| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeze Wang, Yi Liu, Xuehui Liu, Lixiao Zhou, Xindi Ma, Junyao Liu, Lei Wang, Huicai Gu. Activation of forkhead box O3a by mono(2-ethylhexyl)phthalate and its role in protection against mono(2-ethylhexyl)phthalate-induced oxidative stress and apoptosis in human cardiomyocytes. Journal of applied toxicology : JAT. vol 41. issue 4. 2021-07-16. PMID:33029813. |
overexpression of foxo3a decreased the production of ros and the apoptosis rate induced by mehp, and the expression of mn-sod and arc was further increased after mehp exposure. |
2021-07-16 |
2023-08-13 |
human |
| Zeze Wang, Yi Liu, Xuehui Liu, Lixiao Zhou, Xindi Ma, Junyao Liu, Lei Wang, Huicai Gu. Activation of forkhead box O3a by mono(2-ethylhexyl)phthalate and its role in protection against mono(2-ethylhexyl)phthalate-induced oxidative stress and apoptosis in human cardiomyocytes. Journal of applied toxicology : JAT. vol 41. issue 4. 2021-07-16. PMID:33029813. |
in contrast, knockdown of foxo3a resulted in increased ros production and apoptosis and suppressed the expression of mn-sod and arc in the presence of mehp. |
2021-07-16 |
2023-08-13 |
human |
| Zeze Wang, Yi Liu, Xuehui Liu, Lixiao Zhou, Xindi Ma, Junyao Liu, Lei Wang, Huicai Gu. Activation of forkhead box O3a by mono(2-ethylhexyl)phthalate and its role in protection against mono(2-ethylhexyl)phthalate-induced oxidative stress and apoptosis in human cardiomyocytes. Journal of applied toxicology : JAT. vol 41. issue 4. 2021-07-16. PMID:33029813. |
activation of foxo3a defends against mehp-induced oxidative stress and apoptosis by upregulating the expression of mn-sod and arc in ac16 cardiomyocytes. |
2021-07-16 |
2023-08-13 |
human |
| Shanshan Xu, Yubo Ma, Yuting Chen, Faming Pa. Role of Forkhead box O3a transcription factor in autoimmune diseases. International immunopharmacology. vol 92. 2021-06-25. PMID:33412391. |
forkhead box o3a (foxo3a) transcription factor, the most important member of forkhead box o family, is closely related to cell proliferation, apoptosis, autophagy, oxidative stress and aging. |
2021-06-25 |
2023-08-13 |
human |
| Shanshan Xu, Yubo Ma, Yuting Chen, Faming Pa. Role of Forkhead box O3a transcription factor in autoimmune diseases. International immunopharmacology. vol 92. 2021-06-25. PMID:33412391. |
the activity of foxo3a mainly regulated by phosphorylation of protein kinase b. foxo3a plays a vital role in promoting the apoptosis of immune cells. |
2021-06-25 |
2023-08-13 |
human |
| Shanshan Xu, Yubo Ma, Yuting Chen, Faming Pa. Role of Forkhead box O3a transcription factor in autoimmune diseases. International immunopharmacology. vol 92. 2021-06-25. PMID:33412391. |
foxo3a inhibits dendritic cells from producing interleukin-6, which inhibits b-cell lymphoma-2 (bcl-2) and bcl-xl expression, thereby sparing resting t cells from apoptosis and increasing the survival of antigen-stimulated t cells. |
2021-06-25 |
2023-08-13 |
human |
| Yue Zhou, Lian-Jun Cai, Li-Hui Xu, Yu Guo, Nuo Chen, Qing Ya. The role of sirt1 in the retinal ganglion cells cultured by high glucose. International ophthalmology. vol 41. issue 3. 2021-06-18. PMID:33174070. |
after 48 h of infection, the viability of rgc was detected by cck8 kit, the apoptosis rate was detected by fcm analysis, and the protein expression of p53, foxo3a, nf-κ b, caspase-3 was detected by western blot. |
2021-06-18 |
2023-08-13 |
Not clear |
