| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kuan-Ho Lin, Shang-Chuan Ng, Shang-Yeh Lu, Yueh-Min Lin, Shu-Hui Lin, Tzu-Cheng Su, Chih-Yang Huang, Wei-Wen Ku. Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210. The Journal of nutritional biochemistry. 2024-01-07. PMID:38185348. |
we also showed that foxo3a, upregulated by dats treatment, may bind to the mir-210 promoter to enhance its expression and downregulates jnk expression to attenuate age-induced cardiac apoptosis. |
2024-01-07 |
2024-01-10 |
Not clear |
| Kuan-Ho Lin, Shang-Chuan Ng, Shang-Yeh Lu, Yueh-Min Lin, Shu-Hui Lin, Tzu-Cheng Su, Chih-Yang Huang, Wei-Wen Ku. Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210. The Journal of nutritional biochemistry. 2024-01-07. PMID:38185348. |
oral administration of dats enhanced foxo3a expression in the heart and reduced diabetes-induced heart apoptosis. |
2024-01-07 |
2024-01-10 |
Not clear |
| Kuan-Ho Lin, Shang-Chuan Ng, Shang-Yeh Lu, Yueh-Min Lin, Shu-Hui Lin, Tzu-Cheng Su, Chih-Yang Huang, Wei-Wen Ku. Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210. The Journal of nutritional biochemistry. 2024-01-07. PMID:38185348. |
our findings indicate that dats mediates age-induced cardiac cell apoptosis attenuation by promoting foxo3a nuclear transactivation to enhance mir-210 expression and regulate jnk activation. |
2024-01-07 |
2024-01-10 |
Not clear |
| Suryaa Manoharan, Kunjkumar Prajapati, Ekambaram Peruma. Natural bioactive compounds and FOXO3a in cancer therapeutics: An update. Fitoterapia. 2024-01-03. PMID:38168566. |
foxo3a promotes its anticancer effects by upregulating the levels of its downstream targets, including bim, fasl, and bax, leading to apoptosis. |
2024-01-03 |
2024-01-06 |
Not clear |
| Jian-Heng Hao, Yue-Meng Zhao, Hai-Jun Wang, Yu-Xia Cao, Ying Lan, Lai-Xi J. [Mechanism of protective effect of resveratrol on poor ovarian response in mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114185. |
animal experiments showed that the model group had higher rate of estrous cycle disorders, lower number and poorer morphology of normally developed follicles at all levels, more atretic follicles, higher apoptosis of ovarian granulosa cells, lower number of retrieved oocytes, lower ovarian wet weight and ovarian index, higher serum levels of fsh and lh, lower levels of amh and e_2, higher expression levels of hif-1α, foxo3a and bax, and lower expression levels of pi3k, akt, and bcl-2 in the ovarian tissue than the normal group. |
2023-12-19 |
2023-12-23 |
mouse |
| Zhe Zhang, Qinghua Zhang, Yani Yu, Shan S. Epigallocatechin gallate inhibits ovarian cancer cell growth and induces cell apoptosis via activation of FOXO3A. In vitro cellular & developmental biology. Animal. 2023-12-01. PMID:38038884. |
epigallocatechin gallate inhibits ovarian cancer cell growth and induces cell apoptosis via activation of foxo3a. |
2023-12-01 |
2023-12-10 |
Not clear |
| Jun Chen, Yi Yang, Shuo Wang, Kaixin Zhan. Crocin improves lower extremity deep venous thrombosis by regulating the PIM1/FOXO3a axis. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 9. 2023-10-09. PMID:37807309. |
moreover, the knockdown of pim1 suppressed apoptosis and promoted angiogenesis in thrombin-huvecs treated with crocin, while overexpression of foxo3a reversed the effects. |
2023-10-09 |
2023-10-15 |
human |
