| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T K Li, K Yin, Z Chen, Y Bao, S X Zhan. MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5. Genetics and molecular research : GMR. vol 16. issue 1. 2017-04-12. PMID:28290615. |
down-regulation of mir-214 and/or enhancement of rassf5 expression markedly increased foxo3a phosphorylation, bim expression, caspase 3 activity, and apoptosis. |
2017-04-12 |
2023-08-13 |
Not clear |
| T K Li, K Yin, Z Chen, Y Bao, S X Zhan. MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5. Genetics and molecular research : GMR. vol 16. issue 1. 2017-04-12. PMID:28290615. |
moreover, mir-214 regulated kb cell apoptosis through targeted inhibition of rassf5 expression, foxo3a phosphorylation, and bim expression, suggesting its possible application as a novel therapeutic oral cancer target. |
2017-04-12 |
2023-08-13 |
Not clear |
| Susana F Sampaio, Ana F Branco, Aleksandra Wojtala, Ignacio Vega-Naredo, Mariusz R Wieckowski, Paulo J Oliveir. p66Shc signaling is involved in stress responses elicited by anthracycline treatment of rat cardiomyoblasts. Archives of toxicology. vol 90. issue 7. 2017-03-03. PMID:26318906. |
we further tested whether the transcriptional factor foxo3a, which activates target genes responsible for apoptosis and cell cycle arrest, is also involved in p66shc-dependent redox signaling pathway. |
2017-03-03 |
2023-08-13 |
rat |
| Mi-Hua Liu, Yuan Zhang, Jun He, Tian-Ping Tan, Shao-Jian Wu, Dong-Ming Guo, Hui He, Juan Peng, Zhi-Han Tang, Zhi-Sheng Jian. Hydrogen sulfide protects H9c2 cardiac cells against doxorubicin-induced cytotoxicity through the PI3K/Akt/FoxO3a pathway. International journal of molecular medicine. vol 37. issue 6. 2017-02-28. PMID:27081862. |
notably, pre-treatment of the h9c2 cells with nahs significantly attenuated the nuclear localization of foxo3a as well as the apoptosis of h9c2 cells induced by dox. |
2017-02-28 |
2023-08-13 |
Not clear |
| Chaoyun Pan, Dihan Zhu, Jianjiang Zhuo, Limin Li, Dong Wang, Chen-Yu Zhang, Yuan Liu, Ke Ze. Role of Signal Regulatory Protein α in Arsenic Trioxide-induced Promyelocytic Leukemia Cell Apoptosis. Scientific reports. vol 6. 2017-02-27. PMID:27010069. |
in the present study, we demonstrate that overexpression of sirpα in acute promyelocytic leukemia (apl) cells results in apoptosis possibly via inhibiting the β-catenin signaling pathway and upregulating foxo3a. |
2017-02-27 |
2023-08-13 |
Not clear |
| Robert P Feehan, Lisa M Shant. Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation. Cellular signalling. vol 28. issue 8. 2017-02-22. PMID:27058291. |
the activity of foxo3a is reduced as a result of protein kinase b (akt/pkb) activation, which is downstream of mtorc2; however, the specific function of foxo3a during uvb-induced apoptosis is unclear. |
2017-02-22 |
2023-08-13 |
Not clear |
| Robert P Feehan, Lisa M Shant. Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation. Cellular signalling. vol 28. issue 8. 2017-02-22. PMID:27058291. |
in contrast, loss of mtorc2 causes foxo3a to be localized to the nucleus and sensitizes cells to uvb-induced apoptosis. |
2017-02-22 |
2023-08-13 |
Not clear |
