| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weiguo Bao, Feng Pan, Ling Chen, Guohai Su, Xiaoyuan Gao, Ying Li, Qiang Sun, Jinhui Sun, Kun He, Hui Son. The PI3K/AKT Pathway and FOXO3a Transcription Factor Mediate High Glucose-Induced Apoptosis in Neonatal Rat Ventricular Myocytes. Iranian Red Crescent medical journal. vol 16. issue 4. 2014-06-09. PMID:24910802. |
the pi3k/akt pathway and foxo3a transcription factor mediate high glucose-induced apoptosis in neonatal rat ventricular myocytes. |
2014-06-09 |
2023-08-13 |
rat |
| Weiguo Bao, Feng Pan, Ling Chen, Guohai Su, Xiaoyuan Gao, Ying Li, Qiang Sun, Jinhui Sun, Kun He, Hui Son. The PI3K/AKT Pathway and FOXO3a Transcription Factor Mediate High Glucose-Induced Apoptosis in Neonatal Rat Ventricular Myocytes. Iranian Red Crescent medical journal. vol 16. issue 4. 2014-06-09. PMID:24910802. |
the roles of pi3k/akt pathway and foxo3a in mediating high glucose-induced apoptosis in cardiomyocytes remain unclear. |
2014-06-09 |
2023-08-13 |
rat |
| Azusa Tanaka-Nakanishi, Jun-ichirou Yasunaga, Ken Takai, Masao Matsuok. HTLV-1 bZIP factor suppresses apoptosis by attenuating the function of FoxO3a and altering its localization. Cancer research. vol 74. issue 1. 2014-05-27. PMID:24177179. |
htlv-1 bzip factor suppresses apoptosis by attenuating the function of foxo3a and altering its localization. |
2014-05-27 |
2023-08-12 |
human |
| Azusa Tanaka-Nakanishi, Jun-ichirou Yasunaga, Ken Takai, Masao Matsuok. HTLV-1 bZIP factor suppresses apoptosis by attenuating the function of FoxO3a and altering its localization. Cancer research. vol 74. issue 1. 2014-05-27. PMID:24177179. |
collectively, our results indicated that hbz impairs transcription of the bim and fasl genes by disrupting foxo3a function, broadening understanding of how hbz acts to promote proliferation of htlv-1-infected t cells by blocking their apoptosis. |
2014-05-27 |
2023-08-12 |
human |
| Monika Z Kaczmarek, Ryan J Holland, Stephen A Lavanier, Jami A Troxler, Valentyna I Fesenkova, Charlotte A Hanson, Joan L Cmarik, Joseph E Saavedra, Larry K Keefer, Sandra K Ruscett. Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells. Leukemia research. vol 38. issue 3. 2014-04-21. PMID:24461365. |
this correlates with the activation of the tumor suppressor foxo3a and increased expression of various caspases, leading to apoptosis. |
2014-04-21 |
2023-08-12 |
Not clear |
| Peixin Yang, Xuezheng Li, Cheng Xu, Richard L Eckert, E Albert Reece, Horst Ronald Zielke, Fang Wan. Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects. Science signaling. vol 6. issue 290. 2014-04-03. PMID:23982205. |
hyperglycemia-induced apoptosis and the development of neural tube defects were reduced with genetic ablation of either foxo3a or casp8 or inhibition of ask1 by thioredoxin. |
2014-04-03 |
2023-08-12 |
human |
| Wen Yu, Zan Wan, Xue-Feng Qiu, Yun Chen, Yu-Tian Da. Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats. Asian journal of andrology. vol 15. issue 5. 2014-03-25. PMID:23792339. |
in contrast, resveratrol downregulated the expression of p53 and foxo3a, which regulate apoptosis and oxidative stress. |
2014-03-25 |
2023-08-12 |
rat |
| Aldo Germani, Antonio Matrone, Valentina Grossi, Alessia Peserico, Paola Sanese, Micaela Liuzzi, Rocco Palermo, Stefania Murzilli, Antonio Francesco Campese, Giuseppe Ingravallo, Gianluca Canettieri, Tugsan Tezil, Cristiano Simon. Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A. Cancer letters. vol 344. issue 1. 2014-03-25. PMID:24215867. |
our results indicate that foxo3a activation up-regulates transcription of its target genes (p21, pten, bim and gadd45), which forces both chemosensitive and chemoresistant crc cells to undergo apoptosis. |
2014-03-25 |
2023-08-12 |
Not clear |
| De-Yuan Li, Yi Qu, Jin-Hui Li, Li Zhang, Tao Xiong, De-Zhi M. [Role of the FOXO3a transcription factor in neuronal apoptosis in neonatal rats with hypoxic-ischemic brain damage]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 15. issue 11. 2014-03-25. PMID:24229603. |
[role of the foxo3a transcription factor in neuronal apoptosis in neonatal rats with hypoxic-ischemic brain damage]. |
2014-03-25 |
2023-08-12 |
rat |
| De-Yuan Li, Yi Qu, Jin-Hui Li, Li Zhang, Tao Xiong, De-Zhi M. [Role of the FOXO3a transcription factor in neuronal apoptosis in neonatal rats with hypoxic-ischemic brain damage]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 15. issue 11. 2014-03-25. PMID:24229603. |
to explore the role and mechanisms of foxo3a nuclear translocation in neuronal apoptosis after hypoxia-ischemia (hi). |
