| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Liu, Anirudh Arun, Lakia Ellis, Carina Peritore, Gizem Donme. Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein. The Journal of biological chemistry. vol 287. issue 39. 2012-12-07. PMID:22898818. |
we demonstrate that sirt2 deacetylates foxo3a, activates bim, and induces apoptosis only in 1-methyl-4-phenylpyridinium-treated cells. |
2012-12-07 |
2023-08-12 |
mouse |
| Anna Wilk, Katarzyna Urbanska, Maja Grabacka, Jennifer Mullinax, Cezary Marcinkiewicz, David Impastato, John J Estrada, Krzysztof Reis. Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro. Cell cycle (Georgetown, Tex.). vol 11. issue 14. 2012-11-26. PMID:22732497. |
fenofibrate-induced nuclear translocation of foxo3a triggers bim-mediated apoptosis in glioblastoma cells in vitro. |
2012-11-26 |
2023-08-12 |
Not clear |
| Anna Wilk, Katarzyna Urbanska, Maja Grabacka, Jennifer Mullinax, Cezary Marcinkiewicz, David Impastato, John J Estrada, Krzysztof Reis. Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro. Cell cycle (Georgetown, Tex.). vol 11. issue 14. 2012-11-26. PMID:22732497. |
sirna-mediated inhibition of foxo3a attenuated fenofibrate-induced apoptosis, indicating a direct involvement of this transcription factor in the fenofibrate action against glioblastoma. |
2012-11-26 |
2023-08-12 |
Not clear |
| Hsiao-Ling Tseng, Chia-Jung Li, Lin-Huang Huang, Chun-Yao Chen, Chun-Hao Tsai, Chun-Nan Lin, Hsue-Yin Hs. Quercetin 3-O-methyl ether protects FL83B cells from copper induced oxidative stress through the PI3K/Akt and MAPK/Erk pathway. Toxicology and applied pharmacology. vol 264. issue 1. 2012-11-19. PMID:22842013. |
our results indicated that cu(2+)-induced apoptosis in fl83b cells occurred via the generation of ros, upregulation and phosphorylation of erk, overexpression of 14-3-3, inactivation of akt, and the downregulation of foxo3a and mnsod. |
2012-11-19 |
2023-08-12 |
mouse |
| Q Liu, L Yi, S Sadiq-Ali, S M Koontz, A Wood, N Zhu, S H Jackso. PP2A-dependent control of transcriptionally active FOXO3a in CD8(+) central memory lymphocyte survival requires p47(phox). Cell death & disease. vol 3. 2012-11-08. PMID:22914323. |
forkhead box o3a (foxo3a) transcription factor is regulated by complex post-translational modifications that allow for transcriptional control of various apoptosis factors including pro-apoptotic bim. |
2012-11-08 |
2023-08-12 |
mouse |
| Nanako Hamada, Yasunori Fujita, Toshio Kojima, Aya Kitamoto, Yukihiro Akao, Yoshinori Nozawa, Masafumi It. MicroRNA expression profiling of NGF-treated PC12 cells revealed a critical role for miR-221 in neuronal differentiation. Neurochemistry international. vol 60. issue 8. 2012-10-12. PMID:22465943. |
finally, mir-221 decreased expression of foxo3a and apaf-1, both of which are known to be involved in apoptosis in pc12 cells. |
2012-10-12 |
2023-08-12 |
rat |
| Xiang Zhong, Wei Li, Xuexin Huang, Lili Zhang, Mireguli Yimamu, Nasir Raiput, Yanmin Zhou, Tian Wan. Impairment of cellular immunity is associated with overexpression of heat shock protein 70 in neonatal pigs with intrauterine growth retardation. Cell stress & chaperones. vol 17. issue 4. 2012-10-02. PMID:22270614. |
furthermore, sirna-mediated hsp70 downregulation increased nf-κb activity, inhibited expression of foxo3a, and decreased cell apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Jingchun Gao, Xiangjun Yang, Ping Yin, Wenfeng Hu, Hongfeng Liao, Zhihui Miao, Chao Pan, Na L. The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer. International journal of oncology. vol 40. issue 4. 2012-08-31. PMID:22159921. |
knockdown of mirk by small interfering rna (sirna) resulted in cell apoptosis and sensitized cells to cisplatin accompanied by nuclear translocation of foxo1 and/or foxo3a as well as increased bim, tradd, cleaved caspase-3 and parp. |
2012-08-31 |
2023-08-12 |
Not clear |
| Kun Wang, Bo Long, Jian-Qin Jiao, Jian-Xun Wang, Jin-Ping Liu, Qian Li, Pei-Feng L. miR-484 regulates mitochondrial network through targeting Fis1. Nature communications. vol 3. 2012-07-26. PMID:22510686. |
in exploring the underlying mechanism of mir-484 downregulation upon apoptosis, we observe that foxo3a transactivates mir-484 expression. |
2012-07-26 |
2023-08-12 |
mouse |
| Kun Wang, Bo Long, Jian-Qin Jiao, Jian-Xun Wang, Jin-Ping Liu, Qian Li, Pei-Feng L. miR-484 regulates mitochondrial network through targeting Fis1. Nature communications. vol 3. 2012-07-26. PMID:22510686. |
foxo3a transgenic or knockout mice exhibit, respectively, a high or low level of mir-484 and a reduced or enhanced mitochondrial fission, apoptosis and myocardial infarction. |
2012-07-26 |
2023-08-12 |
mouse |
| A H Chaanine, D Jeong, L Liang, E R Chemaly, K Fish, R E Gordon, R J Hajja. JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure. Cell death & disease. vol 3. 2012-07-24. PMID:22297293. |
