| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vidyalakshmi Chandramohan, Nora D Mineva, Brian Burke, Sébastien Jeay, Min Wu, Jian Shen, William Yang, Stephen R Hann, Gail E Sonenshei. c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor. Journal of cellular biochemistry. vol 104. issue 6. 2008-10-15. PMID:18393360. |
previously, we observed that b cell receptor (surface igm) engagement of wehi 231 immature b lymphoma cells with an anti-igm antibody results in activation of foxo3a, growth arrest and apoptosis. |
2008-10-15 |
2023-08-12 |
Not clear |
| Silvia D Stan, Eun-Ryeong Hahm, Renaud Warin, Shivendra V Sing. Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo. Cancer research. vol 68. issue 18. 2008-10-14. PMID:18794155. |
these results point toward an important role of foxo3a and bim in regulation of wa-mediated apoptosis in human breast cancer cells. |
2008-10-14 |
2023-08-12 |
mouse |
| Mahdad Noursadeghi, Jhen Tsang, Robert F Miller, David R Kat. Comment on "Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages". Journal of immunology (Baltimore, Md. : 1950). vol 180. issue 12. 2008-09-05. PMID:18523241. |
comment on "transcription factor foxo3a mediates apoptosis in hiv-1-infected macrophages". |
2008-09-05 |
2023-08-12 |
Not clear |
| David Allard, Nichola Figg, Martin R Bennett, Trevor D Littlewoo. Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3. The Journal of biological chemistry. vol 283. issue 28. 2008-08-28. PMID:18458087. |
we conclude that akt and its downstream targets foxo3a and gsk3 regulate a survival pathway in vsmcs and that their deregulation due to a reduction of igf1r signaling may promote apoptosis in atherosclerosis. |
2008-08-28 |
2023-08-12 |
human |
| A N Cornforth, J S Davis, E Khanifar, K L Nastiuk, J J Krolewsk. FOXO3a mediates the androgen-dependent regulation of FLIP and contributes to TRAIL-induced apoptosis of LNCaP cells. Oncogene. vol 27. issue 32. 2008-08-21. PMID:18391984. |
foxo3a mediates the androgen-dependent regulation of flip and contributes to trail-induced apoptosis of lncap cells. |
2008-08-21 |
2023-08-12 |
rat |
| Naohiro Kawamura, Fumitaka Kugimiya, Yasushi Oshima, Shinsuke Ohba, Toshiyuki Ikeda, Taku Saito, Yusuke Shinoda, Yosuke Kawasaki, Naoshi Ogata, Kazuto Hoshi, Toru Akiyama, William S Chen, Nissim Hay, Kazuyuki Tobe, Takashi Kadowaki, Yoshiaki Azuma, Sakae Tanaka, Kozo Nakamura, Ung-il Chung, Hiroshi Kawaguch. Akt1 in osteoblasts and osteoclasts controls bone remodeling. PloS one. vol 2. issue 10. 2008-07-15. PMID:17957242. |
notably, our findings revealed a novel role of akt1/forkhead box class o (foxo) 3a/bim axis in the apoptosis of osteoblasts: akt1 phosphorylates the transcription factor foxo3a to prevent its nuclear localization, leading to impaired transactivation of its target gene bim which was also shown to be a potent proapoptotic molecule in osteoblasts. |
2008-07-15 |
2023-08-12 |
mouse |
| Beibei Cai, Zhengui Xi. p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription. Apoptosis : an international journal on programmed cell death. vol 13. issue 6. 2008-07-09. PMID:18465250. |
p38 map kinase mediates arsenite-induced apoptosis through foxo3a activation and induction of bim transcription. |
2008-07-09 |
2023-08-12 |
Not clear |
| Beibei Cai, Zhengui Xi. p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription. Apoptosis : an international journal on programmed cell death. vol 13. issue 6. 2008-07-09. PMID:18465250. |
rnai knock down of foxo3a inhibited bim promoter activity, bim(el) protein expression, and arsenite-induced apoptosis. |
2008-07-09 |
2023-08-12 |
Not clear |
| Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, Satoru Tatematsu, Yoshikazu Hara, Hitoshi Minakuchi, Naoki Washida, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Ito. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochemical and biophysical research communications. vol 372. issue 1. 2008-06-20. PMID:18485895. |
h(2)o(2) induced the nuclear accumulation of forkhead transcription factor, foxo3a and the gene silencing of foxo3a enhanced h(2)o(2)-induced apoptosis. |
2008-06-20 |
2023-08-12 |
Not clear |
| Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, Satoru Tatematsu, Yoshikazu Hara, Hitoshi Minakuchi, Naoki Washida, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Ito. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochemical and biophysical research communications. vol 372. issue 1. 2008-06-20. PMID:18485895. |
in contrast, excess ros upregulates sirt1, which activates foxo3a and catalase leading to rescuing apoptosis. |
2008-06-20 |
2023-08-12 |
