| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Florian Schubert, Juliane Rapp, Prisca Brauns-Schubert, Lisa Schlicher, Kerstin Stock, Manuela Wissler, Martina Weiß, Céline Charvet, Christoph Borner, Ulrich Maure. Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling. Cell death & disease. vol 9. issue 5. 2019-11-07. PMID:29686375. |
thus, the suppression of gsk-3 is the key function of pi3k signaling in order to prevent the induction of puma by foxo3a and p53 and thereby apoptosis upon growth factor withdrawal. |
2019-11-07 |
2023-08-13 |
Not clear |
| Robert P Feehan, Amanda M Nelson, Lisa M Shant. Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL. Cellular signalling. vol 52. 2019-10-22. PMID:30172026. |
inhibition of mtorc2 enhances uvb-induced apoptosis in keratinocytes through a mechanism dependent on the foxo3a transcriptional target noxa but independent of trail. |
2019-10-22 |
2023-08-13 |
human |
| Robert P Feehan, Amanda M Nelson, Lisa M Shant. Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL. Cellular signalling. vol 52. 2019-10-22. PMID:30172026. |
we have shown previously that mtorc2 inhibition sensitizes keratinocytes to uvb-induced apoptosis mediated by the transcription factor foxo3a. |
2019-10-22 |
2023-08-13 |
human |
| Robert P Feehan, Amanda M Nelson, Lisa M Shant. Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL. Cellular signalling. vol 52. 2019-10-22. PMID:30172026. |
foxo3a is a key regulator of apoptosis and a tumor suppressor in several cancer types. |
2019-10-22 |
2023-08-13 |
human |
| Robert P Feehan, Amanda M Nelson, Lisa M Shant. Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL. Cellular signalling. vol 52. 2019-10-22. PMID:30172026. |
activation of foxo3a promotes apoptosis through the coordinated expression of a variety of target genes, including trail and noxa. |
2019-10-22 |
2023-08-13 |
human |
| Robert P Feehan, Amanda M Nelson, Lisa M Shant. Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL. Cellular signalling. vol 52. 2019-10-22. PMID:30172026. |
similar to knockdown of foxo3a, noxa knockdown reversed the sensitization to uvb-induced apoptosis caused by mtorc2 inhibition. |
2019-10-22 |
2023-08-13 |
human |
| Robert P Feehan, Amanda M Nelson, Lisa M Shant. Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL. Cellular signalling. vol 52. 2019-10-22. PMID:30172026. |
in contrast, loss of trail by either knockdown or knockout actually enhanced expression of nuclear foxo3a, which maintained apoptosis. |
2019-10-22 |
2023-08-13 |
human |
| Robert P Feehan, Amanda M Nelson, Lisa M Shant. Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL. Cellular signalling. vol 52. 2019-10-22. PMID:30172026. |
taken together, these studies provide strong evidence that mtorc2 controls uvb-induced apoptosis by regulating noxa expression downstream of foxo3a. |
2019-10-22 |
2023-08-13 |
human |
| Yuan-Yuan Liu, Yi-Nan Zhang, Qing-Shan Yan. Downregulated expression of microRNA-329 inhibits apoptosis of nigral dopaminergic neurons by regulating CDKN2D expression via the FoxO3a signaling pathway in rats with Parkinson's disease. Journal of cellular physiology. vol 233. issue 11. 2019-09-26. PMID:29761857. |
downregulated expression of microrna-329 inhibits apoptosis of nigral dopaminergic neurons by regulating cdkn2d expression via the foxo3a signaling pathway in rats with parkinson's disease. |
2019-09-26 |
2023-08-13 |
rat |
| Yuan-Yuan Liu, Yi-Nan Zhang, Qing-Shan Yan. Downregulated expression of microRNA-329 inhibits apoptosis of nigral dopaminergic neurons by regulating CDKN2D expression via the FoxO3a signaling pathway in rats with Parkinson's disease. Journal of cellular physiology. vol 233. issue 11. 2019-09-26. PMID:29761857. |
our data suggested that downregulated mir-329 could inhibit apoptosis of nigral dopaminergic neurons in a rat model of pd by upregulating the expression of cdkn2d via the activation of the foxo3a signaling pathway. |
2019-09-26 |
2023-08-13 |
rat |
| Yingji Jin, Yoshito Takeda, Yasushi Kondo, Lokesh P Tripathi, Sujin Kang, Hikari Takeshita, Hanako Kuhara, Yohei Maeda, Masayoshi Higashiguchi, Kotaro Miyake, Osamu Morimura, Taro Koba, Yoshitomo Hayama, Shohei Koyama, Kaori Nakanishi, Takeo Iwasaki, Satoshi Tetsumoto, Kazuyuki Tsujino, Muneyoshi Kuroyama, Kota Iwahori, Haruhiko Hirata, Takayuki Takimoto, Mayumi Suzuki, Izumi Nagatomo, Ken Sugimoto, Yuta Fujii, Hiroshi Kida, Kenji Mizuguchi, Mari Ito, Takashi Kijima, Hiromi Rakugi, Eisuke Mekada, Isao Tachibana, Atsushi Kumanogo. Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging. Scientific reports. vol 8. issue 1. 2019-09-25. PMID:29572511. |
importantly, sirna knockdown of cd9 and cd81 in lung epithelial cells additively decreased sirt1 and foxo3a expression, but reciprocally upregulated the expression of p21 and p53, leading to reduced cell proliferation and elevated apoptosis. |
