| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kunpeng Qin, Hao Tang, Yi Ren, Di Yang, Yetian Li, Wei Huang, Yunfeng Wu, Zongsheng Yi. Melatonin promotes sirtuin 1 expression and inhibits IRE1α-XBP1S-CHOP to reduce endoplasmic reticulum stress-mediated apoptosis in chondrocytes. Frontiers in pharmacology. vol 13. 2022-08-29. PMID:36034777. |
lps-stimulated human primary chondrocytes induced er stress and significantly upregulated the er chaperone glucose-regulated protein 78 (grp78) and increased the expression level of c/ebp-homologous protein (chop), a key mediator of er stress--induced apoptosis. |
2022-08-29 |
2023-08-14 |
mouse |
| Feiyang Ma, Yihui Huo, Huayu Li, Fan Yang, Jianzhao Liao, Qingyue Han, Ying Li, Jiaqiang Pan, Lianmei Hu, Jianying Guo, Zhaoxin Tan. New insights into the interaction between duodenal toxicity and microbiota disorder under copper exposure in chicken: Involving in endoplasmic reticulum stress and mitochondrial toxicity. Chemico-biological interactions. 2022-08-28. PMID:36030842. |
meanwhile, cu could induce endoplasmic reticulum stress, mitophagy, and mitochondria-mediated apoptosis in the duodenum, with the evidence by the elevated levels of grp78, grp94, lc3Ⅱ/lc3Ⅰ and caspase-3 protein expression. |
2022-08-28 |
2023-08-14 |
chicken |
| Hong-Ju Liu, Min Dong, Wei-Dan Jiang, Pei Wu, Yang Liu, Xiao-Wan Jin, Sheng-Yao Kuang, Ling Tang, Lu Zhang, Lin Feng, Xiao-Qiu Zho. Acute nitrite exposure-induced oxidative damage, endoplasmic reticulum stress, autophagy and apoptosis caused gill tissue damage of grass carp (Ctenopharyngodon idella): Relieved by dietary protein. Ecotoxicology and environmental safety. vol 243. 2022-08-22. PMID:35994904. |
further research found that a suitable dietary protein suppressed the nitrite-induced endoplasmic reticulum stress (ers) 78 kda glucose-regulated protein (grp78) related signaling pathway which possibly activated autophagy and apoptosis. |
2022-08-22 |
2023-08-14 |
Not clear |
| Woo-Jin Lee, Eun-Ju Jung, Ju-Mi Hwang, Jeong-Won Bae, Woo-Sung Kwo. GRP78 plays a key role in sperm function via the PI3K/PDK1/AKT pathway. Reproductive toxicology (Elmsford, N.Y.). 2022-08-16. PMID:35973673. |
furthermore, grp78 is expressed on the surface of most common cancer cells, such as cells of breast, lung, liver, and prostate cancers, and plays a role in apoptosis and cell proliferation via the pi3k/pdk1/akt signaling pathway. |
2022-08-16 |
2023-08-14 |
Not clear |
| Kasturi Ganguly, Uday Kishore, Siddhanath M Metkari, Taruna Mada. Immunomodulatory Role of Surfactant Protein-D in a Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Model. Frontiers in immunology. vol 13. 2022-07-25. PMID:35874783. |
we recently reported selective induction of intrinsic apoptosis by a recombinant fragment of human sp-d (rfhsp-d) in the human prostate cancer (pca) biopsy explants and cells with glucose regulated protein of 78 (grp78) as one of the key interacting partners. |
2022-07-25 |
2023-08-14 |
mouse |
| Hanlin Wang, Chengyao Chiang, Chenyang Xue, Lu Zhou, Shuaihu Li, Yaqi Zhou, Zhucheng Zhang, Meng Xie, Tian Xiao, Hongyi Hu, Lizhi Zhu, Cheng Long, Yongdong Zou, Ting Wang, Duo Zhen. Dezocine induces apoptosis in human cervical carcinoma Hela cells via the endoplasmic reticulum stress pathway. Toxicology research. vol 11. issue 3. 2022-07-05. PMID:35782639. |
further mechanistic studies demonstrated that dezocine activated er stress by upregulating the expression of grp78, ire1 and p-jnk, and that dezocine-induced apoptosis was attenuated when the er stress pathway was blocked. |
2022-07-05 |
2023-08-14 |
human |
| Xiaojing Li, YiChen Bai, Wenjing Zhu, Xu Shi, Shiwen X. The endoplasmic reticulum-mitochondrial crosstalk is involved in the mitigation mechanism of eucalyptol on imidacloprid toxicity in Ctenopharyngodon idellus kidney cells. Fish & shellfish immunology. 2022-06-16. PMID:35709895. |
