| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Ca. 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells. Molecular medicine reports. vol 12. issue 4. 2016-06-22. PMID:26151347. |
the aim of the present study was to investigate the molecular mechanism of 8‑bromo‑7‑methoxychrysin (brmc)‑induced apoptosis via the akt/forkhead box o3a (foxo3a) pathway in cisplatin (ddp)‑sensitive and ‑resistant ovarian cancer cells. |
2016-06-22 |
2023-08-13 |
human |
| Lirui Zhang, Xiaofeng Yang, Xu Li, Chen Li, Le Zhao, Yuanyuan Zhou, Huilian Ho. Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a. International journal of molecular medicine. vol 36. issue 4. 2016-06-20. PMID:26310353. |
foxo3a target genes involved in cell cycle progression and apoptosis were also investigated, and combined treatment with butein and cisplatin resulted in the downregulation of cyclin d1 and bcl-2 and the upregulation of p27 and bax. |
2016-06-20 |
2023-08-13 |
mouse |
| Eveline A I F Queiroz, Zuleica B Fortes, Mário A A da Cunha, Aneli M Barbosa, Neelam Khaper, Robert F H Dekke. Antiproliferative and pro-apoptotic effects of three fungal exocellular β-glucans in MCF-7 breast cancer cells is mediated by oxidative stress, AMP-activated protein kinase (AMPK) and the Forkhead transcription factor, FOXO3a. The international journal of biochemistry & cell biology. vol 67. 2016-06-06. PMID:26255117. |
exposure to β-glucans increased apoptosis, necrosis, oxidative stress, mrna expression of p53, p27 and bax; the activity of amp-activated protein-kinase, forkhead transcription factor foxo3a, bax and caspase-3; and decreased the activity of p70s6k in mcf-7 cells. |
2016-06-06 |
2023-08-13 |
Not clear |
| Eveline A I F Queiroz, Zuleica B Fortes, Mário A A da Cunha, Aneli M Barbosa, Neelam Khaper, Robert F H Dekke. Antiproliferative and pro-apoptotic effects of three fungal exocellular β-glucans in MCF-7 breast cancer cells is mediated by oxidative stress, AMP-activated protein kinase (AMPK) and the Forkhead transcription factor, FOXO3a. The international journal of biochemistry & cell biology. vol 67. 2016-06-06. PMID:26255117. |
this study demonstrated for the first time that the apoptosis induced by β-glucans was mediated by amp-activated protein-kinase and forkhead transcription factor, foxo3a. |
2016-06-06 |
2023-08-13 |
Not clear |
| Huanan Wang, Lingling Zhang, Xu Yang, Yipeng Jin, Shimin Pei, Di Zhang, Hong Zhang, Bin Zhou, Yingjie Zhang, Degui Li. PUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancer. Oncotarget. vol 6. issue 16. 2016-05-12. PMID:25965911. |
nvp-bez235 effectively up-regulated puma expression, mainly through inactivation of pi3k/akt and activation of foxo3a, leading to cell apoptosis even in the p53-/- hct-116 cells. |
2016-05-12 |
2023-08-13 |
Not clear |
| Anup Shrestha, Saroj Nepal, Mi Jin Kim, Jae Hoon Chang, Sang-Hyun Kim, Gil-Saeng Jeong, Chul-Ho Jeong, Gyu Hwan Park, Sunghee Jung, Jaecheong Lim, Eunha Cho, Soyoung Lee, Pil-Hoon Par. Critical Role of AMPK/FoxO3A Axis in Globular Adiponectin-Induced Cell Cycle Arrest and Apoptosis in Cancer Cells. Journal of cellular physiology. vol 231. issue 2. 2016-04-22. PMID:26089158. |
transfection with foxo3a sirna inhibited gacrp-induced caspase-3/7 activation and fasl expression, suggesting that foxo3a signaling also plays an important role in gacrp-induced apoptosis of cancer cells. |
2016-04-22 |
2023-08-13 |
human |
