| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carlo Colombo, Ottavia Porzio, Ming Liu, Ornella Massa, Mario Vasta, Silvana Salardi, Luciano Beccaria, Carla Monciotti, Sonia Toni, Oluf Pedersen, Torben Hansen, Luca Federici, Roberta Pesavento, Francesco Cadario, Giorgio Federici, Paolo Ghirri, Peter Arvan, Dario Iafusco, Fabrizio Barbett. Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus. The Journal of clinical investigation. vol 118. issue 6. 2008-07-10. PMID:18451997. |
in these experiments, expression of the mutant proinsulins was also associated with increased grp78 protein expression and xbp1 mrna splicing, 2 markers of endoplasmic reticulum stress, and with increased apoptosis. |
2008-07-10 |
2023-08-12 |
mouse |
| Shinichi Takano, Takashi Ando, Nobuhiko Hiramatsu, Asuka Kanayama, Shinya Maekawa, Yuko Ohnuma, Nobuyuki Enomoto, Hideoki Ogawa, Adrienne W Paton, James C Paton, Masanori Kitamura, Atsuhito Naka. T cell receptor-mediated signaling induces GRP78 expression in T cells: the implications in maintaining T cell viability. Biochemical and biophysical research communications. vol 371. issue 4. 2008-06-18. PMID:18457657. |
in addition, the specific knockdown of grp78 protein expression induced apoptosis in mouse el-4 t cell line associated with chop induction and caspase-3 activation. |
2008-06-18 |
2023-08-12 |
mouse |
| Nicole Rauschert, Stephanie Brändlein, Elisabeth Holzinger, Frank Hensel, Hans-Konrad Müller-Hermelink, H Peter Vollmer. A new tumor-specific variant of GRP78 as target for antibody-based therapy. Laboratory investigation; a journal of technical methods and pathology. vol 88. issue 4. 2008-05-28. PMID:18268478. |
the chaperone grp78 is a member of the heat-shock protein 70 (hsp70) family and is responsible for cellular homeostasis by preventing stress-induced apoptosis. |
2008-05-28 |
2023-08-12 |
human |
| Takashi Kusunoki, Koji Shimoke, Satoko Komatsubara, Soichiro Kishi, Toshihiko Ikeuch. p-Nonylphenol induces endoplasmic reticulum stress-mediated apoptosis in neuronally differentiated PC12 cells. Neuroscience letters. vol 431. issue 3. 2008-05-02. PMID:18162324. |
here we report that p-nonylphenol, one of the edcs, induced apoptosis with up-regulation of glucose-regulated protein 78 (grp78) expression and activation of caspase-12, which are involved in endoplasmic reticulum (er) stress specific phenomena, in ngf-treated neuronally differentiated pc12 cells. |
2008-05-02 |
2023-08-12 |
Not clear |
| Chih-Wen Shu, Fang-Chun Sun, Jun-Hung Cho, Chih-Chien Lin, Pei-Feng Liu, Ping-Yen Chen, Margaret Dah-Tsyr Chang, Hua-Wen Fu, Yiu-Kay La. GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis. Journal of cellular physiology. vol 215. issue 3. 2008-04-29. PMID:18064632. |
grp78 and raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis. |
2008-04-29 |
2023-08-12 |
human |
| Chih-Wen Shu, Fang-Chun Sun, Jun-Hung Cho, Chih-Chien Lin, Pei-Feng Liu, Ping-Yen Chen, Margaret Dah-Tsyr Chang, Hua-Wen Fu, Yiu-Kay La. GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis. Journal of cellular physiology. vol 215. issue 3. 2008-04-29. PMID:18064632. |
aebsf, an inhibitor of serine protease, diminished grp78 induction, enhanced mitochondrial permeability, and augmented apoptosis in h460 cells during er stress. |
2008-04-29 |
2023-08-12 |
human |
| Chih-Wen Shu, Fang-Chun Sun, Jun-Hung Cho, Chih-Chien Lin, Pei-Feng Liu, Ping-Yen Chen, Margaret Dah-Tsyr Chang, Hua-Wen Fu, Yiu-Kay La. GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis. Journal of cellular physiology. vol 215. issue 3. 2008-04-29. PMID:18064632. |
additionally, overexpression of grp78 and/or raf-1 protected cells from er stress-induced apoptosis. |
2008-04-29 |
2023-08-12 |
human |
| Chih-Wen Shu, Fang-Chun Sun, Jun-Hung Cho, Chih-Chien Lin, Pei-Feng Liu, Ping-Yen Chen, Margaret Dah-Tsyr Chang, Hua-Wen Fu, Yiu-Kay La. GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis. Journal of cellular physiology. vol 215. issue 3. 2008-04-29. PMID:18064632. |
taken together, our results indicate that grp78 may stabilize raf-1 to maintain mitochondrial permeability and thus protect cells from er stress-induced apoptosis. |
2008-04-29 |
2023-08-12 |
human |
| Elida Lai, George Bikopoulos, Michael B Wheeler, Maria Rozakis-Adcock, Allen Volchu. Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. American journal of physiology. Endocrinology and metabolism. vol 294. issue 3. 2008-04-24. PMID:18198352. |
although overexpressing grp78 in ins-1 cells partially reduced susceptibility to thapsigargin, this failed to reduce palmitate-induced er stress or apoptosis. |
2008-04-24 |
2023-08-12 |
mouse |
| Elida Lai, George Bikopoulos, Michael B Wheeler, Maria Rozakis-Adcock, Allen Volchu. Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. American journal of physiology. Endocrinology and metabolism. vol 294. issue 3. 2008-04-24. PMID:18198352. |