2014-03-25 |
2023-08-12 |
rat |
| Ummuhani Ozel Turkcu, Nilgun Solak Tekin, Tuba Gokdogan Edgunlu, Sevim Karakas Celik, Setenay One. The association of FOXO3A gene polymorphisms with serum FOXO3A levels and oxidative stress markers in vitiligo patients. Gene. vol 536. issue 1. 2014-03-04. PMID:24333267. |
foxo3a is the forkhead members of the class o (foxo) transcription factors, and plays an important role in cell cycle regulation, apoptosis, oxidative stress, and dna repair. |
2014-03-04 |
2023-08-12 |
human |
| Hon-Kit Andus Wong, Tatiana Veremeyko, Nehal Patel, Cynthia A Lemere, Dominic M Walsh, Christine Esau, Charles Vanderburg, Anna M Krichevsk. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Human molecular genetics. vol 22. issue 15. 2014-01-31. PMID:23585551. |
de-repression of foxo3a death axis by microrna-132 and -212 causes neuronal apoptosis in alzheimer's disease. |
2014-01-31 |
2023-08-12 |
human |
| Jia-Kun Shen, Hua-Ping Du, Qiuling Ma, Min Yang, Yun-Gui Wang, Jie Ji. 4-Chlorobenzoyl berbamine, a novel berbamine derivative, induces apoptosis in multiple myeloma cells through the IL-6 signal transduction pathway and increases FOXO3a-Bim expression. Oncology reports. vol 30. issue 1. 2014-01-17. PMID:23624712. |
these results suggest that bbd9 induces apoptosis in mm cells through the inhibition of the il-6 signaling pathway, leading to foxo3a activation and upregulation of pro-apoptotic bim. |
2014-01-17 |
2023-08-12 |
Not clear |
| Teng Yu, Jiang Ji, Yong-li Gu. MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells. Biochemical and biophysical research communications. vol 441. issue 1. 2014-01-14. PMID:24134840. |
mst1 activation by curcumin mediates jnk activation, foxo3a nuclear translocation and apoptosis in melanoma cells. |
2014-01-14 |
2023-08-12 |
Not clear |
| Teng Yu, Jiang Ji, Yong-li Gu. MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells. Biochemical and biophysical research communications. vol 441. issue 1. 2014-01-14. PMID:24134840. |
in conclusion, we suggested that mst1 activation by curcumin mediates jnk activation, foxo3a nuclear translocation and apoptosis in melanoma cells. |
2014-01-14 |
2023-08-12 |
Not clear |
| Claudia Giampietri, Simonetta Petrungaro, Fabrizio Padula, Alessio D'Alessio, Elettra Sara Marini, Antonio Facchiano, Antonio Filippini, Elio Zipar. Autophagy modulators sensitize prostate epithelial cancer cell lines to TNF-alpha-dependent apoptosis. Apoptosis : an international journal on programmed cell death. vol 17. issue 11. 2014-01-10. PMID:22923157. |
conversely in pc3 but not in lncap cells, rapamycin stimulated tnf-alpha-dependent apoptosis; such effect was associated with reduced c-flip promoter activity and foxo3a activation. |
2014-01-10 |
2023-08-12 |
Not clear |
| Xu-Feng Qi, Yun-Jian Li, Zhuo-Ying Chen, Soo-Ki Kim, Kyu-Jae Lee, Dong-Qing Ca. Involvement of the FoxO3a pathway in the ischemia/reperfusion injury of cardiac microvascular endothelial cells. Experimental and molecular pathology. vol 95. issue 2. 2013-11-18. PMID:23948278. |
thus, we used rat cmecs following simulated i/r to examine foxo3a activation and signaling in relation to survival, the cell cycle and apoptosis in cmecs. |
2013-11-18 |
2023-08-12 |
rat |
| Xu-Feng Qi, Yun-Jian Li, Zhuo-Ying Chen, Soo-Ki Kim, Kyu-Jae Lee, Dong-Qing Ca. Involvement of the FoxO3a pathway in the ischemia/reperfusion injury of cardiac microvascular endothelial cells. Experimental and molecular pathology. vol 95. issue 2. 2013-11-18. PMID:23948278. |
collectively, our results indicate that the foxo3a pathway is involved in the i/r injury of cmecs at least in part through the regulation of cell cycle arrest and apoptosis, suggesting that the foxo3a pathway may be a novel therapeutic target that protects against microvascular endothelial damage in ischemic hearts. |
2013-11-18 |
2023-08-12 |
rat |
| Mohammad Shoeb, Kota V Ramana, Satish K Srivastav. Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors. Free radical biology & medicine. vol 63. 2013-11-01. PMID:23732517. |
knockdown of foxo3a significantly (>80%) abolished ar inhibition-induced upregulation of dr5 and dr4 and apoptosis in colon cancer cells. |
2013-11-01 |
2023-08-12 |
human |
| P Sanphui, S C Biswa. FoxO3a is activated and executes neuron death via Bim in response to β-amyloid. Cell death & disease. vol 4. 2013-10-23. PMID:23661003. |
the forkhead transcription factor foxo3a has emerged as an important mediator of cell fate including apoptosis. |
2013-10-23 |
2023-08-12 |
mouse |