| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Gong, Xiaozheng Cao, Jianguo Cao, Xiaohong Yang, Wenbin Zen. Casticin suppresses the carcinogenesis of small cell lung cancer H446 cells through activation of AMPK/FoxO3a signaling. Oncology reports. vol 40. issue 3. 2018-11-06. PMID:30015975. |
casticin, a natural polymethoxyflavone isolated from a. annua, v. trifolia, and v. agnus‑castus induces apoptosis in cancer cells by activating foxo3a. |
2018-11-06 |
2023-08-13 |
Not clear |
| Xuan-Yan Shi, Wei Ding, Tie-Qiu Li, Yi-Xiong Zhang, Shan-Chao Zha. Histone Deacetylase (HDAC) Inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), Induces Apoptosis in Prostate Cancer Cell Lines via the Akt/FOXO3a Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-08-06. PMID:29211704. |
western blotting, the sirna assay, and qpcr showed that foxo3a, the bcl-2 family of proteins, survivin, and fasl were involved in saha-induced apoptosis in prostate cancer cells grown in vitro. |
2018-08-06 |
2023-08-13 |
human |
| Wen Zeng, Hanjun Dai, Ming Yan, Xiaojun Cai, Hong Luo, Min Ke, Zeming Li. Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation. Journal of immunology research. vol 2017. 2018-06-21. PMID:29124072. |
furthermore, we show that this foxo3a activation is responsible for the dac-induced differentiation of skm-1 cells into monocytes, as well as for skm-1 cell cycle arrest, apoptosis, and autophagy. |
2018-06-21 |
2023-08-13 |
human |
| Qi Xiao, Qifa Ye, Wei Wang, Jiansheng Xiao, Biqi Fu, Zhiping Xia, Xingjian Zhang, Zhongzhong Liu, Xianpeng Zen. Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway. Molecular medicine reports. vol 16. issue 5. 2018-06-06. PMID:28944825. |
forkhead box o3 (foxo3a) has been defined as a critical mediator in cellular processes, including oxidative stress, apoptosis, inflammation, cell death and dna repair; however, the protection function in mild hypothermia has not been reported previously. |
2018-06-06 |
2023-08-13 |
Not clear |
| Ping Chen, Shina Xu, Jinlong Q. Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway. Journal of cellular biochemistry. vol 119. issue 1. 2018-05-29. PMID:28585698. |
transfection with foxo3a sirna inhibited the lycopene-induced increase in cell apoptosis, bax and cleaved parp expression. |
2018-05-29 |
2023-08-13 |
mouse |
| Brent E Fitzwalter, Christina G Towers, Kelly D Sullivan, Zdenek Andrysik, Maria Hoh, Michael Ludwig, Jim O'Prey, Kevin M Ryan, Joaquin M Espinosa, Michael J Morgan, Andrew Thorbur. Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover. Developmental cell. vol 44. issue 5. 2018-05-29. PMID:29533771. |
autophagy inhibition mediates apoptosis sensitization in cancer therapy by relieving foxo3a turnover. |
2018-05-29 |
2023-08-13 |
Not clear |
| Brent E Fitzwalter, Christina G Towers, Kelly D Sullivan, Zdenek Andrysik, Maria Hoh, Michael Ludwig, Jim O'Prey, Kevin M Ryan, Joaquin M Espinosa, Michael J Morgan, Andrew Thorbur. Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover. Developmental cell. vol 44. issue 5. 2018-05-29. PMID:29533771. |
increased foxo3a upon autophagy inhibition stimulates transcription of the pro-apoptotic bbc3/puma gene to cause apoptosis sensitization. |
2018-05-29 |
2023-08-13 |
Not clear |
| Patrice Codogno, Etienne More. FOXO3a Provides a Quickstep from Autophagy Inhibition to Apoptosis in Cancer Therapy. Developmental cell. vol 44. issue 5. 2018-05-21. PMID:29533768. |
foxo3a provides a quickstep from autophagy inhibition to apoptosis in cancer therapy. |
2018-05-21 |
2023-08-13 |
Not clear |
| Patrice Codogno, Etienne More. FOXO3a Provides a Quickstep from Autophagy Inhibition to Apoptosis in Cancer Therapy. Developmental cell. vol 44. issue 5. 2018-05-21. PMID:29533768. |
foxo3a, a member of the forkhead transcription factor family, has roles in apoptosis and autophagy. |
2018-05-21 |
2023-08-13 |
Not clear |
| Patrice Codogno, Etienne More. FOXO3a Provides a Quickstep from Autophagy Inhibition to Apoptosis in Cancer Therapy. Developmental cell. vol 44. issue 5. 2018-05-21. PMID:29533768. |
(2018) describe how the blockade of foxo3a turnover, which normally occurs through autophagy, sensitizes cancer cells to apoptosis through foxo3a-mediated stimulation of pro-apoptotic puma/bbc3 expression. |
2018-05-21 |
2023-08-13 |
Not clear |
| Shuangyue Liu, Xiao Zhang, Meiling Sun, Tao Xu, Aimei Wan. FoxO3a plays a key role in the protective effects of pomegranate peel extract against amikacin-induced ototoxicity. International journal of molecular medicine. vol 40. issue 1. 2018-03-16. PMID:28560451. |
taken together, our experimental findings suggest that phosphorylated foxo3a mediates amk-induced apoptosis in balb/c mice cochlea. |
