| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunzeng Zou, Li Lin, Yong Ye, Jianming Wei, Ning Zhou, Yanyan Liang, Hui Gong, Lei Li, Jian Wu, Yunbo Li, Zhenhua Jia, Yiling Wu, Jingmin Zhou, Junbo G. Qiliqiangxin inhibits the development of cardiac hypertrophy, remodeling, and dysfunction during 4 weeks of pressure overload in mice. Journal of cardiovascular pharmacology. vol 59. issue 3. 2012-07-02. PMID:22075750. |
at 4 weeks after transverse aorta constriction, although the development of cardiac dysfunction and remodeling and the increases in apoptosis, autophagy, tumor necrosis factor α/insulin-like growth factor-1, and angiotensin ii type 1 receptor expression were abrogated comparably between ql and losartan treatments, ql, but not losartan, enhanced proliferation of cardiomyocytes, which was paralleled with dowregulation of ccaat/enhancer-binding protein β, upregulation of cbp/p300-interacting transactivator with ed-rich carboxy-terminal domain 4, and increases in erbb2 and erbb4 phosphorylation. |
2012-07-02 |
2023-08-12 |
mouse |
| Yongqin Zhang, Philip E Dubé, M Kay Washington, Fang Yan, D Brent Pol. ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival. Laboratory investigation; a journal of technical methods and pathology. vol 92. issue 3. 2012-04-19. PMID:22157714. |
delayed recovery in mice with epithelial deletion of erbb2 or erbb3 was associated with increased colonic expression of tumor necrosis factor alpha and increased epithelial apoptosis. |
2012-04-19 |
2023-08-12 |
mouse |
| Wenle Xia, Zuguo Liu, Rongrong Zong, Leihua Liu, Sumin Zhao, Sarah S Bacus, Yubin Mao, Jia He, Julia D Wulfkuhle, Emanuel F Petricoin, Takuya Osada, Xiao-Yi Yang, Zachary C Hartman, Timothy M Clay, Kimberly L Blackwell, Herbert K Lyerly, Neil L Specto. Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors. Molecular cancer therapeutics. vol 10. issue 8. 2011-12-19. PMID:21673090. |
when expressed in the nuclei of lapatinib-sensitive erbb2(+) breast cancer cells, truncated erbb2 rendered cells resistant to lapatinib-induced apoptosis. |
2011-12-19 |
2023-08-12 |
Not clear |
| Attila A Seyhan, Usha Varadarajan, Sung Choe, Yan Liu, John McGraw, Matthew Woods, Stuart Murray, Amy Eckert, Wei Liu, Terence E Rya. A genome-wide RNAi screen identifies novel targets of neratinib sensitivity leading to neratinib and paclitaxel combination drug treatments. Molecular bioSystems. vol 7. issue 6. 2011-09-07. PMID:21487605. |
erbb2 is frequently activated in tumors, and influences a wide array of cellular functions, including proliferation, apoptosis, cell motility and adhesion. |
2011-09-07 |
2023-08-12 |
human |
| Ming-Chieh Shun, Weiping Yu, Sook-Kyung Park, Bob G Sanders, Kimberly Klin. Downregulation of Epidermal Growth Factor Receptor Expression Contributes to alpha-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines. Journal of oncology. vol 2010. 2011-07-14. PMID:20224651. |
ectopic overexpression and sirna knockdown studies showed that erbb2, erbb3, akt, flip and survivin are involved in alpha-tea-induce apoptosis and that alpha-tea downregulates flip and survivin via suppression of pakt, which is mediated by erbb2 and erb3. |
2011-07-14 |
2023-08-12 |
human |
| M A Khan, S Mittal, S Kumar, J Sengupta, D Ghos. Quantitative analysis of six gene products as candidate markers of early placental villi development in the human. Indian journal of physiology and pharmacology. vol 54. issue 4. 2011-06-30. PMID:21675027. |
taking together our previous array based data and the present study we conclude that a categorical balance exists between the expression of erbb2 and hdac1 genes affecting cell proliferation and differentiation in one hand, and cxcr4 and tnfrsf1a affecting chemotaxis, inflammatory response and apoptosis on the other hand. |
2011-06-30 |
2023-08-12 |
human |
| Zhigang Bai, Yingjiang Ye, Bin Liang, Feng Xu, Hui Zhang, Yanbin Zhang, Jiarou Peng, Danhua Shen, Zhirong Cui, Zhongtao Zhang, Shan Wan. Proteomics-based identification of a group of apoptosis-related proteins and biomarkers in gastric cancer. International journal of oncology. vol 38. issue 2. 2011-04-19. PMID:21165559. |
the identified proteins were functionally classified using bioinformatics methods, showing that the 9 proteins identified were related to bcl2, bax, erbb2 and casp3 proteins and involved in the process of apoptosis. |
2011-04-19 |
2023-08-12 |
Not clear |
| Irem Dogan, Ahmet Cumaoglu, Aysel Aricioglu, Abdullah Ekmekc. Inhibition of ErbB2 by herceptin reduces viability and survival, induces apoptosis and oxidative stress in Calu-3 cell line. Molecular and cellular biochemistry. vol 347. issue 1-2. 2011-03-28. PMID:20936496. |
inhibition of erbb2 by herceptin reduces viability and survival, induces apoptosis and oxidative stress in calu-3 cell line. |
2011-03-28 |
2023-08-12 |
human |
| Irem Dogan, Ahmet Cumaoglu, Aysel Aricioglu, Abdullah Ekmekc. Inhibition of ErbB2 by herceptin reduces viability and survival, induces apoptosis and oxidative stress in Calu-3 cell line. Molecular and cellular biochemistry. vol 347. issue 1-2. 2011-03-28. PMID:20936496. |
in this study, we aimed to block erbb2 signaling with herceptin and assess cytotoxicity and effects on apoptosis, oxidative stress, nuclear factor kappa-b (nf-kb), and survivin expression in calu-3 cell line. |
2011-03-28 |
2023-08-12 |
human |
| Shuanglin Xiang, Zhenhua Sun, Qiongzhi He, Feng Yan, Yijun Wang, Jian Zhan. Aspirin inhibits ErbB2 to induce apoptosis in cervical cancer cells. Medical oncology (Northwood, London, England). vol 27. issue 2. 2011-01-12. PMID:19424877. |
aspirin inhibits erbb2 to induce apoptosis in cervical cancer cells. |
2011-01-12 |
2023-08-12 |
Not clear |
| Shuanglin Xiang, Zhenhua Sun, Qiongzhi He, Feng Yan, Yijun Wang, Jian Zhan. Aspirin inhibits ErbB2 to induce apoptosis in cervical cancer cells. Medical oncology (Northwood, London, England). vol 27. issue 2. 2011-01-12. PMID:19424877. |
to further investigate the underlying mechanism by which aspirin exerts its apoptosis effects, we studied the erbb2 downstream cell survival signaling pathways and the expression of anti-apoptosis gene bcl-2. |
2011-01-12 |
2023-08-12 |
Not clear |
| Shuanglin Xiang, Zhenhua Sun, Qiongzhi He, Feng Yan, Yijun Wang, Jian Zhan. Aspirin inhibits ErbB2 to induce apoptosis in cervical cancer cells. Medical oncology (Northwood, London, England). vol 27. issue 2. 2011-01-12. PMID:19424877. |
these data reveal that aspirin significantly induces apoptosis and inhibits proliferation, which maybe via inhibiting erbb2 downstream cell survival signaling pathways. |
2011-01-12 |
2023-08-12 |
Not clear |
| L Huck, S M Pontier, D M Zuo, W J Mulle. beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 35. 2010-11-15. PMID:20713705. |
animals bearing beta1-integrin-deficient erbb2 tumors exhibited significantly reduced tumor volume, which was associated with increased tumor cell apoptosis and a reduction in tumor angiogenesis. |
2010-11-15 |
2023-08-12 |
mouse |
| Zichen Zhang, Regina A Oyesanya, Deanna J W Campbell, Jorge A Almenara, Jennifer L Dewitt, Alphonse E Siric. Preclinical assessment of simultaneous targeting of epidermal growth factor receptor (ErbB1) and ErbB2 as a strategy for cholangiocarcinoma therapy. Hepatology (Baltimore, Md.). vol 52. issue 3. 2010-10-07. PMID:20607690. |
lapatinib was an even more potent inhibitor of cholangiocarcinoma cell growth and inducer of apoptosis than either tryphostin when tested in vitro against these respective cholangiocarcinoma cell lines, regardless of differences in their levels of erbb1 or erbb2 protein expression and/or mechanism of activation. |
2010-10-07 |
2023-08-12 |
human |
| S Wang, X Huang, C-K Lee, B Li. Elevated expression of erbB3 confers paclitaxel resistance in erbB2-overexpressing breast cancer cells via upregulation of Survivin. Oncogene. vol 29. issue 29. 2010-08-27. PMID:20498641. |
consistently, knockdown of erbb3 expression with a specific short hairpin rna (shrna) in breast cancer cells with coexpression of both erbb2 and erbb3 enhances paclitaxel-induced apoptosis evidenced by increased dna fragmentation, poly (adp-ribose) polymerase (parp) cleavage and activation of caspase-3 and -8. |
2010-08-27 |
2023-08-12 |
Not clear |
| Ling Gao, Fengsheng Li, Bo Dong, Junquan Zhang, Yalan Rao, Yue Cong, Bingzhi Mao, Xiaohua Che. Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells. International journal of radiation oncology, biology, physics. vol 77. issue 4. 2010-07-27. PMID:20610043. |
inhibition of stat3 and erbb2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells. |
2010-07-27 |
2023-08-12 |
human |
| Ranjita Banerjee, Ying Huang, James P McNamee, Margarita Todorova, Bertrand J Jean-Claud. The combi-targeting concept: selective targeting of the epidermal growth factor receptor- and Her2-expressing cancer cells by the complex combi-molecule RB24. The Journal of pharmacology and experimental therapeutics. vol 334. issue 1. 2010-07-13. PMID:20348204. |
6-(3-acetoxymethyl-3-methyltriazenyl)-4-(3'-bromophenylamino)quinazoline (rb24) showed significant antiproliferative activity against human breast cancer cells, and transfection of one such cell line, mda-mb-435, with erbb1 or erbb2 (her2) dramatically enhanced cell death by apoptosis. |
2010-07-13 |
2023-08-12 |
human |
| Chia-Chien Hsieh, Blanca Hernández-Ledesma, Ben O de Lume. Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chemico-biological interactions. vol 186. issue 2. 2010-07-01. PMID:20457246. |
synergistic down-regulatory effects were observed for erbb2, akt1, pik3r1, fos and jun signaling genes, whose amplification has been reported as being responsible for breast cancer cell growth and resistance to apoptosis. |
2010-07-01 |
2023-08-12 |
human |
| Jay P Reddy, Sirisha Peddibhotla, Wen Bu, Jing Zhao, Svasti Haricharan, Yi-Chieh Nancy Du, Katrina Podsypanina, Jeffrey M Rosen, Larry A Donehower, Yi L. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 8. 2010-04-05. PMID:20133707. |
furthermore, in this somatic erbb2 tumor model, atm, and thus ddr, is required for p53 stabilization, apoptosis, and senescence. |
2010-04-05 |
2023-08-12 |
mouse |
| Kermit L Carraway, George Theodoropoulos, Goldi A Kozloski, Coralie A Carothers Carrawa. Muc4/MUC4 functions and regulation in cancer. Future oncology (London, England). vol 5. issue 10. 2010-02-24. PMID:20001800. |
muc4/muc4 can also modulate cell apoptosis via multiple mechanisms, both erbb2 dependent and independent. |
2010-02-24 |
2023-08-12 |
human |