| Shuangze Han, Xinfang Yu, Ruirui Wang, Xiaocong Wang, LuLu Liu, Qing Zhao, RongBo Xie, Ming Li, Zhong Su Zho. Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma. Journal of Cancer. vol 14. issue 13. 2023-09-06. PMID:37670974. |
moreover, tan iia inhibited akt activation from inducing foxo3a dephosphorylation and puma-mediated apoptosis. |
2023-09-06 |
2023-10-07 |
Not clear |
| Yusuke Urushihara, Takuma Hashimoto, Yohei Fujishima, Yoshio Hoso. AMPK/FOXO3a Pathway Increases Activity and/or Expression of ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 and Induces Radioresistance under Nutrient Starvation. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37629008. |
knockdown of foxo3a increased the incidence of apoptosis after irradiation under nutrient starvation. |
2023-08-26 |
2023-09-07 |
Not clear |
| Lin Li, Weitong Qi, Yujiao Zhu, Mingming Yin, Chen Chen, Meng Wei, Zhenzhen Huang, Zhuhua Su, Jizong Jiang, Mingxue Zhang, Yihua Be. Danlou Tablet Protects Against Cardiac Remodeling and Dysfunction after Myocardial Ischemia/Reperfusion Injury through Activating AKT/FoxO3a Pathway. Journal of cardiovascular translational research. 2023-04-10. PMID:37036598. |
mechanistically, dan inhibited myocardial apoptosis through phosphorylating akt and foxo3a, thereby inhibiting downstream bim and puma expressions. |
2023-04-10 |
2023-08-14 |
human |
| Xun Chen, Qian Zhang, Tao Song, Wentao Zhang, Yan Yang, Ning Duan, Fei Con. Vitamin D deficiency triggers intrinsic apoptosis by impairing SPP1-dependent antiapoptotic signaling in chronic hematogenous osteomyelitis. Gene. 2023-04-06. PMID:37024063. |
foxo3a then upregulates the expression of the apoptotic genes bax (bcl2-associated x-protein), bid (bh3 interacting death domain), and bim (bcl2-interacting mediator of cell death), to induce apoptosis. |
2023-04-06 |
2023-08-14 |
mouse |
| Suryaa Manoharan, Hemamalini Vedagiri, Ekambaram Peruma. Potent FOXO3a Activators from Biologically Active Compound Library for Cancer Therapeutics: An in silico Approach. Applied biochemistry and biotechnology. 2023-04-05. PMID:37017892. |
the forkhead transcription factor foxo3a is a member of the foxo subfamily, which controls a number of cellular processes including apoptosis, proliferation, cell cycle progression, dna damage, and carcinogenesis. |
2023-04-05 |
2023-08-14 |
Not clear |
| Hui Yang, Yuting Chen, Minjuan Zeng, Haipeng Wu, Xiangli Zou, Tiantian Fang, Lu Zhai, Hairong Liang, Hao Luo, Gaiqin Tian, Qizhan Liu, Huanwen Tan. Long non-coding RNA LINC01480 is activated by Foxo3a and promotes hydroquinone-induced TK6 cell apoptosis by inhibiting the PI3K/AKT pathway. Ecotoxicology and environmental safety. vol 255. 2023-03-19. PMID:36934544. |
long non-coding rna linc01480 is activated by foxo3a and promotes hydroquinone-induced tk6 cell apoptosis by inhibiting the pi3k/akt pathway. |
2023-03-19 |
2023-08-14 |
Not clear |
| Hui Yang, Yuting Chen, Minjuan Zeng, Haipeng Wu, Xiangli Zou, Tiantian Fang, Lu Zhai, Hairong Liang, Hao Luo, Gaiqin Tian, Qizhan Liu, Huanwen Tan. Long non-coding RNA LINC01480 is activated by Foxo3a and promotes hydroquinone-induced TK6 cell apoptosis by inhibiting the PI3K/AKT pathway. Ecotoxicology and environmental safety. vol 255. 2023-03-19. PMID:36934544. |
from these findings, we can conclude that linc01480 is activated by foxo3a, and promotes hq-induced apoptosis by inhibiting the pi3k/akt pathway, suggesting that linc01480 might become a possible target for therapeutic intervention of hq-induced toxicity. |
