| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Yu, Xingyou Liu, Keyao Wang, Huimin Wang, Yufeng Han, Jie Kang, Ruiqiang Deng, Huaijun Zhou, Zhibian Dua. Underlying mechanism of Qiling Jiaogulan Powder in the treatment of broiler ascites syndrome. Poultry science. vol 102. issue 1. 2022-11-05. PMID:36334473. |
qljp may regulate lung oxidative stress, the cell cycle and apoptosis by activating the foxo3a signaling pathway to interfere with the occurrence and development of as in broilers. |
2022-11-05 |
2023-08-14 |
Not clear |
| Huan Zhou, Pengyu Pan, Qiuyu Zhao, Wenjun Liu, Ye Sun, Jianbo Wang, Chunying Liu, Chun Wan. Overcoming Basal Autophagy, Kangai Injection Enhances Cisplatin Cytotoxicity by Regulating FOXO3a-Dependent Autophagic Cell Death and Apoptosis in Human Lung Adenocarcinoma A549/DDP Cells. BioMed research international. vol 2022. 2022-09-12. PMID:36093402. |
we also found that the apoptosis and autophagic cell death induced by cotreatment of kai and cisplatin in a549/ddp cells were foxo3a-dependent as indicated by decreased p-foxo3a expression and increased foxo3a nuclear localization, respectively. |
2022-09-12 |
2023-08-14 |
human |
| Suming Pan, Xiangguo Zhang, Yugan Guo, Yin L. DPCPX induces Bim-dependent apoptosis in nasopharyngeal carcinoma cells. Cell biology international. 2022-08-22. PMID:35989488. |
dpcpx induced bim-dependent apoptosis in npc cells irrespective of p53 status via the foxo3a pathway following pi3k/akt inhibition. |
2022-08-22 |
2023-08-14 |
Not clear |
| Ricássio S Barberino, Thae Lanne B G Lins, Alane P O Monte, Regina Lucia S Silva, Kíscyla O Andrade, Daniela S P Campinho, Raimundo C Palheta Junior, Johan E J Smitz, Maria Helena T Mato. Epigallocatechin-3-gallate attenuates cyclophosphamide-induced damage in mouse ovarian tissue via suppressing inflammation, apoptosis, and expression of phosphorylated Akt, FOXO3a and rpS6. Reproductive toxicology (Elmsford, N.Y.). 2022-08-18. PMID:35981663. |
epigallocatechin-3-gallate attenuates cyclophosphamide-induced damage in mouse ovarian tissue via suppressing inflammation, apoptosis, and expression of phosphorylated akt, foxo3a and rps6. |
2022-08-18 |
2023-08-14 |
mouse |
| Yaxin Zhang, Jihang Dai, Lianqi Yan, Qun Lin, Haixiang Miao, Xingkai Wang, Jingcheng Wang, Yu Su. DL-3-N-Butylphthalide Promotes Cartilage Extracellular Matrix Synthesis and Inhibits Osteoarthritis Development by Regulating FoxO3a. Oxidative medicine and cellular longevity. vol 2022. 2022-08-01. PMID:35910845. |
nbp upregulated the expression of foxo3a by inhibiting the pi3k/akt pathway, which subsequently inhibited the apoptosis of human oa chondrocytes. |
2022-08-01 |
2023-08-14 |
human |
| Lei Meng, Bin Feng, Liming Luan, Zhihao Fang, Guangyu Zha. MeCP2 inhibits ischemic neuronal injury by enhancing methylation of the FOXO3a promoter to repress the SPRY2-ZEB1 axis. Experimental & molecular medicine. 2022-08-01. PMID:35915222. |
using functional analysis, we demonstrated that mecp2 accelerated foxo3a methylation and subsequently inhibited its expression, thus repressing the apoptosis of neuronal cells. |
2022-08-01 |
2023-08-14 |
mouse |
| Eleanor K Greenwood, Dafina M Angelova, Hadassah M I Büchner, David R Brow. The AICD fragment of APP initiates a FoxO3a mediated response via FANCD2. Molecular and cellular neurosciences. 2022-07-28. PMID:35901928. |
