| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eun J Choi, Gun-Hee Ki. 5-Fluorouracil combined with apigenin enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells. Oncology reports. vol 22. issue 6. 2010-02-17. PMID:19885610. |
to investigate the mechanism by which the combination of 5-fluorouracil and apigenin induces apoptosis, erbb2 expression was analyzed. |
2010-02-17 |
2023-08-12 |
human |
| Eun J Choi, Gun-Hee Ki. 5-Fluorouracil combined with apigenin enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells. Oncology reports. vol 22. issue 6. 2010-02-17. PMID:19885610. |
taken together, our results suggest that 5-fluorouracil acts synergistically with apigenin inhibiting cell growth and inducing apoptosis via the down-regulation of erbb2 expression and akt signaling. |
2010-02-17 |
2023-08-12 |
human |
| A V Lucs, W J Muller, S K Muthuswam. Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity. Oncogene. vol 29. issue 2. 2010-02-01. PMID:19826412. |
we report that erbb2 induces cell proliferation and loss of 3d organization by redundant mechanisms, whereas it disrupts apical basal polarity and inhibits apoptosis using tyr 1201 and tyr 1226/7, respectively. |
2010-02-01 |
2023-08-12 |
human |
| A V Lucs, W J Muller, S K Muthuswam. Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity. Oncogene. vol 29. issue 2. 2010-02-01. PMID:19826412. |
the tyr 1226/7 binds shc, and the knockdown of shc blocks the ability of erbb2 to inhibit apoptosis and mediate paclitaxel resistance. |
2010-02-01 |
2023-08-12 |
human |
| A V Lucs, W J Muller, S K Muthuswam. Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity. Oncogene. vol 29. issue 2. 2010-02-01. PMID:19826412. |
furthermore, we identify a novel function for shc as a regulator of apoptosis and drug resistance in human mammary epithelial cells transformed by erbb2. |
2010-02-01 |
2023-08-12 |
human |
| Paolo Spallarossa, Paola Altieri, Paolo Pronzato, Concetta Aloi, Giorgio Ghigliotti, Antonio Barsotti, Claudio Brunell. Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexrazoxane. The Journal of pharmacology and experimental therapeutics. vol 332. issue 1. 2010-01-26. PMID:19841470. |
data demonstrate that 1) the toxic effects of epirubicin mainly occur through nad(p)h oxidase activation; 2) the erbb2 overexpression induced by epirubicin is a redox-sensitive mechanism largely dependent on nad(p)h oxidase; 3) the loss of erbb2-related functions caused by b10 determines marginal cellular changes in untreated cells, but causes massive death by apoptosis in cells previously exposed to a prosenescent dose of epirubicin, 4) dexrazoxane promotes survival pathways, as demonstrated by the activation of akt and the pi3k-dependent erbb2 overexpression; and 5) it also prevents epirubicin-induced senescence and renders epirubicin-treated cells more resistant to treatment with b10. |
2010-01-26 |
2023-08-12 |
rat |
| Amanda K Arrington, Peter S Dahlberg, Julia Davydova, Selwyn M Vickers, Masato Yamamot. ERBB2 suppression decreases cell growth via apoptosis in gastrointestinal adenocarcinomas. Surgery. vol 146. issue 2. 2009-08-18. PMID:19628076. |
erbb2 suppression decreases cell growth via apoptosis in gastrointestinal adenocarcinomas. |
2009-08-18 |
2023-08-12 |
Not clear |
| Amanda K Arrington, Peter S Dahlberg, Julia Davydova, Selwyn M Vickers, Masato Yamamot. ERBB2 suppression decreases cell growth via apoptosis in gastrointestinal adenocarcinomas. Surgery. vol 146. issue 2. 2009-08-18. PMID:19628076. |
this study uses sirna to knockdown erbb2 in gi adenocarcinoma cell lines to evaluate cell viability, apoptosis, and changes in cell cycle. |
2009-08-18 |
2023-08-12 |
Not clear |
| M L Dos Santos, K P Gimenes, W A Silva, M A Naga. Transcriptome changes induced by docetaxel in human mammary cell lines expressing different levels of ERBB2. International journal of molecular medicine. vol 23. issue 6. 2009-07-30. PMID:19424599. |
we generated sage libraries from two human mammary cell lines expressing basal (hb4a) and high (c5.2) levels of erbb2 before and after intensive exposure to docetaxel and identified potential erbb2 target genes implicated in a variety of cellular processes including cell proliferation, cell adhesion, apoptosis and cytoskeleton organization. |
2009-07-30 |
2023-08-12 |
human |
| Valerie S Hawthorne, Wen-Chien Huang, Christopher L Neal, Ling-Min Tseng, Mien-Chie Hung, Dihua Y. ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells. Molecular cancer research : MCR. vol 7. issue 4. 2009-05-14. PMID:19372587. |
our previous work has shown that erbb2 inhibits taxol-induced apoptosis in breast cancer cells by transcriptionally up-regulating p21(cip1). |
