| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junya Ning, Xiaotan Wang, Nan Li, Xiaoling Cui, Na Li, Baoxiang Zhao, Junying Miao, Zhaomin Li. ZBM-H-induced activation of GRP78 ATPase promotes apoptosis via annexin A7 in A549 lung cancer cells. Journal of cellular biochemistry. 2022-02-04. PMID:35118704. |
zbm-h-induced activation of grp78 atpase promotes apoptosis via annexin a7 in a549 lung cancer cells. |
2022-02-04 |
2023-08-13 |
Not clear |
| Junya Ning, Xiaotan Wang, Nan Li, Xiaoling Cui, Na Li, Baoxiang Zhao, Junying Miao, Zhaomin Li. ZBM-H-induced activation of GRP78 ATPase promotes apoptosis via annexin A7 in A549 lung cancer cells. Journal of cellular biochemistry. 2022-02-04. PMID:35118704. |
the mechanism of grp78 atpase in cell apoptosis has however not yet been clarified. |
2022-02-04 |
2023-08-13 |
Not clear |
| Junya Ning, Xiaotan Wang, Nan Li, Xiaoling Cui, Na Li, Baoxiang Zhao, Junying Miao, Zhaomin Li. ZBM-H-induced activation of GRP78 ATPase promotes apoptosis via annexin A7 in A549 lung cancer cells. Journal of cellular biochemistry. 2022-02-04. PMID:35118704. |
collectively, these data provide new evidence for the mechanism by which zbm-h-induced activation of grp78 atpase regulates apoptosis of a549 lung cancer cells. |
2022-02-04 |
2023-08-13 |
Not clear |
| Xun Fu, Jianmin Liu, Daoquan Liu, Yongying Zhou, Yuhang Guo, Zhen Wang, Shu Yang, Weixiang He, Ping Chen, Xinghuan Wang, Michael E DiSanto, Xinhua Zhan. Glucose-regulated protein 78 modulates cell growth, epithelial-mesenchymal transition, and oxidative stress in the hyperplastic prostate. Cell death & disease. vol 13. issue 1. 2022-01-25. PMID:35075122. |
in addition, grp78 knockdown (kd) slowed cell growth and induced apoptosis, without effects on the cell cycle stage of both cell lines. |
2022-01-25 |
2023-08-13 |
human |
| Chiang-Wen Lee, Cathy Chia-Yu Huang, Miao-Ching Chi, Kuan-Han Lee, Kuo-Ti Peng, Mei-Ling Fang, Yao-Chang Chiang, Ju-Fang Li. Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines. Molecules (Basel, Switzerland). vol 27. issue 2. 2022-01-21. PMID:35056691. |
naringenin induced endoplasmic reticulum (er) stress-mediated apoptosis through the upregulation of er stress markers, grp78 and grp94. |
2022-01-21 |
2023-08-13 |
human |
| Moon Yi Ko, Sung-Ae Hyun, Sumi Jang, Joung-Wook Seo, Jaerang Rho, Byung-Seok Lee, Minhan K. Butylparaben Induces the Neuronal Death Through the ER Stress-Mediated Apoptosis of Primary Cortical Neurons. Neurotoxicity research. 2022-01-04. PMID:34981454. |
interestingly, butylparaben-induced activation of apoptosis involved the upstream activation of er stress proteins such as grp78, chop, and atf4. |
2022-01-04 |
2023-08-13 |
Not clear |
| Xin Luo, Junjie Xu, Ran Zhao, Jiajia Qin, Xiaoyu Wang, Yu Yan, Li-Jing Wang, Guang Wang, Xuesong Yan. The role of inactivated NF-κB in the occurrence of premature ovarian failure. The American journal of pathology. 2021-12-31. PMID:34971586. |
in the successfully established nf-κb-inactivated mouse model, the results showed that the reduced expression of nuclear p65 and the increased expression of iκbα in ovarian granulosa cells; the reduced numbers of antral follicles; the reduction of ki67/pcna-labeled cell proliferation and enhanced fas/fasl-dependent apoptosis in granulosa cells; the declined level of e2 and amh; the decreased expressions of fshr and cyp19a1 in granulosa cells, which was reversed in the context of blocking nf-κb signaling with bay 11-7082; the decreased expressions of grp78, atf6, perk and ire1 in granulosa cells. |