these results suggest that jnk signaling is a critical modulator of the transcription factor foxo3a driving the expression of its effector, bnip3, in heart failure and that jnk, through bnip3, induces mitochondrial apoptosis and mitophagy. |
2012-07-24 |
2023-08-12 |
rat |
| Zhaodong Li, Haisheng Zhang, Ying Chen, Li Fan, Jing Fan. Forkhead transcription factor FOXO3a protein activates nuclear factor κB through B-cell lymphoma/leukemia 10 (BCL10) protein and promotes tumor cell survival in serum deprivation. The Journal of biological chemistry. vol 287. issue 21. 2012-07-23. PMID:22474286. |
knockdown of foxo3a enhanced cell apoptosis under serum-free conditions, which was inhibited by overexpression of bcl10. |
2012-07-23 |
2023-08-12 |
Not clear |
| Zhiwei Zhao, Jingjing Wang, Jingsheng Tang, Xinyu Liu, Qian Zhong, Fang Wang, Wenbin Hu, Zhu Yuan, Chunlai Nie, Yuquan We. JNK- and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cells. The Biochemical journal. vol 444. issue 2. 2012-07-13. PMID:22394200. |
further experiments demonstrated that akt-mediated foxo3a (forkhead box o3a) nuclear translocation and the jnk (c-jun n-terminal kinase)/c-jun pathway only partially trigger puma induction and apoptosis, whereas dominant-negative c-jun expression with foxo3a reduction completely inhibits puma expression and cell death. |
2012-07-13 |
2023-08-12 |
Not clear |
| X-X Kong, Y-C Fu, J-J Xu, X-L Zhuang, Z-G Chen, L-L Lu. Resveratrol, an effective regulator of ovarian development and oocyte apoptosis. Journal of endocrinological investigation. vol 34. issue 11. 2012-07-10. PMID:21738004. |
these results suggest that resveratrol may delay oocyte nest breakdown and inhibit both the primordial-to-developing-follicle transition and apoptosis by decreasing the activation of foxo3a, bim, and p27kip1, thus augmenting the resting follicle reserves, maintaining regular estrous cycles of early aged rats and delaying climacterium. |
2012-07-10 |
2023-08-12 |
rat |
| Mariko Takami, Robert B Love, Makio Iwashim. TGF-β converts apoptotic stimuli into the signal for Th9 differentiation. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 9. 2012-06-11. PMID:22461692. |
conversely, when an active form of exogenous tgf-β is present, conventional t cells become resistant to pica and undergo robust expansion instead of apoptosis, with reduction of the proapoptotic protein bim and foxo3a. |
2012-06-11 |
2023-08-12 |
Not clear |
| Eun-Jung Lim, Dae-Weon Park, Tae-Whal Jeong, Byung-Rho Chin, Yoe-Sik Bae, Suk-Hwan Bae. TRAIL is involved in CpG ODN-mediated anti-apoptotic signals. Oncology reports. vol 27. issue 4. 2012-05-30. PMID:22159760. |
knockdown of foxo3a by sirna decreased trail expression and apoptosis in serum-starved cells. |
2012-05-30 |
2023-08-12 |
Not clear |
| Eun-Jung Lim, Dae-Weon Park, Tae-Whal Jeong, Byung-Rho Chin, Yoe-Sik Bae, Suk-Hwan Bae. TRAIL is involved in CpG ODN-mediated anti-apoptotic signals. Oncology reports. vol 27. issue 4. 2012-05-30. PMID:22159760. |
in contrast, foxo3a overexpression increased apoptosis by serum starvation, and cpg odns blocked these effects through trail expression. |
2012-05-30 |
2023-08-12 |
Not clear |
| Jessica Dal Col, Katy Mastorci, Damiana Antonia Faè, Elena Muraro, Debora Martorelli, Giorgio Inghirami, Riccardo Dolcett. Retinoic acid/alpha-interferon combination inhibits growth and promotes apoptosis in mantle cell lymphoma through Akt-dependent modulation of critical targets. Cancer research. vol 72. issue 7. 2012-05-24. PMID:22311672. |
pharmacologic suppression of akt, but not of torc1, increases noxa protein levels and downregulates bfl-1 protein supporting the conclusion that the inhibition of the akt pathway, the resulting foxo3a activation and noxa upregulation are critical molecular mechanisms underlying ra/ifn-α-dependent mcl cell apoptosis. |
2012-05-24 |
2023-08-12 |
Not clear |
| Gunjan Sharma, Susanta Kar, Shreyasi Palit, Pijush K Da. 18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. Journal of cellular physiology. vol 227. issue 5. 2012-04-02. PMID:21732363. |
silencing of foxo3a resulted in marked attenuation in the expression of bim as well as protection against gra-mediated apoptosis. |
2012-04-02 |
2023-08-12 |
human |
| Ka-Kei Ho, Victoria A McGuire, Chuay-Yeng Koo, Kyle W Muir, Natalia de Olano, Evie Maifoshie, Douglas J Kelly, Ursula B McGovern, Lara J Monteiro, Ana R Gomes, Angel R Nebreda, David G Campbell, J Simon C Arthur, Eric W-F La. Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. The Journal of biological chemistry. vol 287. issue 2. 2012-02-27. PMID:22128155. |
foxo3a is a forkhead transcription factor that regulates a multitude of important cellular processes, including proliferation, apoptosis, differentiation, and metabolism. |
2012-02-27 |
2023-08-12 |
mouse |