2023-03-19 |
2023-08-14 |
Not clear |
| Wenliang Gong, Xinyu Li, Yuliang Feng, Ming Ji, Dianjun Zhang, Binjie Chen, Siman Wang, Xiafang Wu, Lulu Cui, Baoman Li, Maosheng Xi. Novel pathogenesis of post-traumatic stress disorder studied in transgenic mice. Journal of psychiatric research. vol 161. 2023-03-18. PMID:36933445. |
we initially discovered that pathological stress associated with ptsd increased the activation of glycogen synthesis kinase-beta (gsk-3β) in neurons and induced the translocation of the transcription factor forkhead box-class o3a (foxo3a) from the cytoplasm to the nucleus, which decreased the expression of uncoupling protein 2 (ucp2) and increased mitochondrial production of reactive oxygen species (ros) to trigger neuronal apoptosis in the prefrontal cortex (pfc). |
2023-03-18 |
2023-08-14 |
mouse |
| Aniello Maiese, Federica Spina, Giacomo Visi, Fabio Del Duca, Alessandra De Matteis, Raffaele La Russa, Marco Di Paolo, Paola Frati, Vittorio Finesch. The Expression of FOXO3a as a Forensic Diagnostic Tool in Cases of Traumatic Brain Injury: An Immunohistochemical Study. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768906. |
this study shows the important role of foxo3a in neuronal autophagy and apoptosis regulation and suggests foxo3a as a possible potential pharmacological target. |
2023-02-11 |
2023-08-14 |
human |
| Zhangdi Xu, Bihui Pan, Yi Miao, Yue Li, Shuchao Qin, Jinhua Liang, Yilin Kong, Xinyu Zhang, Jing Tang, Yi Xia, Huayuan Zhu, Li Wang, Jianyong Li, Jiazhu Wu, Wei X. Prognostic value and therapeutic targeting of XPO1 in chronic lymphocytic leukemia. Clinical and experimental medicine. 2023-02-04. PMID:36738306. |
we showed the effects of selinexor on proliferation inhibition, cell cycle arrest, and apoptosis in cll cell lines with jvm3, mec1, and ibrutinib-resistant (mr) cells via nuclear retention of cargo proteins of iκbα, p65, p50, and foxo3a. |
2023-02-04 |
2023-08-14 |
Not clear |
| Beini Sun, Hongce Chen, Xiaoping Wang, Tongsheng Che. Regorafenib induces Bim-mediated intrinsic apoptosis by blocking AKT-mediated FOXO3a nuclear export. Cell death discovery. vol 9. issue 1. 2023-01-31. PMID:36720853. |
regorafenib induces bim-mediated intrinsic apoptosis by blocking akt-mediated foxo3a nuclear export. |
2023-01-31 |
2023-08-14 |
Not clear |
| Beini Sun, Hongce Chen, Xiaoping Wang, Tongsheng Che. Regorafenib induces Bim-mediated intrinsic apoptosis by blocking AKT-mediated FOXO3a nuclear export. Cell death discovery. vol 9. issue 1. 2023-01-31. PMID:36720853. |
most importantly, akt agonist (sc79) not only inhibited rego-induced foxo3a nuclear localization and apoptosis but also restored the proliferation and migration ability of cancer cells, further demonstrating that rego prevented foxo3a nuclear export by deactivating pi3k/akt. |
2023-01-31 |
2023-08-14 |
Not clear |
| Pallabi Bhattacharyya, Atanu Biswas, Subhas C Biswa. Brain-enriched miR-128: Reduced in exosomes from Parkinson's patient plasma, improves synaptic integrity, and prevents 6-OHDA mediated neuronal apoptosis. Frontiers in cellular neuroscience. vol 16. 2023-01-30. PMID:36713778. |
this neuroprotective effect was found to be induced by mir-128-mediated inhibition of foxo3a activation, a transcription factor involved in apoptosis. |
2023-01-30 |
2023-08-14 |
Not clear |