| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L-N Zheng, F-Q Guo, Z-S Li, Z Wang, J-H Ma, T Wang, J-F Wei, W-W Zhan. Dexmedetomidine protects against lidocaine-induced neurotoxicity through SIRT1 downregulation-mediated activation of FOXO3a. Human & experimental toxicology. vol 39. issue 9. 2021-03-16. PMID:32228195. |
upregulation of sirt1 or downregulation of foxo3a significantly inhibited lidocaine-induced changes in both cell viability and apoptosis. |
2021-03-16 |
2023-08-13 |
mouse |
| b' Iva Poto\\xc4\\x8dnjak, Lidija \\xc5\\xa0imi\\xc4\\x87, Ivana Gobin, Iva Vukeli\\xc4\\x87, Robert Domitrovi\\xc4\\x8. Antitumor activity of luteolin in human colon cancer SW620 cells is mediated by the ERK/FOXO3a signaling pathway. Toxicology in vitro : an international journal published in association with BIBRA. vol 66. 2021-03-10. PMID:32268164.' |
treatment with the mitogen-activated protein kinase kinase (mek) inhibitor pd0325901 inhibited erk-dependent foxo3a phosphorylation, resulting in increased foxo3a expression and apoptosis, with the suppression of autophagy. |
2021-03-10 |
2023-08-13 |
human |
| Yating Yin, Feifei Chen, Jianhua Li, Jing Yang, Qiang Li, Peisheng Ji. AURKA Enhances Autophagy of Adipose Derived Stem Cells to Promote Diabetic Wound Repair via Targeting FOXO3a. The Journal of investigative dermatology. vol 140. issue 8. 2021-03-08. PMID:32004564. |
here, we showed that adscs subjected to high glucose stress displayed an obvious induction of aurka and foxo3a, and a significant increase in autophagy and apoptosis. |
2021-03-08 |
2023-08-13 |
mouse |
| Hunian Li, Ping Chou, Fang Du, Liang Sun, Jie Liu, Wei Wan. Depleting microRNA-183-3p improves renal tubulointerstitial fibrosis after acute kidney injury via SIRT1/PUMA/FOXO3a deacetylation. Life sciences. vol 269. 2021-02-16. PMID:33450262. |
therefore, this study is started to explore the potential role of mir-183-3p from the perspective of sirtuin (sirt1)/forkhead box o3a (foxo3a)/p53 up-regulated modulator of apoptosis (puma) in aki. |
2021-02-16 |
2023-08-13 |
Not clear |
| Zhan Zhang, Chenxi Huang, Ping Wang, Junjun Gao, Xin Liu, Yingying Li, Shujun Yan, Ying Sh. HIF‑1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions. Molecular medicine reports. vol 21. issue 6. 2021-02-12. PMID:32323858. |
hif‑1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating foxo3a under hypoxic conditions. |
2021-02-12 |
2023-08-13 |
Not clear |
| Zhan Zhang, Chenxi Huang, Ping Wang, Junjun Gao, Xin Liu, Yingying Li, Shujun Yan, Ying Sh. HIF‑1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions. Molecular medicine reports. vol 21. issue 6. 2021-02-12. PMID:32323858. |
thus, the aims of the present study were to investigate the expression levels of hif‑1α and foxo3a in placental samples of early onset severe pe, and their effect on trophoblastic apoptosis under hypoxic conditions. |
2021-02-12 |
2023-08-13 |
Not clear |
| Zhan Zhang, Chenxi Huang, Ping Wang, Junjun Gao, Xin Liu, Yingying Li, Shujun Yan, Ying Sh. HIF‑1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions. Molecular medicine reports. vol 21. issue 6. 2021-02-12. PMID:32323858. |
furthermore, knockdown of foxo3a using a specific small interfering rna (sirna) decreased apoptosis in htr8/svneo cells. |
2021-02-12 |
2023-08-13 |
Not clear |
| Zhan Zhang, Chenxi Huang, Ping Wang, Junjun Gao, Xin Liu, Yingying Li, Shujun Yan, Ying Sh. HIF‑1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions. Molecular medicine reports. vol 21. issue 6. 2021-02-12. PMID:32323858. |
therefore, the present results indicated that the elevated expression of hif‑1α increased trophoblastic apoptosis by regulating foxo3a, which may be involved in the pathogenesis of pe. |
2021-02-12 |
2023-08-13 |
Not clear |
| Hao-Nien Chen, Kang-Hao Liang, Jun-Kai Lai, Chun-Hsin Lan, Mei-Ying Liao, Shao-Hsi Hung, Yi-Ting Chuang, Kai-Chi Chen, William Wei-Fu Tsuei, Han-Chung W. EpCAM Signaling Promotes Tumor Progression and Protein Stability of PD-L1 through the EGFR Pathway. Cancer research. vol 80. issue 22. 2021-02-12. PMID:32978170. |
treatment with the epcam neutralizing antibody, epab2-6, inhibited akt and foxo3a phosphorylation, increased foxo3a nuclear translocation, and upregulated high temperature requirement a2 (htra2) expression to promote apoptosis while decreasing pd-l1 protein levels to enhance the cytotoxic activity of cd8 |
2021-02-12 |
2023-08-13 |
Not clear |
| Priyankar Sanphui, Anoy Kumar Das, Subhas C Biswa. Forkhead Box O3a requires BAF57, a subunit of chromatin remodeler SWI/SNF complex for induction of p53 up-regulated modulator of apoptosis (Puma) in a model of Parkinson's disease. Journal of neurochemistry. vol 154. issue 5. 2021-02-04. PMID:31971251. |