Not clear |
| Tomohiro Nakamura, Kazuichi Sakamot. Forkhead transcription factor FOXO subfamily is essential for reactive oxygen species-induced apoptosis. Molecular and cellular endocrinology. vol 281. issue 1-2. 2008-04-14. PMID:18035477. |
because ros-induced cell death was suppressed by co-transfection of a foxo3a mutant that lacks the activation-domain of transcription, transactivation of pro-apoptotic genes by foxo was necessary to cause ros-induced apoptosis. |
2008-04-14 |
2023-08-12 |
Not clear |
| S Dong, S Kang, S Lonial, H J Khoury, J Viallet, J Che. Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and Bcl-2 inhibitor GX15-070. Leukemia. vol 22. issue 3. 2008-03-27. PMID:18079735. |
we recently demonstrated that disrupting 14-3-3/ligand association by a peptide-based 14-3-3 competitive antagonist r18 induces significant apoptosis, partially through reactivation of akt-inhibited proapoptotic foxo3a, in fgfr1 fusion-transformed hematopoietic cells. |
2008-03-27 |
2023-08-12 |
human |
| S Dong, S Kang, S Lonial, H J Khoury, J Viallet, J Che. Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and Bcl-2 inhibitor GX15-070. Leukemia. vol 22. issue 3. 2008-03-27. PMID:18079735. |
here, we report that targeting 14-3-3 by r18 effectively induced significant apoptosis in ba/f3 and k562 cells expressing bcr-abl, similarly through liberation and reactivation of foxo3a. |
2008-03-27 |
2023-08-12 |
human |
| Janna Krol, Richard E Francis, André Albergaria, Andrew Sunters, Andreas Polychronis, R Charles Coombes, Eric W-F La. The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells. Molecular cancer therapeutics. vol 6. issue 12 Pt 1. 2008-03-19. PMID:18089711. |
in the sensitive cells, gefitinib treatment causes cell cycle arrest predominantly at the g(0)-g(1) phase and apoptosis, which is associated with foxo3a dephosphorylation at akt sites and nuclear translocation, whereas in the resistant cells, foxo3a stays phosphorylated and remains in the cytoplasm. |
2008-03-19 |
2023-08-12 |
human |
| Min Cui, Yunlong Huang, Yong Zhao, Jialin Zhen. Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages. Journal of immunology (Baltimore, Md. : 1950). vol 180. issue 2. 2008-03-10. PMID:18178829. |
transcription factor foxo3a mediates apoptosis in hiv-1-infected macrophages. |
2008-03-10 |
2023-08-12 |
human |
| Min Cui, Yunlong Huang, Yong Zhao, Jialin Zhen. Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages. Journal of immunology (Baltimore, Md. : 1950). vol 180. issue 2. 2008-03-10. PMID:18178829. |
in the present study, we investigated the involvement of transcription factor foxo3a in the regulation of hiv-1-mediated apoptosis in macrophages. |
2008-03-10 |
2023-08-12 |
human |
| Nicole Engel, Ulrich Mahlknech. Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation. International journal of molecular medicine. vol 21. issue 2. 2008-03-07. PMID:18204789. |
sirt1 regulates different cellular processes such as proliferation, differentiation and apoptosis through deacetylation of important regulatory proteins such as p53, foxo3a and nfkappab. |
2008-03-07 |
2023-08-12 |
human |
| Zainab Jagani, Amrik Singh, Roya Khosravi-Fa. FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis. Biochimica et biophysica acta. vol 1785. issue 1. 2008-02-15. PMID:17980712. |
as substrates of survival kinases such as akt, the foxo family of transcription factors, particularly foxo3a, has emerged as playing an important role in the cell cycle arrest and apoptosis of hematopoietic cells. |
2008-02-15 |
2023-08-12 |
Not clear |
| Hae-Young Lee, Hyun-Jung You, Joo-Yun Won, Seock-Won Youn, Hyun-Jai Cho, Kyung-Woo Park, Woong-Yang Park, Jeong-Sun Seo, Young-Bae Park, Kenneth Walsh, Byung-Hee Oh, Hyo-Soo Ki. Forkhead factor, FOXO3a, induces apoptosis of endothelial cells through activation of matrix metalloproteinases. Arteriosclerosis, thrombosis, and vascular biology. vol 28. issue 2. 2008-02-14. PMID:18063811. |
forkhead factor, foxo3a, induces apoptosis of endothelial cells through activation of matrix metalloproteinases. |
2008-02-14 |
2023-08-12 |
Not clear |
| Hae-Young Lee, Hyun-Jung You, Joo-Yun Won, Seock-Won Youn, Hyun-Jai Cho, Kyung-Woo Park, Woong-Yang Park, Jeong-Sun Seo, Young-Bae Park, Kenneth Walsh, Byung-Hee Oh, Hyo-Soo Ki. Forkhead factor, FOXO3a, induces apoptosis of endothelial cells through activation of matrix metalloproteinases. Arteriosclerosis, thrombosis, and vascular biology. vol 28. issue 2. 2008-02-14. PMID:18063811. |
the forkhead factor, foxo3a, is known to induce apoptosis in endothelial cells (ecs). |
2008-02-14 |
2023-08-12 |
Not clear |