foxo3a is a transcription factor associated with neuronal longevity and apoptosis. |
2022-07-28 |
2023-08-14 |
Not clear |
| Yong-Qing Zhang, Rui-Lin Chen, Li-Qun Shang, Shu-Mei Yan. Nicotine-induced miR-21-3p promotes chemoresistance in lung cancer by negatively regulating FOXO3a. Oncology letters. vol 24. issue 2. 2022-06-29. PMID:35765274. |
the regulatory effect of mir-21-3p and foxo3a on lung cancer cell proliferation and apoptosis induced by docetaxel or cisplatin treatment was evaluated by performing cell counting kit-8 and annexin v/pi staining assays, respectively. |
2022-06-29 |
2023-08-14 |
Not clear |
| Chao Yu, Tingting Li, Jialu Li, Binbin Cui, Na Liu, George Bayliss, Shougang Zhuan. Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin-induced acute kidney injury. Journal of cellular and molecular medicine. 2022-06-23. PMID:35734954. |
mechanistically, eed226 treatment inhibited cisplatin-induced phosphorylation of p53 and foxo3a, two transcriptional factors contributing to apoptosis, and preserved expression of sirtuin 3 and pgc1α, two proteins associated with mitochondrial protection in vivo and in vitro. |
2022-06-23 |
2023-08-14 |
Not clear |
| Huaxiang Shi, Pengfei Li, Hu Zhou, Zhiyong Nie, Jingxin Zhang, Xin Sui, Jiabin Guo, Yongan Wang, Liyun Wan. Dynamic cerebral blood flow changes with FOXOs stimulation are involved in neuronal damage associated with high-altitude cerebral edema in mice. Brain research. 2022-06-20. PMID:35724762. |
similarly, western blot assays revealed upregulation of foxo1a, foxo3a, caspase-3 and bax, and downregulation of bcl-2, indicating a temporal influence of ahh on mitochondrial function and neuronal apoptosis. |
2022-06-20 |
2023-08-14 |
mouse |
| Ying Liu, Yu Wang, Xiaoge Li, Yi Jia, Jianxun Wang, Xiang A. FOXO3a in cancer drug resistance. Cancer letters. 2022-05-11. PMID:35545128. |
recent studies have shown that foxo3a dysregulation contributes to drug resistance development through various mechanisms, including modulating oncogenic signaling pathways, evading apoptosis, promoting excessive drug efflux, inducing autophagy, facilitating epithelial to mesenchymal transition, enhancing dna damage repair, and altering the characteristics of cancer stem cells. |
2022-05-11 |
2023-08-13 |
Not clear |
| Jie Zhang, Xuejie Han, Jing Chang, Jian Liu, Yingming Liu, Hongxia Wang, Fenghe Du, Xiangjun Zeng, Caixia Gu. Soluble RAGE attenuates myocardial I/R injuries via FoxO3-Bnip3 pathway. Cellular and molecular life sciences : CMLS. vol 79. issue 5. 2022-05-02. PMID:35501612. |
srage inhibited mitochondrial depolarization and cardiac apoptosis during i/r, which correlated with reduced expression of bnip3, sirt2, phosphorylation of akt and foxo3a which translocated into nucleus in cultured cardiomyocytes. |
2022-05-02 |
2023-08-13 |
mouse |
| Chao Wang, Xiaohong Tu, Yufen Jiang, Panpan Jiao, Xiaohong Deng, Yuancai Xie, Long Zhan. Prognostic value of high FOXO3a expression in patients with solid tumors: A meta-analysis and systematic review. The International journal of biological markers. 2022-04-29. PMID:35484793. |
foxo3a (previously termed fkhrl1), plays an evolutionarily conserved role in the control of biological process, including dna damage, apoptosis, and cell cycle regulation. |
