| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benkai Bao, Dong Gao, Ning Li, Manman Wu, Chengfen Xin. Near-Infrared Light Regulation of Tumor PI3K/Akt Signaling Pathway for Enhancing Cancer Cell Apoptosis through Conjugated Polymer Nanoparticles. ACS applied bio materials. vol 3. issue 4. 2022-01-13. PMID:35025292. |
therefore, the phosphorylation of gsk-3β downstream of the signaling pathway is reduced, and the phosphorylation of foxo3a is enhanced, which can promote apoptosis of cancer cells. |
2022-01-13 |
2023-08-13 |
Not clear |
| Zhe-Bin Dong, Heng-Miao Wu, Yi-Cheng He, Zhong-Ting Huang, Yi-Hui Weng, Hong Li, Chao Liang, Wei-Ming Yu, Wei Che. MiRNA-124-3p.1 sensitizes hepatocellular carcinoma cells to sorafenib by regulating FOXO3a by targeting AKT2 and SIRT1. Cell death & disease. vol 13. issue 1. 2022-01-11. PMID:35013144. |
we also found that mir-124-3p.1 maintains the dephosphorylation and acetylation of foxo3a, leading to the nuclear location of foxo3a and enhanced sorafenib-induced apoptosis. |
2022-01-11 |
2023-08-13 |
mouse |
| Yan Wang, Chun Jie Wu, Yu Du, Yu Qing Liu, Jing Ran Cai, Xue Qing Wu, Shu Qun H. SIRT2 tyrosine nitration by peroxynitrite in response to renal ischaemia/reperfusion injury. Free radical research. 2022-01-04. PMID:34979841. |
notably, peroxynitrite-evoked nitration of sirt2 destroyed its enzymatic activity and the capability to deacetylate foxo3a, and enhanced expression of bim and caspase3, facilitating renal cell apoptosis in renal ischaemia/reperfusion and sin-1(peroxynitrite donor) treatment in vitro, and these effects were reversed by fetmpyp, a peroxynitrite decomposition scavenger. |
2022-01-04 |
2023-08-13 |
rat |
| Tao Wang, Fei Zhang, Wuxun Peng, Lei Wang, Jian Zhang, Wentao Dong, Xiaobin Tian, Chuan Ye, Yanlin Li, Yuekun Gon. Overexpression of NMNAT3 improves mitochondrial function and enhances anti-oxidative stress of bone marrow mesenchymal stem cells via the NAD+-Sirt3 pathway. Bioscience reports. 2022-01-04. PMID:34981121. |
we further revealed the mechanism of nmnat3-mediated resistance to stress-induced apoptosis in bmscs. we increased the level of nicotinamide adenine dinucleotide (nad+) by overexpressing nmnat3 in bmscs and found that it could significantly increase the activity of silent mating type information regulation 2 homolog 3 (sirt3) and significantly decrease the acetylation levels of sirt3-dependent deacetylation-related proteins isocitrate dehydrogenase 2 (idh2) and forkhead-box protein o3a (foxo3a). these findings show that nmnat3 may increase the activity of sirt3 by increasing nad+ levels. our results confirm that the nmnat3-nad+-sirt3 axis is a potential mechanism for improving mitochondrial function and enhancing anti-oxidative stress of bmscs. in this study, we take advantage of the role of nmnat3 in inhibiting stress-induced apoptosis of bmscs and provide new methods and ideas for breaking through the bottleneck of transplantation efficacy of bmscs in the clinic. |
2022-01-04 |
2023-08-13 |
Not clear |
| Feng Yun Yang, Lu Zhang, Yan Zheng, He Don. Dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box O3a (FOXO3a)/p53-upregulated modulator of apoptosis (PUMA) signaling signaling. Bioengineered. vol 13. issue 1. 2022-01-03. PMID:34974801. |
dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box o3a (foxo3a)/p53-upregulated modulator of apoptosis (puma) signaling signaling. |
2022-01-03 |
2023-08-13 |
mouse |
