| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Srinivas Venkateswarlu, Dawn M Dawson, Patricia St Clair, Anjana Gupta, James K V Willson, Michael G Brattai. Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells. Oncogene. vol 21. issue 1. 2002-02-19. PMID:11791178. |
the aim of this study was to determine whether constitutive erbb2 activation controls growth and apoptosis in colon cancer cells. |
2002-02-19 |
2023-08-12 |
Not clear |
| Srinivas Venkateswarlu, Dawn M Dawson, Patricia St Clair, Anjana Gupta, James K V Willson, Michael G Brattai. Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells. Oncogene. vol 21. issue 1. 2002-02-19. PMID:11791178. |
heregulin neutralizing antibody treatment of growth arrested geo cells also generated apoptosis as reflected by parp cleavage and dna fragmentation indicating a cell survival signal was also induced by the constitutively activated erbb2. |
2002-02-19 |
2023-08-12 |
Not clear |
| D Y. Mechanisms of ErbB2-mediated paclitaxel resistance and trastuzumab-mediated paclitaxel sensitization in ErbB2-overexpressing breast cancers. Seminars in oncology. vol 28. issue 5 Suppl 16. 2001-12-28. PMID:11706391. |
one of the molecular mechanisms of erbb2-mediated paclitaxel resistance is that overexpression of the erbb2 receptor leads to deregulation of the g2/m cell cycle check-point that inhibits paclitaxel-induced apoptosis. |
2001-12-28 |
2023-08-12 |
Not clear |
| S Ginath, J Menczer, Y Friedmann, H Aingorn, A Aviv, K Tajima, A Dantes, M Glezerman, I Vlodavsky, A Amsterda. Expression of heparanase, Mdm2, and erbB2 in ovarian cancer. International journal of oncology. vol 18. issue 6. 2001-07-26. PMID:11351242. |
histologically confirmed malignant ovarian tissue from ten women and tissue from 2 benign ovarian tumors and 4 normal ovaries were assessed for heparanase presence, activity and localization, incidence of apoptosis and expression of the oncogenes erbb2 and mdm2. |
2001-07-26 |
2023-08-12 |
Not clear |
| J W Davis, F T Lauer, A D Burdick, L G Hudson, S W Burchie. Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production. Cancer research. vol 61. issue 8. 2001-05-10. PMID:11309286. |
these effects were specific for an egfr-mediated pathway because cotreatment with ag825, an erbb2 inhibitor, had little effect on apoptosis. |
2001-05-10 |
2023-08-12 |
human |
| K M Darcy, D Zangani, A L Wohlhueter, R Y Huang, M M Vaughan, J A Russell, M M I. Changes in ErbB2 (her-2/neu), ErbB3, and ErbB4 during growth, differentiation, and apoptosis of normal rat mammary epithelial cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 48. issue 1. 2000-02-10. PMID:10653587. |
changes in erbb2 (her-2/neu), erbb3, and erbb4 during growth, differentiation, and apoptosis of normal rat mammary epithelial cells. |
2000-02-10 |
2023-08-12 |
rat |
| J M Daly, M A Olayioye, A M Wong, R Neve, H A Lane, F G Maurer, N E Hyne. NDF/heregulin-induced cell cycle changes and apoptosis in breast tumour cells: role of PI3 kinase and p38 MAP kinase pathways. Oncogene. vol 18. issue 23. 1999-06-30. PMID:10376522. |
g1 progression was associated with erbb2 transactivation of erbb3 and subsequent stimulation of the phosphatidylinositol 3-kinase (pi3k) pathway whereas apoptosis was dependent on p38 mapk. |
1999-06-30 |
2023-08-12 |
Not clear |
| D Yu, T Jing, B Liu, J Yao, M Tan, T J McDonnell, M C Hun. Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. Molecular cell. vol 2. issue 5. 1998-12-24. PMID:9844631. |
overexpression of erbb2 blocks taxol-induced apoptosis by upregulation of p21cip1, which inhibits p34cdc2 kinase. |
1998-12-24 |
2023-08-12 |
Not clear |
| J Grim, J Deshane, G P Siegal, R D Alvarez, P DiFiore, D T Curie. The level of erbB2 expression predicts sensitivity to the cytotoxic effects of an intracellular anti-erbB2 sFv. Journal of molecular medicine (Berlin, Germany). vol 76. issue 6. 1998-08-13. PMID:9625302. |
transient cotransfection of erbb2 mutant and chimeric molecules demonstrated that the cytoplasmic domain of erbb2, or the homologous cytoplasmic domain of the epidermal growth factor receptor, is required for apoptosis induction. |
1998-08-13 |
2023-08-12 |
Not clear |
| J Grim, J Deshane, G P Siegal, R D Alvarez, P DiFiore, D T Curie. The level of erbB2 expression predicts sensitivity to the cytotoxic effects of an intracellular anti-erbB2 sFv. Journal of molecular medicine (Berlin, Germany). vol 76. issue 6. 1998-08-13. PMID:9625302. |
in summary, the results presented here indicate that the carboxy-terminus of the intracellular domain of the erbb2 molecule is involved in the induction of apoptosis. |
1998-08-13 |
2023-08-12 |
Not clear |
| J M Daly, C B Jannot, R R Beerli, D Graus-Porta, F G Maurer, N E Hyne. Neu differentiation factor induces ErbB2 down-regulation and apoptosis of ErbB2-overexpressing breast tumor cells. Cancer research. vol 57. issue 17. 1997-09-24. PMID:9288791. |
neu differentiation factor induces erbb2 down-regulation and apoptosis of erbb2-overexpressing breast tumor cells. |
1997-09-24 |
2023-08-12 |
Not clear |
| J M Daly, C B Jannot, R R Beerli, D Graus-Porta, F G Maurer, N E Hyne. Neu differentiation factor induces ErbB2 down-regulation and apoptosis of ErbB2-overexpressing breast tumor cells. Cancer research. vol 57. issue 17. 1997-09-24. PMID:9288791. |
the results demonstrate for the first time that ndf induces apoptosis of tumor cells overexpressing erbb2. |
1997-09-24 |
2023-08-12 |
Not clear |