| Tianyu Sun, Jingge Zhang, Bo Deng, Xiaoqing Fan, Tan Long, Hua Jin, Shaolin Tao, Poming Kang, Qunyou Ta. FOXO1 and FOXO3a sensitize non-small-cell lung cancer cells to cisplatin-induced apoptosis independent of Bim. Acta biochimica et biophysica Sinica. vol 52. issue 12. 2021-06-08. PMID:33167006. |
foxo1 and foxo3a sensitize non-small-cell lung cancer cells to cisplatin-induced apoptosis independent of bim. |
2021-06-08 |
2023-08-13 |
Not clear |
| Tianyu Sun, Jingge Zhang, Bo Deng, Xiaoqing Fan, Tan Long, Hua Jin, Shaolin Tao, Poming Kang, Qunyou Ta. FOXO1 and FOXO3a sensitize non-small-cell lung cancer cells to cisplatin-induced apoptosis independent of Bim. Acta biochimica et biophysica Sinica. vol 52. issue 12. 2021-06-08. PMID:33167006. |
moreover, inhibition of foxo1 and foxo3a attenuated cisplatin-induced cell apoptosis independent of bim, a pro-apoptotic protein downstream of the foxos. |
2021-06-08 |
2023-08-13 |
Not clear |
| Zhixin Liu, Youjie Li, Gaohan She, Xiaofeng Zheng, Liying Shao, Pingyu Wang, Min Pang, Shuyang Xie, Yunxiao Su. Resveratrol induces cervical cancer HeLa cell apoptosis through the activation and nuclear translocation promotion of FOXO3a. Die Pharmazie. vol 75. issue 6. 2021-05-20. PMID:32539920. |
resveratrol induces cervical cancer hela cell apoptosis through the activation and nuclear translocation promotion of foxo3a. |
2021-05-20 |
2023-08-13 |
Not clear |
| Zhixin Liu, Youjie Li, Gaohan She, Xiaofeng Zheng, Liying Shao, Pingyu Wang, Min Pang, Shuyang Xie, Yunxiao Su. Resveratrol induces cervical cancer HeLa cell apoptosis through the activation and nuclear translocation promotion of FOXO3a. Die Pharmazie. vol 75. issue 6. 2021-05-20. PMID:32539920. |
resveratrol could also inactivate the basal extracellular signal-regulated kinase (erk) activity, causing foxo3a activation and resulting in hela cell apoptosis. |
2021-05-20 |
2023-08-13 |
Not clear |
| Zhixin Liu, Youjie Li, Gaohan She, Xiaofeng Zheng, Liying Shao, Pingyu Wang, Min Pang, Shuyang Xie, Yunxiao Su. Resveratrol induces cervical cancer HeLa cell apoptosis through the activation and nuclear translocation promotion of FOXO3a. Die Pharmazie. vol 75. issue 6. 2021-05-20. PMID:32539920. |
in summary, both mechanisms stimulated the accumulation of activated foxo3a, promoted its nuclear translocation, and ultimately caused hela cell apoptosis. |
2021-05-20 |
2023-08-13 |
Not clear |
| Xiaowen Chen, Wenting Liu, Jing Xiao, Ying Zhang, Yihua Chen, Congwei Luo, Qianyin Huang, Fenfen Peng, Wangqiu Gong, Shuting Li, Xiaoyang He, Yiyi Zhuang, Na Wu, Yanxia Liu, Yuxian Wang, Haibo Lon. FOXO3a accumulation and activation accelerate oxidative stress-induced podocyte injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 10. 2021-04-30. PMID:32786113. |
downregulation of foxo3a decreased aopps-induced podocyte apoptosis and restored the levels of podocyte markers nephrin and podocin, and upregulation of foxo3a exacerbated these changes in podocytes after aopps treatment. |
2021-04-30 |
2023-08-13 |
Not clear |
| Naeun Lee, Nirmala Tilija Pun, Won-Jun Jang, Jung Woo Bae, Chul-Ho Jeon. Pitavastatin induces apoptosis in oral squamous cell carcinoma through activation of FOXO3a. Journal of cellular and molecular medicine. vol 24. issue 12. 2021-04-29. PMID:32406610. |
pitavastatin induces apoptosis in oral squamous cell carcinoma through activation of foxo3a. |
2021-04-29 |
2023-08-13 |
human |
