| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenxiu Zhu, Rui Zhang, Song Liu, Jiawei Tian, Xiaobing Lv, Fei Yu, Hui Xi. The effect of nanoparticles of cobalt-chromium on human aortic endothelial cells in vitro. Journal of applied toxicology : JAT. vol 41. issue 12. 2021-11-12. PMID:33959985. |
the expression of grp78, chop, and cleaved-caspase12 proteins has increased when exposed to cocr nanoparticles, suggesting that cocr nanoparticles induced cell apoptosis through endoplasmic reticulum (er) stress-mediated apoptotic pathway. |
2021-11-12 |
2023-08-13 |
human |
| Xinwei Jiang, Xia Li, Wenjun Feng, Yige Qin, Zhen Li, Hua Nie, Weibing Qin, Lu Han, Weibin Ba. Baking of methionine-choline deficient diet aggravates testis injury in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 154. 2021-11-08. PMID:33940107. |
the spermatocyte apoptosis was mediated by reticulum stress, including grp78, xbp-1 and chop gene expression. |
2021-11-08 |
2023-08-13 |
mouse |
| Sina Kavalakatt, Abdelkrim Khadir, Dhanya Madhu, Heikki A Koistinen, Fahd Al-Mulla, Jaakko Tuomilehto, Jehad Abubaker, Ali Tis. Urocortin 3 overexpression reduces ER stress and heat shock response in 3T3-L1 adipocytes. Scientific reports. vol 11. issue 1. 2021-11-05. PMID:34341463. |
ucn3 overexpression significantly downregulated heat shock proteins (hsp60, hsp72 and hsp90) and er stress response markers (grp78, perk, atf6, and ire1α) and attenuated inflammation (tnfα) and apoptosis (chop). |
2021-11-05 |
2023-08-13 |
Not clear |
| Kun Fu, Liqiang Chen, Shuai Hu, Yan Guo, Wei Zhang, Yunan Ba. Grape seed proanthocyanidins attenuate apoptosis in ischemic stroke. Acta neurologica Belgica. vol 121. issue 2. 2021-11-01. PMID:30835051. |
moreover, gsp attenuated er stress-associated apoptosis by inhibiting grp78 and caspase-12. |
2021-11-01 |
2023-08-13 |
mouse |
| Kun Xiao, Shengchao Ma, Long Xu, Ning Ding, Hui Zhang, Lin Xie, Lingbo Xu, Yun Jiao, Huiping Zhang, Yideng Jian. Interaction between PSMD10 and GRP78 accelerates endoplasmic reticulum stress-mediated hepatic apoptosis induced by homocysteine. Gut pathogens. vol 13. issue 1. 2021-10-26. PMID:34666830. |
interaction between psmd10 and grp78 accelerates endoplasmic reticulum stress-mediated hepatic apoptosis induced by homocysteine. |
2021-10-26 |
2023-08-13 |
Not clear |
| Lihong Pi, Xiaoming Li, Qi Song, Yupeng Shen, Xiuying Lu, Bin D. Knockdown of glucose-regulated protein 78 abrogates chemoresistance of hypopharyngeal carcinoma cells to cisplatin induced by unfolded protein in response to severe hypoxia. Oncology letters. vol 7. issue 3. 2021-10-21. PMID:24527073. |
however, the role of grp78 in regulating the cell growth and apoptosis of hypopharyngeal carcinoma cells, with regard to the severity of hypoxia, remains unclear. |
2021-10-21 |
2023-08-12 |
human |
| Lihong Pi, Xiaoming Li, Qi Song, Yupeng Shen, Xiuying Lu, Bin D. Knockdown of glucose-regulated protein 78 abrogates chemoresistance of hypopharyngeal carcinoma cells to cisplatin induced by unfolded protein in response to severe hypoxia. Oncology letters. vol 7. issue 3. 2021-10-21. PMID:24527073. |
knockdown of grp78 with short hairpin rna inhibited cell proliferation and promoted apoptosis under severely hypoxic conditions, even with cisplatin treatment, indicating that grp78 confers fadu cells resistant to chemotherapy in response to severe hypoxia. |
2021-10-21 |
