| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhen-Yu Hong, Hyeon Jung Lee, Dong Yeob Shin, Suk Kyoung Kim, Miran Seo, Eun Jig Le. Inhibition of Akt/FOXO3a signaling by constitutively active FOXO3a suppresses growth of follicular thyroid cancer cell lines. Cancer letters. vol 314. issue 1. 2012-01-18. PMID:21974806. |
akt-dependent foxo3a cytoplasmic translocation is an important tumorigenic mechanism for escaping from apoptosis in cancer cells. |
2012-01-18 |
2023-08-12 |
mouse |
| Lilja E Laatikainen, Mariarosaria Incoronato, Maria Domenica Castellone, Juha P Laurila, Massimo Santoro, Mikko O Laukkane. SOD3 decreases ischemic injury derived apoptosis through phosphorylation of Erk1/2, Akt, and FoxO3a. PloS one. vol 6. issue 8. 2012-01-05. PMID:21909393. |
sod3 decreases ischemic injury derived apoptosis through phosphorylation of erk1/2, akt, and foxo3a. |
2012-01-05 |
2023-08-12 |
rat |
| Jolyon Terragni, Gauri Nayak, Swati Banerjee, Jose-Luis Medrano, Julie R Graham, James F Brennan, Sean Sepulveda, Geoffrey M Coope. The E-box binding factors Max/Mnt, MITF, and USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 signaling. The Journal of biological chemistry. vol 286. issue 42. 2011-12-07. PMID:21873430. |
both mitf and usf1 were activated by glycogen synthase kinase (gsk) 3, with gsk3 phosphorylation sites on usf1 identified as the previously described activating site threonine 153 as well as serine 186. sirna against mitf as well as against foxo3a protected cells from apoptosis following pi 3-kinase inhibition. |
2011-12-07 |
2023-08-12 |
Not clear |
| Jinling Hou, Shaohui Wang, Yan Chen Shang, Zhao Zhong Chong, Kenneth Maies. Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress. Current neurovascular research. vol 8. issue 3. 2011-11-21. PMID:21722091. |
epo through sirt1 averts apoptosis through activation of protein kinase b (akt1) and the phosphorylation and cytoplasmic retention of the forkhead transcription factor foxo3a. |
2011-11-21 |
2023-08-12 |
Not clear |
| Julien van Grevenynghe, Rafael A Cubas, Alessandra Noto, Sandrina DaFonseca, Zhong He, Yoav Peretz, Abdelali Filali-Mouhim, Franck P Dupuy, Francesco A Procopio, Nicolas Chomont, Robert S Balderas, Elias A Said, Mohamed-Rachid Boulassel, Cecile L Tremblay, Jean-Pierre Routy, Rafick-Pierre Sékaly, Elias K Hadda. Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis. The Journal of clinical investigation. vol 121. issue 10. 2011-11-21. PMID:21926463. |
we further showed that foxo3a silencing by sirna resulted in decreased expression of trail and apoptosis levels in memory b cells from st subjects. |
2011-11-21 |
2023-08-12 |
human |
| Y-M Cho, H-F Pu, W J Huang, L-T Ho, S-W Wang, P S Wan. Role of serum- and glucocorticoid-inducible kinase-1 in regulating torsion-induced apoptosis in rats. International journal of andrology. vol 34. issue 4. 2011-11-15. PMID:20738430. |
this study investigated whether torsion-induced apoptosis is associated with changes in phosphoinositide-dependent protein kinase-1 (pdk1), sgk1 and forkhead transcription factor foxo3a expression and/or phosphorylation in rats. |
2011-11-15 |
2023-08-12 |
rat |
| Y-M Cho, H-F Pu, W J Huang, L-T Ho, S-W Wang, P S Wan. Role of serum- and glucocorticoid-inducible kinase-1 in regulating torsion-induced apoptosis in rats. International journal of andrology. vol 34. issue 4. 2011-11-15. PMID:20738430. |
this animal study suggests that pdk1, sgk1 and foxo3a are involved in torsion-induced apoptosis and that medical therapy should be performed as early as 2 h after the occurrence of torsion to prevent further damage. |
2011-11-15 |
2023-08-12 |
rat |
| Sanjit K Roy, Rakesh K Srivastava, Sharmila Shanka. Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. Journal of molecular signaling. vol 5. 2011-07-14. PMID:20642839. |
mammalian forkhead members of the class o (foxo) transcription factors, including foxo1, foxo3a, and foxo4, are implicated in the regulation of several biological processes, including the stress resistance, metabolism, cell cycle, apoptosis and dna repair. |
2011-07-14 |
2023-08-12 |
Not clear |
| Kim H T Paraiso, Yun Xiang, Vito W Rebecca, Ethan V Abel, Y Ann Chen, A Cecilia Munko, Elizabeth Wood, Inna V Fedorenko, Vernon K Sondak, Alexander R A Anderson, Antoni Ribas, Maurizia Dalla Palma, Katherine L Nathanson, John M Koomen, Jane L Messina, Keiran S M Smalle. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer research. vol 71. issue 7. 2011-07-11. PMID:21317224. |
dual treatment of pten- cells with plx4720 and a pi3k inhibitor enhanced bim expression at both the mrna and protein level and increased the level of apoptosis through a mechanism involving akt3 and the activation of foxo3a. |
2011-07-11 |
2023-08-12 |
Not clear |
