| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Liu, Jiang Yin, Chengkun Wang, Yixue Gu, Min Deng, Zhimin H. FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells. Anti-cancer drugs. vol 25. issue 8. 2015-05-12. PMID:24814195. |
furthermore, activation of foxo3a induced cell apoptosis irrespective of p53 status, whereas p53 may act as foxo3a downstream molecules involved in cisplatin-induced cell apoptosis. |
2015-05-12 |
2023-08-13 |
human |
| Wei-Guo Ji, Xu-Dong Zhang, Xiang-Dong Sun, Xiang-Qi Wang, Bao-Ping Chang, Ming-Zhi Zhan. miRNA-155 modulates the malignant biological characteristics of NK/T-cell lymphoma cells by targeting FOXO3a gene. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 34. issue 6. 2015-05-04. PMID:25480585. |
it was concluded that reduction in mirna-155 expression can inhibit the proliferation of snk-6 lymphoma cells and promote their apoptosis, which may be associated with regulation of foxo3a gene. |
2015-05-04 |
2023-08-13 |
human |
| Rinat Gabbay-Benziv, E Albert Reece, Fang Wang, Peixin Yan. Birth defects in pregestational diabetes: Defect range, glycemic threshold and pathogenesis. World journal of diabetes. vol 6. issue 3. 2015-04-21. PMID:25897357. |
activation of the apoptosis signal-regulating kinase 1 (ask1)-forkhead transcription factor 3a (foxo3a)-caspase 8 pathway causes apoptosis in the developing neural tube leading to neural tube defects (ntds). |
2015-04-21 |
2023-08-13 |
human |
| Yong-Zhan Zhen, Ya-Jun Lin, Kai-Ji Li, Xiao-Shan Yang, Yu-Fang Zhao, Jie Wei, Jing-Bo Wei, Gang H. Gambogic Acid lysinate induces apoptosis in breast cancer mcf-7 cells by increasing reactive oxygen species. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-04-13. PMID:25866542. |
at knockdown of foxo3a, cell apoptosis induced by gal can be partly blocked. |
2015-04-13 |
2023-08-13 |
human |
| Fulvia Farabegoli, Marzia Govoni, Carmen Ciavarella, Marina Orlandi, Alessio Pap. A RXR ligand 6-OH-11-O-hydroxyphenanthrene with antitumour properties enhances (-)-epigallocatechin-3-gallate activity in three human breast carcinoma cell lines. BioMed research international. vol 2014. 2015-03-30. PMID:25013807. |
furthermore, the transcription factor forkhead box o3 (foxo3a), a protein able to trigger apoptosis through upregulation of genes necessary for cell death, was activated. |
2015-03-30 |
2023-08-13 |
human |
| Shengyi Peng, Siqi Zhao, Feng Yan, Jinbo Cheng, Li Huang, Hong Chen, Qingsong Liu, Xunming Ji, Zengqiang Yua. HDAC2 selectively regulates FOXO3a-mediated gene transcription during oxidative stress-induced neuronal cell death. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 3. 2015-03-24. PMID:25609639. |
forkhead box o3a (foxo3a) is a key transcription factor involved in neuronal apoptosis. |
2015-03-24 |
2023-08-13 |
mouse |
| Shengyi Peng, Siqi Zhao, Feng Yan, Jinbo Cheng, Li Huang, Hong Chen, Qingsong Liu, Xunming Ji, Zengqiang Yua. HDAC2 selectively regulates FOXO3a-mediated gene transcription during oxidative stress-induced neuronal cell death. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 3. 2015-03-24. PMID:25609639. |
in the present study, we show that histone deacetylase 2 (hdac2) forms a physical complex with foxo3a, which plays an important role in foxo3a-dependent gene transcription and oxidative stress-induced mouse cerebellar granule neuron (cgn) apoptosis. |
2015-03-24 |
2023-08-13 |
mouse |
| Xiao-bo Yang, Jing-jing Zhao, Chun-yu Huang, Qi-jing Wang, Ke Pan, Dan-dan Wang, Qiu-zhong Pan, Shan-shan Jiang, Lin Lv, Xiang Gao, Huang-wei Chen, Jia-yin Yao, Min Zhi, Jian-chuan Xi. Decreased expression of the FOXO3a gene is associated with poor prognosis in primary gastric adenocarcinoma patients. PloS one. vol 8. issue 10. 2015-02-24. PMID:24194912. |
foxo3a, a member of the forkhead class 'o' (foxo) transcription factor family, controls a wide spectrum of biological processes, such as dna damage repair, apoptosis, and cell cycle regulation. |
2015-02-24 |
2023-08-12 |
Not clear |
| Simon Taylor, Matthew Lam, Chathyan Pararasa, James Ep Brown, Amtul R Carmichael, Helen R Griffith. Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review. Cancer cell international. vol 15. issue 1. 2015-02-13. PMID:25678856. |
downstream of growth factor receptors, signal transduction proceeds via phosphatidylinositol 3-kinase (pi3k), akt and foxo3a inhibition, the latter being partly responsible for coordinated increases in glycolysis and apoptosis resistance. |
2015-02-13 |
2023-08-13 |
Not clear |
| Joanna Tucka, Haixiang Yu, Kelly Gray, Nichola Figg, Janet Maguire, Brian Lam, Martin Bennett, Trevor Littlewoo. Akt1 regulates vascular smooth muscle cell apoptosis through FoxO3a and Apaf1 and protects against arterial remodeling and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. vol 34. issue 11. 2015-02-09. PMID:25234814. |
akt1 regulates vascular smooth muscle cell apoptosis through foxo3a and apaf1 and protects against arterial remodeling and atherosclerosis. |
2015-02-09 |
2023-08-13 |
human |