2023-08-12 |
human |
| Lihong Pi, Xiaoming Li, Qi Song, Yupeng Shen, Xiuying Lu, Bin D. Knockdown of glucose-regulated protein 78 abrogates chemoresistance of hypopharyngeal carcinoma cells to cisplatin induced by unfolded protein in response to severe hypoxia. Oncology letters. vol 7. issue 3. 2021-10-21. PMID:24527073. |
furthermore, knockdown of grp78 resulted in a significant increase in chop and bax expression levels and a decrease in bcl-2 expression levels with simultaneous increase in the levels of apoptosis under severely hypoxic conditions. |
2021-10-21 |
2023-08-12 |
human |
| Koji Takada, Jun Hirose, Soichiro Yamabe, Yushuke Uehara, Hiroshi Mizut. Endoplasmic reticulum stress mediates nitric oxide-induced chondrocyte apoptosis. Biomedical reports. vol 1. issue 2. 2021-10-21. PMID:24648941. |
snp-treated chondrocytes showed an increase in chop and grp78 mrna expression and underwent apoptosis. |
2021-10-21 |
2023-08-12 |
rat |
| Koji Takada, Jun Hirose, Soichiro Yamabe, Yushuke Uehara, Hiroshi Mizut. Endoplasmic reticulum stress mediates nitric oxide-induced chondrocyte apoptosis. Biomedical reports. vol 1. issue 2. 2021-10-21. PMID:24648941. |
sodium 4-phenylbutyrate (pba), an ers inhibitor, reduced chop and grp78, as well as snp-stimulated apoptosis of chondrocytes, without affecting the snp-dependent generation of no. |
2021-10-21 |
2023-08-12 |
rat |
| Qiang Zuo, Yunsheng Ou, Shenxi Zhong, Haoyang Yu, Fangbiao Zhan, Muzi Zhan. Targeting GRP78 enhances the sensitivity of HOS osteosarcoma cells to pyropheophorbide-α methyl ester-mediated photodynamic therapy via the Wnt/β-catenin signaling pathway. Acta biochimica et biophysica Sinica. vol 53. issue 10. 2021-10-15. PMID:34494093. |
apoptosis and reactive oxygen species (ros) levels were detected by hoechst staining and flow cytometry, cell viability was detected by cell counting kit-8 assay, grp78 protein fluorescence intensity was detected by immunofluorescence, and apoptosis-related proteins, cell proliferation-related proteins, and wnt pathway-related proteins were detected by western blot. |
2021-10-15 |
2023-08-13 |
human |
| Qiang Zuo, Yunsheng Ou, Shenxi Zhong, Haoyang Yu, Fangbiao Zhan, Muzi Zhan. Targeting GRP78 enhances the sensitivity of HOS osteosarcoma cells to pyropheophorbide-α methyl ester-mediated photodynamic therapy via the Wnt/β-catenin signaling pathway. Acta biochimica et biophysica Sinica. vol 53. issue 10. 2021-10-15. PMID:34494093. |
the results showed that mppα-pdt can induce hos cell apoptosis and increase grp78 expression. |
2021-10-15 |
2023-08-13 |
human |
| Jingjing Wu, Youqile Wu, Xuemei Lia. Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy. Biology open. vol 9. issue 11. 2021-10-13. PMID:33115703. |
targeted inhibition of grp78 by ha15 promotes apoptosis of lung cancer cells accompanied by er stress and autophagy. |
2021-10-13 |
2023-08-13 |
Not clear |
| Ahmet Yardim, Fatih Mehmet Kandemir, Selcuk Ozdemir, Sefa Kucukler, Selim Comakli, Cihan Gur, Hamit Celi. Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-κB, ATF-6 pathways and activating Nrf2, Akt pathways. Neurotoxicology. vol 81. 2021-10-12. PMID:33038355. |
additionally, vincristine was determined to cause er stress and apoptosis by increasing perk, ire1, atf-6, and grp78 and caspase 3 and bax expressions and by decreasing bcl-2 expressions. |
2021-10-12 |
2023-08-13 |
rat |
