| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chang-Qing Zhao, Yue-Hui Zhang, Sheng-Dan Jiang, Lei-Sheng Jiang, Li-Yang Da. Both endoplasmic reticulum and mitochondria are involved in disc cell apoptosis and intervertebral disc degeneration in rats. Age (Dordrecht, Netherlands). vol 32. issue 2. 2010-08-09. PMID:19960285. |
we found that ivdd, induced by unbalanced dynamic and static forces in the rats, was accompanied by increased disc cell apoptosis and enhanced expression of grp78, gadd153, caspase-12, and cytochrome c. annular cell apoptosis induced by sodium nitroprusside was confirmed by morphologic observation and flow cytometry. |
2010-08-09 |
2023-08-12 |
rat |
| Chang-Qing Zhao, Yue-Hui Zhang, Sheng-Dan Jiang, Lei-Sheng Jiang, Li-Yang Da. Both endoplasmic reticulum and mitochondria are involved in disc cell apoptosis and intervertebral disc degeneration in rats. Age (Dordrecht, Netherlands). vol 32. issue 2. 2010-08-09. PMID:19960285. |
with increased apoptosis, the expression of grp78, gadd153, and caspase-12 upregulated, mitochondrial membrane potential decreased, and accumulation of cytochrome c in the cytosol manifested. |
2010-08-09 |
2023-08-12 |
rat |
| T Shrestha-Bhattarai, V M Rangneka. Cancer-selective apoptotic effects of extracellular and intracellular Par-4. Oncogene. vol 29. issue 27. 2010-07-30. PMID:20440265. |
moreover, recent findings indicate that the par-4 protein is secreted by cells, and extracellular par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor grp78. |
2010-07-30 |
2023-08-12 |
Not clear |
| Rong-Yang Dai, Yao Chen, Jing Fu, Li-Wei Dong, Yi-Bin Ren, Guang-Zhen Yang, You-Wen Qian, Jie Cao, Shan-Hua Tang, Sheng-Li Yang, Hong-Yang Wan. p28GANK inhibits endoplasmic reticulum stress-induced cell death via enhancement of the endoplasmic reticulum adaptive capacity. Cell research. vol 19. issue 11. 2010-06-22. PMID:19736567. |
taken together, our results indicate that p28(gank) inhibits er stress-induced apoptosis in hcc cells, at least in part, by enhancing the adaptive response and grp78 expression. |
2010-06-22 |
2023-08-12 |
human |
| Ying-Ju Chen, Chien-Lin Wu, Ju-Fang Liu, Yi-Chin Fong, Sheng-Feng Hsu, Te-Mao Li, Yi-Chang Su, Shing-Hwa Liu, Chih-Hsin Tan. Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress. Cancer letters. vol 291. issue 1. 2010-04-16. PMID:19880244. |
transfection of cells with grp78 or calpain sirna reduced honokiol-mediated cell apoptosis in jj012 cells. |
2010-04-16 |
2023-08-12 |
human |
| Ju-Fang Liu, Wei-Hung Yang, Yi-Chin Fong, Sheng-Chu Kuo, Chih-Shiang Chang, Chih-Hsin Tan. BFPP, a phloroglucinol derivative, induces cell apoptosis in human chondrosarcoma cells through endoplasmic reticulum stress. Biochemical pharmacology. vol 79. issue 10. 2010-04-08. PMID:20067774. |
transfection of cells with grp78 or calpain sirna reduced bfpp-mediated cell apoptosis in jj012 cells. |
2010-04-08 |
2023-08-12 |
human |
| Soichiro Kishi, Koji Shimoke, Yosuke Nakatani, Takafumi Shimada, Nobuaki Okumura, Katsuya Nagai, Kazuo Shin-Ya, Toshihiko Ikeuch. Nerve growth factor attenuates 2-deoxy-d-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78. Neuroscience research. vol 66. issue 1. 2010-04-06. PMID:19766678. |
nerve growth factor attenuates 2-deoxy-d-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of grp78. |
2010-04-06 |
2023-08-12 |
Not clear |