2021-12-31 |
2023-08-13 |
mouse |
| Feng Wang, Lili Ha. Upregulation of serum and glucocorticoid-regulated kinase 1 (SGK1) ameliorates doxorubicin-induced cardiotoxic injury, apoptosis, inflammation and oxidative stress by suppressing glucose regulated protein 78 (GRP78)-mediated endoplasmic reticulum stress. Bioengineered. 2021-12-13. PMID:34898378. |
upregulation of serum and glucocorticoid-regulated kinase 1 (sgk1) ameliorates doxorubicin-induced cardiotoxic injury, apoptosis, inflammation and oxidative stress by suppressing glucose regulated protein 78 (grp78)-mediated endoplasmic reticulum stress. |
2021-12-13 |
2023-08-13 |
Not clear |
| Feng Wang, Lili Ha. Upregulation of serum and glucocorticoid-regulated kinase 1 (SGK1) ameliorates doxorubicin-induced cardiotoxic injury, apoptosis, inflammation and oxidative stress by suppressing glucose regulated protein 78 (GRP78)-mediated endoplasmic reticulum stress. Bioengineered. 2021-12-13. PMID:34898378. |
the suppressing effects of sgk1 on doxorubicin-induced cardiotoxic injury, apoptosis, inflammation, oxidative stress and ers in h9c2 cells were partially abolished upon grp78 overexpression. |
2021-12-13 |
2023-08-13 |
Not clear |
| Priyanka Chaudhary, Shweta Sharma, Reema Singh, Ranjana Ary. Elucidation of ER stress and UPR pathway in sialic acid-deficient cells: Pathological relevance to GNEM. Journal of cellular biochemistry. vol 122. issue 12. 2021-12-10. PMID:34555215. |
grp78 was upregulated with increased x-box-binding protein-1 (xbp-1) splicing and ccaat/enhancer-binding protein (c/ebp) homologous protein (chop) upregulation leading to increased apoptosis of gne mutant cells. |
2021-12-10 |
2023-08-13 |
Not clear |
| Lei Huang, Qi Liu, Tongtong Zhou, Jing Zhang, Qianwen Tian, Qiaolin Zhang, Wei Wei, Huaxun W. Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's syndrome. International immunopharmacology. vol 101. issue Pt A. 2021-12-09. PMID:34710848. |
in addition, β-arrestin2 depletion downregulated grp78-atf6-chop apoptosis signaling to alleviate cell apoptosis, and the effect depended on the interaction between grp78 and β-arrestin2. |
2021-12-09 |
2023-08-13 |
mouse |
| Yu Zhang, Can Cao, Shujin Du, Lijie Fan, Dong Zhang, Xiangting Wang, Ming H. Estrogen Regulates Endoplasmic Reticulum Stress-Mediated Apoptosis by ERK-p65 Pathway to Promote Endometrial Angiogenesis. Reproductive sciences (Thousand Oaks, Calif.). vol 28. issue 4. 2021-11-30. PMID:33409875. |
in addition, e2 not only activated erk signaling pathway but also inhibited p65 phosphorylation along with its translocation from nucleus to the cytoplasm, and subsequently inhibiting grp78 expression, which led to inhibition of cell apoptosis. |
2021-11-30 |
2023-08-13 |
human |
| In-Hwa Park, Guang-Yin Shen, Yi-Sun Song, Young Jong Cho, Byung Sik Kim, Yonggu Lee, Young-Hyo Lim, Jeong-Hun Shin, Kyung-Soo Ki. Granulocyte colony-stimulating factor reduces the endoplasmic reticulum stress in a rat model of diabetic cardiomyopathy. Endocrine journal. vol 68. issue 11. 2021-11-29. PMID:34121048. |
the rate of cardiomyocyte apoptosis and the expression levels of proteins related to er stress, including glucose-regulated protein 78 (grp78), caspase-9, and caspase-12 were analyzed in the cardiac tissue. |
2021-11-29 |
2023-08-13 |
rat |
