| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard Seonghun Nho, Mark Peterson, Polla Hergert, Craig A Henk. FoxO3a (Forkhead Box O3a) deficiency protects Idiopathic Pulmonary Fibrosis (IPF) fibroblasts from type I polymerized collagen matrix-induced apoptosis via caveolin-1 (cav-1) and Fas. PloS one. vol 8. issue 4. 2013-10-22. PMID:23580232. |
foxo3a (forkhead box o3a) deficiency protects idiopathic pulmonary fibrosis (ipf) fibroblasts from type i polymerized collagen matrix-induced apoptosis via caveolin-1 (cav-1) and fas. |
2013-10-22 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Mark Peterson, Polla Hergert, Craig A Henk. FoxO3a (Forkhead Box O3a) deficiency protects Idiopathic Pulmonary Fibrosis (IPF) fibroblasts from type I polymerized collagen matrix-induced apoptosis via caveolin-1 (cav-1) and Fas. PloS one. vol 8. issue 4. 2013-10-22. PMID:23580232. |
here we demonstrate that this low foxo3a activity confers ipf fibroblasts with resistance to collagen-mediated apoptosis. |
2013-10-22 |
2023-08-12 |
Not clear |
| Areumnuri Kim, Jung-Eun Lee, Seung-Sook Lee, Cherin Kim, Sun-Joo Lee, Won-Suk Jang, Sunhoo Par. Coexistent mutations of KRAS and PIK3CA affect the efficacy of NVP-BEZ235, a dual PI3K/MTOR inhibitor, in regulating the PI3K/MTOR pathway in colorectal cancer. International journal of cancer. vol 133. issue 4. 2013-08-12. PMID:23475782. |
moreover, bez235 treatment resulted in induction of foxo3a activity and its induced transcription of bim activation, which sensitized cells to cytotoxic agents leading to apoptosis in double mutant cells in vitro and in vivo. |
2013-08-12 |
2023-08-12 |
Not clear |
| Evan E Santo, Peter Stroeken, Peter V Sluis, Jan Koster, Rogier Versteeg, Ellen M Westerhou. FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma. Cancer research. vol 73. issue 7. 2013-06-25. PMID:23378341. |
treatment of neuroblastoma cells with the dual pi3k/mtor inhibitor pi-103 activated foxo3a and triggered apoptosis. |
2013-06-25 |
2023-08-12 |
Not clear |
| Evan E Santo, Peter Stroeken, Peter V Sluis, Jan Koster, Rogier Versteeg, Ellen M Westerhou. FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma. Cancer research. vol 73. issue 7. 2013-06-25. PMID:23378341. |
conversely, apoptosis induced by pi-103 or the akt inhibitor mk-2206 was potentiated by foxo3a overexpression. |
2013-06-25 |
2023-08-12 |
Not clear |
| Justyna Kopycinska, Agnieszka Kempińska-Podhorodecka, Tara Haas, Elwyn Elias, Ronald A DePinho, Jihye Paik, Piotr Milkiewicz, Malgorzata Milkiewic. Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis. Liver international : official journal of the International Association for the Study of the Liver. vol 33. issue 2. 2013-06-11. PMID:23295054. |
in this study, we analysed a signalling pathway that comprises the transcription factor foxo3a and its downstream target bim, a bcl-2 interacting mediator of apoptosis. |
2013-06-11 |
2023-08-12 |
Not clear |
| Raffaele Frazzi, Riccardo Valli, Ione Tamagnini, Bruno Casali, Norbert Latruffe, Francesco Merl. Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation. International journal of cancer. vol 132. issue 5. 2013-05-22. PMID:22833338. |
resveratrol-mediated apoptosis of hodgkin lymphoma cells involves sirt1 inhibition and foxo3a hyperacetylation. |
2013-05-22 |
2023-08-12 |
human |
| Daoyuan Lu, Jinping Liu, Jianqin Jiao, Bo Long, Qian Li, Weiqi Tan, Peifeng L. Transcription factor Foxo3a prevents apoptosis by regulating calcium through the apoptosis repressor with caspase recruitment domain. The Journal of biological chemistry. vol 288. issue 12. 2013-05-15. PMID:23382383. |
transcription factor foxo3a prevents apoptosis by regulating calcium through the apoptosis repressor with caspase recruitment domain. |
2013-05-15 |
2023-08-12 |
mouse |
| Daoyuan Lu, Jinping Liu, Jianqin Jiao, Bo Long, Qian Li, Weiqi Tan, Peifeng L. Transcription factor Foxo3a prevents apoptosis by regulating calcium through the apoptosis repressor with caspase recruitment domain. The Journal of biological chemistry. vol 288. issue 12. 2013-05-15. PMID:23382383. |
the forkhead family of transcription factor foxo3a plays a pivotal role in apoptosis; however, its role in regulating cardiac apoptosis remains to be fully elucidated. |
2013-05-15 |
2023-08-12 |
mouse |
| Daoyuan Lu, Jinping Liu, Jianqin Jiao, Bo Long, Qian Li, Weiqi Tan, Peifeng L. Transcription factor Foxo3a prevents apoptosis by regulating calcium through the apoptosis repressor with caspase recruitment domain. The Journal of biological chemistry. vol 288. issue 12. 2013-05-15. PMID:23382383. |
we showed that enforced expression of foxo3a inhibits cardiomyocyte apoptosis, whereas knockdown of endogenous foxo3a sensitizes cardiomyocytes to undergo apoptosis. |