finally, min6 cells depleted of grp78 were more susceptible to tunicamycin-induced apoptosis but not to palmitate-induced apoptosis compared with control cells. |
2008-04-24 |
2023-08-12 |
mouse |
| Gordon P Meares, Anna A Zmijewska, Richard S Jop. HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation. Cellular signalling. vol 20. issue 2. 2008-04-14. PMID:18083346. |
we identified several new partners of hsp105, including glycogen synthase kinase-3 (gsk3), a promoter of er stress-induced apoptosis, and grp78, a key component of the upr. |
2008-04-14 |
2023-08-12 |
Not clear |
| Jiahao Liu, Weike Mao, Chikao Iwai, Shuji Fukuoka, Raju Vulapalli, Huanlei Huang, Tingchung Wang, Virendra K Sharma, Shey-Shing Sheu, Michael Fu, Chang-Seng Lian. Adoptive passive transfer of rabbit beta1-adrenoceptor peptide immune cardiomyopathy into the Rag2-/- mouse: participation of the ER stress. Journal of molecular and cellular cardiology. vol 44. issue 2. 2008-04-03. PMID:18155231. |
this was associated with increase in heart weight, myocyte apoptosis, activation of caspase-3, -9 and -12, and increased er stress as evidenced by upregulation of grp78 and chop and cleavage of atf6. |
2008-04-03 |
2023-08-12 |
mouse |
| Yiqun G Shellman, William R Howe, Leslie A Miller, Nathaniel B Goldstein, Theresa R Pacheco, Roop L Mahajan, Susan M LaRue, David A Norri. Hyperthermia induces endoplasmic reticulum-mediated apoptosis in melanoma and non-melanoma skin cancer cells. The Journal of investigative dermatology. vol 128. issue 4. 2008-04-02. PMID:17989736. |
last, analysis of grp78 expression and caspase 12 or 4 activation indicated that hyperthermia induced endoplasmic reticulum-mediated apoptosis. |
2008-04-02 |
2023-08-12 |
Not clear |
| Yoshihiko Kakinuma, Rajesh G Katare, Mikihiko Arikawa, Kazuyo Muramoto, Fumiyasu Yamasaki, Takayuki Sat. A HIF-1alpha-related gene involved in cell protection from hypoxia by suppression of mitochondrial function. FEBS letters. vol 582. issue 2. 2008-04-01. PMID:18155669. |
we identified apoptosis inhibitor (ai) gene as being differentially expressed between von hippel lindau (vhl) protein-positive cells with high levels of grp78 expression and vhl-negative cells with lower grp levels, using cdna subtraction. |
2008-04-01 |
2023-08-12 |
Not clear |
| Yoshihiko Kakinuma, Rajesh G Katare, Mikihiko Arikawa, Kazuyo Muramoto, Fumiyasu Yamasaki, Takayuki Sat. A HIF-1alpha-related gene involved in cell protection from hypoxia by suppression of mitochondrial function. FEBS letters. vol 582. issue 2. 2008-04-01. PMID:18155669. |
ai decreased grp78 level, suppressed mitochondrial function, reduced oxygen consumption and, ultimately, suppressed hypoxia-induced apoptosis. |
2008-04-01 |
2023-08-12 |
Not clear |
| Dezheng Dong, Min Ni, Jianze Li, Shigang Xiong, Wei Ye, Jenilyn J Virrey, Changhui Mao, Risheng Ye, Miao Wang, Ligaya Pen, Louis Dubeau, Susan Groshen, Florence M Hofman, Amy S Le. Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer research. vol 68. issue 2. 2008-02-14. PMID:18199545. |
our results reveal three major mechanisms mediated by grp78 for cancer progression: enhancement of tumor cell proliferation, protection against apoptosis, and promotion of tumor angiogenesis. |
2008-02-14 |
2023-08-12 |
mouse |
| M Yokouchi, N Hiramatsu, K Hayakawa, A Kasai, Y Takano, J Yao, M Kitamur. Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response. Cell death and differentiation. vol 14. issue 8. 2007-12-20. PMID:17464326. |
cadmium chloride (cdcl(2)) induced expression of endogenous er stress markers, grp78, grp94 and chop in vitro and in vivo, and subsequently caused cytological changes typical of apoptosis. |
2007-12-20 |
2023-08-12 |
Not clear |
| M Yokouchi, N Hiramatsu, K Hayakawa, A Kasai, Y Takano, J Yao, M Kitamur. Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response. Cell death and differentiation. vol 14. issue 8. 2007-12-20. PMID:17464326. |
attenuation of er stress by transfection with er chaperone grp78 or orp150 suppressed cdcl(2)-triggered apoptosis. |
2007-12-20 |
2023-08-12 |
Not clear |
| M Yokouchi, N Hiramatsu, K Hayakawa, A Kasai, Y Takano, J Yao, M Kitamur. Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response. Cell death and differentiation. vol 14. issue 8. 2007-12-20. PMID:17464326. |
cdcl(2) also triggered activation of the inositol-requiring er-to-nucleus signal kinase 1 (ire1)-x-box-binding protein 1 (xbp1) pathway and inhibition of xbp1 attenuated apoptosis independent of grp78 and chop. |
2007-12-20 |
2023-08-12 |
Not clear |
| Toshikazu Suzuki, Jun Lu, Muhammed Zahed, Kazuko Kita, Nobuo Suzuk. Reduction of GRP78 expression with siRNA activates unfolded protein response leading to apoptosis in HeLa cells. Archives of biochemistry and biophysics. vol 468. issue 1. 2007-12-18. PMID:17936241. |
reduction of grp78 expression with sirna activates unfolded protein response leading to apoptosis in hela cells. |
2007-12-18 |
2023-08-12 |
human |