| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong Liu, Li-Li Luo, Yuan-Shu Qian, Yu-Cai Fu, Xu-Xia Sui, Yi-Jie Geng, Da-Na Huang, Shi-Tong Gao, Ren-Li Zhan. FOXO3a is involved in the apoptosis of naked oocytes and oocytes of primordial follicles from neonatal rat ovaries. Biochemical and biophysical research communications. vol 381. issue 4. 2009-04-28. PMID:19258007. |
these results suggest that foxo3a is involved in oocyte apoptosis in the neonatal rat ovary, and the scf-pi3k/akt-foxo3a signaling pathway mediates oocyte apoptosis and primordial follicle formation. |
2009-04-28 |
2023-08-12 |
rat |
| C Bertoli, T Copetti, E W-F Lam, F Demarchi, C Schneide. Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A. Oncogene. vol 28. issue 5. 2009-02-19. PMID:19029949. |
notably, foxo3a depletion in capns1-/- mefs reduces both the induction of bim and apoptosis. |
2009-02-19 |
2023-08-12 |
mouse |
| C Bertoli, T Copetti, E W-F Lam, F Demarchi, C Schneide. Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A. Oncogene. vol 28. issue 5. 2009-02-19. PMID:19029949. |
both okadaic acid treatment and silencing of the protein phosphatase 2a (pp2a) catalytic subunit can partially reduce starvation-induced foxo3a activation and apoptosis in capns1-/- fibroblasts. |
2009-02-19 |
2023-08-12 |
mouse |
| Byung-Chul Ki. FoxO3a mediates transforming growth factor-beta1-induced apoptosis in FaO rat hepatoma cells. BMB reports. vol 41. issue 10. 2009-02-09. PMID:18959820. |
foxo3a mediates transforming growth factor-beta1-induced apoptosis in fao rat hepatoma cells. |
2009-02-09 |
2023-08-12 |
rat |
| Byung-Chul Ki. FoxO3a mediates transforming growth factor-beta1-induced apoptosis in FaO rat hepatoma cells. BMB reports. vol 41. issue 10. 2009-02-09. PMID:18959820. |
foxo3a is a member of the forkhead box class o (foxo) transcription factor family and an important regulator of apoptosis. |
2009-02-09 |
2023-08-12 |
rat |
| Byung-Chul Ki. FoxO3a mediates transforming growth factor-beta1-induced apoptosis in FaO rat hepatoma cells. BMB reports. vol 41. issue 10. 2009-02-09. PMID:18959820. |
this work aimed to elucidate the involvement of foxo3a in transforming growth factor-beta1 (tgf-beta1)-induced apoptosis in fao rat hepatoma cells. |
2009-02-09 |
2023-08-12 |
rat |
| Byung-Chul Ki. FoxO3a mediates transforming growth factor-beta1-induced apoptosis in FaO rat hepatoma cells. BMB reports. vol 41. issue 10. 2009-02-09. PMID:18959820. |
it thus appears that foxo3a plays a crucial mediatory role in the tgf-beta1 signaling pathway leading to apoptosis. |
2009-02-09 |
2023-08-12 |
rat |
| Alicja Dabrowska, Nayoung Kim, Anna Aldovin. Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 12. 2009-01-27. PMID:19050264. |
tat-induced foxo3a is a key mediator of apoptosis in hiv-1-infected human cd4+ t lymphocytes. |
2009-01-27 |
2023-08-12 |
human |
| Alicja Dabrowska, Nayoung Kim, Anna Aldovin. Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 12. 2009-01-27. PMID:19050264. |
apoptosis in these cells is triggered by the alteration of the egr1-pten-akt (early growth response-1/phosphate and tensin homolog deleted on chromosome 10/akt) and p53 pathways, which converge on the foxo3a (forkhead box transcription factor o class 3a) transcriptional activator. |
2009-01-27 |
2023-08-12 |
human |
| Alicja Dabrowska, Nayoung Kim, Anna Aldovin. Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 12. 2009-01-27. PMID:19050264. |
the foxo3a target genes fas ligand and trail, involved in the extrinsic apoptotic pathway, and puma, noxa, and bim, which are part of the intrinsic apoptotic pathway, were also up-regulated, indicating that hiv infection leads to apoptosis by the engagement of multiple apoptotic pathways. |
2009-01-27 |
2023-08-12 |
human |
| Alicja Dabrowska, Nayoung Kim, Anna Aldovin. Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 12. 2009-01-27. PMID:19050264. |