| Robert P Feehan, Lisa M Shant. Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation. Cellular signalling. vol 28. issue 8. 2017-02-22. PMID:27058291. |
taken together, these studies provide strong evidence that inhibition of mtorc2 enhances uvb-induced apoptosis in a foxo3a-dependent manner, and suggest that foxo3a activation by mtorc2 inhibitors may be a valuable chemopreventive target in nmsc. |
2017-02-22 |
2023-08-13 |
Not clear |
| Mi-Hua Liu, Guo-Hua Li, Li-Jun Peng, Shun-Lin Qu, Yuan Zhang, Juan Peng, Xin-Yuan Luo, Heng-Jing Hu, Zhong Ren, Yao Liu, Hui Tang, Lu-Shan Liu, Zhi-Han Tang, Zhi-Sheng Jian. PI3K/Akt/FoxO3a signaling mediates cardioprotection of FGF-2 against hydrogen peroxide-induced apoptosis in H9c2 cells. Molecular and cellular biochemistry. vol 414. issue 1-2. 2016-12-13. PMID:26899709. |
stimulation with h2o2 decreased the phosphorylation of akt and foxo3a, and induced nuclear localization of foxo3a and apoptosis of h9c2 cells. |
2016-12-13 |
2023-08-13 |
Not clear |
| T P Das, S Suman, H Alatassi, M K Ankem, C Damodara. Inhibition of AKT promotes FOXO3a-dependent apoptosis in prostate cancer. Cell death & disease. vol 7. 2016-12-13. PMID:26913603. |
foxo3a is upstream of par-4 signaling, which is required for induction of apoptosis in crpc cells. |
2016-12-13 |
2023-08-13 |
mouse |
| T P Das, S Suman, H Alatassi, M K Ankem, C Damodara. Inhibition of AKT promotes FOXO3a-dependent apoptosis in prostate cancer. Cell death & disease. vol 7. 2016-12-13. PMID:26913603. |
our studies suggest that par-4 is one of the key transcriptional targets of foxo3a, and par-4 activation is required for induction of apoptosis in crpc cells. |
2016-12-13 |
2023-08-13 |
mouse |
| Ching-Feng Chiu, Yi-Wen Chang, Kuang-Tai Kuo, Yu-Shiuan Shen, Chien-Ying Liu, Yang-Hao Yu, Ching-Chia Cheng, Kang-Yun Lee, Feng-Chi Chen, Min-Kung Hsu, Tsang-Chih Kuo, Jui-Ti Ma, Jen-Liang S. NF-κB-driven suppression of FOXO3a contributes to EGFR mutation-independent gefitinib resistance. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 18. 2016-12-13. PMID:27091996. |
foxo3a, a transcription factor of the forkhead family, triggers apoptosis, but the mechanistic details involved in egfr-tki resistance and cancer stemness remain largely unclear. |
2016-12-13 |
2023-08-13 |
Not clear |
| Mi-Hua Liu, Xiao-Long Lin, Jian Li, Jun He, Tian-Ping Tan, Shao-Jian Wu, Shan Yu, Li Chen, Jun Liu, Wei Tian, Yu-Dan Chen, Hong-Yun Fu, Cong Yuan, Yuan Zhan. Resveratrol induces apoptosis through modulation of the Akt/FoxO3a/Bim pathway in HepG2 cells. Molecular medicine reports. vol 13. issue 2. 2016-10-31. PMID:26709007. |
the present study assessed whether resveratrol-induced apoptosis was mediated via the activation of the forkhead box o3a (foxo3a) transcription factor. |
2016-10-31 |
2023-08-13 |
Not clear |
| Mi-Hua Liu, Xiao-Long Lin, Jian Li, Jun He, Tian-Ping Tan, Shao-Jian Wu, Shan Yu, Li Chen, Jun Liu, Wei Tian, Yu-Dan Chen, Hong-Yun Fu, Cong Yuan, Yuan Zhan. Resveratrol induces apoptosis through modulation of the Akt/FoxO3a/Bim pathway in HepG2 cells. Molecular medicine reports. vol 13. issue 2. 2016-10-31. PMID:26709007. |
the present study demonstrated that resveratrol induced apoptosis in hepg2 cells through activation of the transcription factor foxo3a and increasing the expression of bim protein. |