the results showed that imi exposure caused a higher grp78 levels, activated atf6, perk-eif2α and ire1-xbp1 pathways, led to the decline of atpase activities and atp content, induced the expression of cytokine (tnf-α, il-1β, il-6 and inf-γ), triggered bcl2/bax-mediated apoptosis and rip1/rip3/mlkl-dependent necroptosis in the cik cell line. |
2022-06-16 |
2023-08-14 |
Not clear |
| Paulina Sokołowska, Małgorzata Siatkowska, Marta Jóźwiak-Bębenista, Piotr Komorowski, Marta Koptas, Edward Kowalczyk, Anna Wiktorowska-Owczare. Diclofenac Diminished the Unfolded Protein Response (UPR) Induced by Tunicamycin in Human Endothelial Cells. Molecules (Basel, Switzerland). vol 27. issue 11. 2022-06-10. PMID:35684385. |
additionally, the drug diminished the significant upregulation and release of the grp78 protein, as evaluated using the elisa assay, which was likely to be involved in the mechanism of the upr activation resulting in apoptosis induction in endothelial cells. |
2022-06-10 |
2023-08-14 |
human |
| Jia Chen, Ke-Hong Chen, Li-Ming Wang, Jia Luo, Quan-You Zheng, Ya-Ni H. Decoy receptor 2 mediates the apoptosis-resistant phenotype of senescent renal tubular cells and accelerates renal fibrosis in diabetic nephropathy. Cell death & disease. vol 13. issue 6. 2022-06-06. PMID:35661704. |
additionally, grp78 knockdown decreased the apoptosis resistance of hg-induced senescent rtecs with upregulated cleaved caspase 3 and increased the percentage of apoptotic rtecs. |
2022-06-06 |
2023-08-14 |
mouse |
| Na Li, Jinqiong Li, Jiantao Jia, Xia Yao, Yan Zh. miR-148a targets XBP1 to regulate trophoblast apoptosis induced by plasma reticulum stress in preeclampsia. Medicine. vol 101. issue 13. 2022-04-14. PMID:35421066. |
grp78, chop, and caspase-12 expression result in anti-mir-148a group was decreased.mir-148a can regulate the ers-mediated apoptosis by targeting xbp1, thereby intervening in the occurrence and development of pe. |
2022-04-14 |
2023-08-13 |
Not clear |
| Mustafa Onur Yıldız, Hamit Çelik, Cuneyt Caglayan, Fatih Mehmet Kandemir, Cihan Gür, İbrahim Bayav, Aydın Genç, Özge Kandemi. Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy. Neurotoxicology. 2022-04-12. PMID:35413380. |
moreover, hesperidin was able to down-regulate the mrna transcript levels of apoptosis and endoplasmic reticulum stress markers such as caspase-3, bax, bcl-2, perk, ire1, atf6, and grp78 in naf-induced neurotoxicity. |
2022-04-12 |
2023-08-13 |
rat |
| Ning Li, Yali Zhao, Fangyu Wang, Lianjun Song, Mingwu Qiao, Tianlin Wang, Xianqing Huan. Folic acid alleviates lead acetate-mediated cardiotoxicity by down-regulating the expression levels of Nrf2, HO-1, GRP78, and CHOP proteins. Environmental science and pollution research international. 2022-03-24. PMID:35322363. |
the expression of stress-related proteins such as grp78 and chop also increased, leading to cardiomyocyte apoptosis. |
2022-03-24 |
2023-08-13 |
rat |
| Liuxie Yang, Zhenhuan Li, Yueping Ouyan. Taurine attenuates ER stress‑associated apoptosis and catabolism in nucleus pulposus cells. Molecular medicine reports. vol 25. issue 5. 2022-03-22. PMID:35315493. |
cell counting kit‑8, western blotting, tunel, immunofluorescence assays and reverse transcription‑quantitative pcr were applied to measure cell viability, the expression of er stress‑associated proteins (grp78, chop and caspase‑12), apoptosis and the levels of metabolic factors associated with ecm (mmp‑1, 3, 9, adamts‑4, 5 and collagen ii), respectively. |
2022-03-22 |
2023-08-13 |
Not clear |
| Abhishek Singh, Parul Gupta, Shubhangini Tiwari, Amit Mishra, Sarika Sing. Guanabenz mitigates the neuropathological alterations and cell death in Alzheimer's disease. Cell and tissue research. 2022-02-23. PMID:35195784. |
in conjunction, guanabenz also attenuated the ad-related oxidative stress, impaired mitochondrial functionality (mmp, cytochrome-c translocation, atp level, and mitochondrial complex i activity), endoplasmic reticulum stress (grp78, gadd153, cleaved caspase-12), neuronal apoptosis (bcl-2, bax, cleaved caspase-3), and dna fragmentation. |
