| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fang Wang, Xuemei Chen, Bo Sun, Yujia Ma, Wenbin Niu, Jun Zhai, Yingpu Su. Hypermethylation-mediated downregulation of lncRNA PVT1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with Foxo3a. Journal of cellular physiology. vol 236. issue 7. 2021-10-14. PMID:33393111. |
moreover, downregulating pvt1 promoted granulosa cell apoptosis by increasing the foxo3a protein levels. |
2021-10-14 |
2023-08-13 |
mouse |
| Fang Wang, Xuemei Chen, Bo Sun, Yujia Ma, Wenbin Niu, Jun Zhai, Yingpu Su. Hypermethylation-mediated downregulation of lncRNA PVT1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with Foxo3a. Journal of cellular physiology. vol 236. issue 7. 2021-10-14. PMID:33393111. |
hypermethylation-induced downregulation of pvt1 promotes granulosa cell apoptosis in poi by inhibiting foxo3a phosphorylation and increases the foxo3a transcription activity. |
2021-10-14 |
2023-08-13 |
mouse |
| Cheng Li, Xiao Miao, Shudong Wang, Yucheng Liu, Jian Sun, Quan Liu, Lu Cai, Yonggang Wan. Elabela may regulate SIRT3-mediated inhibition of oxidative stress through Foxo3a deacetylation preventing diabetic-induced myocardial injury. Journal of cellular and molecular medicine. vol 25. issue 1. 2021-09-30. PMID:33244875. |
in this study, elabela treatment was found to have profound protective effects against diabetes-induced cardiac oxidative stress, inflammation, fibrosis and apoptosis; these protective effects may depend heavily upon sirt3-mediated foxo3a deacetylation. |
2021-09-30 |
2023-08-13 |
Not clear |
| Li Liu, Zhen Tian, Yalin Zhang, Peijun Liu, Zhiqian Xin, Yong Zhao, Yifan Li, Shan Miao, Junling Shi, Zhinan Chen, Jiyuan Liu, Hai Zhan. Ligand-based discovery of small molecules suppressing cancer cell proliferation via autophagic flux inhibition. Journal of molecular medicine (Berlin, Germany). vol 98. issue 11. 2021-09-27. PMID:32897390. |
further tests revealed that foxo3a and its downstream target genes regulating autophagy, apoptosis, and cell cycle progression were activated and overexpressed, suggesting such effects of lz02/01 on autophagy and apoptosis were associated with the activation and overexpression of foxo3a. |
2021-09-27 |
2023-08-13 |
mouse |
| Lingli Chen, Santie Li, Jianyu Zhu, Anfu You, Xingzhou Huang, Xinchu Yi, Mei Xu. Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway. Journal of cellular and molecular medicine. vol 25. issue 6. 2021-09-23. PMID:33523605. |
further studies revealed that mangiferin increased foxo3a deacetylation by up-regulating sirt1, thus preventing apoptosis, and adenovirus-mediated constitutive acetylation of foxo3a restricted the anti-apoptotic effects of mangiferin in vivo and in vitro. |
2021-09-23 |
2023-08-13 |
mouse |
| Hao Chen, Xin Tang, Ting-Li Han, Jia-Nan Zhu, Wei Zhou, Philip N Baker, Chang Chen, Hua Zhan. Potential role of FoxO3a in the regulation of trophoblast development and pregnancy complications. Journal of cellular and molecular medicine. vol 25. issue 9. 2021-09-22. PMID:33811439. |
western blot, immunohistochemistry, cell counting kit-8, wound-healing assay, matrigel invasion assay, cell apoptosis, cell cycle assay, rna sequencing, qrt-pcr and chip-qpcr were performed on the cells to study the potential role of foxo3a and the underlying mechanism. |
2021-09-22 |
2023-08-13 |
Not clear |
| Hao Chen, Xin Tang, Ting-Li Han, Jia-Nan Zhu, Wei Zhou, Philip N Baker, Chang Chen, Hua Zhan. Potential role of FoxO3a in the regulation of trophoblast development and pregnancy complications. Journal of cellular and molecular medicine. vol 25. issue 9. 2021-09-22. PMID:33811439. |
foxo3a depletion significantly reduced transcription of the promoter region of intercellular cell adhesion molecule-1 (icam1) gene in chip assays and led to reduced invasion and migration of trophoblast cells, arrested cell cycle in g1 phase and increased apoptosis under oxidative stress. |
2021-09-22 |
2023-08-13 |
Not clear |
| Cheng Qian, Qiang Li. FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β‑catenin signaling pathway. Molecular medicine reports. vol 24. issue 5. 2021-09-21. PMID:34515328. |
foxo3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the wnt/β‑catenin signaling pathway. |
2021-09-21 |
2023-08-13 |
Not clear |
| Cheng Qian, Qiang Li. FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β‑catenin signaling pathway. Molecular medicine reports. vol 24. issue 5. 2021-09-21. PMID:34515328. |
the overexpression of foxo3a inhibited the proliferation, invasion and migration of nephroblastoma cells, while inducing apoptosis. |
2021-09-21 |
2023-08-13 |
Not clear |
| Cheng Qian, Qiang Li. FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β‑catenin signaling pathway. Molecular medicine reports. vol 24. issue 5. 2021-09-21. PMID:34515328. |
cell apoptosis was predominantly increased by overexpressed foxo3a, which was reversed by shrna‑axin2‑1. |