2016-10-31 |
2023-08-13 |
Not clear |
| Gao-Xiang Zhao, Li-Hui Xu, Hao Pan, Qiu-Ru Lin, Mei-Yun Huang, Ji-Ye Cai, Dong-Yun Ouyang, Xian-Hui H. The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling. Oncotarget. vol 6. issue 36. 2016-10-18. PMID:26517515. |
supporting this, foxo3a knockdown attenuated fasl and bim upregulation and apoptosis induction in gos+vpa-treated cells. |
2016-10-18 |
2023-08-13 |
mouse |
| Gao-Xiang Zhao, Li-Hui Xu, Hao Pan, Qiu-Ru Lin, Mei-Yun Huang, Ji-Ye Cai, Dong-Yun Ouyang, Xian-Hui H. The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling. Oncotarget. vol 6. issue 36. 2016-10-18. PMID:26517515. |
furthermore, blocking proteasome activity by mg132 prevented the downregulation of cyclin a2, dephosphorylation of akt and foxo3a, and induction of apoptosis in cells co-treated with gos and vpa. |
2016-10-18 |
2023-08-13 |
mouse |
| Míriam Tarrado-Castellarnau, Roldán Cortés, Miriam Zanuy, Josep Tarragó-Celada, Ibrahim H Polat, Richard Hill, Teresa W M Fan, Wolfgang Link, Marta Cascant. Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition. Pharmacological research. vol 102. 2016-09-20. PMID:26375988. |
interestingly, sodium selenite, another selenium compound, did not induce any significant effects on foxo3a translocation despite inducing apoptosis. |
2016-09-20 |
2023-08-13 |
human |
| Ya-Qin Hou, Yao Yao, Yong-Li Bao, Zhen-Bo Song, Cheng Yang, Xiu-Li Gao, Wen-Jing Zhang, Lu-Guo Sun, Chun-Lei Yu, Yan-Xin Huang, Guan-Nan Wang, Yu-Xin L. Juglanthraquinone C Induces Intracellular ROS Increase and Apoptosis by Activating the Akt/Foxo Signal Pathway in HCC Cells. Oxidative medicine and cellular longevity. vol 2016. 2016-09-08. PMID:26682007. |
the subsequent results suggested that jc treatment suppressed nuclear localization and increased phosphorylated levels of foxo3a, and the overexpression of foxo3a abrogated jc-induced apoptosis. |
2016-09-08 |
2023-08-13 |
Not clear |
| Ya-Qin Hou, Yao Yao, Yong-Li Bao, Zhen-Bo Song, Cheng Yang, Xiu-Li Gao, Wen-Jing Zhang, Lu-Guo Sun, Chun-Lei Yu, Yan-Xin Huang, Guan-Nan Wang, Yu-Xin L. Juglanthraquinone C Induces Intracellular ROS Increase and Apoptosis by Activating the Akt/Foxo Signal Pathway in HCC Cells. Oxidative medicine and cellular longevity. vol 2016. 2016-09-08. PMID:26682007. |
most importantly, the inactivation of foxo3a induced by jc further led to an increase of intracellular ros levels by suppressing ros scavenging enzymes, and the antioxidant n-acetyl-l-cysteine and catalase successfully decreased jc-induced apoptosis. |
2016-09-08 |
2023-08-13 |
Not clear |
| Victor A Neel, Kristina Todorova, Jun Wang, Eunjeong Kwon, Minjeong Kang, Qingsong Liu, Nathanael Gray, Sam W Lee, Anna Mandinov. Sustained Akt Activity Is Required to Maintain Cell Viability in Seborrheic Keratosis, a Benign Epithelial Tumor. The Journal of investigative dermatology. vol 136. issue 3. 2016-07-11. PMID:26739095. |
akt inhibition suppressed phosphorylation of downstream targets of akt kinase that are critical for cell survival, including mdm2 and foxo3a, and induced apoptosis. |
2016-07-11 |
2023-08-13 |
Not clear |