| N A Youngson, N Vickaryous, A van der Horst, T Epp, S Harten, J S Fleming, K K Khanna, D M de Kretser, Emma Whitela. A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice. Mammalian genome : official journal of the International Mammalian Genome Society. vol 22. issue 3-4. 2011-06-20. PMID:21347845. |
foxo3a is a transcription factor with roles in cell cycle control, apoptosis, neural and hematopoietic cell differentiation, and dna repair. |
2011-06-20 |
2023-08-12 |
mouse |
| Liang Fang, HuiMng Wang, Lin Zhou, Da Y. Akt-FOXO3a signaling axis dysregulation in human oral squamous cell carcinoma and potent efficacy of FOXO3a-targeted gene therapy. Oral oncology. vol 47. issue 1. 2011-04-27. PMID:21109483. |
transfection of a constitutively active form of foxo3a (foxo3a(3a)) in oscc cells induced significant g₁-phase arrest and apoptosis as compared with control and transfection of a wild-type foxo3a (foxo3a(wt)). |
2011-04-27 |
2023-08-12 |
human |
| Liang Fang, Huiming Wang, Lin Zhou, Da Y. FOXO3a reactivation mediates the synergistic cytotoxic effects of rapamycin and cisplatin in oral squamous cell carcinoma cells. Toxicology and applied pharmacology. vol 251. issue 1. 2011-02-24. PMID:21092744. |
rapamycin combined with cisplatin as its feedback akt activation inhibitor revealed the most dramatic foxo3a nuclear localization and reactivation with the prevention of its feedback loop and exposed significant synergistic effects of decreased cell proliferation and increased apoptosis in vitro and decreased tumor size in vivo. |
2011-02-24 |
2023-08-12 |
Not clear |
| Jieru Meng, Bingliang Fang, Yong Liao, Christine M Chresta, Paul D Smith, Jack A Rot. Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim. PloS one. vol 5. issue 9. 2011-02-18. PMID:20885957. |
moreover, the silencing of foxo3a by sirna abrogated azd6244-induced cell apoptosis. |
2011-02-18 |
2023-08-12 |
human |
| Eun-Jung Lim, Dae-Weon Park, Jin-Gu Lee, Chu-Hee Lee, Yoe-Sik Bae, Young-Chul Hwang, Jae-Weon Jeong, Byung-Rho Chin, Suk-Hwan Bae. Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression. Experimental & molecular medicine. vol 42. issue 10. 2011-02-17. PMID:20739833. |
toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of foxo3a activity and induction of flip expression. |
2011-02-17 |
2023-08-12 |
Not clear |
| Eun-Jung Lim, Dae-Weon Park, Jin-Gu Lee, Chu-Hee Lee, Yoe-Sik Bae, Young-Chul Hwang, Jae-Weon Jeong, Byung-Rho Chin, Suk-Hwan Bae. Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression. Experimental & molecular medicine. vol 42. issue 10. 2011-02-17. PMID:20739833. |
overexpression of foxo3a increased apoptosis induced by serum deprivation and cpg odn blocked these effects through flip expression. |
2011-02-17 |
2023-08-12 |
Not clear |
| Eun-Jung Lim, Dae-Weon Park, Jin-Gu Lee, Chu-Hee Lee, Yoe-Sik Bae, Young-Chul Hwang, Jae-Weon Jeong, Byung-Rho Chin, Suk-Hwan Bae. Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression. Experimental & molecular medicine. vol 42. issue 10. 2011-02-17. PMID:20739833. |
in contrast, sirna knock-down of foxo3a decreased apoptosis by serum deprivation. |
2011-02-17 |
2023-08-12 |
Not clear |
| Nayoung Kim, Sami Kukkonen, Sumeet Gupta, Anna Aldovin. Association of Tat with promoters of PTEN and PP2A subunits is key to transcriptional activation of apoptotic pathways in HIV-infected CD4+ T cells. PLoS pathogens. vol 6. issue 9. 2011-02-14. PMID:20862322. |
apoptosis in hiv-1-infected cd4+ primary t cells is triggered by the alteration of the pi3k and p53 pathways, which converge on the foxo3a transcriptional activator. |
2011-02-14 |
2023-08-12 |
Not clear |
| Kou Peng, Yi Li, Ling Long, Dong Li, Qiuli Jia, Yidong Wang, Qingyu Shen, Yamei Tang, Lu Wen, Hsiang-Fu Kung, Ying Pen. Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic development in zebrafish. Neuroscience letters. vol 484. issue 2. 2011-01-13. PMID:20674670. |
knockdown of foxo3a induces increased neuronal apoptosis during embryonic development in zebrafish. |
2011-01-13 |
2023-08-12 |
zebrafish |
| Kou Peng, Yi Li, Ling Long, Dong Li, Qiuli Jia, Yidong Wang, Qingyu Shen, Yamei Tang, Lu Wen, Hsiang-Fu Kung, Ying Pen. Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic development in zebrafish. Neuroscience letters. vol 484. issue 2. 2011-01-13. PMID:20674670. |
by using foxo3a morpholino antisense oligonucleotides, we observed that foxo3a loss-of-function led to neural developmental defects, including increased neural apoptosis as detected by acridine orange and terminal deoxynucleotidyl transferase biotin-dutp nick end labeling. |
2011-01-13 |
2023-08-12 |
zebrafish |
| Xu-Xia Sui, Li-Li Luo, Jin-Jie Xu, Yu-Cai F. Evidence that FOXO3a is involved in oocyte apoptosis in the neonatal rat ovary. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 88. issue 4. 2010-12-15. PMID:20651833. |
evidence that foxo3a is involved in oocyte apoptosis in the neonatal rat ovary. |
2010-12-15 |
2023-08-12 |
rat |