2021-09-21 |
2023-08-13 |
Not clear |
| Cheng Qian, Qiang Li. FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β‑catenin signaling pathway. Molecular medicine reports. vol 24. issue 5. 2021-09-21. PMID:34515328. |
in conclusion, the findings of the present study suggested that foxo3a may inhibit nephroblastoma cell proliferation, migration and invasion, while inducing apoptosis, by downregulating the wnt/β‑catenin signaling pathway. |
2021-09-21 |
2023-08-13 |
Not clear |
| Dan Ding, Xiang Ao, Mengyang Li, Shuo Miao, Ying Liu, Zhijuan Lin, Mengyu Wang, Yuqi He, Jianxun Wan. FOXO3a-dependent Parkin regulates the development of gastric cancer by targeting ATP-binding cassette transporter E1. Journal of cellular physiology. vol 236. issue 4. 2021-09-20. PMID:32914432. |
forkhead box o3 (foxo3a) is a crucial transcription factor that involves in the regulation of cancer cell proliferation, apoptosis, and metabolism. |
2021-09-20 |
2023-08-13 |
Not clear |
| Dan Ding, Xiang Ao, Mengyang Li, Shuo Miao, Ying Liu, Zhijuan Lin, Mengyu Wang, Yuqi He, Jianxun Wan. FOXO3a-dependent Parkin regulates the development of gastric cancer by targeting ATP-binding cassette transporter E1. Journal of cellular physiology. vol 236. issue 4. 2021-09-20. PMID:32914432. |
here, we found that foxo3a inhibits cell proliferation, migration, and promotes apoptosis in gc by regulating parkin expression at the transcriptional level. |
2021-09-20 |
2023-08-13 |
Not clear |
| Xiaohui Tan, Dunpeng Cai, Na Chen, Sihao Du, Dongfang Qiao, Xia Yue, Tao Wang, Jia Li, Weibing Xie, Huijun Wan. Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway. Toxicology letters. vol 350. 2021-09-20. PMID:34214594. |
chop inhibits protein kinase b phosphorylation and further inhibits forkhead box class o3a (foxo3a) dephosphorylation, resulting in increased p53 upregulated molecular of apoptosis (puma) transcription. |
2021-09-20 |
2023-08-13 |
human |
| De-Bo Zou, Zongyou Mou, Wenliang Wu, Haichun Li. TRIM33 protects osteoblasts from oxidative stress-induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation. Aging cell. vol 20. issue 7. 2021-08-17. PMID:34101965. |
trim33 protects osteoblasts from oxidative stress-induced apoptosis in osteoporosis by inhibiting foxo3a ubiquitylation and degradation. |
2021-08-17 |
2023-08-13 |
Not clear |
| Changting Wang, Chunxiao Wang, Chengzhi Qiu, Zhiming S. Targeted Regulation of FoxO3a by miR-372 to Mediate Gastric Carcinoma Cell Apoptosis and DDP Drug Resistance. Cancer biotherapy & radiopharmaceuticals. vol 35. issue 10. 2021-08-06. PMID:32379491. |
targeted regulation of foxo3a by mir-372 to mediate gastric carcinoma cell apoptosis and ddp drug resistance. |
2021-08-06 |
2023-08-13 |
Not clear |
| Ozlem Ekremoglu, Asli Ko. The role of SIRT5 and p53 proteins in the sensitivity of colon cancer cells to chemotherapeutic agent 5-Fluorouracil. Molecular biology reports. vol 48. issue 7. 2021-08-05. PMID:34279763. |
sirt5 is known to deacetylate foxo3a which plays roles in the induction of apoptosis via bim protein. |
2021-08-05 |
2023-08-13 |
Not clear |
| A P O Monte, M É S Bezerra, V G Menezes, B B Gouveia, R S Barberino, T L B G Lins, V R P Barros, J M S Santos, N J Donfack, M H T Mato. Involvement of Phosphorylated Akt and FOXO3a in the Effects of Growth and Differentiation Factor-9 (GDF-9) on Inhibition of Follicular Apoptosis and Induction of Granulosa Cell Proliferation After In Vitro Culture of Sheep Ovarian Tissue. Reproductive sciences (Thousand Oaks, Calif.). vol 28. issue 8. 2021-07-28. PMID:33409876. |
involvement of phosphorylated akt and foxo3a in the effects of growth and differentiation factor-9 (gdf-9) on inhibition of follicular apoptosis and induction of granulosa cell proliferation after in vitro culture of sheep ovarian tissue. |
2021-07-28 |
2023-08-13 |
Not clear |
| Retraction. Journal of cellular physiology. 2021-07-21. PMID:34287851. |
retraction: "downregulated expression of microrna-329 inhibits apoptosis of nigral dopaminergic neurons by regulating cdkn2d expression via the foxo3a signaling pathway in rats with parkinson's disease," by yuan-yuan liu, yi-nan zhang, qing-shan yang, j cell physiol. |
2021-07-21 |
2023-08-13 |
rat |
| Zeze Wang, Yi Liu, Xuehui Liu, Lixiao Zhou, Xindi Ma, Junyao Liu, Lei Wang, Huicai Gu. Activation of forkhead box O3a by mono(2-ethylhexyl)phthalate and its role in protection against mono(2-ethylhexyl)phthalate-induced oxidative stress and apoptosis in human cardiomyocytes. Journal of applied toxicology : JAT. vol 41. issue 4. 2021-07-16. PMID:33029813. |
the expression of foxo3a and its target genes, mitochondrial superoxide dismutase (mn-sod) and apoptosis repressor with caspase recruitment domain (arc), increased after mehp exposure, but the expression of p-foxo3a protein was decreased. |
2021-07-16 |
2023-08-13 |
human |