2018-03-16 |
2023-08-13 |
mouse |
| Zhiwen Zeng, Xue Wang, Sanjeev K Bhardwaj, Xuanhe Zhou, Peter J Little, Remi Quirion, Lalit K Srivastava, Wenhua Zhen. The Atypical Antipsychotic Agent, Clozapine, Protects Against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/FoxO3a Signaling Pathway. Molecular neurobiology. vol 54. issue 5. 2018-03-09. PMID:27173157. |
our results showed that corticosterone decreases the phosphorylation of akt and foxo3a, leading to the nuclear localization of foxo3a and the apoptosis of pc12 cells, while clozapine concentration dependently protected pc12 cells against corticosterone insult. |
2018-03-09 |
2023-08-13 |
Not clear |
| Yan Wang, Yu Mu, Xiaorui Zhou, Huaixue Ji, Xing Gao, Wen Wen Cai, Qiuhua Guan, Tie X. SIRT2-mediated FOXO3a deacetylation drives its nuclear translocation triggering FasL-induced cell apoptosis during renal ischemia reperfusion. Apoptosis : an international journal on programmed cell death. vol 22. issue 4. 2018-03-06. PMID:28078537. |
sirt2-mediated foxo3a deacetylation drives its nuclear translocation triggering fasl-induced cell apoptosis during renal ischemia reperfusion. |
2018-03-06 |
2023-08-13 |
Not clear |
| Yan Wang, Yu Mu, Xiaorui Zhou, Huaixue Ji, Xing Gao, Wen Wen Cai, Qiuhua Guan, Tie X. SIRT2-mediated FOXO3a deacetylation drives its nuclear translocation triggering FasL-induced cell apoptosis during renal ischemia reperfusion. Apoptosis : an international journal on programmed cell death. vol 22. issue 4. 2018-03-06. PMID:28078537. |
results demonstrated that when sirt2 was activated by renal ischemia/reperfusion, activated sirt2 could bind to and deacetylate foxo3a, promoting foxo3a nuclear translocation which resulted in an increase of nuclear foxo3a along with fasl expression and activation of caspase8 and caspase3, triggering cell apoptosis during renal ischemia/reperfusion. |
2018-03-06 |
2023-08-13 |
Not clear |
| Long Cheng, Yuan-Yuan Liu, Pei-Hua Lu, Yi Peng, Qiang Yuan, Xin-Shi Gu, Yong Jin, Min-Bin Chen, Xu-Ming Ba. Identification of DNA-PKcs as a primary resistance factor of TIC10 in hepatocellular carcinoma cells. Oncotarget. vol 8. issue 17. 2018-03-05. PMID:28415690. |
dna-pkcs inhibition, knockdown or mutation facilitated tic10-induced foxo3a nuclear translocation, trail/dr5 expression and cell apoptosis. |
2018-03-05 |
2023-08-13 |
mouse |
| Lucía Pronsato, Lorena Milanesi, Andrea Vasconsuelo, Anabela La Coll. Testosterone modulates FoxO3a and p53-related genes to protect C2C12 skeletal muscle cells against apoptosis. Steroids. vol 124. 2018-02-28. PMID:28554727. |
testosterone modulates foxo3a and p53-related genes to protect c2c12 skeletal muscle cells against apoptosis. |
2018-02-28 |
2023-08-13 |
Not clear |
| Yongbiao Chen, Lizhi Lv, Huifeng Pi, Weijia Qin, Jianwei Chen, Dengfang Guo, Jianyu Lin, Xiaobing Chi, Zhelong Jiang, Hejun Yang, Yi Jian. Dihydromyricetin protects against liver ischemia/reperfusion induced apoptosis via activation of FOXO3a-mediated autophagy. Oncotarget. vol 7. issue 47. 2018-02-26. PMID:27793014. |
in summary, these findings identify dhm as a novel hepatoprotective small molecule by elevating foxo3a expression and nuclear translocation, stimulating autophagy-related genes and suppressing liver i/r-induced apoptosis, suggesting foxo3a may have therapeutic value in liver cell protection in liver i/r injury. |
2018-02-26 |
2023-08-13 |
mouse |
| Dan Wu, Mulin Liang, Hongxing Dang, Fang Fang, Feng Xu, Chengjun Li. Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway. Biochemical and biophysical research communications. vol 495. issue 2. 2018-02-20. PMID:29198702. |
hyperoxic conditions increased levels of bim, bax, and foxo3a, which induced proliferation restriction and apoptosis of aeciis. |
2018-02-20 |
2023-08-13 |
Not clear |
| Deyuan Li, Lili Luo, Min Xu, Jinlin Wu, Lina Chen, Jinhui Li, Zhongqiang Liu, Guoyan Lu, Yang Wang, Lina Qia. AMPK activates FOXO3a and promotes neuronal apoptosis in the developing rat brain during the early phase after hypoxia-ischemia. Brain research bulletin. vol 132. 2018-02-09. PMID:28499802. |
ampk activates foxo3a and promotes neuronal apoptosis in the developing rat brain during the early phase after hypoxia-ischemia. |
2018-02-09 |
2023-08-13 |
rat |
| Deyuan Li, Lili Luo, Min Xu, Jinlin Wu, Lina Chen, Jinhui Li, Zhongqiang Liu, Guoyan Lu, Yang Wang, Lina Qia. AMPK activates FOXO3a and promotes neuronal apoptosis in the developing rat brain during the early phase after hypoxia-ischemia. Brain research bulletin. vol 132. 2018-02-09. PMID:28499802. |
forkhead transcriptional factor (foxo3a) has been revealed to be a critical effector of ampk-mediated celluar apoptosis. |
2018-02-09 |
2023-08-13 |
rat |