| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samyah T Alanazi, Samir A Salama, Musaad M Althobaiti, Rana A Alotaibi, Ammar A AlAbdullatif, Arafa Musa, Gamaleldin I Haris. Alleviation of Copper-Induced Hepatotoxicity by Bergenin: Diminution of Oxidative Stress, Inflammation, and Apoptosis via Targeting SIRT1/FOXO3a/NF-κB Axes and p38 MAPK Signaling. Biological trace element research. 2024-09-30. PMID:39347884. |
collectively, these findings highlight the alleviating activity of bergenin against the copper-induced hepatotoxicity via controlling oxidative stress, inflammation, and apoptosis potentially through upregulation of sirt1, activation of foxo3a along with suppression of nf-κb and p38 mapk signaling. |
2024-09-30 |
2024-10-02 |
rat |
| Cunqi Lv, Qingyu Zeng, Lei Qi, Yuanyuan Wang, Jiacheng Li, Huixin Sun, Linlin Du, Shuxiu Hao, Guijin Li, Chen Feng, Yu Zhang, Cheng Wang, Xinshu Wang, Rong Ma, Tong Wang, Qi L. Sodium Selenite Induces Autophagy and Apoptosis in Cervical Cancer Cells via Mitochondrial ROS-Activated AMPK/mTOR/FOXO3a Pathway. Antioxidants (Basel, Switzerland). vol 13. issue 8. 2024-08-29. PMID:39199249. |
further research has revealed that ss induces cell autophagy and apoptosis through the ampk/mtor/foxo3a pathway, characterized by the upregulation of p-ampk/ampk, foxo3a, lc3-ii, cleaved-caspase3, and cleaved-parp and the downregulation of p-mtor/mtor and p62. |
2024-08-29 |
2024-09-01 |
mouse |
| Manead Khin, Lydia J Davis, Daniel D Lantvit, Jimmy Orjala, Joanna E Burdett. Aulosirazole Stimulates FOXO3a Nuclear Translocation to Regulate Apoptosis and Cell-Cycle Progression in High-Grade Serous Ovarian Cancer (HGSOC) Cells. Molecular pharmacology. vol 106. issue 3. 2024-08-16. PMID:39079718. |
aulosirazole stimulates foxo3a nuclear translocation to regulate apoptosis and cell-cycle progression in high-grade serous ovarian cancer (hgsoc) cells. |
2024-08-16 |
2024-08-19 |
Not clear |
| Sugandh Saxena, Sumit Kumar Anand, Ankita Sharma, Poonam Kakka. Involvement of Sirt1-FoxO3a-Bnip3 axis and autophagy mediated mitochondrial turnover in according protection to hyperglycemic NRK-52E cells by Berberine. Toxicology in vitro : an international journal published in association with BIBRA. 2024-08-10. PMID:39127087. |
treatment with srt-1720 (sirt1 activator) enhanced autophagy, decreased apoptosis, upregulated expression of downstream moieties (foxo3a and bnip3) and ameliorated mitochondria related anomalies while nicotinamide (sirt1 inhibitor) treatment exhibited reversal of the same. |
2024-08-10 |
2024-08-13 |
Not clear |
| Sugandh Saxena, Sumit Kumar Anand, Ankita Sharma, Poonam Kakka. Involvement of Sirt1-FoxO3a-Bnip3 axis and autophagy mediated mitochondrial turnover in according protection to hyperglycemic NRK-52E cells by Berberine. Toxicology in vitro : an international journal published in association with BIBRA. 2024-08-10. PMID:39127087. |
knocking down foxo3a disrupted autophagy and stimulated apoptosis. |
2024-08-10 |
2024-08-13 |
Not clear |
| Qin-Qin Liu, Gui-Hua Wu, Xiao-Chun Wang, Xiao-Wen Xiong, Rui-Wang, Bao-Le Ya. The role of Foxo3a in neuron-mediated cognitive impairment. Frontiers in molecular neuroscience. vol 17. 2024-07-04. PMID:38962803. |
the regulatory cascade of foxo3a transactivation implicates multiple downstream signaling pathways encompassing mitochondrial function, oxidative stress, autophagy, and apoptosis, collectively affecting neuronal activity. |
2024-07-04 |
2024-07-10 |
human |
