12 |
rat |
| Dezheng Dong, Christopher Stapleton, Biquan Luo, Shigang Xiong, Wei Ye, Yi Zhang, Niyati Jhaveri, Genyuan Zhu, Risheng Ye, Zhi Liu, Kevin W Bruhn, Noah Craft, Susan Groshen, Florence M Hofman, Amy S Le. A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis. Cancer research. vol 71. issue 8. 2011-07-15. PMID:21467168. |
previously, using a transgene-induced mammary tumor model, we showed that grp78 heterozygosity impeded cancer growth through suppression of tumor cell proliferation and promotion of apoptosis and the grp78(+/-) mice exhibited dramatic reduction (70%) in the microvessel density (mvd) of the endogenous mammary tumors, while having no effect on the mvd of normal organs. |
2011-07-15 |
2023-08-12 |
mouse |
| Swetlana Mactier, Silke Henrich, Yiping Che, Philippa L Kohnke, Richard I Christopherso. Comprehensive proteomic analysis of the effects of purine analogs on human Raji B-cell lymphoma. Journal of proteome research. vol 10. issue 3. 2011-06-13. PMID:21182289. |
up-regulation of several stress-associated proteins found in the endoplasmic reticulum (er) including grp78, erp57, and orp150 suggests that purine analog-induced apoptosis may result from er stress and unfolded protein response. |
2011-06-13 |
2023-08-12 |
human |
| Gustaaf de Ridder, Rupa Ray, Uma K Misra, Salvatore V Pizz. Modulation of the unfolded protein response by GRP78 in prostate cancer. Methods in enzymology. vol 489. 2011-05-05. PMID:21266234. |
biological roles for cell-surface grp78 include competing nh(2)-domain and cooh-domain agonist receptor activities that induce opposite effects on proliferation and apoptosis. |
2011-05-05 |
2023-08-12 |
Not clear |
| Ju-Fang Liu, Yi-Chin Fong, Kai-Wei Chang, Sheng-Chu Kuo, Chih-Shiang Chang, Chih-Hsin Tan. FPTB, a novel CA-4 derivative, induces cell apoptosis of human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways. Journal of cellular biochemistry. vol 112. issue 2. 2011-05-03. PMID:21268067. |
transfection of cells with grp78 or calpain sirna reduced fptb-mediated cell apoptosis. |
2011-05-03 |
2023-08-12 |
human |