| Soichiro Kishi, Koji Shimoke, Yosuke Nakatani, Takafumi Shimada, Nobuaki Okumura, Katsuya Nagai, Kazuo Shin-Ya, Toshihiko Ikeuch. Nerve growth factor attenuates 2-deoxy-d-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78. Neuroscience research. vol 66. issue 1. 2010-04-06. PMID:19766678. |
we found that nerve growth factor (ngf) prevented 2dg-triggered er stress-mediated apoptosis, but not the induction of grp78 expression, in pc12 cells. |
2010-04-06 |
2023-08-12 |
Not clear |
| Soichiro Kishi, Koji Shimoke, Yosuke Nakatani, Takafumi Shimada, Nobuaki Okumura, Katsuya Nagai, Kazuo Shin-Ya, Toshihiko Ikeuch. Nerve growth factor attenuates 2-deoxy-d-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78. Neuroscience research. vol 66. issue 1. 2010-04-06. PMID:19766678. |
when a specific inhibitor of phosphatidylinositol 3-kinase (pi3-k), ly294002, was added to 2dg plus ngf-treated cells, both the effects of ngf on 2dg-induced apoptosis and grp78 expression were significantly diminished. |
2010-04-06 |
2023-08-12 |
Not clear |
| Soichiro Kishi, Koji Shimoke, Yosuke Nakatani, Takafumi Shimada, Nobuaki Okumura, Katsuya Nagai, Kazuo Shin-Ya, Toshihiko Ikeuch. Nerve growth factor attenuates 2-deoxy-d-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78. Neuroscience research. vol 66. issue 1. 2010-04-06. PMID:19766678. |
in addition, versipelostatin (vst), a specific inhibitor of grp78 expression, and small interfering rna (sirna) against grp78 mrna also decreased both the effects of ngf on 2dg-induced apoptosis and grp78 expression. |
2010-04-06 |
2023-08-12 |
Not clear |
| Soichiro Kishi, Koji Shimoke, Yosuke Nakatani, Takafumi Shimada, Nobuaki Okumura, Katsuya Nagai, Kazuo Shin-Ya, Toshihiko Ikeuch. Nerve growth factor attenuates 2-deoxy-d-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78. Neuroscience research. vol 66. issue 1. 2010-04-06. PMID:19766678. |
these results suggest that the ngf-activated pi3-k/akt signaling pathway plays a protective role against er stress-mediated apoptosis via enhanced expression of grp78 in pc12 cells. |
2010-04-06 |
2023-08-12 |
Not clear |
| Wai-Leng Lee, Tuan-Nan Wen, Jeng-Yuan Shiau, Lie-Fen Shyu. Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells. Journal of proteome research. vol 9. issue 1. 2010-03-30. PMID:19894775. |
western blot analysis of marker proteins (e.g., pdi, grp78, txnd5, caspase-12, caspase-3 and parp) further verified that induction of endoplasmic reticulum stress was associated with apoptosis induced by both deoxyelephantopin and paclitaxel, but only deoxyelephantopin inhibited proteasomal proteolysis in ts/a cells. |
2010-03-30 |
2023-08-12 |
mouse |
| U K Misra, S V Pizz. PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells. Biochemical and biophysical research communications. vol 391. issue 1. 2010-03-15. PMID:19913499. |
antibodies against the cooh-terminal domain of cell surface grp78 induce apoptosis in cancer cell lines via activation of p53 signaling. |
2010-03-15 |
2023-08-12 |
Not clear |
| Chao Zhao, Wei Zhang, Xiaochen Tian, Caiyun Fang, Haojie Lu, Zhenghong Yuan, Pengyuan Yang, Yumei We. Proteomic analysis of cell lines expressing small hepatitis B surface antigen revealed decreased glucose-regulated protein 78 kDa expression in association with higher susceptibility to apoptosis. Journal of medical virology. vol 82. issue 1. 2010-02-26. PMID:19950238. |