| Yan Cao, Maiying Fan, Yanfang Pei, Lei Su, Weiwei Xiao, Fang Chen, Jie Huang, Xiehong Liu, Zhengtao Gu, Zhongwei Zhang, Fangfang Yuan, Yu Jiang, Xiaotong Ha. CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Deficiency Attenuates Heatstroke-Induced Intestinal Injury. Inflammation. 2021-11-29. PMID:34841454. |
we observed the role of chop in apoptosis-mediated intestinal epithelial cell injury secondary to hs by evaluating cell viability, lactate dehydrogenase release, apoptosis levels, and grp78, perk, atf4, chop, bcl-2, and bax mrna and protein expression. |
2021-11-29 |
2023-08-13 |
mouse |
| Ting-Wei Liu, Fan Liu, Jian Kan. Let-7b-5p is involved in the response of endoplasmic reticulum stress in acute pulmonary embolism through upregulating the expression of stress-associated endoplasmic reticulum protein 1. IUBMB life. vol 72. issue 8. 2021-11-23. PMID:32534478. |
furthermore, our data show that the unfolded protein response was triggered and activation of unfolded proteins grp78, perk, rnf121, and chop occurred through the perk-chop pathway, resulting in an inflammatory response and apoptosis of lung epithelial cells. |
2021-11-23 |
2023-08-13 |
Not clear |
| Yi-Nan Liu, Yu-Dong Mu, Hui Wang, Meng Zhang, Ya-Wen Shi, Ge Mi, Lei-Xuan Peng, Jing-Hong Che. Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis. Toxicology. vol 464. 2021-11-22. PMID:34673134. |
this study found that the expressions of grp78, chop, and caspase-12 is higher in t-2 toxin group than in control group both in vivo and in vitro, and the t-2 toxin administration promoted chondrocyte apoptosis, suppressed matrix synthesis, and accelerated cellular catabolism via the ers signaling pathway. |
2021-11-22 |
2023-08-13 |
rat |
| Liang Han, Yanhao Xu, Yuxiu Sh. Molecular Mechanism of the ATF6α/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats. Journal of molecular neuroscience : MN. vol 71. issue 12. 2021-11-19. PMID:33738762. |
in experiment 2, compared with that in the control group, the protein and mrna expression of atf6α, grp78, s1p, s2p, chop, and caspase-12 and the apoptosis rate were significantly increased in the sps 7 d group (p < 0.01). |
2021-11-19 |
2023-08-13 |
rat |
| Liang Han, Yanhao Xu, Yuxiu Sh. Molecular Mechanism of the ATF6α/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats. Journal of molecular neuroscience : MN. vol 71. issue 12. 2021-11-19. PMID:33738762. |
however, the protein and mrna expression of atf6α, grp78, s1p, s2p, chop, and caspase-12 and the apoptosis rate were significantly decreased after aebsf pretreatment (p < 0.01). |
2021-11-19 |
2023-08-13 |
rat |
| Liang Han, Yanhao Xu, Yuxiu Sh. Molecular Mechanism of the ATF6α/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats. Journal of molecular neuroscience : MN. vol 71. issue 12. 2021-11-19. PMID:33738762. |
in experiment 3, compared with that in the control group, the protein and mrna expression of atf6α, grp78, s1p, s2p, chop, and caspase-12 and the apoptosis rate were increased in the sps 14 d group (p < 0.05). |
2021-11-19 |
2023-08-13 |
rat |
| Liang Han, Yanhao Xu, Yuxiu Sh. Molecular Mechanism of the ATF6α/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats. Journal of molecular neuroscience : MN. vol 71. issue 12. 2021-11-19. PMID:33738762. |
however, the protein and mrna expression of atf6α, grp78, s1p, s2p, chop, and caspase-12 and the apoptosis rate were decreased after aebsf pretreatment (p < 0.05). |
2021-11-19 |
2023-08-13 |
rat |