| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shao-Hua Su, Yue-Qing Wang, Yi-Fang Wu, Da-Peng Wang, Qi Lin, Jian Ha. Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 may protect against cognitive impairment in rats of chronic cerebral hypoperfusion via PI3K/AKT signaling. Behavioural brain research. vol 313. 2018-01-25. PMID:27424778. |
moreover, win and urb reversed the decreases in map-2 and synaptophysin expression resulting from cch, and stimulated bdnf and cb1 expression as well as creb, foxo3a, gsk-3β, and bad phosphorylation, confirming that win and urb mediate neuroprotection by preventing neuronal apoptosis and improving cognition via pi3k/akt signaling. |
2018-01-25 |
2023-08-13 |
rat |
| Chih-Chung Feng, Chien-Chung Lin, Yi-Ping Lai, Tung-Sheng Chen, Shibu Marthandam Asokan, Jing-Ying Lin, Kuan-Ho Lin, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huan. Hypoxia suppresses myocardial survival pathway through HIF-1α-IGFBP-3-dependent signaling and enhances cardiomyocyte autophagic and apoptotic effects mainly via FoxO3a-induced BNIP3 expression. Growth factors (Chur, Switzerland). vol 34. issue 3-4. 2018-01-12. PMID:27366871. |
knockdown of foxo3a or bnip3 significantly abrogated hypoxia-induced autophagy and mitochondria-dependent apoptosis. |
2018-01-12 |
2023-08-13 |
rat |
| Mark Borris D Aldonza, Ji-Young Hong, Sang Kook Le. Paclitaxel-resistant cancer cell-derived secretomes elicit ABCB1-associated docetaxel cross-resistance and escape from apoptosis through FOXO3a-driven glycolytic regulation. Experimental & molecular medicine. vol 49. issue 1. 2018-01-12. PMID:28104912. |
further study revealed that the deletion of foxo3a transcription exacerbates glycolytic shift-induced apoptosis by rescuing trail expression. |
2018-01-12 |
2023-08-13 |
Not clear |
| Mark Borris D Aldonza, Ji-Young Hong, Sang Kook Le. Paclitaxel-resistant cancer cell-derived secretomes elicit ABCB1-associated docetaxel cross-resistance and escape from apoptosis through FOXO3a-driven glycolytic regulation. Experimental & molecular medicine. vol 49. issue 1. 2018-01-12. PMID:28104912. |
therefore, the therapeutic inhibition of foxo3a might direct glycolysis to induce apoptosis and overcome multidrug resistance in cancer cells. |
2018-01-12 |
2023-08-13 |
Not clear |
| Luyu Zhou, Ruibei Li, Cuiyun Liu, Teng Sun, Lynn Htet Htet Aung, Chao Chen, Jinning Gao, Yanfang Zhao, Kun Wan. Foxo3a inhibits mitochondrial fission and protects against doxorubicin-induced cardiotoxicity by suppressing MIEF2. Free radical biology & medicine. vol 104. 2017-12-14. PMID:28137654. |
foxo3a attenuates dox-induced mitochondrial fission and apoptosis in cardiomyocytes. |
2017-12-14 |
2023-08-13 |
mouse |
| Luyu Zhou, Ruibei Li, Cuiyun Liu, Teng Sun, Lynn Htet Htet Aung, Chao Chen, Jinning Gao, Yanfang Zhao, Kun Wan. Foxo3a inhibits mitochondrial fission and protects against doxorubicin-induced cardiotoxicity by suppressing MIEF2. Free radical biology & medicine. vol 104. 2017-12-14. PMID:28137654. |
cardiac specific foxo3a transgenic mice show reduced mitochondrial fission, apoptosis and cardiotoxicity upon dox administration. |
2017-12-14 |
2023-08-13 |
mouse |