| Anup Shrestha, Saroj Nepal, Mi Jin Kim, Jae Hoon Chang, Sang-Hyun Kim, Gil-Saeng Jeong, Chul-Ho Jeong, Gyu Hwan Park, Sunghee Jung, Jaecheong Lim, Eunha Cho, Soyoung Lee, Pil-Hoon Par. Critical Role of AMPK/FoxO3A Axis in Globular Adiponectin-Induced Cell Cycle Arrest and Apoptosis in Cancer Cells. Journal of cellular physiology. vol 231. issue 2. 2016-04-22. PMID:26089158. |
in addition, suppression of ampk also blocked gacrp-induced cell cycle arrest and further attenuated gacrp-induced caspase-3/7 activation, indicating that ampk signaling plays a pivotal role in both gacrp-induced cell cycle arrest and apoptosis via acting as an upstream signaling of foxo3a. |
2016-04-22 |
2023-08-13 |
human |
| Goutam Dey, Rashmi Bharti, Gunaseelan Dhanarajan, Subhasis Das, Kaushik Kumar Dey, B N Prashanth Kumar, Ramkrishna Sen, Mahitosh Manda. Marine lipopeptide Iturin A inhibits Akt mediated GSK3β and FoxO3a signaling and triggers apoptosis in breast cancer. Scientific reports. vol 5. 2016-03-24. PMID:25974307. |
marine lipopeptide iturin a inhibits akt mediated gsk3β and foxo3a signaling and triggers apoptosis in breast cancer. |
2016-03-24 |
2023-08-13 |
human |
| Fang Li, Huan Qu, Heng-Chang Cao, Mei-Hong Li, Chen Chen, Xiao-Fan Chen, Bo Yu, Lin Yu, Le-Min Zheng, Wei Zhan. Both FOXO3a and FOXO1 are involved in the HGF-protective pathway against apoptosis in endothelial cells. Cell biology international. vol 39. issue 10. 2016-03-21. PMID:25952685. |
both foxo3a and foxo1 are involved in the hgf-protective pathway against apoptosis in endothelial cells. |
2016-03-21 |
2023-08-13 |
Not clear |
| Fang Li, Huan Qu, Heng-Chang Cao, Mei-Hong Li, Chen Chen, Xiao-Fan Chen, Bo Yu, Lin Yu, Le-Min Zheng, Wei Zhan. Both FOXO3a and FOXO1 are involved in the HGF-protective pathway against apoptosis in endothelial cells. Cell biology international. vol 39. issue 10. 2016-03-21. PMID:25952685. |
in this study, we aimed to explore whether foxo1 and foxo3a play similar roles in hgf-mediated protection against apoptosis in mature endothelial cells. |
2016-03-21 |
2023-08-13 |
Not clear |
| Xiaoli Zhang, Haiyu Zhang, Qing Gao, Shufang Ji, Lujun Bing, Jing Ha. Sohlh2 inhibits the apoptosis of mouse primordial follicle oocytes via C-kit/PI3K/Akt/Foxo3a signalling pathway. Reproductive biomedicine online. vol 30. issue 5. 2016-02-08. PMID:25773528. |
tdt (terminal deoxynucleotidyl transferase)-mediated dudp nick-end labelling assay was carried out to detect the oocyte apoptosis; immunocytochemical staining and quantitative real time-polymerase chain reaction detected the expression of c-kit and forkhead box o3a (foxo3a); western blot was performed to detect the expression of sohlh2, c-kit, saerine/threonine kinases (akt1) and foxo3a. |
2016-02-08 |
2023-08-13 |
mouse |
| Xiaoli Zhang, Haiyu Zhang, Qing Gao, Shufang Ji, Lujun Bing, Jing Ha. Sohlh2 inhibits the apoptosis of mouse primordial follicle oocytes via C-kit/PI3K/Akt/Foxo3a signalling pathway. Reproductive biomedicine online. vol 30. issue 5. 2016-02-08. PMID:25773528. |
the results showed that sohlh2 inhibited oocyte apoptosis and upregulated c-kit expression; sohlh2 decreased the endonuclear foxo3a via the upregulation of phosphorylated akt1 (p-akt1) and phosphorylated foxo3a (p-foxo3a) but not total akt1 (t-akt1) or total foxo3a (t-foxo3a); sohlh2 increased p-akt1 but not t-akt1; the pi3k (phosphotidylinsitol-3-kinase) inhibitor ly294002 ameliorated the role of sohlh2 on phosphorylation of akt1 and foxo3a. |
2016-02-08 |
2023-08-13 |
mouse |
| Deniz Coskun, Pinar Obakan, Elif Damla Arisan, Ajda Çoker-Gürkan, Narçin Palavan-Ünsa. Epibrassinolide alters PI3K/MAPK signaling axis via activating Foxo3a-induced mitochondria-mediated apoptosis in colon cancer cells. Experimental cell research. vol 338. issue 1. 2015-12-29. PMID:26318418. |