2022-02-23 |
2023-08-13 |
rat |
| He-Yan Zhou, Yu-Ying Sun, Ping Chang, Han-Chang Huan. Curcumin Inhibits Cell Damage and Apoptosis Caused by Thapsigargin-Induced Endoplasmic Reticulum Stress Involving the Recovery of Mitochondrial Function Mediated by Mitofusin-2. Neurotoxicity research. 2022-02-22. PMID:35192145. |
curcumin attenuated tg-induced damage on cell viability and apoptosis and downregulated the protein levels of grp78, pser981-perk, and pser51-eif2α. |
2022-02-22 |
2023-08-13 |
Not clear |
| Yi-Nan Cao, Yong Wang, Longsheng Zhang, Yujia Hou, Jinhua Shan, Mengjie Li, Cairui Chen, Yufeng Zhou, Enfang Shan, Jie Wan. Protective effect of endoplasmic reticulum stress inhibition on 5-fluorouracil-induced oral mucositis. European journal of pharmacology. 2022-02-13. PMID:35151644. |
in the clinic, 5-fu could increase cell apoptosis and cause oral mucosa damage while increasing the expression of the ers marker genes grp78 and c/ebp-homologous protein (chop). |
2022-02-13 |
2023-08-13 |
mouse |
| Yi-Nan Cao, Yong Wang, Longsheng Zhang, Yujia Hou, Jinhua Shan, Mengjie Li, Cairui Chen, Yufeng Zhou, Enfang Shan, Jie Wan. Protective effect of endoplasmic reticulum stress inhibition on 5-fluorouracil-induced oral mucositis. European journal of pharmacology. 2022-02-13. PMID:35151644. |
our study found that 5-fu could induce severe ers, upregulate the expression of grp78 and chop, raise oxidative stress and increase the expression of inflammatory factors by activating the nf-κb pathway, thus causing cell apoptosis and finally leading to oral mucosal injury. |
2022-02-13 |
2023-08-13 |
mouse |
| Byung Sik Kim, In-Hwa Park, A-Hyeon Lee, Hyun-Jin Kim, Young-Hyo Lim, Jeong-Hun Shi. Sacubitril/valsartan reduces endoplasmic reticulum stress in a rat model of doxorubicin-induced cardiotoxicity. Archives of toxicology. 2022-02-13. PMID:35152301. |
in addition, sacubitril/valsartan significantly downregulated the expression levels of proteins related to apoptosis and er stress, including bax, caspase 3, grp78, perk, ire-1α, atf-6, eif-2α, atf-4, and chop, in the myocardium of a rat model of doxorubicin-induced cardiotoxicity in vivo and doxorubicin-treated h9c2 cardiomyocytes in vitro. |
2022-02-13 |
2023-08-13 |
rat |
| Jian Zhang, Wanyuan Dong, Yuhong Ren, Dongzhi We. SAC-TRAIL, a novel anticancer fusion protein: expression, purification, and functional characterization. Applied microbiology and biotechnology. 2022-02-08. PMID:35133472. |
prostate apoptosis response-4 (par-4) selectively induces apoptosis in cancer cells after binding to the cell surface receptor, grp78. |
2022-02-08 |
2023-08-13 |
Not clear |
| Qian Wang, Wenying Chen, Boyang Zhang, Zilu Gao, Qipeng Zhang, Huiqiong Deng, Lingyun Han, Xiao Li She. Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication. Chemico-biological interactions. 2022-02-06. PMID:35123991. |
results indicated that a 24 h-treatment with 64 and 256 μm pfoa could remarkably induce mitochondrial-mediated apoptosis via initiating the vicious cycle between endoplasmic reticulum stress and oxidative stress, thereby increasing the level of calcium ion and decreasing the level of ΔΨm, simultaneously elevating the protein expressions of cyclophilin d (cypd), bcl-2 homologous antagonist/killer (bak), bcl-2-associated x protein (bax), bcl-2-like protein 11 (bim), cytochrome c (cyt-c), 78 kda glucose-regulated protein (grp78), ccaat/enhancer-binding protein (c/ebp) homologous protein (chop), and thioredoxin-interacting protein (txnip), while inhibiting the protein expression of tumor necrosis factor receptor-associated protein 1 (trap1), lon protease 1 (lonp1), pro-caspase-9, b-cell lymphoma-2 (bcl-2), and sigma 1-type opioid receptor (sig-1r) (p < 0.05). |
2022-02-06 |
2023-08-13 |
human |