| Xiao-Dan Hao, Jin-Xiu Liu, Jing-Sai Zhan. Longevity factor FOXO3a: A potential therapeutic target for age-related ocular diseases. Life sciences. 2024-06-07. PMID:38848943. |
the forkhead box protein o3 (foxo3a) belongs to the subgroup o of the forkhead transcription factor family and plays an important role in regulating the aging process by participating in the regulation of various life processes, including cell cycle arrest, apoptosis, autophagy, oxidative stress, and dna repair. |
2024-06-07 |
2024-06-10 |
Not clear |
| Ya Wen, Yan Li, Jinli Guo, Kaijian Shan. Expression of FoxO3a in sepsis mice and its association with lymphocyte apoptosis. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 5. 2024-05-30. PMID:38814205. |
expression of foxo3a in sepsis mice and its association with lymphocyte apoptosis. |
2024-05-30 |
2024-06-08 |
mouse |
| Ya Wen, Yan Li, Jinli Guo, Kaijian Shan. Expression of FoxO3a in sepsis mice and its association with lymphocyte apoptosis. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 5. 2024-05-30. PMID:38814205. |
this study investigated forkhead box o3a (foxo3a) expression in peripheral blood of sepsis mice and its correlation with lymphocyte apoptosis. |
2024-05-30 |
2024-06-08 |
mouse |
| Ya Wen, Yan Li, Jinli Guo, Kaijian Shan. Expression of FoxO3a in sepsis mice and its association with lymphocyte apoptosis. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 5. 2024-05-30. PMID:38814205. |
in sepsis mice, inhibited foxo3a signaling in lymphocytes leads to enhanced apoptosis, elevated ros, and immune cell dysfunction, contributing to increased mortality. |
2024-05-30 |
2024-06-08 |
mouse |
| Amira A El-Gazar, Soad Z El-Emam, Shorouk M El-Sayyad, Shereen S El-Mancy, Sahar M Fayez, Nermin M Sheta, Asmaa K Al-Mokaddem, Ghada M Raga. Pegylated polymeric micelles of boswellic acid-selenium mitigates repetitive mild traumatic brain injury: Regulation of miR-155 and miR-146a/BDNF/ Klotho/Foxo3a cue. International immunopharmacology. vol 134. 2024-05-05. PMID:38705029. |
besides, connexin43 (cx43) expression as well as klotho and brain-derived neurotrophic factor (bdnf) were upregulated with diminished neuronal cell death and apoptosis because of reduced forkhead box class o3a(foxo3a) expression in the pmbs-treated group. |
2024-05-05 |
2024-05-08 |
rat |
| Mohamed S Abdel-Bakky, Hamdoon A Mohammed, Nesreen I Mahmoud, Elham Amin, Mansour Alsharidah, Osamah Al Rugaie, Mohamed G Ewee. Targeting the PI3K/pAKT/mTOR/NF-κB/FOXO3a signaling pathway for suppressing the development of hepatocellular carcinoma in rats: Role of the natural remedic Suaeda vermiculata forssk. Environmental toxicology. 2024-03-20. PMID:38506534. |
liver toxicity and tumor markers (hgfr, p-akt, pi3k, mtor, nf-κb, foxo3a), apoptosis markers, and histopathological changes were analyzed. |
2024-03-20 |
2024-03-23 |
rat |
| Wenqiu Mei, Bingyin Mei, Jing Chang, Yifei Liu, Yanhong Zhou, Ni Zhu, Meichun H. Role and regulation of FOXO3a: new insights into breast cancer therapy. Frontiers in pharmacology. vol 15. 2024-03-20. PMID:38505423. |
foxo3a plays a pivotal role in various cellular processes, including apoptosis, proliferation, cell cycle regulation, and drug resistance. |
2024-03-20 |
2024-03-23 |
Not clear |
| Statement of Retraction: Dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box O3a (FOXO3a)/p53-upregulated modulator of apoptosis (PUMA) signaling signaling. Bioengineered. vol 15. issue 1. 2024-02-20. PMID:38376902. |