2013-05-15 |
2023-08-12 |
mouse |
| Daoyuan Lu, Jinping Liu, Jianqin Jiao, Bo Long, Qian Li, Weiqi Tan, Peifeng L. Transcription factor Foxo3a prevents apoptosis by regulating calcium through the apoptosis repressor with caspase recruitment domain. The Journal of biological chemistry. vol 288. issue 12. 2013-05-15. PMID:23382383. |
this study reveals that foxo3a maintains calcium homeostasis and inhibits cardiac apoptosis through trans-activation of the arc promoter. |
2013-05-15 |
2023-08-12 |
mouse |
| Aurelien Caballero-Caballero, Tobias Engel, Jaime Martinez-Villarreal, Amaya Sanz-Rodriguez, Patrick Chang, Mark Dunleavy, Claire M Mooney, Eva M Jimenez-Mateos, Clara K Schindler, David C Henshal. Mitochondrial localization of the forkhead box class O transcription factor FOXO3a in brain. Journal of neurochemistry. vol 124. issue 6. 2013-04-29. PMID:23278239. |
foxo3a is member of the forkhead box class o transcription factors, which functions in diverse pathways to regulate cellular metabolism, differentiation, and apoptosis. |
2013-04-29 |
2023-08-12 |
mouse |
| Laura A Marlow, Christina A von Roemeling, Simon J Cooper, Yilin Zhang, Stephen D Rohl, Shilpi Arora, Irma M Gonzales, David O Azorsa, Honey V Reddi, Han W Tun, Heike R Döppler, Peter Storz, Robert C Smallridge, John A Coplan. Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: a paradigm shift that impacts current therapeutic strategies. Journal of cell science. vol 125. issue Pt 18. 2013-04-26. PMID:22718346. |
the forkhead transcription factor, foxo3a, is a known suppressor of primary tumor growth through transcriptional regulation of key genes regulating cell cycle arrest and apoptosis. |
2013-04-26 |
2023-08-12 |
human |
| Yun-Jeong Choe, Tae Joung Ha, Kyoung-Won Ko, Sun-Young Lee, Seok Joon Shin, Ho-Shik Ki. Anthocyanins in the black soybean (Glycine max L.) protect U2OS cells from apoptosis by inducing autophagy via the activation of adenosyl monophosphate-dependent protein kinase. Oncology reports. vol 28. issue 6. 2013-04-16. PMID:22992992. |
in addition, sirna against forkhead box o3a (foxo3a), a downstream target of ampk, suppressed atc-induced autophagy and p27kip1 sirna increased apoptosis in atc-treated cells. |
2013-04-16 |
2023-08-12 |
human |
| Apeng Yang, Jiexian Ma, Min Wu, Wenming Qin, Botao Zhao, Yi Shi, Youxin Jin, Yanhui Xi. Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies. Leukemia & lymphoma. vol 53. issue 12. 2013-04-15. PMID:22582938. |
foxo3a has been implicated in tumor suppression and gc-induced apoptosis, suggesting that foxo3a has potential as a therapeutic target. |
2013-04-15 |
2023-08-12 |
mouse |
| Kevin R Kelly, Steffan T Nawrocki, Claudia M Espitia, Mengkun Zhang, Johnny J Yang, Swaminathan Padmanabhan, Jeffrey Ecsedy, Francis J Giles, Jennifer S Care. Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism. International journal of cancer. vol 131. issue 11. 2013-03-08. PMID:22488249. |
here, we report that alisertib disrupted cell viability, diminished clonogenic survival, induced expression of the foxo3a targets p27 and bim and triggered apoptosis. |
2013-03-08 |
2023-08-12 |
mouse |
| J H Kim, J-S Choi, B H Le. PI3K/Akt and MAPK pathways evoke activation of FoxO transcription factor to undergo neuronal apoptosis in brain of the silkworm Bombyx mori (Lepidoptera: Bombycidae). Cellular and molecular biology (Noisy-le-Grand, France). vol Suppl.58. 2013-02-11. PMID:23046871. |
the forkhead box o (foxo) transcription factors, including foxo1, foxo3a, foxo4, and foxo6, are implicated in the regulation of cell apoptosis and survival. |
2013-02-11 |
2023-08-12 |
Not clear |
| Matt Lam, Amtul R Carmichael, Helen R Griffith. An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression. PloS one. vol 7. issue 6. 2013-01-04. PMID:22761954. |
an aqueous extract of fagonia cretica induces dna damage, cell cycle arrest and apoptosis in breast cancer cells via foxo3a and p53 expression. |
2013-01-04 |
2023-08-12 |
Not clear |
| Lei Liu, Anirudh Arun, Lakia Ellis, Carina Peritore, Gizem Donme. Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein. The Journal of biological chemistry. vol 287. issue 39. 2012-12-07. PMID:22898818. |
we show here that sirt2 deacetylates foxo3a, increases rna and protein levels of bim, and as a result, enhances apoptosis in the mptp model of pd. |
2012-12-07 |
2023-08-12 |
mouse |
| Lei Liu, Anirudh Arun, Lakia Ellis, Carina Peritore, Gizem Donme. Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein. The Journal of biological chemistry. vol 287. issue 39. 2012-12-07. PMID:22898818. |
deletion of sirt2 leads to the reduction of apoptosis due to an increase in acetylation of foxo3a and a decrease in bim levels. |
2012-12-07 |
2023-08-12 |
mouse |