| Ting Xie, Jiurong Liang, Yan Geng, Ningshan Liu, Adrianne Kurkciyan, Vrishika Kulur, Dong Leng, Nan Deng, Zhenqiu Liu, Jianbo Song, Peter Chen, Paul W Noble, Dianhua Jian. MicroRNA-29c Prevents Pulmonary Fibrosis by Regulating Epithelial Cell Renewal and Apoptosis. American journal of respiratory cell and molecular biology. vol 57. issue 6. 2017-12-06. PMID:28799781. |
mir-29c protects epithelial cells from apoptosis by targeting forkhead box o3a (foxo3a). |
2017-12-06 |
2023-08-13 |
mouse |
| Ava Safaroghli-Azar, Davood Bashash, Parisa Sadreazami, Majid Momeny, Seyed H Ghaffar. PI3K-δ inhibition using CAL-101 exerts apoptotic effects and increases doxorubicin-induced cell death in pre-B-acute lymphoblastic leukemia cells. Anti-cancer drugs. vol 28. issue 4. 2017-11-16. PMID:28125433. |
cal-101 also leads to induction of caspase-dependent apoptosis probably through reactive oxygen species-dependent upregulation of foxo3a and subsequent induction of the proapoptotic target genes of p53. |
2017-11-16 |
2023-08-13 |
Not clear |
| Yimeng Li, Ao Li, Jingfang Wu, Yingzi He, Huiqian Yu, Renjie Chai, Huawei L. MiR-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a. Cell death & disease. vol 7. issue 9. 2017-10-25. PMID:27607577. |
mir-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting foxo3a. |
2017-10-25 |
2023-08-13 |
Not clear |
| Gabriella Mamede Andrade, Juliano Coelho da Silveira, Claudia Perrini, Maite Del Collado, Samuel Gebremedhn, Dawit Tesfaye, Flávio Vieira Meirelles, Felipe Pereci. The role of the PI3K-Akt signaling pathway in the developmental competence of bovine oocytes. PloS one. vol 12. issue 9. 2017-10-13. PMID:28922408. |
using pi3k-akt responsive genes, we showed decreased foxo3a levels and bax levels in lower quality groups, indicating changes in cell cycle progression, oxidative response and apoptosis. |
2017-10-13 |
2023-08-13 |
cattle |
| Vikas Singh, Praveen Prakhar, R S Rajmani, Kasturi Mahadik, Salik Miskat Borbora, Kithiganahalli Narayanaswamy Balaj. Histone Methyltransferase SET8 Epigenetically Reprograms Host Immune Responses to Assist Mycobacterial Survival. The Journal of infectious diseases. vol 216. issue 4. 2017-09-28. PMID:28931237. |
set8, along with foxo3a, mediates an active nqo1-pgc1-α complex, which promotes the anti-inflammatory m2 macrophage phenotype, and assists trxr1-regulated arrest of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. |
2017-09-28 |
2023-08-13 |
mouse |
| Wei Qiang, Fang Sui, Jingjing Ma, Xinru Li, Xiaojuan Ren, Yuan Shao, Jiazhe Liu, Haixia Guan, Bingyin Shi, Peng Ho. Proteasome inhibitor MG132 induces thyroid cancer cell apoptosis by modulating the activity of transcription factor FOXO3a. Endocrine. vol 56. issue 1. 2017-09-26. PMID:28220348. |
proteasome inhibitor mg132 induces thyroid cancer cell apoptosis by modulating the activity of transcription factor foxo3a. |
2017-09-26 |
2023-08-13 |
Not clear |
| Jong Cheon Joo, Jung Hoo Hwang, Eunbi Jo, Young-Rang Kim, Dae Joon Kim, Kyung-Bok Lee, Soo Jung Park, Ik-Soon Jan. Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma. Oncotarget. vol 8. issue 7. 2017-08-11. PMID:28099944. |
cordycepin induces apoptosis by caveolin-1-mediated jnk regulation of foxo3a in human lung adenocarcinoma. |
2017-08-11 |
2023-08-13 |
mouse |