2022-04-29 |
2023-08-13 |
Not clear |
| Conghua Lu, Rui Yu, Chong Zhang, Caiyu Lin, Yuanyao Dou, Di Wu, Yonghong Pan, Tao Peng, Huan Tang, Rui Han, Yong H. Protective autophagy decreases lorlatinib cytotoxicity through Foxo3a-dependent inhibition of apoptosis in NSCLC. Cell death discovery. vol 8. issue 1. 2022-04-23. PMID:35459209. |
meanwhile, we found that the combination of lorlatinib and cq, an inhibitor of autophagy, inhibited autophagy and promoted apoptosis both in vitro and in vivo, which sensitized cells to lorlatinib through the dephosphorylation of foxo3a and promoted nuclear translocation, then activation of foxo3a/bim axis. |
2022-04-23 |
2023-08-13 |
Not clear |
| Mona A Kortam, Asmaa S Alawady, Nermin Abdel Hamid Sadik, Nevine Fath. Fenofibrate mitigates testosterone induced benign prostatic hyperplasia via regulation of Akt/FOXO3a pathway and modulation of apoptosis and proliferation in rats. Archives of biochemistry and biophysics. 2022-04-17. PMID:35430215. |
fenofibrate significantly suppressed ps473 akt expression causing foxo3a nuclear inclusion, which triggered induction of apoptosis. |
2022-04-17 |
2023-08-13 |
rat |
| Nirmala Tilija Pun, Naeun Lee, Sang-Hoon Song, Chul-Ho Jeon. Pitavastatin Induces Cancer Cell Apoptosis by Blocking Autophagy Flux. Frontiers in pharmacology. vol 13. 2022-04-07. PMID:35387352. |
further, the foxo3a protein accumulated due to the blockade of autophagy flux which in turn was associated with the induction of er stress by transcriptional upregulation of perk-chop pathway, subsequently causing apoptosis due to pitavastatin treatment. |
2022-04-07 |
2023-08-13 |
human |
| Nirmala Tilija Pun, Naeun Lee, Sang-Hoon Song, Chul-Ho Jeon. Pitavastatin Induces Cancer Cell Apoptosis by Blocking Autophagy Flux. Frontiers in pharmacology. vol 13. 2022-04-07. PMID:35387352. |
taken together, pitavastatin-mediated blockade of autophagy flux caused an accumulation of foxo3a protein, thereby leading to the induction of perk, ultimately causing chop-mediated apoptosis in cancer cells. |
2022-04-07 |
2023-08-13 |
human |
| Saba Ubaid, Shivani Pandey, Mohd Sohail Akhtar, Mohammad Rumman, Babita Singh, Abbas Ali Mahd. SIRT1 Mediates Neuroprotective and Neurorescue Effects of Camel α-Lactalbumin and Oleic Acid Complex on Rotenone-Induced Parkinson's Disease. ACS chemical neuroscience. 2022-04-06. PMID:35385250. |
sirt1 upregulates the expression of foxo3a and hsf-1, thus inhibiting apoptosis and maintaining the homeostasis of cellular proteins. |
2022-04-06 |
2023-08-13 |
Not clear |
| Rui Chen, Min Yan. Melatonin Inhibits OGD/R-Induced H9c2 Cardiomyocyte Pyroptosis via Regulation of MT2/miR-155/FOXO3a/ARC Axis. International heart journal. vol 63. issue 2. 2022-03-31. PMID:35354753. |
melatonin treatment also led to an increased level of apoptosis repressor with caspase recruitment domain (arc), which was inhibited by foxo3a sirna. |
2022-03-31 |
2023-08-13 |
Not clear |
| Xiaozhi Li, Longyu Jin, M Yuchao, Zhibin Jiang, Hao Tang, Xiyuan Ton. Xanthohumol inhibits non-small cell lung cancer by activating PUMA-mediated apoptosis. Toxicology. 2022-03-08. PMID:35259468. |
silent puma or foxo3a impaired xanthohumol-induced apoptosis in nsclc cells. |
2022-03-08 |
2023-08-13 |
mouse |