| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tao Wei, Jun-Da Li, Yu-Jing Wang, Wei Zhao, Fan Duan, Yan Wang, Ling-Ling Xia, Zhao-Bin Jiang, Xun Song, Yu-Qiong Zhu, Wen-Yi Shao, Ze Wang, Kang-Sheng Bi, Hui Li, Xiao-Chu Zhang, Dong-Liang Jia. p-Nrf2/HO-1 Pathway Involved in Methamphetamine-induced Executive Dysfunction through Endoplasmic Reticulum Stress and Apoptosis in the Dorsal Striatum. Neurotoxicity research. 2023-05-18. PMID:37199892. |
immunoblot analysis of nuclear factor-e2-related factor 2 (nrf2), phosphorylated nrf2 (p-nrf2), heme-oxygenase-1 (ho-1), glucose regulated protein 78(grp78), c/ebp homologous protein (chop), bcl-2, bax and caspase3 was performed to evaluate the levels of oxidative stress, endoplasmic reticulum (er) stress and apoptosis in the dorsal striatum (dstr). |
2023-05-18 |
2023-08-14 |
mouse |
| Huiqiong Deng, Wenying Chen, Boyang Zhang, Yiwen Zhang, Lingyun Han, Qipeng Zhang, Song Yao, Hongwei Wang, Xiao Li She. Excessive ER-phagy contributes to ochratoxin A-induced apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-04-20. PMID:37080527. |
a 24 h-treatment of 1-4 μm ota could markedly induce apoptosis via increasing the protein expressions of grp78, p-eif2α, chop, lc3b-ii, bak, and bax, and inhibiting the protein expressions of ddrgk1, uba5, lonp1, tex264, fam134b, p-mtor, p62, and bcl-2 in hk-2 cells (p < 0.05). |
2023-04-20 |
2023-08-14 |
human |
| Ravshan Burikhanov, Saptadwipa Ganguly, Sally Ellingson, Vitaliy M Sviripa, Nathalia Araujo, Shunqiang Li, Prasanna Venkatraman, Mahadev Rao, Anuradha Choughule, Christine F Brainson, Chang-Guo Zhan, H Peter Spielmann, David S Watt, Ramaswamy Govindan, Vivek M Rangneka. Crizotinib induces Par-4 secretion from normal cells and GRP78 expression on the cancer cell surface for selective tumor growth inhibition. American journal of cancer research. vol 13. issue 3. 2023-04-10. PMID:37034206. |
lung cancer cells develop resistance to apoptosis by suppressing the secretion of the tumor suppressor par-4 protein (also known as pawr) and/or down-modulating the par-4 receptor grp78 on the cell surface (csgrp78). |
2023-04-10 |
2023-08-14 |
mouse |
| Rongrong Xu, Yali Liu, Man Hao, Gui Ca. Apelin-36 alleviates LPS-induced trophoblast cell injury by inhibiting GRP78/ASK1/JNK signaling. Tissue & cell. vol 82. 2023-04-03. PMID:37011515. |
the inhibition on lps-induced trophoblast cell apoptosis and the promotion on invasion and migration by apelin-36 was counteracted by grp78 overexpression. |
2023-04-03 |
2023-08-14 |
Not clear |
| Elif Ayazoglu Demir, Selim Demir, Ilke Onur Kazaz, Hatice Kucuk, Nihal Turkmen Alemdar, Ali Buyuk, Ahmet Mentese, Yuksel Aliyaziciogl. Arbutin abrogates testicular ischemia/reperfusion injury in rats through repression of inflammation and ER stress. Tissue & cell. vol 82. 2023-03-15. PMID:36921493. |
the levels of dna damage [8-hydroxy-2'-deoxyguanosine (8-ohdg)], antioxidant system [superoxide dismutase (sod) and catalase (cat)], pro-inflammatory cytokines [high mobility group box 1 (hmgb1), nuclear factor kappa b protein 65 (nf-κb p65), tumor necrosis factor-alpha (tnf-α), interleukin-6 (il-6) and myeloperoxidase (mpo)], er stress [78-kda glucose-regulated protein (grp78), activating transcription factor 6 (atf6) and ccaat-enhancer-binding protein homologous protein (chop)] and apoptosis (caspase-3) markers in testicular tissues were determined using commercial enzyme-linked immunosorbent assay (elisa) kits. |
2023-03-15 |
2023-08-14 |
rat |
| Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wan. Autophagy attenuates placental apoptosis, oxidative stress and fetal growth restriction in pregnant ewes. Environment international. vol 173. 2023-02-25. PMID:36841186. |
data illustrated that exposure to bpa enhanced autophagy (ulk1, beclin-1, lc3, parkin, and pink1), ers (grp78, chop10, atf4, and atf6) and apoptosis (caspase 3, bcl-2, bax, p53) but decreased the antioxidant (cat, nrf2, ho-1, and nqo1)-related mrna and protein expressions as well as impaired the mitochondrial function. |
2023-02-25 |
2023-08-14 |
cat |
| Guochao Song, Fengyi Weng, Bin Zou, Jing Zhao, Jingyi Jin, Dongming Yan, Kai Huang, Xing Sun, Cheng-Hai Liu, Yi-Yang Hu, Yue Li, Furong Qi. Potential therapeutic action of Tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway. Clinical science (London, England : 1979). 2023-02-16. PMID:36795945. |
furthermore, in both mice with ca- and anit-induced cholestasis, tudca decreased expression of grp78 and ccaat/enhancer-binding protein homologous protein (chop); reduced death receptor 5 (dr5) transcription, caspase-8 activation, and bid cleavage; and subsequently inhibited activation of executioner caspases and apoptosis in liver. |
2023-02-16 |
2023-08-14 |
mouse |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Don. Geraniol-Mediated Suppression of Endoplasmic Reticulum Stress Protects against Cerebral Ischemia-Reperfusion Injury via the PERK-ATF4-CHOP Pathway. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613992. |
geraniol effectively attenuated cerebral infarction and pathological injury after ciri, had a protective effect against ciri, significantly reduced the expression of the er-stress-related proteins p-perk, atf4, chop, and grp78 and the pro-apoptotic protein bax, increased the expression of the anti-apoptotic protein bcl-2, and reduced the occurrence of apoptosis. |
2023-01-08 |
2023-08-14 |
rat |
| Qipeng Zhang, Wenying Chen, Boyang Zhang, Yiwen Zhang, Yuqing Xiao, Yichen An, Lingyun Han, Huiqiong Deng, Song Yao, Hongwei Wang, Xiao Li She. Lonp1 and Sig-1R contribute to the counteraction of ursolic acid against ochratoxin A-induced mitochondrial apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-01-01. PMID:36587836. |
results indicated that a 24 h-treatment of 5 μm ota could significantly induce mitochondrial-mediated apoptosis via repressing lonp1 and sig-1r, thereby enhancing the protein expressions of grp78, p-perk, p-eif2α, chop, ire1α, and bax, and inhibiting the protein expression of bcl-2 in hk-2 cells, which could be remarkably relieved by a 2 h-pre-treatment of 4 μm ua (p < 0.05). |
2023-01-01 |
2023-08-14 |
human |
| Rui Cheng, Zhiming Zhang, Chunhua Zhan, Tianlong Qin, Li Wang, Xuezhen Zhan. Environmentally relevant concentrations of selenite trigger reproductive toxicity by affecting oocyte development and promoting larval apoptosis. Environmental pollution (Barking, Essex : 1987). 2022-11-14. PMID:36375579. |
furthermore, exposure to na₂seo₃ downregulated the transcription level of genes on the hpg axis, decreased the phosphorylation level of cyclinb and the protein content of camp-dependent protein kinase (pka), and upregulated the expression of genes (eif2s1a and chop) and proteins (grp78, chop) related to endoplasmic reticulum stress (ers) and apoptosis. |
2022-11-14 |
2023-08-14 |
zebrafish |
| Lin Wang, Da Li, Xueting Su, Yuechao Zhao, Aixue Huang, Hui Li, Jie Li, Wei Xia, Tianqi Jia, Hongwen Zhang, Jie Dong, Xuemei Liu, Ningsheng Sha. AGO4 suppresses tumor growth by modulating autophagy and apoptosis via enhancing TRIM21-mediated ubiquitination of GRP78 in a p53-independent manner. Oncogene. 2022-11-13. PMID:36371565. |
