| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shenwei Zhang, Yilin Zhao, Ming Xu, Li Yu, Yujie Zhao, Jianghong Chen, Yiqiang Yuan, Qiangsun Zheng, Xiaolin Ni. FoxO3a modulates hypoxia stress induced oxidative stress and apoptosis in cardiac microvascular endothelial cells. PloS one. vol 8. issue 11. 2014-09-23. PMID:24278276. |
exposure to low oxygen tension stimulated ros accumulation and increased apoptosis in cmecs within 6-24 h. hypoxia also significantly increased the expressions of hif-1α and foxo3a. |
2014-09-23 |
2023-08-12 |
Not clear |
| Shenwei Zhang, Yilin Zhao, Ming Xu, Li Yu, Yujie Zhao, Jianghong Chen, Yiqiang Yuan, Qiangsun Zheng, Xiaolin Ni. FoxO3a modulates hypoxia stress induced oxidative stress and apoptosis in cardiac microvascular endothelial cells. PloS one. vol 8. issue 11. 2014-09-23. PMID:24278276. |
furthermore, hypoxia-induced ros formation and apoptosis in cmecs were correlated with the disturbance of bcl-2 family proteins, which were abolished by foxo3a silencing with sirna. |
2014-09-23 |
2023-08-12 |
Not clear |
| Shenwei Zhang, Yilin Zhao, Ming Xu, Li Yu, Yujie Zhao, Jianghong Chen, Yiqiang Yuan, Qiangsun Zheng, Xiaolin Ni. FoxO3a modulates hypoxia stress induced oxidative stress and apoptosis in cardiac microvascular endothelial cells. PloS one. vol 8. issue 11. 2014-09-23. PMID:24278276. |
in conclusion, our data provide evidence that foxo3a leads to ros accumulation in cmecs, and in parallel, induces the disturbance of bcl-2 family proteins which results in apoptosis. |
2014-09-23 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Polla Herger. FoxO3a and disease progression. World journal of biological chemistry. vol 5. issue 3. 2014-09-16. PMID:25225602. |
although each foxo family member has its own role, unlike the other foxo families, foxo3a has been extensively studied because of its rather unique and pivotal regulation of cell proliferation, apoptosis, metabolism, stress management and longevity. |
2014-09-16 |
2023-08-13 |
Not clear |
| Jian-Gang Wang, Xing-Xing Zheng, Guang-Yao Zeng, Ying-Jun Zhou, Hong Yua. Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma. Oncology reports. vol 31. issue 1. 2014-09-05. PMID:24247909. |
purified vitexin compound 1 induces apoptosis through activation of foxo3a in hepatocellular carcinoma. |
2014-09-05 |
2023-08-12 |
human |
| Jian-Gang Wang, Xing-Xing Zheng, Guang-Yao Zeng, Ying-Jun Zhou, Hong Yua. Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma. Oncology reports. vol 31. issue 1. 2014-09-05. PMID:24247909. |
in the present study, we examined the molecular mechanisms by which activation of the foxo3a transcription factor mediated vb1-induced apoptosis in hepatocellular carcinoma (hcc) cells. |
2014-09-05 |
2023-08-12 |
human |
| Jian-Gang Wang, Xing-Xing Zheng, Guang-Yao Zeng, Ying-Jun Zhou, Hong Yua. Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma. Oncology reports. vol 31. issue 1. 2014-09-05. PMID:24247909. |
knockdown of akt1 by small interfering rna (sirna) and the mek1/2 inhibitor, pd98059, enhanced vb1-induced apoptosis and foxo3a transcriptional activity. |
2014-09-05 |
2023-08-12 |
human |
| Jian-Gang Wang, Xing-Xing Zheng, Guang-Yao Zeng, Ying-Jun Zhou, Hong Yua. Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma. Oncology reports. vol 31. issue 1. 2014-09-05. PMID:24247909. |
suppression of foxo3a expression by sirna inhibited vb1-induced apoptosis. |
2014-09-05 |
2023-08-12 |
human |
| Kyoung-Jae Won, Bo Kyung Kim, Gyoonhee Han, Kyeong Lee, Young-Jin Jung, Hwan-Mook Kim, Kyung Bin Song, Kyung-Sook Chung, Misun Wo. NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24085402. |
nsc126188 induces apoptosis of prostate cancer pc-3 cells through inhibition of akt membrane translocation, foxo3a activation, and rhob transcription. |
2014-09-02 |
2023-08-12 |
Not clear |
| Kyoung-Jae Won, Bo Kyung Kim, Gyoonhee Han, Kyeong Lee, Young-Jin Jung, Hwan-Mook Kim, Kyung Bin Song, Kyung-Sook Chung, Misun Wo. NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24085402. |
pc-3 cells transiently overexpressing foxo3a exhibited increased rhob expression and apoptosis in response to nsc126188. |
2014-09-02 |
2023-08-12 |
Not clear |
| Kyoung-Jae Won, Bo Kyung Kim, Gyoonhee Han, Kyeong Lee, Young-Jin Jung, Hwan-Mook Kim, Kyung Bin Song, Kyung-Sook Chung, Misun Wo. NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24085402. |