2009-05-14 |
2023-08-12 |
human |
| Irina N Alimova, Bolin Liu, Zeying Fan, Susan M Edgerton, Thomas Dillon, Stuart E Lind, Ann D Tho. Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell cycle (Georgetown, Tex.). vol 8. issue 6. 2009-05-08. PMID:19221498. |
metformin did not induce apoptosis (as measured by dna fragmentation and parp cleavage) in luminal a, b or erbb2 subtype breast cancer cell lines. |
2009-05-08 |
2023-08-12 |
human |
| Hongyu Liu, Chuanbing Zang, Anna Emde, Maricarmen D Planas-Silva, Marleen Rosche, Andrea Kühnl, Carsten-Oliver Schulz, Elena Elstner, Kurt Possinger, Jan Eucke. Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer. European journal of pharmacology. vol 591. issue 1-3. 2008-10-15. PMID:18588872. |
the effects of honokiol might be reversely related to the expression level of human epidermal growth receptor 2, (her-2, also known as erbb2, c-erbb2) since knockdown of her-2 expression by sirna significantly enhanced the sensitivity of the her-2 over-expressed bt-474 cells to the honokiol-induced apoptosis. |
2008-10-15 |
2023-08-12 |
mouse |
| Elena Quaglino, Cristina Mastini, Guido Forni, Federica Cavall. ErbB2 transgenic mice: a tool for investigation of the immune prevention and treatment of mammary carcinomas. Current protocols in immunology. vol Chapter 20. 2008-09-22. PMID:18729063. |
erbb2 is involved in normal physiological processes, such as embryogenesis, cell proliferation, differentiation, adhesion motility, and apoptosis, while its malfunction or overexpression is responsible for development defects, diabetes, and cancer. |
2008-09-22 |
2023-08-12 |
mouse |
| E Vairaktaris, S Spyridonidou, V Papakosta, A Vylliotis, A Lazaris, D Perrea, C Yapijakis, E Patsouri. The hamster model of sequential oral oncogenesis. Oral oncology. vol 44. issue 4. 2008-09-18. PMID:18061531. |
we investigated the expression of oncogenes egfr, erbb2, erbb3, fgfr-2, fgfr-3, c-myc, n-ras, ets-1, h-ras, c-fos and c-jun, apoptosis markers bax and bcl-2, tumour suppressor genes p53 and p16, and cell proliferation marker ki-67 in the sequential stages of hamster oral oncogenesis. |
2008-09-18 |
2023-08-12 |
human |
| Toshimitsu Yamaoka, Fang Yan, Hanwei Cao, Stuart S Hobbs, Rebecca S Dise, Wei Tong, D Brent Pol. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 33. 2008-09-16. PMID:18701712. |
transactivation of egf receptor and erbb2 protects intestinal epithelial cells from tnf-induced apoptosis. |
2008-09-16 |
2023-08-12 |
mouse |
| Toshimitsu Yamaoka, Fang Yan, Hanwei Cao, Stuart S Hobbs, Rebecca S Dise, Wei Tong, D Brent Pol. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 33. 2008-09-16. PMID:18701712. |
activation of egfr, erbb2, akt, src, and apoptosis were determined in vivo and in vitro. |
2008-09-16 |
2023-08-12 |
mouse |
| Toshimitsu Yamaoka, Fang Yan, Hanwei Cao, Stuart S Hobbs, Rebecca S Dise, Wei Tong, D Brent Pol. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 33. 2008-09-16. PMID:18701712. |
tnf also activated erbb2, and loss of erbb2 expression increased tnf-induced apoptosis. |
2008-09-16 |
2023-08-12 |
mouse |
| Griselda Herrero-Martin, Abelardo López-Riva. Statins activate a mitochondria-operated pathway of apoptosis in breast tumor cells by a mechanism regulated by ErbB2 and dependent on the prenylation of proteins. FEBS letters. vol 582. issue 17. 2008-09-15. PMID:18582466. |
statins activate a mitochondria-operated pathway of apoptosis in breast tumor cells by a mechanism regulated by erbb2 and dependent on the prenylation of proteins. |
2008-09-15 |
2023-08-12 |
Not clear |
| Griselda Herrero-Martin, Abelardo López-Riva. Statins activate a mitochondria-operated pathway of apoptosis in breast tumor cells by a mechanism regulated by ErbB2 and dependent on the prenylation of proteins. FEBS letters. vol 582. issue 17. 2008-09-15. PMID:18582466. |
we have examined the role of the mitochondria-operated pathway of apoptosis in the cell death induced by statins in breast tumor cells and its regulation by protein prenylation and erbb2 overexpression. |
2008-09-15 |
2023-08-12 |
Not clear |
| Giuliana Cavalloni, Ivana Sarotto, Ymera Pignochino, Loretta Gammaitoni, Giorgia Migliardi, Luca Sgro, Wanda Piacibello, Mauro Risio, Massimo Aglietta, Francesco Leon. Granulocyte-colony stimulating factor upregulates ErbB2 expression on breast cancer cell lines and converts primary resistance to trastuzumab. Anti-cancer drugs. vol 19. issue 7. 2008-09-08. PMID:18594210. |
trastuzumab alone inhibited colony formation in soft agar but did not induce apoptosis on bc cells with no or low erbb2 genomic amplification. |
2008-09-08 |
2023-08-12 |
Not clear |