the inactivation of pi3k/akt by ebr treatment led to upregulation of foxo3a, which in turn induced apoptosis in hct 116 and ht-29 cells. |
2015-12-29 |
2023-08-13 |
Not clear |
| Francesca Pellicano, Mary T Scott, G Vignir Helgason, Lisa E M Hopcroft, Elaine K Allan, Mark Aspinall-O'Dea, Mhairi Copland, Andrew Pierce, Brian J P Huntly, Anthony D Whetton, Tessa L Holyoak. The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors. Stem cells (Dayton, Ohio). vol 32. issue 9. 2015-12-08. PMID:24806995. |
while stable expression of an active foxo3a mutant induced a similar level of quiescence to tkis alone, shrna-mediated knockdown of foxo3a drove cml cells into cell cycle and potentiated tki-induced apoptosis. |
2015-12-08 |
2023-08-13 |
mouse |
| Vimal Veeriah, Uttara Saran, Akila Swaminathan, Uma Maheswari Balaguru, Pradeep Thangaraj, Shunmugam Nagarajan, Vinoth Kumar Rajendran, Suvro Chatterje. Cadmium-induced embryopathy: nitric oxide rescues teratogenic effects of cadmium. Toxicological sciences : an official journal of the Society of Toxicology. vol 144. issue 1. 2015-11-30. PMID:25490952. |
cd also caused the down-regulation of foxo1, and up-regulation of foxo3a and caspase 3-mediated apoptosis. |
2015-11-30 |
2023-08-13 |
chicken |
| Jiao Wang, Shu Liu, Yancun Yin, Mingjin Li, Bo Wang, Li Yang, Yangfu Jian. FOXO3-mediated up-regulation of Bim contributes to rhein-induced cancer cell apoptosis. Apoptosis : an international journal on programmed cell death. vol 20. issue 3. 2015-11-16. PMID:25501496. |
knockdown of foxo3a or bim abrogates rhein-induced caspase cleavage and apoptosis. |
2015-11-16 |
2023-08-13 |
Not clear |
| K Ozbilgin, B Kahraman, A Turan, C Atay, S Vatansever, S Inan, T Ozçaki. The expression of Forkhead transcription factors in decidua and placenta in patients with missed abortion. Clinical and experimental obstetrics & gynecology. vol 42. issue 4. 2015-10-30. PMID:26411222. |
foxo3a has a function in decidualization, in placental development, and also in inhibition of apoptosis. |
2015-10-30 |
2023-08-13 |
Not clear |
| Fang Wang, E Albert Reece, Peixin Yan. Advances in revealing the molecular targets downstream of oxidative stress-induced proapoptotic kinase signaling in diabetic embryopathy. American journal of obstetrics and gynecology. vol 213. issue 2. 2015-10-13. PMID:25595581. |
apoptosis signal-regulating kinase 1 (ask1) activated by oxidative stress stimulates nuclear translocation of foxo3a, resulting in the overexpression of tumor necrosis factor receptor 1-associated death domain protein, which, in turn, leads to caspase-8 activation and apoptosis. |
2015-10-13 |
2023-08-13 |
Not clear |
| Fang Wang, E Albert Reece, Peixin Yan. Advances in revealing the molecular targets downstream of oxidative stress-induced proapoptotic kinase signaling in diabetic embryopathy. American journal of obstetrics and gynecology. vol 213. issue 2. 2015-10-13. PMID:25595581. |
these observations indicate that maternal diabetes-induced oxidative stress stimulates the activation of ask1, jnk1/2, foxo3a, tumor necrosis factor receptor 1-associated death domain protein, caspase-8 cleavage, and finally, apoptosis and diabetic embryopathy. |
2015-10-13 |
2023-08-13 |
Not clear |
| Anthony Atal. Re: Estrogen receptor β upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer. The Journal of urology. vol 193. issue 5. 2015-09-30. PMID:25895808. |
re: estrogen receptor β upregulates foxo3a and causes induction of apoptosis through puma in prostate cancer. |
2015-09-30 |
2023-08-13 |
Not clear |