taken together, nsc126188 induces apoptosis of pc-3 cells by interfering with membrane recruitment of akt, resulting in akt dephosphorylation and foxo3a activation, which leads to transcription of rhob. |
2014-09-02 |
2023-08-12 |
Not clear |
| Lei Liu, Anirudh Arun, Lakia Ellis, Carina Peritore, Gizem Donme. SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway. Frontiers in aging neuroscience. vol 6. 2014-08-26. PMID:25157229. |
we show here that sirt2 deacetylates foxo3a, increases rna and protein levels of bim, and as a result enhances apoptosis in the mptp model of pd. |
2014-08-26 |
2023-08-13 |
mouse |
| Lei Liu, Anirudh Arun, Lakia Ellis, Carina Peritore, Gizem Donme. SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway. Frontiers in aging neuroscience. vol 6. 2014-08-26. PMID:25157229. |
deletion of sirt2 leads to the reduction of apoptosis due to an increase in acetylation of foxo3a and a decrease in bim levels. |
2014-08-26 |
2023-08-13 |
mouse |
| Lei Liu, Anirudh Arun, Lakia Ellis, Carina Peritore, Gizem Donme. SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway. Frontiers in aging neuroscience. vol 6. 2014-08-26. PMID:25157229. |
we demonstrate that sirt2 deacetylates foxo3a, activates bim, and induces apoptosis only in mpp(+)-treated cells. |
2014-08-26 |
2023-08-13 |
mouse |
| Chaoming Peng, Junli Ma, Xue Gao, Peng Tian, Wenzhang Li, Lei Zhan. High glucose induced oxidative stress and apoptosis in cardiac microvascular endothelial cells are regulated by FoxO3a. PloS one. vol 8. issue 11. 2014-07-07. PMID:24260294. |
high glucose induced oxidative stress and apoptosis in cardiac microvascular endothelial cells are regulated by foxo3a. |
2014-07-07 |
2023-08-12 |
Not clear |
| Rumana Akhter, Priyankar Sanphui, Subhas Chandra Biswa. The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death. The Journal of biological chemistry. vol 289. issue 15. 2014-06-20. PMID:24567336. |
the essential role of p53-up-regulated modulator of apoptosis (puma) and its regulation by foxo3a transcription factor in β-amyloid-induced neuron death. |
2014-06-20 |
2023-08-12 |
Not clear |
| Hao Liu, Bin-Hua Zhou, Xu Qiu, Hong-Sheng Wang, Fan Zhang, Rui Fang, Xian-Feng Wang, Shao-Hui Cai, Jun Du, Xian-Zhang B. T63, a new 4-arylidene curcumin analogue, induces cell cycle arrest and apoptosis through activation of the reactive oxygen species-FOXO3a pathway in lung cancer cells. Free radical biology & medicine. vol 53. issue 12. 2014-06-17. PMID:23085518. |
moreover, the antioxidant n-acetylcysteine markedly blocked the above effects, and small interfering rna-mediated knockdown of foxo3a also significantly decreased t63-induced cell cycle arrest and apoptosis. |
2014-06-17 |
2023-08-12 |
human |
| Guangfei Xu, Jiao Liu, Katsuhiko Yoshimoto, Gang Chen, Takeo Iwata, Noriko Mizusawa, Zhiqing Duan, Chunhua Wan, Junkang Jian. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces expression of p27(kip¹) and FoxO3a in female rat cerebral cortex and PC12 cells. Toxicology letters. vol 226. issue 3. 2014-06-11. PMID:24594276. |
in this study, we constructed an acute tcdd injury female rat model, and investigated the effects of tcdd on apoptosis and expression of cell cycle regulators, forkhead box class o 3a (foxo3a) and p27(kip1), in the central nervous system (cns). |
2014-06-11 |
2023-08-12 |
rat |
| Guangfei Xu, Jiao Liu, Katsuhiko Yoshimoto, Gang Chen, Takeo Iwata, Noriko Mizusawa, Zhiqing Duan, Chunhua Wan, Junkang Jian. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces expression of p27(kip¹) and FoxO3a in female rat cerebral cortex and PC12 cells. Toxicology letters. vol 226. issue 3. 2014-06-11. PMID:24594276. |
in vitro experiments using pc12, a rat neuron-like pheochromocytoma cell line, also revealed that tcdd induced apoptosis and an increase in foxo3a and p27(kip1) expression. |
2014-06-11 |
2023-08-12 |
rat |
| Guangfei Xu, Jiao Liu, Katsuhiko Yoshimoto, Gang Chen, Takeo Iwata, Noriko Mizusawa, Zhiqing Duan, Chunhua Wan, Junkang Jian. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces expression of p27(kip¹) and FoxO3a in female rat cerebral cortex and PC12 cells. Toxicology letters. vol 226. issue 3. 2014-06-11. PMID:24594276. |
furthermore, knockdown of foxo3a expression inhibited p27(kip1) transcription and tcdd-induced apoptosis. |
2014-06-11 |
2023-08-12 |
rat |