| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karin Söderlund, Gizeh Pérez-Tenorio, Olle Stå. Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells. International journal of oncology. vol 26. issue 1. 2005-05-02. PMID:15586221. |
the hypothesis of this study was that erbb2 confers resistance to radiation-induced apoptosis in breast cancer cells through the phosphatidylinositol 3-kinase (pi3-k)/akt signalling pathway. |
2005-05-02 |
2023-08-12 |
human |
| Xiu-Fang Wang, Paul K Witting, Brian A Salvatore, Jiri Neuzi. Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway. Biochemical and biophysical research communications. vol 326. issue 2. 2005-01-18. PMID:15582575. |
we conclude that alpha-tos causes efficient apoptosis in breast cancer cells independent of their erbb2 status. |
2005-01-18 |
2023-08-12 |
Not clear |
| Ryuji Fukazawa, Thomas A Miller, Yukio Kuramochi, Stefan Frantz, Young Dae Kim, Mark A Marchionni, Ralph A Kelly, Douglas B Sawye. Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt. Journal of molecular and cellular cardiology. vol 35. issue 12. 2004-07-30. PMID:14654373. |
treatment with the erbb2 antibody had no effect on anthracycline-induced apoptosis. |
2004-07-30 |
2023-08-12 |
rat |
| Wentao Yang, Kristine S Klos, Xiaoyan Zhou, Jun Yao, Ying Yang, Terry L Smith, Daren Shi, Dihua Y. ErbB2 overexpression in human breast carcinoma is correlated with p21Cip1 up-regulation and tyrosine-15 hyperphosphorylation of p34Cdc2: poor responsiveness to chemotherapy with cyclophoshamide methotrexate, and 5-fluorouracil is associated with Erb2 overexpression and with p21Cip1 overexpression. Cancer. vol 98. issue 6. 2003-09-30. PMID:12973835. |
the underlying molecular mechanism is that erbb2 inhibits p34(cdc2) activation, which is required for taxol-induced apoptosis, by up-regulating p21(cip1) and by hyperphosphorylating p34(cdc2) on tyrosine-15. |
2003-09-30 |
2023-08-12 |
human |
| E Gabriella Barbacci, Leslie R Pustilnik, Ann Marie K Rossi, Erling Emerson, Penny E Miller, Brian P Boscoe, Eric D Cox, Kenneth K Iwata, Jitesh P Jani, Kathleen Provoncha, John C Kath, Zhengyu Liu, James D Moye. The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells. Cancer research. vol 63. issue 15. 2003-09-23. PMID:12907618. |
apoptosis is triggered in both skbr3 and another high erbb2-expressing cell line, bt474, by exposure to 1 micro m cp-654577, but this effect is not observed in mcf7 cells that express low erbb2. |
2003-09-23 |
2023-08-12 |
mouse |
| M Castedo, J-L Perfettini, T Roumier, G Kroeme. Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell death and differentiation. vol 9. issue 12. 2003-07-30. PMID:12478465. |
this applies to several clinically important settings, for instance to paclitaxel-induced killing of breast cancer cells, in which the erbb2 receptor kinase can mediate apoptosis inhibition through inactivation of cdk1. |
2003-07-30 |
2023-08-12 |
Not clear |
| Davina A Lewis, Steven A Hurwitz, Dan F Spanda. UVB-induced apoptosis in normal human keratinocytes: role of the erbB receptor family. Experimental cell research. vol 284. issue 2. 2003-06-16. PMID:12651163. |
furthermore, the inhibition of uvb-induced apoptosis could also be observed using neutralizing antibodies to either erbb1 or erbb2. |
2003-06-16 |
2023-08-12 |
human |
| Yan Ping Hu, Bushra Haq, Kermit L Carraway, Niramol Savaraj, Theodore J Lampidi. Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma cells. Biochemical pharmacology. vol 65. issue 9. 2003-06-16. PMID:12732353. |
due to the size, glycosylation, and location in the plasma membrane of the sialomucin complex muc4, which has been implicated in erbb2 signaling, in the repression of apoptosis and cell adhesion, and in tumor metastasis, studies were initiated to determine whether its presence could influence cell sensitivity to anticancer drugs. |
2003-06-16 |
2023-08-12 |
human |
| Sangkyou Lee, Wentao Yang, Keng-Hsueh Lan, Shankar Sellappan, Kristine Klos, Gabriel Hortobagyi, Mien-Chie Hung, Dihua Y. Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells. Cancer research. vol 62. issue 20. 2002-11-29. PMID:12384528. |
because activation of p34(cdc2) is required for taxol-induced apoptosis and because overexpression of erbb2 blocks taxol-induced apoptosis by inhibiting p34(cdc2) activation, we studied the effect of herceptin treatment on p34(cdc2) kinase activation and apoptosis in taxol-treated human breast carcinoma cell lines mda-mb-435, skbr3, mda-mb-453, and 435.eb, which is an erbb2 transfectant of mda-mb-435. |
2002-11-29 |
2023-08-12 |
human |
| Jayanta Debnath, Kenna R Mills, Nicole L Collins, Mauricio J Reginato, Senthil K Muthuswamy, Joan S Brugg. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell. vol 111. issue 1. 2002-11-19. PMID:12372298. |