| Feng Yun Yang, Lu Zhang, Yan Zheng, He Don. Dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box O3a (FOXO3a)/p53-upregulated modulator of apoptosis (PUMA) signaling signaling. Bioengineered. vol 13. issue 1. 2022-01-03. PMID:34974801. |
in addition, h/r and i/r injury increased p53 expression and forkhead box o3a (foxo3a)/p53-upregulated modulator of apoptosis (puma) signaling in h9c2 cardiomyocyte cells and cardiomyocytes. |
2022-01-03 |
2023-08-13 |
mouse |
| Yunqi Zhu, Xiangmin Tong, Ying Wang, Xiaoya L. WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute myeloid leukemia. Cell death & disease. vol 13. issue 1. 2021-12-21. PMID:34930905. |
wtip upregulates foxo3a and induces apoptosis through puma in acute myeloid leukemia. |
2021-12-21 |
2023-08-13 |
Not clear |
| Dominika Ewa Habrowska-Górczyńska, Marta Justyna Kozieł, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielsk. FOXO3a and Its Regulators in Prostate Cancer. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830408. |
forkhead box o3 (foxo3a) is a member of a subfamily of forkhead transcription factors involved in the basic processes within a cell, including proliferation, apoptosis, cell cycle regulation, and dna damage. |
2021-11-30 |
2023-08-13 |
Not clear |
| Mohammad Rehan, Deepali Kurundkar, Ashish R Kurundkar, Naomi J Logsdon, Samuel R Smith, Diptiman Chanda, Karen Bernard, Yan Y Sanders, Jessy S Deshane, Kevin G Dsouza, Sunad Rangarajan, Jaroslaw W Zmijewski, Victor J Thannicka. Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice. Nature aging. vol 1. issue 2. 2021-11-29. PMID:34386777. |
over-expression of the sirt3 cdna via airway delivery restored capacity for fibrosis resolution in aged mice, in association with activation of the forkhead box transcription factor, foxo3a, in fibroblasts, upregulation of pro-apoptotic members of the bcl-2 family, and recovery of apoptosis susceptibility. |
2021-11-29 |
2023-08-13 |
mouse |
| Bruna Bortoloni Gouveia, Ricássio de Sousa Barberino, Regina Lucia Dos Santos Silva, Thae Lanne Barbosa Gama Lins, Valéria da Silva Guimarães, Alane Pains Oliveira do Monte, Raimundo Campos Palheta, Maria Helena Tavares de Mato. Involvement of PTEN and FOXO3a Proteins in the Protective Activity of Protocatechuic Acid Against Cisplatin-Induced Ovarian Toxicity in Mice. Reproductive sciences (Thousand Oaks, Calif.). vol 28. issue 3. 2021-11-23. PMID:33174187. |
in conclusion, pca at 20 mg/kg reduced apoptosis, maintained cell proliferation and mitochondrial function, reduced ros production, and increased gsh expression likely through the involvement of pten and foxo3a proteins. |
2021-11-23 |
2023-08-13 |
mouse |
| Yu Wang, Runhong Mei, Shimin Hao, Peng Luo, Penghao Wang, Yaser Almatari, Lei Guo, Lan Gu. Up-regulation of SIRT1 induced by 17beta-estradiol promotes autophagy and inhibits apoptosis in osteoblasts. Aging. vol 13. issue 20. 2021-11-17. PMID:34711685. |
this study aimed to assess whether the up-regulation of sirt1 induced by 17beta-estradiol (17β-e2) could promote autophagy and inhibit apoptosis in osteoblasts via the ampk-mtor and foxo3a pathways, respectively. |
2021-11-17 |
2023-08-13 |
Not clear |
| Tapas Patra, Keith Meyer, Ratna B Ray, Tatsuo Kanda, Ranjit Ra. Akt inhibitor augments anti-proliferative efficacy of a dual mTORC1/2 inhibitor by FOXO3a activation in p53 mutated hepatocarcinoma cells. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34759291. |
mechanistic insights indicate that a combination of azd5363 and azd8055 activated foxo3a to induce bim-associated apoptosis in p53 mutated hcc cells, whereas cells retaining functional p53 enhanced bax. |