| Jong Cheon Joo, Jung Hoo Hwang, Eunbi Jo, Young-Rang Kim, Dae Joon Kim, Kyung-Bok Lee, Soo Jung Park, Ik-Soon Jan. Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma. Oncotarget. vol 8. issue 7. 2017-08-11. PMID:28099944. |
foxo3a sirna downregulated bax protein and attenuated a549 apoptosis, indicating that the cav1-mediated jnk/foxo3a pathway induces the apoptosis of a549 lung cancer cells. |
2017-08-11 |
2023-08-13 |
mouse |
| De-Yuan Li, Jin-Lin Wu, Li-Li Luo, Li-Na Qiao, Zhong-Qiang Liu, Guo-Yan Lu, Yang Wan. [Role of c-Jun N-terminal kinase-mediated FOXO3a nuclear translocation in neuronal apoptosis in neonatal rats with hypoxic-ischemic brain damage]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 19. issue 4. 2017-08-01. PMID:28407836. |
[role of c-jun n-terminal kinase-mediated foxo3a nuclear translocation in neuronal apoptosis in neonatal rats with hypoxic-ischemic brain damage]. |
2017-08-01 |
2023-08-13 |
rat |
| J S Ahn, J Li, E Chen, D G Kent, H J Park, A R Gree. JAK2V617F mediates resistance to DNA damage-induced apoptosis by modulating FOXO3A localization and Bcl-xL deamidation. Oncogene. vol 35. issue 17. 2017-06-23. PMID:26234675. |
jak2v617f mediates resistance to dna damage-induced apoptosis by modulating foxo3a localization and bcl-xl deamidation. |
2017-06-23 |
2023-08-13 |
Not clear |
| Ming Bai, Mingzi Zhang, Fei Long, Nanze Yu, Ang Zeng, Ru Zha. Circulating microRNA-194 regulates human melanoma cells via PI3K/AKT/FoxO3a and p53/p21 signaling pathway. Oncology reports. vol 37. issue 5. 2017-06-22. PMID:28358423. |
pi3k inhibitor, suppressed pi3k, phosphorylation-akt, foxo3a protein expression and increased the effects of microrna-194 overexpression on cell growth, apoptosis, caspase-3/-9 activities and bax/bcl-2 protein expression of human melanoma cells through the induction of p53/p21 signaling pathway. |
2017-06-22 |
2023-08-13 |
human |
| Ni Zeng, Yuetao Zhou, Shaqiu Zhang, Yogesh Singh, Bing Shi, Madhuri S Salker, Florian Lan. 1α,25(OH) 2D3 Sensitive Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Ishikawa Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 41. issue 2. 2017-06-06. PMID:28222424. |
as cytosolic ph impacts on apoptosis, the study further explored the effect of 1,25(oh)2d3 on apoptosis and on the apoptosis regulating kinase akt, transcription factor forkhead box o-3 (foxo3a) and b-cell lymphoma protein bcl-2. |
2017-06-06 |
2023-08-13 |
human |
| Cagri Bodur, Bahriye Karakas, Ahmet Can Timucin, Tugsan Tezil, Huveyda Basag. AMP-activated protein kinase couples 3-bromopyruvate-induced energy depletion to apoptosis via activation of FoxO3a and upregulation of proapoptotic Bcl-2 proteins. Molecular carcinogenesis. vol 55. issue 11. 2017-05-17. PMID:26373689. |
amp-activated protein kinase couples 3-bromopyruvate-induced energy depletion to apoptosis via activation of foxo3a and upregulation of proapoptotic bcl-2 proteins. |
2017-05-17 |
2023-08-13 |
Not clear |
| T K Li, K Yin, Z Chen, Y Bao, S X Zhan. MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5. Genetics and molecular research : GMR. vol 16. issue 1. 2017-04-12. PMID:28290615. |
ras association domain family member 5 (rassf5), a member of the ras association domain family, induces cell apoptosis by phosphorylating foxo3a, which triggers target gene bim (pro-apoptotic factor) activation. |
2017-04-12 |
2023-08-13 |
Not clear |