| Fengxia Yan, Rikang Wang, Shuai Li, Xia Zhao, Yizhou Jiang, Linlin Liu, Jiankang Fang, Xuechu Zhen, Philip Lazarovici, Wenhua Zhen. FoxO3a suppresses neuropeptide W expression in neuronal cells and in rat hypothalamus and its implication in hypothalamic-pituitary-adrenal (HPA) axis. International journal of biological sciences. vol 16. issue 15. 2021-04-07. PMID:33061795. |
foxo3a, a forkhead family member of transcription factors, is involved in the regulation of cell metabolism, proliferation, differentiation and apoptosis. |
2021-04-07 |
2023-08-13 |
rat |
| Yusheng Guo, Xiangsheng Cai, Hanwei Lu, Qiqi Li, Ying Zheng, Zefang Lin, Zexiong Cheng, Maoxiang Yang, Li Zhang, Lei Xiang, Xiaorong Yan. 17β-Estradiol Promotes Apoptosis of HepG2 Cells Caused by Oxidative Stress by Increasing Foxo3a Phosphorylation. Frontiers in pharmacology. vol 12. 2021-04-02. PMID:33790784. |
17β-estradiol promotes apoptosis of hepg2 cells caused by oxidative stress by increasing foxo3a phosphorylation. |
2021-04-02 |
2023-08-13 |
Not clear |
| Yusheng Guo, Xiangsheng Cai, Hanwei Lu, Qiqi Li, Ying Zheng, Zefang Lin, Zexiong Cheng, Maoxiang Yang, Li Zhang, Lei Xiang, Xiaorong Yan. 17β-Estradiol Promotes Apoptosis of HepG2 Cells Caused by Oxidative Stress by Increasing Foxo3a Phosphorylation. Frontiers in pharmacology. vol 12. 2021-04-02. PMID:33790784. |
within a certain concentration range, 17β-estradiol induced oxidative stress and apoptosis of hepg2 cells, downregulated erα-36 expression, and increased akt and foxo3a phosphorylation. |
2021-04-02 |
2023-08-13 |
Not clear |
| Mingkun Zhu, Sasa Miao, Wenting Zhou, Shaaban Saad Elnesr, Xinyang Dong, Xiaoting Zo. MAPK, AKT/FoxO3a and mTOR pathways are involved in cadmium regulating the cell cycle, proliferation and apoptosis of chicken follicular granulosa cells. Ecotoxicology and environmental safety. vol 214. 2021-03-31. PMID:33706141. |
low-dose cd exposure (1 μm) induced the granulosa cell proliferation, upregulated the mrna levels of rsk1 and rheb, activated foxo3a, akt, erk1/2, mtor and p70s6k1 phosphorylation, and promoted cell cycle progression from phase g1 to s. however, high-dose cd exposure (15 μm) induced reactive oxygen species (ros) generation and cell apoptosis, upregulated the mrna levels of the inflammatory factors, ask1, jnk, p38 and tak1, downregulated the expressions of rsk1 and rheb genes, and inhibited the phosphorylation of erk1/2, mtor and p70s6k1 proteins, and the cell cycle progression. |
2021-03-31 |
2023-08-13 |
chicken |
| b' Iva Poto\\xc4\\x8dnjak, Jelena Marini\\xc4\\x87, Lara Bati\\xc4\\x8di\\xc4\\x87, Lidija \\xc5\\xa0imi\\xc4\\x87, Dalibor Brozni\\xc4\\x87, Robert Domitrovi\\xc4\\x8. Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 142. 2021-03-29. PMID:32504734.' |
mechanistically, aucubin suppressed the activation of several signaling pathways involved in inflammation and apoptosis, including nuclear factor-kappa b (nf-κb), signal transducer and activator of transcription 3 (stat3), akt, extracellular signal-regulated kinase 1/2 (erk1/2) and forkhead box o3a (foxo3a). |
2021-03-29 |
2023-08-13 |
mouse |
| L-N Zheng, F-Q Guo, Z-S Li, Z Wang, J-H Ma, T Wang, J-F Wei, W-W Zhan. Dexmedetomidine protects against lidocaine-induced neurotoxicity through SIRT1 downregulation-mediated activation of FOXO3a. Human & experimental toxicology. vol 39. issue 9. 2021-03-16. PMID:32228195. |
in the present study, we designed in vitro and in vivo models to investigate the potential effects of lidocaine and dex on sirt1 and foxo3a and to verify whether sirt1/foxo3a-mediated regulation of apoptosis is involved in dex-induced neuroprotective effects against lidocaine. |
2021-03-16 |
2023-08-13 |
mouse |