2021-11-17 |
2023-08-13 |
Not clear |
| Arzu Keskin-Aktan, Kazime Gonca Akbulut, Samira Abdi, Hakan Akbulu. SIRT2 and FOXO3a expressions in the cerebral cortex and hippocampus of young and aged male rats: antioxidant and anti-apoptotic effects of melatonin. Biologia futura. 2021-10-28. PMID:34708398. |
forkhead box-class o3a (foxo3a) transcription factor is one of the main targets of sirt2, and sirt2-mediated foxo3a deacetylation is closely related to aging, oxidative stress, and apoptosis. |
2021-10-28 |
2023-08-13 |
rat |
| Xiao-Chun Zhao, Xiao-Cheng Cao, Fei Liu, Mei-Fang Quan, Kai-Qun Ren, Jian-Guo Ca. Regulation of the FOXO3a/Bim signaling pathway by 5,7-dihydroxy-8-nitrochrysin in MDA-MB-453 breast cancer cells. Oncology letters. vol 5. issue 3. 2021-10-21. PMID:23425937. |
silencing of foxo3a resulted in a marked attenuation in the expression of bim, as well as protection against noc-mediated apoptosis. |
2021-10-21 |
2023-08-12 |
human |
| Ling Jiang, Xiao-Cheng Cao, Jian-Guo Cao, Fei Liu, Mei-Fang Quan, Xi-Feng Sheng, Kai-Qun Re. Casticin induces ovarian cancer cell apoptosis by repressing FoxM1 through the activation of FOXO3a. Oncology letters. vol 5. issue 5. 2021-10-21. PMID:23761826. |
casticin induces ovarian cancer cell apoptosis by repressing foxm1 through the activation of foxo3a. |
2021-10-21 |
2023-08-12 |
human |
| Li-Ping Liu, Xiao-Cheng Cao, Fei Liu, Mei-Fang Quan, Xi-Feng Sheng, Kai-Qun Re. Casticin induces breast cancer cell apoptosis by inhibiting the expression of forkhead box protein M1. Oncology letters. vol 7. issue 5. 2021-10-21. PMID:24765206. |
notably, silencing foxo3a expression by sirna-mediated gene knockdown attenuated casticin-mediated apoptosis. |
2021-10-21 |
2023-08-13 |
Not clear |
| Li-Ping Liu, Xiao-Cheng Cao, Fei Liu, Mei-Fang Quan, Xi-Feng Sheng, Kai-Qun Re. Casticin induces breast cancer cell apoptosis by inhibiting the expression of forkhead box protein M1. Oncology letters. vol 7. issue 5. 2021-10-21. PMID:24765206. |
collectively, these findings suggest that foxo3a is a critical mediator of the inhibitory effects of casticin on apoptosis in breast cancer cells. |
2021-10-21 |
2023-08-13 |
Not clear |
| Zhigang Li, Na Yi, Rou Chen, Yilei Meng, Yumei Wang, Huan Liu, Wenze Cao, Yi Hu, Yanqiong Gu, Chang Tong, Min Lu, Li Li, Luying Pen. miR-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting FOXO3A. Cellular signalling. vol 74. 2021-10-19. PMID:32707074. |
mir-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting foxo3a. |
2021-10-19 |
2023-08-13 |
mouse |
| Zhigang Li, Na Yi, Rou Chen, Yilei Meng, Yumei Wang, Huan Liu, Wenze Cao, Yi Hu, Yanqiong Gu, Chang Tong, Min Lu, Li Li, Luying Pen. miR-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting FOXO3A. Cellular signalling. vol 74. 2021-10-19. PMID:32707074. |
furthermore, overexpression or knockdown of mir-29b-3p showed its crucial roles on regulation of apoptosis and production of pro-inflammatory cytokines in nrcms through directly targeting foxo3a. |
2021-10-19 |
2023-08-13 |
mouse |
| Fang Wang, Xuemei Chen, Bo Sun, Yujia Ma, Wenbin Niu, Jun Zhai, Yingpu Su. Hypermethylation-mediated downregulation of lncRNA PVT1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with Foxo3a. Journal of cellular physiology. vol 236. issue 7. 2021-10-14. PMID:33393111. |
hypermethylation-mediated downregulation of lncrna pvt1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with foxo3a. |
2021-10-14 |
2023-08-13 |
mouse |