some have been implicated in apoptosis, including glucose-regulated protein 78 kda (grp78), heterogeneous nuclear ribonucleoprotein h3 (hnrnp h), rho gdp dissociation inhibitor (gdi), cystatin b, far upstream element-binding protein (fusebp), and tnf receptor-associated protein 1 (trap1). |
2010-02-26 |
2023-08-12 |
Not clear |
| Chao Zhao, Wei Zhang, Xiaochen Tian, Caiyun Fang, Haojie Lu, Zhenghong Yuan, Pengyuan Yang, Yumei We. Proteomic analysis of cell lines expressing small hepatitis B surface antigen revealed decreased glucose-regulated protein 78 kDa expression in association with higher susceptibility to apoptosis. Journal of medical virology. vol 82. issue 1. 2010-02-26. PMID:19950238. |
replenishing grp78 improved cellular resistance to apoptosis, whereas reduction of grp78 by sirna increased susceptibility even in the absence of shbs. |
2010-02-26 |
2023-08-12 |
Not clear |
| Jui-Ling Hsu, Po-Cheng Chiang, Jih-Hwa Gu. Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78. Naunyn-Schmiedeberg's archives of pharmacology. vol 380. issue 5. 2009-12-29. PMID:19777212. |
furthermore, the cells transfected with grp78 sirna were partly resistant to tunicamycin-induced apoptosis but not the inhibitory effect on cell-cycle regulators indicating that grp78 and g1 arrest are two independent factors to tunicamycin-induced resistance mechanism. |
2009-12-29 |
2023-08-12 |
human |
| Chih-Hsin Tang, Yung-Cheng Chiu, Chun-Fa Huang, Ya-Wen Chen, Po-Chun Che. Arsenic induces cell apoptosis in cultured osteoblasts through endoplasmic reticulum stress. Toxicology and applied pharmacology. vol 241. issue 2. 2009-11-17. PMID:19695276. |
transfection of cells with grp78 or calpain sirna reduced as-mediated cell apoptosis in osteoblasts. |
2009-11-17 |
2023-08-12 |
mouse |
| Martina Stessl, Martina Marchetti-Deschmann, Johannes Winkler, Bodo Lachmann, Günter Allmaier, Christian R No. A proteomic study reveals unspecific apoptosis induction and reduction of glycolytic enzymes by the phosphorothioate antisense oligonucleotide oblimersen in human melanoma cells. Journal of proteomics. vol 72. issue 6. 2009-11-16. PMID:19523545. |
several proteins linked to apoptosis and stress response, among those galectin-1, cofilin-1, grp78, hsp60, nucleophosmin, and peroxiredoxins, were identified and found to be down-regulated after oblimersen treatment. |
2009-11-16 |
2023-08-12 |
human |
| Tzu-Ching Kuo, Jai-Sing Yang, Meng-Wei Lin, Shu-Chun Hsu, Jen-Jyh Lin, Hui-Ju Lin, Te-Chun Hsia, Ching-Lung Liao, Mei-Due Yang, Ming-Jen Fan, W G Wood, Jing-Gung Chun. Emodin has cytotoxic and protective effects in rat C6 glioma cells: roles of Mdr1a and nuclear factor kappaB in cell survival. The Journal of pharmacology and experimental therapeutics. vol 330. issue 3. 2009-09-21. PMID:19549930. |
c6 cells also expressed grp78 to decrease emodin-induced endoplasmic reticulum (er) stress that would cause apoptosis in c6 cells, and grp78 inhibited the expression of gadd153 to enhance the expression of bcl-2 that could balance the er- and mitochondria-induced apoptosis of c6 cells. |
2009-09-21 |
2023-08-12 |
rat |
| Nizar M Mhaidat, Feras Q Alali, Sina M Matalqah, Ismail I Matalka, Saied A Jaradat, Nour A Al-Sawalha, Rick F Thorn. Inhibition of MEK sensitizes paclitaxel-induced apoptosis of human colorectal cancer cells by downregulation of GRP78. Anti-cancer drugs. vol 20. issue 7. 2009-09-11. PMID:19521235. |
inhibition of mek sensitizes paclitaxel-induced apoptosis of human colorectal cancer cells by downregulation of grp78. |
2009-09-11 |
2023-08-12 |
human |