| Joanna Tucka, Haixiang Yu, Kelly Gray, Nichola Figg, Janet Maguire, Brian Lam, Martin Bennett, Trevor Littlewoo. Akt1 regulates vascular smooth muscle cell apoptosis through FoxO3a and Apaf1 and protects against arterial remodeling and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. vol 34. issue 11. 2015-02-09. PMID:25234814. |
akt1 protects against vsmc apoptosis largely through inactivating target proteins such as forkhead class o transcription factor 3a (foxo3a), but akt1 signaling is reduced and foxo3a activity is increased in human atherosclerosis. |
2015-02-09 |
2023-08-13 |
human |
| Joanna Tucka, Haixiang Yu, Kelly Gray, Nichola Figg, Janet Maguire, Brian Lam, Martin Bennett, Trevor Littlewoo. Akt1 regulates vascular smooth muscle cell apoptosis through FoxO3a and Apaf1 and protects against arterial remodeling and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. vol 34. issue 11. 2015-02-09. PMID:25234814. |
we therefore sought to determine whether inhibition of vsmc apoptosis via akt1 activation regulates vessel remodeling and atherogenesis and to identify foxo3a target proteins that mediate vsmc apoptosis. |
2015-02-09 |
2023-08-13 |
human |
| Ella Zeldich, Ci-Di Chen, Teresa A Colvin, Erin A Bove-Fenderson, Jennifer Liang, Tracey B Tucker Zhou, David A Harris, Carmela R Abraha. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. The Journal of biological chemistry. vol 289. issue 35. 2015-01-22. PMID:25037225. |
klotho-induced phosphorylation of the pi3k/akt pathway, a pathway important in apoptosis and longevity, was associated with sustained inhibitory phosphorylation of the transcription factor forkhead box o3a (foxo3a) and was essential for the induction of prx-2. |
2015-01-22 |
2023-08-13 |
mouse |
| Jingjing Wu, Qin Tang, Shunyu Zhao, Fang Zheng, Yan Wu, Ge Tang, Swei Sunny Hah. Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin. International journal of oncology. vol 45. issue 1. 2015-01-15. PMID:24806432. |
together, our studies show that curcumin inhibits growth and induces apoptosis of npc cells through erk1/2-mediated increase in the protein expression and interaction of p53 and foxo3a. |
2015-01-15 |
2023-08-13 |
human |
| Keun Suk Yang, Ji Hee Lim, Tae Woo Kim, Min Young Kim, Yaeni Kim, Sungjin Chung, Seok Joon Shin, Beom Soon Choi, Hyung Wook Kim, Yong-Soo Kim, Yoon Sik Chang, Hye Won Kim, Cheol Whee Par. Vascular endothelial growth factor-receptor 1 inhibition aggravates diabetic nephropathy through eNOS signaling pathway in db/db mice. PloS one. vol 9. issue 4. 2015-01-09. PMID:24759928. |
in conclusion, the specific blockade of vegfr1 with gnqwfi caused severe renal injury related to profound suppression of the pi3k-akt, foxo3a and enos-nox pathway, giving rise to the oxidative stress-induced apoptosis of glomerular cells in type 2 diabetic nephropathy. |
2015-01-09 |
2023-08-13 |
mouse |
| Roldán Cortés, Míriam Tarrado-Castellarnau, Daniel Talancón, Concepción López, Wolfgang Link, Daniel Ruiz, Josep Joan Centelles, Josefina Quirante, Marta Cascant. A novel cyclometallated Pt(II)-ferrocene complex induces nuclear FOXO3a localization and apoptosis and synergizes with cisplatin to inhibit lung cancer cell proliferation. Metallomics : integrated biometal science. vol 6. issue 3. 2014-11-04. PMID:24492855. |
a novel cyclometallated pt(ii)-ferrocene complex induces nuclear foxo3a localization and apoptosis and synergizes with cisplatin to inhibit lung cancer cell proliferation. |
2014-11-04 |
2023-08-12 |
Not clear |
| P Dey, A Ström, J-Å Gustafsso. Estrogen receptor β upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer. Oncogene. vol 33. issue 33. 2014-10-14. PMID:24077289. |
estrogen receptor β upregulates foxo3a and causes induction of apoptosis through puma in prostate cancer. |
2014-10-14 |
2023-08-12 |
mouse |
| P Dey, A Ström, J-Å Gustafsso. Estrogen receptor β upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer. Oncogene. vol 33. issue 33. 2014-10-14. PMID:24077289. |
in human prostate cancer cells, we found that erβ causes apoptosis by increasing the expression of pro-apoptotic factor p53-upregulated modulator of apoptosis (puma), independent of p53, but dependent on the forkhead transcription factor class-o family member, foxo3a. |
2014-10-14 |
2023-08-12 |
mouse |
| P Dey, A Ström, J-Å Gustafsso. Estrogen receptor β upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer. Oncogene. vol 33. issue 33. 2014-10-14. PMID:24077289. |
we conclude that erβ induces apoptosis of prostate cancer cells by increasing transcription of foxo3a, leading to an increase of puma and subsequent triggering of apoptosis via the intrinsic pathway involving caspase-9. |
2014-10-14 |
2023-08-12 |
mouse |
| Shenwei Zhang, Yilin Zhao, Ming Xu, Li Yu, Yujie Zhao, Jianghong Chen, Yiqiang Yuan, Qiangsun Zheng, Xiaolin Ni. FoxO3a modulates hypoxia stress induced oxidative stress and apoptosis in cardiac microvascular endothelial cells. PloS one. vol 8. issue 11. 2014-09-23. PMID:24278276. |
foxo3a modulates hypoxia stress induced oxidative stress and apoptosis in cardiac microvascular endothelial cells. |
2014-09-23 |
2023-08-12 |
Not clear |