however, the lumen is filled when oncogenes that enhance proliferation are coexpressed with those that inhibit apoptosis, or when erbb2, which induces both activities, is activated by homodimerization. |
2002-11-19 |
2023-08-12 |
Not clear |
| Wenle Xia, Robert J Mullin, Barry R Keith, Lei-Hua Liu, Hong Ma, David W Rusnak, Gary Owens, Krystal J Alligood, Neil L Specto. Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. Oncogene. vol 21. issue 41. 2002-09-19. PMID:12214266. |
here we show that a small molecule, gw572016, potently inhibits both egfr and erbb2 tyrosine kinases leading to growth arrest and/or apoptosis in egfr and erbb2-dependent tumor cell lines. |
2002-09-19 |
2023-08-12 |
human |
| Wenle Xia, Robert J Mullin, Barry R Keith, Lei-Hua Liu, Hong Ma, David W Rusnak, Gary Owens, Krystal J Alligood, Neil L Specto. Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. Oncogene. vol 21. issue 41. 2002-09-19. PMID:12214266. |
complete inhibition of activated akt in erbb2 overexpressing cells correlated with a 23-fold increase in apoptosis compared with vehicle controls. |
2002-09-19 |
2023-08-12 |
human |
| Eran R Andrechek, William R Hardy, Adele A Girgis-Gabardo, Robert L S Perry, Richard Butler, Frank L Graham, Ronald C Kahn, Michael A Rudnicki, William J Mulle. ErbB2 is required for muscle spindle and myoblast cell survival. Molecular and cellular biology. vol 22. issue 13. 2002-07-18. PMID:12052879. |
consistent with these observations, primary myoblasts lacking erbb2 exhibit extensive apoptosis upon differentiation into myofibers. |
2002-07-18 |
2023-08-12 |
mouse |
| Ming Tan, Tong Jing, Keng-Hsueh Lan, Christopher L Neal, Ping Li, Sangkyou Lee, Dexing Fang, Yoichi Nagata, Jiaxin Liu, Ralph Arlinghaus, Mien-Chie Hung, Dihua Y. Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. Molecular cell. vol 9. issue 5. 2002-07-03. PMID:12049736. |
phosphorylation on tyrosine-15 of p34(cdc2) by erbb2 inhibits p34(cdc2) activation and is involved in resistance to taxol-induced apoptosis. |
2002-07-03 |
2023-08-12 |
Not clear |
| Ming Tan, Tong Jing, Keng-Hsueh Lan, Christopher L Neal, Ping Li, Sangkyou Lee, Dexing Fang, Yoichi Nagata, Jiaxin Liu, Ralph Arlinghaus, Mien-Chie Hung, Dihua Y. Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. Molecular cell. vol 9. issue 5. 2002-07-03. PMID:12049736. |
erbb2 overexpression confers resistance to taxol-induced apoptosis by inhibiting p34(cdc2) activation. |
2002-07-03 |
2023-08-12 |
Not clear |
| Ming Tan, Tong Jing, Keng-Hsueh Lan, Christopher L Neal, Ping Li, Sangkyou Lee, Dexing Fang, Yoichi Nagata, Jiaxin Liu, Ralph Arlinghaus, Mien-Chie Hung, Dihua Y. Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. Molecular cell. vol 9. issue 5. 2002-07-03. PMID:12049736. |
thus, erbb2 membrane rtk can confer resistance to taxol-induced apoptosis by directly phosphorylating cdc2. |
2002-07-03 |
2023-08-12 |
Not clear |
| J A Kelle. Raloxifene. Current drug targets. vol 2. issue 4. 2002-05-24. PMID:11732640. |
this is a reductionist simplification, since their effect varies and ranges from interaction with lipid transduction cascades, covalent binding to proteins and dna, regulation of growth factors, erbb2, mdr1 and probably p53 expression, complexing with e-cadherin/catenin to active induction of apoptosis and many other effects on the genome. |
2002-05-24 |
2023-08-12 |
Not clear |
| Srinivas Venkateswarlu, Dawn M Dawson, Patricia St Clair, Anjana Gupta, James K V Willson, Michael G Brattai. Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells. Oncogene. vol 21. issue 1. 2002-02-19. PMID:11791178. |
the aim of this study was to determine whether constitutive erbb2 activation controls growth and apoptosis in colon cancer cells. |
2002-02-19 |
2023-08-12 |
Not clear |
| Srinivas Venkateswarlu, Dawn M Dawson, Patricia St Clair, Anjana Gupta, James K V Willson, Michael G Brattai. Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells. Oncogene. vol 21. issue 1. 2002-02-19. PMID:11791178. |
heregulin neutralizing antibody treatment of growth arrested geo cells also generated apoptosis as reflected by parp cleavage and dna fragmentation indicating a cell survival signal was also induced by the constitutively activated erbb2. |
2002-02-19 |
2023-08-12 |
Not clear |
| D Y. Mechanisms of ErbB2-mediated paclitaxel resistance and trastuzumab-mediated paclitaxel sensitization in ErbB2-overexpressing breast cancers. Seminars in oncology. vol 28. issue 5 Suppl 16. 2001-12-28. PMID:11706391. |
one of the molecular mechanisms of erbb2-mediated paclitaxel resistance is that overexpression of the erbb2 receptor leads to deregulation of the g2/m cell cycle check-point that inhibits paclitaxel-induced apoptosis. |
2001-12-28 |
2023-08-12 |
Not clear |