2019-09-25 |
2023-08-13 |
mouse |
| Varun V Prabhu, Mala K Talekar, Amriti R Lulla, C Leah B Kline, Lanlan Zhou, Junior Hall, A Pieter J Van den Heuvel, David T Dicker, Jawad Babar, Stephan A Grupp, Mathew J Garnett, Ultan McDermott, Cyril H Benes, Jeffrey J Pu, David F Claxton, Nadia Khan, Wolfgang Oster, Joshua E Allen, Wafik S El-Deir. Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies. Cell cycle (Georgetown, Tex.). vol 17. issue 4. 2019-09-09. PMID:29157092. |
onc201 induced caspase-dependent apoptosis that involved activation of the integrated stress response (atf4/chop) pathway, inhibition of akt phosphorylation, foxo3a activation, downregulation of cyclin d1, iap and bcl-2 family members. |
2019-09-09 |
2023-08-13 |
Not clear |
| Mario Angelo Pagano, Elena Tibaldi, Pierfrancesco Molino, Federica Frezzato, Valentina Trimarco, Monica Facco, Giuseppe Zagotto, Giovanni Ribaudo, Luigi Leanza, Roberta Peruzzo, Ildikò Szabò, Andrea Visentin, Martina Frasson, Gianpietro Semenzato, Livio Trentin, Anna Maria Brunat. Mitochondrial apoptosis is induced by Alkoxy phenyl-1-propanone derivatives through PP2A-mediated dephosphorylation of Bad and Foxo3A in CLL. Leukemia. vol 33. issue 5. 2019-08-13. PMID:30353029. |
mitochondrial apoptosis is induced by alkoxy phenyl-1-propanone derivatives through pp2a-mediated dephosphorylation of bad and foxo3a in cll. |
2019-08-13 |
2023-08-13 |
Not clear |
| Xinyuan Zhao, Yiming Liu, Ganlin Zhu, Yuanyuan Liang, Bo Liu, Yifan Wu, Muxi Han, Wenxing Sun, Yu Han, Gang Chen, Junkang Jian. SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis. The Science of the total environment. vol 646. 2019-04-03. PMID:30235590. |
sirt1 activation by resveratrol clearly attenuated mn-triggered apoptosis and foxo3a activation. |
2019-04-03 |
2023-08-13 |
mouse |
| Xinyuan Zhao, Yiming Liu, Ganlin Zhu, Yuanyuan Liang, Bo Liu, Yifan Wu, Muxi Han, Wenxing Sun, Yu Han, Gang Chen, Junkang Jian. SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis. The Science of the total environment. vol 646. 2019-04-03. PMID:30235590. |
mn markedly increased the expression of bcl-2 interacting mediator of cell death (bim) and p53-up-regulated modulator of apoptosis (puma), whereas downregulation of foxo3a significantly inhibited their upregulation and subsequent apoptosis. |
2019-04-03 |
2023-08-13 |
mouse |
| Ying Liu, Xiang Ao, Wei Ding, Murugavel Ponnusamy, Wei Wu, Xiaodan Hao, Wanpeng Yu, Yifei Wang, Peifeng Li, Jianxun Wan. Critical role of FOXO3a in carcinogenesis. Molecular cancer. vol 17. issue 1. 2019-03-22. PMID:30045773. |
foxo3a is a member of the foxo subfamily of forkhead transcription factors that mediate a variety of cellular processes including apoptosis, proliferation, cell cycle progression, dna damage and tumorigenesis. |
2019-03-22 |
2023-08-13 |
Not clear |
| Ping Dong, Xiyan Zhang, Jian Zhao, Dongliang Li, Liang Li, Bo Yan. Anti-microRNA-132 causes sevoflurane‑induced neuronal apoptosis via the PI3K/AKT/FOXO3a pathway. International journal of molecular medicine. vol 42. issue 6. 2019-02-19. PMID:30272258. |
the promotion of foxo3a inhibited the effects of anti‑mirna‑132 on neuronal apoptosis through the akt/foxo3a pathway in the sevoflurane‑induced in vitro model. |
2019-02-19 |
2023-08-13 |
rat |
| Haixiang Yu, Adam Fellows, Kirsty Foote, Zhaoqing Yang, Nichola Figg, Trevor Littlewood, Martin Bennet. FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13). Arteriosclerosis, thrombosis, and vascular biology. vol 38. issue 3. 2019-01-07. PMID:29326312. |
foxo3a (forkhead transcription factor o subfamily member 3a) links vascular smooth muscle cell apoptosis, matrix breakdown, atherosclerosis, and vascular remodeling through a novel pathway involving mmp13 (matrix metalloproteinase 13). |
2019-01-07 |
2023-08-13 |
human |
| Ya-Fang Chen, Sudhir Pandey, Cecilia Hsuan Day, Yu-Feng Chen, Ai-Zhi Jiang, Tsung-Jung Ho, Ray-Jade Chen, Vijaya V Padma, Wei-Wen Kuo, Chih-Yang Huan. Synergistic effect of HIF-1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition. Journal of cellular physiology. vol 233. issue 4. 2018-12-11. PMID:29030976. |
synergistic effect of hif-1α and foxo3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition. |
2018-12-11 |
2023-08-13 |
Not clear |
| Ya-Fang Chen, Sudhir Pandey, Cecilia Hsuan Day, Yu-Feng Chen, Ai-Zhi Jiang, Tsung-Jung Ho, Ray-Jade Chen, Vijaya V Padma, Wei-Wen Kuo, Chih-Yang Huan. Synergistic effect of HIF-1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition. Journal of cellular physiology. vol 233. issue 4. 2018-12-11. PMID:29030976. |
through this study, we showed the synergistic role of hif-1α and foxo3a in cardiomyocyte apoptosis subjected to hypoxia plus elevated glucose levels. |
2018-12-11 |
2023-08-13 |
Not clear |