ago4 suppresses tumor growth by modulating autophagy and apoptosis via enhancing trim21-mediated ubiquitination of grp78 in a p53-independent manner. |
2022-11-13 |
2023-08-14 |
Not clear |
| Lin Wang, Da Li, Xueting Su, Yuechao Zhao, Aixue Huang, Hui Li, Jie Li, Wei Xia, Tianqi Jia, Hongwen Zhang, Jie Dong, Xuemei Liu, Ningsheng Sha. AGO4 suppresses tumor growth by modulating autophagy and apoptosis via enhancing TRIM21-mediated ubiquitination of GRP78 in a p53-independent manner. Oncogene. 2022-11-13. PMID:36371565. |
ago4 promoted ubiquitination of grp78 by stabilizing trim21, a new specific ubiquitin e3 ligase for promoting k48-linked polyubiquitination of grp78 confirmed in this paper, which resulted in induced cell apoptosis and inhibited autophagy by activating mtor signal pathway. |
2022-11-13 |
2023-08-14 |
Not clear |
| Yaping Chen, Zheming Chen, Weineng Cheng, Yajun Cao, Wen Xu, Wenfang Lai, Yuqin Zhang, Mei Huang, Lihong Na. The Role of the GRP78/PERK/ATF4 Pathway in the Ability of Gua Lou Gui Zhi Decoction to Attenuate Apoptosis by Inhibiting Endoplasmic Reticulum Stress after Ischemia-Reperfusion Injury. Frontiers in bioscience (Landmark edition). vol 27. issue 10. 2022-11-07. PMID:36336865. |
in addition, the unfolded protein response (upr) plays an important role in ers because it activates downstream apoptotic signal transduction and induces apoptosis through the glucose-regulated protein 78 (grp78)/protein kinase r (pkr)-like er kinase (perk)/activating transcription factor 4 (atf4) pathway. |
2022-11-07 |
2023-08-14 |
Not clear |
| Jingjing Zhang, Yanling Tang, Wanjing Xu, Zeyu Hu, Shangzhi Xu, Qiang Ni. Fluoride-Induced Cortical Toxicity in Rats: the Role of Excessive Endoplasmic Reticulum Stress and Its Mediated Defective Autophagy. Biological trace element research. 2022-11-03. PMID:36327065. |
in addition, naf exposure induced excessive endoplasmic reticulum stress and associated apoptosis, as evidenced by elevated ire1α, grp78, cleaved caspase-12, and cleaved caspase-3, as well as defective autophagy, as evidenced by increased expression of beclin1, lc3-ii, and p62 in cortical areas. |
2022-11-03 |
2023-08-14 |
rat |
| Harika Atmaca, Ferdi Oğuz, Suleyman Ilha. Trabectedin (ET-743) in prostate cancer: Endoplasmic reticulum stress-induced apoptotic effect. Andrologia. 2022-09-28. PMID:36168116. |
er stress-related proteins chop, p-eif2α, grp78 and p-perk were also elevated by trabectedin treatment indicating the induction of er stress-induced apoptosis. |
2022-09-28 |
2023-08-14 |
Not clear |
| Wenbing Wu, Hui Gou, Bin Xiang, Ruiman Geng, Jingying Dong, Xiaolong Yang, Dan Chen, Rongyang Dai, Lihong Chen, Ji Li. EGCG Enhances the Chemosensitivity of Colorectal Cancer to Irinotecan through GRP78-MediatedEndoplasmic Reticulum Stress. Journal of oncology. vol 2022. 2022-09-23. PMID:36147440. |
findings showed that egcg alone or in combination with irinotecan can significantly promote intracellular grp78 protein expression, reduce mitochondrial membrane potential and intracellular ros in rko and hct 116 cells, and induce cell apoptosis. |
2022-09-23 |
2023-08-14 |
mouse |
| Wenbing Wu, Hui Gou, Bin Xiang, Ruiman Geng, Jingying Dong, Xiaolong Yang, Dan Chen, Rongyang Dai, Lihong Chen, Ji Li. EGCG Enhances the Chemosensitivity of Colorectal Cancer to Irinotecan through GRP78-MediatedEndoplasmic Reticulum Stress. Journal of oncology. vol 2022. 2022-09-23. PMID:36147440. |