statement of retraction: dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box o3a (foxo3a)/p53-upregulated modulator of apoptosis (puma) signaling signaling. |
2024-02-20 |
2024-02-22 |
Not clear |
| Rasha Abdelhady, Osama A Mohammed, Ahmed S Doghish, Rabab S Hamad, Mustafa Ahmed Abdel-Reheim, Mohannad Mohammad S Alamri, Muffarah Hamid Alharthi, Jaber Alfaifi, Masoud I E Adam, Abdullah Hassan Alhalafi, Nahid A Mohammed, Adamu Imam Isa, Sameh Abdel-Ghany, Mohammed A Attia, Elsayed A Elmorsy, Tohada M Al-Noshokaty, Yousra Nomier, Walaa A El-Dakroury, Sameh Sabe. Linagliptin, a DPP-4 inhibitor, activates AMPK/FOXO3a and suppresses NFκB to mitigate the debilitating effects of diethylnitrosamine exposure in rat liver: Novel mechanistic insights. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 4. 2024-02-14. PMID:38354025. |
foxo3a inactivation, driven by oncogenic stimuli, can lead to abnormal cell growth, suppression of apoptosis, and resistance to anticancer drugs. |
2024-02-14 |
2024-02-16 |
rat |
| Xinwan Wu, Yu Zhou, Hongjiao Xu, Xinyi Zhang, Liangfang Yao, Jinbao Li, Xiang L. PRMT6-FoxO3a attenuates apoptosis by upregulating Parkin expression in intestinal ischemia-reperfusion injury. Shock (Augusta, Ga.). 2024-02-07. PMID:38323918. |
this study aims to investigate the potential regulatory mechanisms involving protein arginine methyltransferase 6 (prmt6), forkhead box o3a (foxo3a), and parkin in iiri and elucidate their roles in mediating cell apoptosis. |
2024-02-07 |
2024-02-09 |
mouse |
| Xinwan Wu, Yu Zhou, Hongjiao Xu, Xinyi Zhang, Liangfang Yao, Jinbao Li, Xiang L. PRMT6-FoxO3a attenuates apoptosis by upregulating Parkin expression in intestinal ischemia-reperfusion injury. Shock (Augusta, Ga.). 2024-02-07. PMID:38323918. |
altogether, our results demonstrated that prmt6 upregulated the expression of parkin by regulating foxo3a methylation level, attenuating the apoptosis induced by iiri. |
2024-02-07 |
2024-02-09 |
mouse |
| Shajidan Abudureyimu, Chunhui He, Wei Xie, Zhuo Chen, Halisha Airikenjiang, Dilihumaer Abulaiti, Yan Cao, Haitang Qiu, Ying G. FOXO3a functions as a transcriptional and co-transcriptional splicing regulator in vascular endothelial cell lines. Gene. 2024-01-29. PMID:38286271. |
recent studies have indicated a connection between forkhead box o3a protein and coronary artery disease, yet the exact role of foxo3a in the regulation of metabolic processes and apoptosis in vascular endothelial cells is still unknown. |
2024-01-29 |
2024-02-01 |
human |
| Zhiqiang Dong, Zongming Guo, Hui Li, Dequan Han, Wei Xie, Shaoning Cui, Wei Zhang, Shuhong Huan. FOXO3a-interacting proteins' involvement in cancer: a review. Molecular biology reports. vol 51. issue 1. 2024-01-25. PMID:38270719. |
due to its role in apoptosis, differentiation, cell cycle arrest, and dna damage repair in stress responses (oxidative stress, hypoxia, chemotherapeutic drugs, and uv irradiation or radiotherapy), foxo3a is considered a key tumor suppressor that determines radiotherapeutic and chemotherapeutic responses in cancer cells. |
2024-01-25 |
2024-01-27 |
Not clear |
| Kuan-Ho Lin, Shang-Chuan Ng, Shang-Yeh Lu, Yueh-Min Lin, Shu-Hui Lin, Tzu-Cheng Su, Chih-Yang Huang, Wei-Wen Ku. Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210. The Journal of nutritional biochemistry. 2024-01-07. PMID:38185348. |
we investigated the dats-mediated attenuation mechanism of age-enhanced cardiac apoptosis by modulating mir-210 and its upstream transcriptional regulator, foxo3a. |
2024-01-07 |
2024-01-10 |
Not clear |