rnai-mediated knockdown of egr1 and foxo3a resulted in reduced apoptosis in hiv-infected hela and cd4(+) t cells, providing further evidence for their critical role in hiv-induced apoptosis and g(0) arrest. |
2009-01-27 |
2023-08-12 |
human |
| Jiexian Ma, Yanhui Xie, Yi Shi, Wenming Qin, Botao Zhao, Youxin Ji. Glucocorticoid-induced apoptosis requires FOXO3A activity. Biochemical and biophysical research communications. vol 377. issue 3. 2008-12-15. PMID:18957280. |
glucocorticoid-induced apoptosis requires foxo3a activity. |
2008-12-15 |
2023-08-12 |
Not clear |
| Jiexian Ma, Yanhui Xie, Yi Shi, Wenming Qin, Botao Zhao, Youxin Ji. Glucocorticoid-induced apoptosis requires FOXO3A activity. Biochemical and biophysical research communications. vol 377. issue 3. 2008-12-15. PMID:18957280. |
in this study, we examined the potential role of the forkhead transcription factor (foxo3a) in dex-induced apoptosis. |
2008-12-15 |
2023-08-12 |
Not clear |
| Jiexian Ma, Yanhui Xie, Yi Shi, Wenming Qin, Botao Zhao, Youxin Ji. Glucocorticoid-induced apoptosis requires FOXO3A activity. Biochemical and biophysical research communications. vol 377. issue 3. 2008-12-15. PMID:18957280. |
unphosphorylated foxo3a, the active form of foxo3a, can translocate into nucleus and induce apoptosis. |
2008-12-15 |
2023-08-12 |
Not clear |
| Jiexian Ma, Yanhui Xie, Yi Shi, Wenming Qin, Botao Zhao, Youxin Ji. Glucocorticoid-induced apoptosis requires FOXO3A activity. Biochemical and biophysical research communications. vol 377. issue 3. 2008-12-15. PMID:18957280. |
knockdown of foxo3a expression using a small interfering rna (sirna) significantly reduces apoptosis in lymphocytes. |
2008-12-15 |
2023-08-12 |
Not clear |
| Jiexian Ma, Yanhui Xie, Yi Shi, Wenming Qin, Botao Zhao, Youxin Ji. Glucocorticoid-induced apoptosis requires FOXO3A activity. Biochemical and biophysical research communications. vol 377. issue 3. 2008-12-15. PMID:18957280. |
this study suggests that foxo3a has a pivotal role in dex-induced apoptosis. |
2008-12-15 |
2023-08-12 |
Not clear |
| Shoukang Zhu, Sarah Evans, Bin Yan, Thomas J Povsic, Victor Tapson, Pascal J Goldschmidt-Clermont, Chunming Don. Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells. Circulation. vol 118. issue 21. 2008-12-09. PMID:18981303. |
transcriptional regulation of bim by foxo3a and akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells. |
2008-12-09 |
2023-08-12 |
Not clear |
| Yiwei Li, Zhiwei Wang, Dejuan Kong, Ran Li, Sanila H Sarkar, Fazlul H Sarka. Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. The Journal of biological chemistry. vol 283. issue 41. 2008-11-10. PMID:18687691. |
it is known that foxo3a and gsk-3beta, targets of akt, regulate cell proliferation and apoptosis. |
2008-11-10 |
2023-08-12 |
Not clear |
| Yiwei Li, Zhiwei Wang, Dejuan Kong, Ran Li, Sanila H Sarkar, Fazlul H Sarka. Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. The Journal of biological chemistry. vol 283. issue 41. 2008-11-10. PMID:18687691. |
by electrophoretic mobility shift assay and chromatin immunoprecipitation assay, we found that isoflavone inhibited foxo3a binding to the promoter of ar and increased foxo3a binding to the p27(kip1) promoter, resulting in the alteration of ar and p27(kip1) expression, the inhibition of cell proliferation, and the induction of apoptosis in both androgen-sensitive and -insensitive pca cells. |
2008-11-10 |
2023-08-12 |
Not clear |
| Vidyalakshmi Chandramohan, Nora D Mineva, Brian Burke, Sébastien Jeay, Min Wu, Jian Shen, William Yang, Stephen R Hann, Gail E Sonenshei. c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor. Journal of cellular biochemistry. vol 104. issue 6. 2008-10-15. PMID:18393360. |
induction of p27 (cdkn1b) gene transcription by forkhead box o proteins such as foxo3a leads to growth arrest and apoptosis. |
2008-10-15 |
2023-08-12 |
Not clear |