the inhibition of grp78 by small interfering rna led to the decrease of the sensitivity of crc cells to the drug combination, while the overexpression of it by plasmid significantly increased the apoptosis of cells after the drug combination. |
2022-09-23 |
2023-08-14 |
mouse |
| Shuai Jiang, Shuai Liu, Yuxuan Hou, Chenxi Lu, Wenwen Yang, Ting Ji, Yang Yang, Zhibin Yu, Zhenxiao Ji. Cardiac-specific overexpression of Claudin-5 exerts protection against myocardial ischemia and reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease. 2022-09-04. PMID:36058416. |
moreover, cldn5 overexpression attenuated myocardial oxidative stress (dhe and protein levels of nrf2, ho-1, and nqo1), inflammatory response (levels of mpo, f4/80, ly6c, and circulating inflammatory cells), mitochondrial dysfunction (protein levels of pgc-1α, nrf1, and tfam), endoplasmic reticulum stress (protein levels of grp78, atf6, and chop and p-perk), energy metabolism disorder (p-ampk and acc), and apoptosis (tunel assay and protein levels of bax and bcl2) in mice subjected to myocardial ir. |
2022-09-04 |
2023-08-14 |
mouse |
| Meng-Yu Zuo, Tong-Juan Tang, Peng Zhou, Xiang Wang, Rui Ding, Jin-Fan Gu, Jian Chen, Liang Wang, Juan Yao, Xiang-Yang Li, Jin-Ling Huan. [Mechanism of atractylenolide Ⅲ in alleviating H9c2 cell apoptosis through ROS/GRP78/caspase-12 signaling pathway based on molecular docking]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 16. 2022-09-01. PMID:36046873. |
this study aims to investigate the effect of atractylenolide Ⅲ(atl-Ⅲ) on hydrogen peroxide(h_2o_2)-induced endoplasmic reticulum stress and apoptosis of h9 c2 cells via the ros/grp78/caspase-12 signaling pathway.the binding activity of atl-Ⅲ to grp78 was determined by molecular docking.the result showed that atl-Ⅲ had a good binding activity to grp78, and the binding activity of atl-Ⅲ was stronger than that of its specific inhibitor.the endoplasmic reticulum stress model of h9 c2 was established by h_2o_2(100 μmol·l~(-1)) treatment.five groups were designed: blank control group, model group, and atl-Ⅲ(15, 30, and 60 μmol·l~(-1)) groups.apoptosis was detected by hoechst/pi double staining and flow cytometry.the levels of superoxide dismutase(sod), malondialdehyde(mda), and lactate dehydrogenase(ldh) were measured by colorimetry.the levels of reactive oxygen species(ros) and calcium(ca~(2+)) in cytoplasm were determined by the fluorescence probe dcfh-da and the calcium fluorescence probe flou-4, respectively.the protein levels of grp78, caspase-12, and caspase-3 were determined by western blot, and the mrna levels of grp78 and caspase-12 by rt-qpcr.n-acetyl-l-cysteine(nac) and 4-phenylbutyric acid(4-pba) were respectively used to inhibit ros and grp78, and then the mechanism of atl-Ⅲ in protecting the cells from endoplasmic reticulum stress induced by h_2o_2 were deduced.atl-Ⅲ(15, 30, and 60 μmol·l~(-1)) decreased the apoptosis rate and ros, mda, and ldh levels(p<0.01), increased the sod activity(p<0.01), and down-regulated the protein levels of grp78, caspase-12, and caspase-3 and the mrna levels of grp78 and caspase-12(p<0.05).the addition of nac decreased the apoptosis rate and ros, mda, grp78, caspase-12, and caspase-3 levels(p<0.01), while it elevated the sod level(p<0.01).the addition of 4-pba also decreased the apoptosis rate and the levels of grp78, caspase-12, caspase-3, and ca~(2+)(p<0.01).the effect of inhibitors were consistent with that of atl-Ⅲ.in conclusion, atl-Ⅲ can protect h9 c2 cardiomyocytes by regulating ros/grp78/caspase-12 signaling pathway to inhibit h_2o_2-induced endoplasmic reticulum stress and apoptosis. |
2022-09-01 |
2023-08-14 |
Not clear |