| Mingchu Fang, Junhui Yuan, Shishuang Jiang, Yingying Hu, Shulin Pan, Jianghu Zhu, Xiaoqin Fu, Huai Jiang, Jian Lin, Peijun Li, Zhenlang Li. Dl-3-n-butylphthalide attenuates hypoxic-ischemic brain injury through inhibiting endoplasmic reticulum stress-induced cell apoptosis and alleviating blood-brain barrier disruption in newborn rats. Brain research. vol 1747. 2021-10-07. PMID:32763236. |
we further demonstrated an inhibitory effect of nbp on endoplasmic reticulum (er) stress-induced apoptosis, evidenced by reduction in er stress-related protein expressions (grp78, xbp-1, pdi and chop), decrease in tunel-positive cells, down-regulation in pro-apoptosis protein (bax and cleaved caspase-3), up-regulation in anti-apoptosis protein (bcl-2). |
2021-10-07 |
2023-08-13 |
human |
| Xin Song, Jing Li, Mengyu Jiao, Yanqing Chen, Keqing Pa. Effect of endoplasmic reticulum stress-induced apoptosis in the role of periodontitis on vascular calcification in a rat model. Journal of molecular histology. vol 52. issue 5. 2021-10-04. PMID:34480678. |
the expression levels of apoptotic factor cysteinyl aspartate specific proteinase 3 (caspase-3), ers-induced apoptotic factors glucose-regulated protein 78 (grp78), 94 (grp94), and ers-induced apoptosis pathways caspase-12, c/ebp homologous protein (chop), and c-jun n-terminal kinase (jnk) were analyzed and compared. |
2021-10-04 |
2023-08-13 |
rat |
| Xin Song, Jing Li, Mengyu Jiao, Yanqing Chen, Keqing Pa. Effect of endoplasmic reticulum stress-induced apoptosis in the role of periodontitis on vascular calcification in a rat model. Journal of molecular histology. vol 52. issue 5. 2021-10-04. PMID:34480678. |
the immunohistochemistry results showed caspase-3, grp78, grp94, and ers-induced apoptosis pathways in the cardiovascular tissues cells in the periodontitis group, vascular calcification group, and combined group. |
2021-10-04 |
2023-08-13 |
rat |
| Di Wang, Yan Li, Qian-Qian Zhai, Yun-Feng Zhu, Bei-Yan Liu, Yun X. Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats. Bosnian journal of basic medical sciences. 2021-09-28. PMID:34582743. |
hsd17b7 overexpression reversed the increase of c/ebp homologous protein (chop) and glucose-regulated protein 78 (grp78) protein levels as well as eif2α phosphorylation level and promotion of cell apoptosis caused by mir-1306-5p overexpression. |
2021-09-28 |
2023-08-13 |
rat |
| Xiaochun Wu, Shengying Zhang, Cuiqin Long, Zhen An, Xiaoyong Xing, Fengqin Wen, Shijun Ba. Mycoplasmas bovis P48 induces apoptosis in EBL cells via an endoplasmic reticulum stress-dependent signaling pathway. Veterinary microbiology. vol 255. 2021-09-20. PMID:33676093. |
to further explore the underlying mechanism, we performed inhibition experiments using er stress inhibitor 4-pba and specific sirna interference against grp78, and found that p48 protein modulated ebl cells apoptosis in an er stress signaling-dependent manner. |
2021-09-20 |
2023-08-13 |
cattle |
| Jing-Ying Zhao, Yu-Bin W. Huaier Extract Attenuates Acute Kidney Injury to Chronic Kidney Disease Transition by Inhibiting Endoplasmic Reticulum Stress and Apoptosis via miR-1271 Upregulation. BioMed research international. vol 2020. 2021-09-13. PMID:33457422. |
furthermore, he reduced the expression of ers markers glucose-regulated protein 78 (grp78) and c/ebp homologous protein (chop) and inhibited apoptosis in the iri group. |
2021-09-13 |
2023-08-13 |
mouse |