| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Damien Calay, Dina Vind-Kezunovic, Aurelie Frankart, Sylviane Lambert, Yves Poumay, Robert Gniadeck. Inhibition of Akt signaling by exclusion from lipid rafts in normal and transformed epidermal keratinocytes. The Journal of investigative dermatology. vol 130. issue 4. 2010-04-16. PMID:20054340. |
diminished akt activity resulted in deactivation of mammalian target of rapamycin, activation of foxo3a, and increased sensitivity to apoptosis stimuli. |
2010-04-16 |
2023-08-12 |
human |
| Takayuki Kojima, Takanari Norose, Keita Tsuchiya, Kazuichi Sakamot. Mouse 3T3-L1 cells acquire resistance against oxidative stress as the adipocytes differentiate via the transcription factor FoxO. Apoptosis : an international journal on programmed cell death. vol 15. issue 1. 2010-03-23. PMID:19842039. |
these results indicated that ros-induced apoptosis in undifferentiated 3t3-l1 cells via the expression of foxo3a, whereas foxo expression suppressed the ros-induced apoptosis in differentiated 3t3-l1 cells via the expression of ros-scavenging enzymes. |
2010-03-23 |
2023-08-12 |
mouse |
| Daniel C Blake, Oliver R Mikse, Willard M Freeman, Christopher R Herzo. FOXO3a elicits a pro-apoptotic transcription program and cellular response to human lung carcinogen nicotine-derived nitrosaminoketone (NNK). Lung cancer (Amsterdam, Netherlands). vol 67. issue 1. 2010-02-23. PMID:19380174. |
we show that restoration of foxo3a in foxo3a-deficient lac cells increases sensitivity to apoptosis caused by a dna-damaging intermediate of nnk. |
2010-02-23 |
2023-08-12 |
human |
| Feng Wang, Christopher B Marshall, Guang-Yao Li, Kazuo Yamamoto, Tak W Mak, Mitsuhiko Ikur. Synergistic interplay between promoter recognition and CBP/p300 coactivator recruitment by FOXO3a. ACS chemical biology. vol 4. issue 12. 2010-02-22. PMID:19821614. |
foxo3a is a transcription factor belonging to the forkhead box o-class (foxo) subfamily, and it regulates metabolism, cell-cycle arrest, cell differentiation, and apoptosis through activating or suppressing gene transcription. |
2010-02-22 |
2023-08-12 |
Not clear |
| Anissa M Jabbour, Carmel P Daunt, Benjamin D Green, Sandra Vogel, Lavinia Gordon, Rachel S Lee, Natasha Silke, Richard B Pearson, Cassandra J Vandenberg, Priscilla N Kelly, Stephen L Nutt, Andreas Strasser, Christoph Borner, Paul G Eker. Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation. Blood. vol 115. issue 2. 2010-01-28. PMID:19965665. |
to investigate which transcriptional regulator is responsible for il-3 deprivation-induced puma expression and apoptosis, we generated wild-type (wt), p53(-/-), and foxo3a(-/-) fdm cells and found that p53(-/-) but not foxo3a(-/-) cells were protected against il-3 withdrawal. |
2010-01-28 |
2023-08-12 |
Not clear |
| Yan Chen Shang, Zhao Zhong Chong, Jinling Hou, Kenneth Maies. FoxO3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis. Current neurovascular research. vol 6. issue 4. 2010-01-26. PMID:19807657. |
foxo3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis. |
2010-01-26 |
2023-08-12 |
Not clear |
| Farida Djouad, Claire Bony, François Canovas, Olivia Fromigué, Thierry Rème, Christian Jorgensen, Danièle Noë. Transcriptomic analysis identifies Foxo3A as a novel transcription factor regulating mesenchymal stem cell chrondrogenic differentiation. Cloning and stem cells. vol 11. issue 3. 2009-12-08. PMID:19751111. |
indeed, stable foxo3a knockdown tends to increase cell survival and decrease apoptosis, mainly in early stages of chondrogenesis. |
2009-12-08 |
2023-08-12 |
human |
| Farida Djouad, Claire Bony, François Canovas, Olivia Fromigué, Thierry Rème, Christian Jorgensen, Danièle Noë. Transcriptomic analysis identifies Foxo3A as a novel transcription factor regulating mesenchymal stem cell chrondrogenic differentiation. Cloning and stem cells. vol 11. issue 3. 2009-12-08. PMID:19751111. |
therefore, our findings suggest that upregulation of foxo3a over the course of chondrogenic differentiation plays a dual role, mainly inhibiting the differentiation process toward hypertrophy and promoting cell apoptosis. |
2009-12-08 |
2023-08-12 |
human |
| Shahenda El-Naggar, Yongqing Liu, Douglas C Dea. Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation. Molecular and cellular biology. vol 29. issue 21. 2009-11-13. PMID:19703998. |
phosphorylation on serine 473 (akt-473) is catalyzed by mtor in a second complex (torc2), and akt-473 phosphorylates foxo3a to inhibit apoptosis. |
2009-11-13 |
2023-08-12 |
Not clear |
| Shahenda El-Naggar, Yongqing Liu, Douglas C Dea. Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation. Molecular and cellular biology. vol 29. issue 21. 2009-11-13. PMID:19703998. |
this leads to constitutive akt-473 and, in turn, phosphorylation of foxo3a and resistance to cell adhesion-dependent apoptosis (anoikis). |