it has been reported that the transcription factor forkhead box o3a (foxo3a) is activated and induces pro-apoptotic protein such as bcl-2-interacting mediator of cell death (bim) and p53 up-regulated modulator of apoptosis (puma) in variety of neuron death paradigms. |
2021-02-04 |
2023-08-13 |
rat |
| Yan Tao, Lan-Lan Li, Shan-Hui Liu, Mei Hon. [FOXO3a signaling pathway in prostate cancer: Progress in studies]. Zhonghua nan ke xue = National journal of andrology. vol 26. issue 8. 2021-02-01. PMID:33377739. |
foxo3a is an important member of the foxo subfamily of forkhead transcription factors, which plays an important role in promoting cell apoptosis, inducing cell cycle arrest, inhibiting cell proliferation and suppressing tumor metastasis through phosphorylation, ubiquitination-mediated degradation and microrna. |
2021-02-01 |
2023-08-13 |
Not clear |
| Ahmad Nasimian, Parvaneh Farzaneh, Fuyuhiko Tamanoi, S Zahra Bathai. Cytosolic and mitochondrial ROS production resulted in apoptosis induction in breast cancer cells treated with Crocin: The role of FOXO3a, PTEN and AKT signaling. Biochemical pharmacology. vol 177. 2020-12-01. PMID:32353423. |
cytosolic and mitochondrial ros production resulted in apoptosis induction in breast cancer cells treated with crocin: the role of foxo3a, pten and akt signaling. |
2020-12-01 |
2023-08-13 |
human |
| Hong Zhang, Fengping Lin, Jiuhua Zhao, Zhengchao Wan. Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development. Frontiers in physiology. vol 11. 2020-12-01. PMID:33250784. |
foxo3a is a member of the forkhead transcription factor family (foxo), which plays an important role in the cell cycle, dna damage repair, apoptosis, oxidative stress, and energy metabolism. |
2020-12-01 |
2023-08-13 |
Not clear |
| Fei Wang, Qiubin Wang, Ming Zhu, Qi Su. Foxo3a aggravates inflammation and induces apoptosis in IL-1-treated rabbit chondrocytes via positively regulating tenascin-c. Folia histochemica et cytobiologica. vol 58. issue 1. 2020-11-09. PMID:32003441. |
foxo3a aggravates inflammation and induces apoptosis in il-1-treated rabbit chondrocytes via positively regulating tenascin-c. osteoarthritis (oa) is the most common degenerative disease in middle-aged and elderly individuals that causes joint deformity and limb disability. |
2020-11-09 |
2023-08-13 |
rabbit |
| Chang Gao, Shengyuan Dang, Jie Zhai, Shimin Zhen. Regulatory mechanism of microRNA-155 in chicken embryo fibroblasts in response to reticuloendotheliosis virus infection. Veterinary microbiology. vol 242. 2020-10-16. PMID:32122614. |
after transfected with mir-155-mimic and mir-155-inhibitor, we found overexpression of mir-155 targeted caspase-6 and foxo3a to inhibit apoptosis and accelerate cell cycle, thus improving viability of rev-infected cefs. |
2020-10-16 |
2023-08-13 |
chicken |
| R Huang, X Song, C-M Wan. MiR-223 regulates CDDP resistance in pancreatic cancer via targeting FoxO3a. European review for medical and pharmacological sciences. vol 23. issue 18. 2020-10-06. PMID:31599414. |
this study explored whether mir-155 regulates the expression of foxo3a and affects the proliferation, apoptosis, and cisplatin (cddp) resistance of oral cancer cells. |
2020-10-06 |
2023-08-13 |
Not clear |
| Hanan Abdelmawgoud, Rehab Refaat El Awad. Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells. Genes & diseases. vol 4. issue 4. 2020-10-01. PMID:30258927. |
sirt1 regulates forkhead box o3a (foxo3a) by both inhibiting foxo3-induced apoptosis and potentiating the ability of foxo3a to resist oxidative stress. |
2020-10-01 |
2023-08-13 |
Not clear |
| Feng Wang, Christopher B Marshall, Mitsuhiko Ikur. Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a. Intrinsically disordered proteins. vol 3. issue 1. 2020-09-30. PMID:28232890. |
foxo3a is a tumor suppressor involved in multiple physiological and pathological processes, and plays essential roles in metabolism, cell cycle arrest, dna repair, and apoptosis. |
2020-09-30 |
2023-08-13 |
human |
| Feng Wang, Christopher B Marshall, Mitsuhiko Ikur. Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a. Intrinsically disordered proteins. vol 3. issue 1. 2020-09-30. PMID:28232890. |
foxo3a has additional functions, such as regulating p53-mediated apoptosis and activating kinase atm. |
2020-09-30 |
2023-08-13 |
human |
| Kaibiao Jiang, Caiguo Zhang, Bo Yu, Bin Chen, Zude Liu, Canglong Hou, Fei Wang, Hongxing Shen, Zhi Che. Autophagic degradation of FOXO3a represses the expression of American journal of cancer research. vol 7. issue 7. 2020-09-30. PMID:28744393. |
autophagic degradation of foxo3a represses the expression of autophagy and apoptosis are the two major modes of cell death, and autophagy usually inhibits apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |