| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maher Chaar, Jeff Kamta, Sihem Ait-Oudhi. Mechanisms, monitoring, and management of tyrosine kinase inhibitors-associated cardiovascular toxicities. OncoTargets and therapy. vol 11. 2020-10-01. PMID:30288058. |
the literature attributes these as side effects of on-target erbb2 binding leading to mitochondrial induced apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lina Li, Liping Jia, Yan Din. Upregulation of miR-375 inhibits human liver cancer cell growth by modulating cell proliferation and apoptosis via targeting ErbB2. Oncology letters. vol 16. issue 3. 2020-09-30. PMID:30127930. |
upregulation of mir-375 inhibits human liver cancer cell growth by modulating cell proliferation and apoptosis via targeting erbb2. |
2020-09-30 |
2023-08-13 |
human |
| Ying Wang, Guilin Zeng, Yicheng Jian. The Emerging Roles of miR-125b in Cancers. Cancer management and research. vol 12. 2020-09-28. PMID:32104088. |
importantly, mir-125b is involved in regulating nf-κb, p53, pi3k/akt/mtor, erbb2, wnt, and another signaling pathways, thereby controlling cell proliferation, differentiation, metabolism, apoptosis, drug resistance and tumor immunity. |
2020-09-28 |
2023-08-13 |
Not clear |
| Lu Yang, Yun Li, Arup Bhattacharya, Yuesheng Zhan. Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant. EBioMedicine. vol 2. issue 5. 2019-11-20. PMID:26086037. |
rhpepd causes erbb2 depletion, disrupts oncogenic signaling orchestrated by erbb2 homodimers and heterodimers, and induces apoptosis. |
2019-11-20 |
2023-08-13 |
mouse |
| Hongyan Yuan, Xiaoyi Wang, Jin Lu, Qiongsi Zhang, Irina Brandina, Ilya Alexandrov, Robert I Glaze. MMTV-NeuT/ATTAC mice: a new model for studying the stromal tumor microenvironment. Oncotarget. vol 9. issue 8. 2019-11-20. PMID:29487713. |
to address this question, a novel transgenic animal model was developed by crossing mmtv-neut mice containing a constitutively active erbb2 gene into the fat-attac (fat apoptosis through targeted activation of caspase 8) background, which expresses an inducible caspase 8 fusion protein targeted to mammary adipose tissue. |
2019-11-20 |
2023-08-13 |
mouse |
| YingHui Wang, Louise Pinet, Nadine Assrir, Latifa Elantak, Françoise Guerlesquin, Ali Badache, Ewen Lescop, Carine van Heijenoor. Biomolecular NMR assignments. vol 12. issue 1. 2019-05-31. PMID:28905237. |
erbb2 (or her2) is a receptor tyrosine kinase that is involved in signaling pathways controlling cell division, motility and apoptosis. |
2019-05-31 |
2023-08-13 |
Not clear |
| Na Li, Mei Han, Ning Zhou, Yong Tang, Xu-Shan Tan. MicroRNA-495 Confers Increased Sensitivity to Chemotherapeutic Agents in Gastric Cancer via the Mammalian Target of Rapamycin (mTOR) Signaling Pathway by Interacting with Human Epidermal Growth Factor Receptor 2 (ERBB2). Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-11. PMID:30147110. |
furthermore, we determined that overexpression of mir-495 and silencing of erbb2 enhanced gc cell chemosensitivity and apoptosis, but inhibited gc cell proliferation. |
2018-12-11 |
2023-08-13 |
human |
| Jun Fu, Luhua Yu, Jie Luo, Rui Huo, Bing Zh. Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NF‑κB signaling pathway. International journal of molecular medicine. vol 42. issue 3. 2018-10-29. PMID:29845222. |
paeonol induces the apoptosis of the sgc‑7901 gastric cancer cell line by downregulating erbb2 and inhibiting the nf‑κb signaling pathway. |
2018-10-29 |
2023-08-13 |
Not clear |
| Jun Fu, Luhua Yu, Jie Luo, Rui Huo, Bing Zh. Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NF‑κB signaling pathway. International journal of molecular medicine. vol 42. issue 3. 2018-10-29. PMID:29845222. |
taken together, paeonol significantly downregulated erbb2 and inhibited the activation of the nf‑κb signaling pathway, thereby inhibiting the proliferation of sgc‑7901 cells and inducing apoptosis. |
2018-10-29 |
2023-08-13 |
Not clear |
| Rastislav Tamaskovic, Martin Schwill, Gabriela Nagy-Davidescu, Christian Jost, Dagmar C Schaefer, Wouter P R Verdurmen, Jonas V Schaefer, Annemarie Honegger, Andreas Plückthu. Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS-p110 crosstalk. Nature communications. vol 7. 2018-09-11. PMID:27255951. |
applying these general principles, we developed biparatopic designed ankyrin repeat proteins (darpins) trapping erbb2 in a dimerization-incompetent state, which entail pan-erbb inhibition and a permanent off state in the oncogenic signalling, thereby triggering extensive apoptosis in erbb2-addicted tumours. |
2018-09-11 |
2023-08-13 |
Not clear |
| Rusheni Munisvaradass, Suresh Kumar, Chandramohan Govindasamy, Khalid S Alnumair, Pooi Ling Mo. Human CD3+ T-Cells with the Anti-ERBB2 Chimeric Antigen Receptor Exhibit Efficient Targeting and Induce Apoptosis in ERBB2 Overexpressing Breast Cancer Cells. International journal of molecular sciences. vol 18. issue 9. 2018-05-03. PMID:28885562. |
human cd3+ t-cells with the anti-erbb2 chimeric antigen receptor exhibit efficient targeting and induce apoptosis in erbb2 overexpressing breast cancer cells. |
2018-05-03 |
2023-08-13 |
human |
| Rusheni Munisvaradass, Suresh Kumar, Chandramohan Govindasamy, Khalid S Alnumair, Pooi Ling Mo. Human CD3+ T-Cells with the Anti-ERBB2 Chimeric Antigen Receptor Exhibit Efficient Targeting and Induce Apoptosis in ERBB2 Overexpressing Breast Cancer Cells. International journal of molecular sciences. vol 18. issue 9. 2018-05-03. PMID:28885562. |
herein, we aimed to establish car in cd3+ t-cells, isolated from human peripheral blood mononucleated cells that could subsequently target and induce apoptosis in the erbb2 overexpressing human breast cancer cell line, skbr3. |
2018-05-03 |
2023-08-13 |
human |
| Chang Li, Xiaoping Li, Shuohui Gao, Chang Li, Lianjun M. MicroRNA-133a Inhibits Proliferation of Gastric Cancer Cells by Downregulating ERBB2 Expression. Oncology research. vol 25. issue 7. 2018-04-23. PMID:28109082. |
interestingly, erbb2 silencing has a similar impact to mir-133a overexpression, in that it significantly induced apoptosis and inhibited erk and akt activation. |
2018-04-23 |
2023-08-13 |
human |
| Leilei Qi, Baotong Zhang, Shiying Zhang, Xinpei Ci, Qiao Wu, Gui Ma, Ang Luo, Liya Fu, Jamie L King, Rita Nahta, Jin-Tang Don. ERRF sensitizes ERBB2-positive breast cancer cells to lapatinib treatment likely by attenuating MCL1 and ERBB2 expression. Oncotarget. vol 8. issue 22. 2018-03-26. PMID:28415602. |
mechanistically, errf expression in resistant cells promoted lapatinib-induced apoptosis by attenuating mcl1 and erbb2 expression. |
2018-03-26 |
2023-08-13 |
Not clear |
| Lu Yang, Yun Li, Arup Bhattacharya, Yuesheng Zhan. Dual inhibition of ErbB1 and ErbB2 in cancer by recombinant human prolidase mutant hPEPD-G278D. Oncotarget. vol 7. issue 27. 2018-01-22. PMID:27286447. |
moreover, hpepd-g278d treatment of mice bearing erbb1-overexpressing tumors leads to tumor regression, which is accompanied by down regulation and decreased phosphorylation of erbb1 and erbb2 as well as decreased phosphorylation of downstream signaling molecules and activation of apoptosis in the tumor tissues. |
2018-01-22 |
2023-08-13 |
mouse |
| Ferdinando Maria Milazzo, Anna Maria Anastasi, Caterina Chiapparino, Antonio Rosi, Barbara Leoni, Loredana Vesci, Fiorella Petronzelli, Rita De Santi. AvidinOX-anchored biotinylated trastuzumab and pertuzumab induce down-modulation of ErbB2 and tumor cell death at concentrations order of magnitude lower than not-anchored antibodies. Oncotarget. vol 8. issue 14. 2017-10-13. PMID:28186982. |
by using several and diverse experimental conditions, we show that when avidinox is conjugated to tumor cells, low antibody concentrations of biotinylated trastuzumab (btrast) or pertuzumab (bpert) prevent internalization of erbb2, induce endoplasmic reticulum stress, cell cycle arrest and apoptosis leading to inhibition of proliferation and erbb2 signaling. |
2017-10-13 |
2023-08-13 |
Not clear |
| Mingjie Lu, Tongshan Wang, Mingfeng He, Wenfang Cheng, Ting Yan, Zebo Huang, Lan Zhang, Huo Zhang, Wei Zhu, Yichao Zhu, Ping Li. Tumor suppressor role of miR-3622b-5p in ERBB2-positive cancer. Oncotarget. vol 8. issue 14. 2017-09-27. PMID:28160563. |
over-expressed mir-3622b-5p reduced the protein level of erbb2, weakened the activation of mtorc1/s6, and induced the apoptosis of erbb2-positive cancer cells. |
2017-09-27 |
2023-08-13 |
human |
| Monica Benvenuto, Laura Masuelli, Enrico De Smaele, Massimo Fantini, Rosanna Mattera, Danilo Cucchi, Elena Bonanno, Enrica Di Stefano, Giovanni Vanni Frajese, Augusto Orlandi, Isabella Screpanti, Alberto Gulino, Andrea Modesti, Roberto Be. In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. Oncotarget. vol 7. issue 8. 2017-01-06. PMID:26843616. |
gdc-0449 and gant-61 exhibited the following effects: a) inhibited breast cancer cell survival; b) induced apoptosis; c) inhibited hh pathway activity by decreasing the mrna expression levels of gli1 and ptch and inhibiting the nuclear translocation of gli1; d) increased/decreased egfr and erbb2 protein expression, reduced p21-ras and erk1/erk2 mapk activities and inhibited akt activation; and e) decreased the nuclear translocation of nf-κb. |
2017-01-06 |
2023-08-13 |
mouse |
| Xin-Zheng Wang, Ya-Kai Hang, Jin-Biao Liu, Yong-Qiang Hou, Ning Wang, Ming-Jun Wan. Over-expression of microRNA-375 inhibits papillary thyroid carcinoma cell proliferation and induces cell apoptosis by targeting ERBB2. Journal of pharmacological sciences. vol 130. issue 2. 2016-12-13. PMID:26806295. |
over-expression of microrna-375 inhibits papillary thyroid carcinoma cell proliferation and induces cell apoptosis by targeting erbb2. |
2016-12-13 |
2023-08-13 |
human |
| Ibrahim F Benter, Fatima Sarkhou, Abeer T Al-Khaldi, Bindu Chandrasekhar, Sreeja Attur, Gursev S Dhaunsi, Mariam H M Yousif, Saghir Akhta. The dual targeting of EGFR and ErbB2 with the inhibitor Lapatinib corrects high glucose-induced apoptosis and vascular dysfunction by opposing multiple diabetes-induced signaling changes. Journal of drug targeting. vol 23. issue 6. 2016-04-25. PMID:26114862. |
the dual targeting of egfr and erbb2 with the inhibitor lapatinib corrects high glucose-induced apoptosis and vascular dysfunction by opposing multiple diabetes-induced signaling changes. |
2016-04-25 |
2023-08-13 |
rat |