2009-11-13 |
2023-08-12 |
Not clear |
| Aleksandra Rizo, Sandra Olthof, Lina Han, Edo Vellenga, Gerald de Haan, Jan Jacob Schuring. Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis. Blood. vol 114. issue 8. 2009-09-30. PMID:19556423. |
the reduced progenitor and stem cell frequencies were associated with increased expression of p14arf and p16ink4a and enhanced apoptosis, which coincided with increased levels of intracellular reactive oxygen species and reduced foxo3a expression. |
2009-09-30 |
2023-08-12 |
human |
| Bo Ding, Nancy C Kirkiles-Smith, Jordan S Pobe. FOXO3a regulates oxygen-responsive expression of tumor necrosis factor receptor 2 in human dermal microvascular endothelial cells. The Journal of biological chemistry. vol 284. issue 29. 2009-09-25. PMID:19473970. |
we conclude that foxo3a regulates oxygen-dependent changes in expression of tnfr2 in hdmecs, controlling sensitivity to tnf-mediated apoptosis. |
2009-09-25 |
2023-08-12 |
human |
| Mohammad Husain, Leonard G Meggs, Himanshu Vashistha, Sonia Simoes, Kevin O Griffiths, Dileep Kumar, Joanna Mikulak, Peter W Mathieson, Moin A Saleem, Luis Del Valle, Sergio Pina-Oviedo, Jin Ying Wang, Surya V Seshan, Ashwani Malhotra, Krzysztof Reiss, Pravin C Singha. Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis. The Journal of biological chemistry. vol 284. issue 24. 2009-08-20. PMID:19383602. |
acute knockdown of foxo3a by small interfering rna induced a 50% increase in micro-36/nl4-3/cidhp apoptosis, indicating that foxo3a-dependent responses promote the survival phenotype in micro-36 cells. |
2009-08-20 |
2023-08-12 |
human |
| Stefan Karger, Carl Weidinger, Kerstin Krause, Sien-Yi Sheu, Thomas Aigner, Oliver Gimm, Kurt-Werner Schmid, Henning Dralle, Dagmar Fuhre. FOXO3a: a novel player in thyroid carcinogenesis? Endocrine-related cancer. vol 16. issue 1. 2009-05-11. PMID:18845647. |
the forkhead box transcription factor foxo3a has recently been identified as central mediator of the cellular response to oxidative stress inducing cell cycle arrest or apoptosis. |
2009-05-11 |
2023-08-12 |
Not clear |
| Stefan Karger, Carl Weidinger, Kerstin Krause, Sien-Yi Sheu, Thomas Aigner, Oliver Gimm, Kurt-Werner Schmid, Henning Dralle, Dagmar Fuhre. FOXO3a: a novel player in thyroid carcinogenesis? Endocrine-related cancer. vol 16. issue 1. 2009-05-11. PMID:18845647. |
our data suggest foxo3a as a novel player of cellular stress response in the thyroid, mediating the thyrocyte's fate either to survive or to undergo apoptosis. |
2009-05-11 |
2023-08-12 |
Not clear |
| Stefan Karger, Carl Weidinger, Kerstin Krause, Sien-Yi Sheu, Thomas Aigner, Oliver Gimm, Kurt-Werner Schmid, Henning Dralle, Dagmar Fuhre. FOXO3a: a novel player in thyroid carcinogenesis? Endocrine-related cancer. vol 16. issue 1. 2009-05-11. PMID:18845647. |
furthermore, pi3k-dependent foxo3a inactivation may be a novel pathomechanism for the escape from apoptosis in thyroid cancer cells, in particular in follicular thyroid carcinoma. |
2009-05-11 |
2023-08-12 |
Not clear |
| Amanda Nordigården, Maria Kraft, Pernilla Eliasson, Verena Labi, Eric W-F Lam, Andreas Villunger, Jan-Ingvar Jönsso. BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3. Blood. vol 113. issue 10. 2009-04-29. PMID:19064725. |
however, only silencing of bim, or its direct transcriptional activator foxo3a, abrogated apoptosis efficiently. |
2009-04-29 |
2023-08-12 |
mouse |
| Hong Liu, Li-Li Luo, Yuan-Shu Qian, Yu-Cai Fu, Xu-Xia Sui, Yi-Jie Geng, Da-Na Huang, Shi-Tong Gao, Ren-Li Zhan. FOXO3a is involved in the apoptosis of naked oocytes and oocytes of primordial follicles from neonatal rat ovaries. Biochemical and biophysical research communications. vol 381. issue 4. 2009-04-28. PMID:19258007. |
foxo3a is involved in the apoptosis of naked oocytes and oocytes of primordial follicles from neonatal rat ovaries. |
2009-04-28 |
2023-08-12 |
rat |
| Hong Liu, Li-Li Luo, Yuan-Shu Qian, Yu-Cai Fu, Xu-Xia Sui, Yi-Jie Geng, Da-Na Huang, Shi-Tong Gao, Ren-Li Zhan. FOXO3a is involved in the apoptosis of naked oocytes and oocytes of primordial follicles from neonatal rat ovaries. Biochemical and biophysical research communications. vol 381. issue 4. 2009-04-28. PMID:19258007. |
however, whether foxo3a mediates the apoptosis of naked oocytes and oocytes of primordial follicles remains unknown. |
2009-04-28 |
2023-08-12 |
rat |
| Hong Liu, Li-Li Luo, Yuan-Shu Qian, Yu-Cai Fu, Xu-Xia Sui, Yi-Jie Geng, Da-Na Huang, Shi-Tong Gao, Ren-Li Zhan. FOXO3a is involved in the apoptosis of naked oocytes and oocytes of primordial follicles from neonatal rat ovaries. Biochemical and biophysical research communications. vol 381. issue 4. 2009-04-28. PMID:19258007. |
as phosphorylated foxo3a increased, oocyte apoptosis was inhibited. |
2009-04-28 |
2023-08-12 |
rat |